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Items: 1 to 50 of 160

1.

Comparison of proteomic quantification approaches for hepatic drug transporters: multiplexed global quantitation correlates with targeted proteomic quantitation.

Vildhede A, Nguyen C, Erickson BK, Kunz RC, Jones R, Kimoto E, Bourbonais F, Rodrigues AD, Varma MV.

Drug Metab Dispos. 2018 Feb 8. pii: dmd.117.079285. doi: 10.1124/dmd.117.079285. [Epub ahead of print]

PMID:
29439128
2.

Role of Hepatic Organic Anion Transporter 2 in the Pharmacokinetics of R- and S-Warfarin: In Vitro Studies and Mechanistic Evaluation.

Bi YA, Lin J, Mathialagan S, Tylaska L, Callegari E, Rodrigues AD, Varma MVS.

Mol Pharm. 2018 Feb 20. doi: 10.1021/acs.molpharmaceut.7b01108. [Epub ahead of print]

PMID:
29433307
3.

Impacts of estrus expression and intensity during a timed-AI protocol on variables associated with fertility and pregnancy success in Bos indicus-influenced beef cows.

Rodrigues AD, Cooke RF, Cipriano RS, Silva LGT, Cerri RLA, Cruppe LH, Meneghetti M, Pohler KG, Vasconcelos JLM.

J Anim Sci. 2018 Feb 15;96(1):236-249. doi: 10.1093/jas/skx043.

PMID:
29408965
4.

Organic Anion Transporter 2 Mediates Hepatic Uptake of Tolbutamide, a CYP2C9 Probe Drug.

Bi YA, Mathialagan S, Tylaska L, Fu M, Keefer J, Vildhede A, Costales C, Rodrigues AD, Varma MVS.

J Pharmacol Exp Ther. 2018 Mar;364(3):390-398. doi: 10.1124/jpet.117.245951. Epub 2018 Jan 11.

5.

A highly selective and sensitive LC-MS/HRMS assay for quantifying coproporphyrins as organic anion-transporting peptide biomarkers.

Ramanathan R, King-Ahmad AJ, Holliman CL, Rodrigues AD.

Bioanalysis. 2017 Nov;9(22):1787-1806. doi: 10.4155/bio-2017-0181. Epub 2017 Oct 5.

PMID:
28978230
6.

Impact of a timed-release FSH treatment from 2 to 6 months of age in bulls I: Endocrine and testicular development of beef bulls.

Harstine BR, Cruppe LH, Abreu FM, Rodrigues AD, Premanandan C, DeJarnette JM, Day ML.

Theriogenology. 2018 Jan 1;105:142-149. doi: 10.1016/j.theriogenology.2017.09.018. Epub 2017 Sep 21.

PMID:
28965026
7.

Impact of a timed-release FSH treatment from 2 to 6 months of age in bulls II: Endocrinology, puberty attainment, and mature sperm production in Holstein bulls.

Harstine BR, Cruppe LH, Abreu FM, Rodrigues AD, DeJarnette JM, Day ML.

Theriogenology. 2018 Jan 1;105:135-141. doi: 10.1016/j.theriogenology.2017.09.019. Epub 2017 Sep 21.

PMID:
28965025
8.

In vitro studies with two human organic anion transporters: OAT2 and OAT7.

Mathialagan S, Costales C, Tylaska L, Kimoto E, Vildhede A, Johnson J, Johnson N, Sarashina T, Hashizume K, Isringhausen CD, Vermeer LMM, Wolff AR, Rodrigues AD.

Xenobiotica. 2017 Oct 13:1-13. doi: 10.1080/00498254.2017.1384595. [Epub ahead of print]

PMID:
28945155
9.

Horticulture in Portugal 1850-1900: The role of science and public utility in shaping knowledge.

Rodrigues AD, Simões A.

Ann Sci. 2017 Jul;74(3):192-213. doi: 10.1080/00033790.2017.1357083. Epub 2017 Aug 7.

PMID:
28782460
10.

A recurrent synonymous mutation in the human androgen receptor gene causing complete androgen insensitivity syndrome.

Batista RL, Rodrigues ADS, Nishi MY, Gomes NL, Faria JAD Junior, Moraes DR, Carvalho LR, Costa EMF, Domenice S, Mendonca BB.

J Steroid Biochem Mol Biol. 2017 Nov;174:14-16. doi: 10.1016/j.jsbmb.2017.07.020. Epub 2017 Jul 22.

PMID:
28743543
11.

Endogenous Probes for Drug Transporters: Balancing Vision With Reality.

Rodrigues AD, Taskar KS, Kusuhara H, Sugiyama Y.

Clin Pharmacol Ther. 2018 Mar;103(3):434-448. doi: 10.1002/cpt.749. Epub 2017 Jul 14. Review.

PMID:
28560712
12.

Correction to Evaluating the Role of Multidrug Resistance Protein 3 (MDR3) Inhibition in Predicting Drug-Induced Liver Injury Using 125 Pharmaceuticals.

Aleo MD, Shah F, He K, Bonin PD, Rodrigues AD.

Chem Res Toxicol. 2017 Jun 19;30(6):1365. doi: 10.1021/acs.chemrestox.7b00124. Epub 2017 May 18. No abstract available.

PMID:
28520417
13.

Evaluating the Role of Multidrug Resistance Protein 3 (MDR3) Inhibition in Predicting Drug-Induced Liver Injury Using 125 Pharmaceuticals.

Aleo MD, Shah F, He K, Bonin PD, Rodrigues AD.

Chem Res Toxicol. 2017 May 15;30(5):1219-1229. doi: 10.1021/acs.chemrestox.7b00048. Epub 2017 May 4.

PMID:
28437613
14.

Evaluation of Renal Transporter Inhibition Using Creatinine as a Substrate In Vitro to Assess the Clinical Risk of Elevated Serum Creatinine.

Mathialagan S, Rodrigues AD, Feng B.

J Pharm Sci. 2017 Sep;106(9):2535-2541. doi: 10.1016/j.xphs.2017.04.009. Epub 2017 Apr 14.

PMID:
28416419
15.

Leveraging of Rifampicin-Dosed Cynomolgus Monkeys to Identify Bile Acid 3-O-Sulfate Conjugates as Potential Novel Biomarkers for Organic Anion-Transporting Polypeptides.

Thakare R, Gao H, Kosa RE, Bi YA, Varma MVS, Cerny MA, Sharma R, Kuhn M, Huang B, Liu Y, Yu A, Walker GS, Niosi M, Tremaine L, Alnouti Y, Rodrigues AD.

Drug Metab Dispos. 2017 Jul;45(7):721-733. doi: 10.1124/dmd.117.075275. Epub 2017 Apr 10.

PMID:
28396527
16.

Erratum to: Reliable Rate Measurements for Active and Passive Hepatic Uptake Using Plated Human Hepatocytes.

Bi YA, Scialis RJ, Lazzaro S, Mathialagan S, Kimoto E, Keefer J, Zhang H, Vildhede AM, Costales C, Rodrigues AD, Tremaine LM, Varma MVS.

AAPS J. 2017 May;19(3):882. doi: 10.1208/s12248-017-0061-0. No abstract available.

PMID:
28233243
17.

Reliable Rate Measurements for Active and Passive Hepatic Uptake Using Plated Human Hepatocytes.

Bi YA, Scialis RJ, Lazzaro S, Mathialagan S, Kimoto E, Keefer J, Zhang H, Vildhede AM, Costales C, Rodrigues AD, Tremaine LM, Varma MVS.

AAPS J. 2017 May;19(3):787-796. doi: 10.1208/s12248-017-0051-2. Epub 2017 Feb 10. Erratum in: AAPS J. 2017 May;19(3):882.

PMID:
28188574
18.

Mid-Atlantic elasmobranchs: Suitable metal scouts?

Torres P, Tristão da Cunha R, Rodrigues ADS.

Mar Pollut Bull. 2017 Apr 15;117(1-2):203-213. doi: 10.1016/j.marpolbul.2017.01.058. Epub 2017 Feb 5.

PMID:
28179057
19.

Discovery of Highly Potent Liver X Receptor β Agonists.

Kick EK, Busch BB, Martin R, Stevens WC, Bollu V, Xie Y, Boren BC, Nyman MC, Nanao MH, Nguyen L, Plonowski A, Schulman IG, Yan G, Zhang H, Hou X, Valente MN, Narayanan R, Behnia K, Rodrigues AD, Brock B, Smalley J, Cantor GH, Lupisella J, Sleph P, Grimm D, Ostrowski J, Wexler RR, Kirchgessner T, Mohan R.

ACS Med Chem Lett. 2016 Oct 23;7(12):1207-1212. eCollection 2016 Dec 8.

20.

Extended Clearance Classification System (ECCS) informed approach for evaluating investigational drugs as substrates of drug transporters.

Varma MV, El-Kattan AF, Feng B, Steyn SJ, Maurer TS, Scott DO, Rodrigues AD, Tremaine LM.

Clin Pharmacol Ther. 2016 Dec 16. doi: 10.1002/cpt.595. [Epub ahead of print] No abstract available.

PMID:
27984654
21.

Post-artificial insemination supplementation with calcium salts of soybean oil influences pregnancy establishment factors in beef cows.

Cipriano RS, Cooke RF, Rodrigues AD, Silva LG, Bohnert DW, Marques RS, Vasconcelos JL, Pires AV, Cerri RL.

J Anim Sci. 2016 Nov;94(11):4892-4902. doi: 10.2527/jas.2016-0916.

PMID:
27898968
22.

Organic Anion Transporter 2: An Enigmatic Human Solute Carrier.

Shen H, Lai Y, Rodrigues AD.

Drug Metab Dispos. 2017 Feb;45(2):228-236. doi: 10.1124/dmd.116.072264. Epub 2016 Nov 21. Review.

23.

Inhibition of Hepatobiliary Transport Activity by the Antibacterial Agent Fusidic Acid: Insights into Factors Contributing to Conjugated Hyperbilirubinemia/Cholestasis.

Lapham K, Novak J, Marroquin LD, Swiss R, Qin S, Strock CJ, Scialis R, Aleo MD, Schroeter T, Eng H, Rodrigues AD, Kalgutkar AS.

Chem Res Toxicol. 2016 Oct 4. [Epub ahead of print]

PMID:
27676153
24.

Molecular Identification and Traceability of Illegal Trading in Lignobrycon myersi (Teleostei: Characiformes), a Threatened Brazilian Fish Species, Using DNA Barcode.

Rodrigues AD, Brandão JH, Bitencourt JA, Jucá-Chagas R, Sampaio I, Schneider H, Affonso PR.

ScientificWorldJournal. 2016;2016:9382613. Epub 2016 Sep 7.

25.

Optical and transport properties correlation driven by amorphous/crystalline disorder in InP nanowires.

Kamimura H, Gouveia RC, Carrocine SC, Souza LD, Rodrigues AD, Teodoro MD, Marques GE, Leite ER, Chiquito AJ.

J Phys Condens Matter. 2016 Nov 30;28(47):475303. doi: 10.1088/0953-8984/28/47/475303. Epub 2016 Sep 23.

PMID:
27662434
26.

Transporter-Mediated Hepatic Uptake Plays an Important Role in the Pharmacokinetics and Drug-Drug Interactions of Montelukast.

Varma MV, Kimoto E, Scialis R, Bi Y, Lin J, Eng H, Kalgutkar AS, El-Kattan AF, Rodrigues AD, Tremaine LM.

Clin Pharmacol Ther. 2017 Mar;101(3):406-415. doi: 10.1002/cpt.520. Epub 2016 Nov 18.

PMID:
27648490
27.

Bioaccumulation of metals and PCBs in Raja clavata.

Torres P, Tristão da Cunha R, Micaelo C, Rodrigues AD.

Sci Total Environ. 2016 Dec 15;573:1021-1030. doi: 10.1016/j.scitotenv.2016.08.187. Epub 2016 Sep 5.

PMID:
27607905
28.

Comprehensive evaluation of liver microsomal cytochrome P450 3A (CYP3A) inhibition: comparison of cynomolgus monkey and human.

Haarhoff ZE, Kramer MA, Zvyaga TA, Zhang J, Bhutani P, Subramanian M, Rodrigues AD.

Xenobiotica. 2017 Jun;47(6):470-478. doi: 10.1080/00498254.2016.1203042. Epub 2016 Aug 8.

PMID:
27498589
29.

Sensitivity of two biomarkers for biomonitoring exposure to fluoride in children and women: A study in a volcanic area.

Linhares DPS, Garcia PV, Amaral L, Ferreira T, Cury JA, Vieira W, Rodrigues ADS.

Chemosphere. 2016 Jul;155:614-620. doi: 10.1016/j.chemosphere.2016.04.092. Epub 2016 May 5.

PMID:
27155929
30.

Effects of different supplemental soya bean oil levels on the performance of prepubertal Saanen goats: Oestrogen and progesterone release.

Bomfim GF, Merighe GK, de Oliveira SA, Rodrigues AD, Augusto L, Teixeira IA, de Resende KT, Negrao JA.

J Anim Physiol Anim Nutr (Berl). 2016 Dec;100(6):1097-1103. doi: 10.1111/jpn.12486. Epub 2016 Feb 22.

PMID:
26898245
31.

Diclofenac and Its Acyl Glucuronide: Determination of In Vivo Exposure in Human Subjects and Characterization as Human Drug Transporter Substrates In Vitro.

Zhang Y, Han YH, Putluru SP, Matta MK, Kole P, Mandlekar S, Furlong MT, Liu T, Iyer RA, Marathe P, Yang Z, Lai Y, Rodrigues AD.

Drug Metab Dispos. 2016 Mar;44(3):320-8. doi: 10.1124/dmd.115.066944. Epub 2015 Dec 29.

32.

Cynomolgus Monkey as a Clinically Relevant Model to Study Transport Involving Renal Organic Cation Transporters: In Vitro and In Vivo Evaluation.

Shen H, Liu T, Jiang H, Titsch C, Taylor K, Kandoussi H, Qiu X, Chen C, Sukrutharaj S, Kuit K, Mintier G, Krishnamurthy P, Fancher RM, Zeng J, Rodrigues AD, Marathe P, Lai Y.

Drug Metab Dispos. 2016 Feb;44(2):238-49. doi: 10.1124/dmd.115.066852. Epub 2015 Nov 25.

33.

Vascular trauma in the Amazon - the challenge of great distances.

Góes Junior AM, Rodrigues AD, Braga FB, de Andrade MC, Abib Sde C.

Rev Col Bras Cir. 2015 Jul-Aug;42(4):244-52. doi: 10.1590/0100-69912015004009. English, Portuguese.

34.

Integrated Pharmacokinetic/Pharmacodynamic Analysis for Determining the Minimal Anticipated Biological Effect Level of a Novel Anti-CD28 Receptor Antagonist BMS-931699.

Yang Z, Wang H, Salcedo TW, Suchard SJ, Xie JH, Schneeweis LA, Fleener CA, Calore JD, Shi R, Zhang SX, Rodrigues AD, Car BD, Marathe PH, Nadler SG.

J Pharmacol Exp Ther. 2015 Dec;355(3):506-15. doi: 10.1124/jpet.115.227249. Epub 2015 Oct 6.

35.

Setting Clinical Exposure Levels of Concern for Drug-Induced Liver Injury (DILI) Using Mechanistic in vitro Assays.

Shah F, Leung L, Barton HA, Will Y, Rodrigues AD, Greene N, Aleo MD.

Toxicol Sci. 2015 Oct;147(2):500-14. doi: 10.1093/toxsci/kfv152. Epub 2015 Jul 23.

PMID:
26206150
36.

[Dietary patterns in menopausal women receiving outpatient care in Southern Brazil].

Hoffmann M, Mendes KG, Canuto R, Garcez Ada S, Theodoro H, Rodrigues AD, Olinto MT.

Cien Saude Colet. 2015 May;20(5):1565-74. doi: 10.1590/1413-81232015205.07942014. Portuguese.

37.

Quantitative Rationalization of Gemfibrozil Drug Interactions: Consideration of Transporters-Enzyme Interplay and the Role of Circulating Metabolite Gemfibrozil 1-O-β-Glucuronide.

Varma MV, Lin J, Bi YA, Kimoto E, Rodrigues AD.

Drug Metab Dispos. 2015 Jul;43(7):1108-18. doi: 10.1124/dmd.115.064303. Epub 2015 May 4.

38.

Evaluation of rosuvastatin as an organic anion transporting polypeptide (OATP) probe substrate: in vitro transport and in vivo disposition in cynomolgus monkeys.

Shen H, Su H, Liu T, Yao M, Mintier G, Li L, Fancher RM, Iyer R, Marathe P, Lai Y, Rodrigues AD.

J Pharmacol Exp Ther. 2015 May;353(2):380-91. doi: 10.1124/jpet.114.221804. Epub 2015 Mar 4.

39.

Organic anion transporting polypeptide-mediated transport of, and inhibition by, asunaprevir, an inhibitor of hepatitis C virus NS3 protease.

Eley T, Han YH, Huang SP, He B, Li W, Bedford W, Stonier M, Gardiner D, Sims K, Rodrigues AD, Bertz RJ.

Clin Pharmacol Ther. 2015 Feb;97(2):159-66. doi: 10.1002/cpt.4. Epub 2014 Dec 20.

PMID:
25670521
40.

Effect of interval from induction of puberty to initiation of a timed AI protocol on pregnancy rate in Nellore heifers.

Rodrigues AD, Peres RF, Lemes AP, Martins T, Pereira MH, Carvalho ER, Day ML, Vasconcelos JL.

Theriogenology. 2014 Sep 15;82(5):760-6. doi: 10.1016/j.theriogenology.2014.06.008. Epub 2014 Jun 19.

PMID:
25034515
41.

Congenital adrenal hyperplasia, ovarian failure and Ehlers-Danlos syndrome due to a 6p deletion.

Moysés-Oliveira M, Mancini TI, Takeno SS, Rodrigues AD, Bachega TA, Bertola D, Melaragno MI.

Sex Dev. 2014;8(4):139-45. doi: 10.1159/000363779. Epub 2014 Jun 26.

PMID:
24970489
42.

Validation of 4β-hydroxycholesterol and evaluation of other endogenous biomarkers for the assessment of CYP3A activity in healthy subjects.

Kasichayanula S, Boulton DW, Luo WL, Rodrigues AD, Yang Z, Goodenough A, Lee M, Jemal M, LaCreta F.

Br J Clin Pharmacol. 2014 Nov;78(5):1122-34. doi: 10.1111/bcp.12425.

43.

Increasing length of an estradiol and progesterone timed artificial insemination protocol decreases pregnancy losses in lactating dairy cows.

Pereira MH, Rodrigues AD, De Carvalho RJ, Wiltbank MC, Vasconcelos JL.

J Dairy Sci. 2014 Mar;97(3):1454-64. doi: 10.3168/jds.2013-7287. Epub 2014 Jan 4.

PMID:
24393173
44.

Expression and characterization of cynomolgus monkey cytochrome CYP3A4 in a novel human embryonic kidney cell-based mammalian system.

Selvakumar S, Bhutani P, Ghosh K, Krishnamurthy P, Kallipatti S, Selvam S, Ramarao M, Mandlekar S, Sinz MW, Rodrigues AD, Subramanian M.

Drug Metab Dispos. 2014 Mar;42(3):369-76. doi: 10.1124/dmd.113.055491. Epub 2013 Dec 13.

45.

Effect of progesterone concentrations, follicle diameter, timing of artificial insemination, and ovulatory stimulus on pregnancy rate to synchronized artificial insemination in postpubertal Nellore heifers.

Martins T, Peres RF, Rodrigues AD, Pohler KG, Pereira MH, Day ML, Vasconcelos JL.

Theriogenology. 2014 Feb;81(3):446-53. doi: 10.1016/j.theriogenology.2013.10.020. Epub 2013 Oct 28.

PMID:
24246423
46.

Drug-induced perturbations of the bile acid pool, cholestasis, and hepatotoxicity: mechanistic considerations beyond the direct inhibition of the bile salt export pump.

Rodrigues AD, Lai Y, Cvijic ME, Elkin LL, Zvyaga T, Soars MG.

Drug Metab Dispos. 2014 Apr;42(4):566-74. doi: 10.1124/dmd.113.054205. Epub 2013 Oct 10. Review. Erratum in: Drug Metab Dispos. 2014 Nov;42(11):1978.

47.

Pharmacokinetics of the NS3 Protease Inhibitor, Asunaprevir (ASV, BMS-650032), in Phase I Studies in Subjects With or Without Chronic Hepatitis C.

Eley T, He B, Huang SP, Li W, Pasquinelli C, Rodrigues AD, Grasela DM, Bertz RJ.

Clin Pharmacol Drug Dev. 2013 Oct;2(4):316-27. doi: 10.1002/cpdd.52. Epub 2013 Aug 16.

PMID:
27121936
48.

Development of novel, 384-well high-throughput assay panels for human drug transporters: drug interaction and safety assessment in support of discovery research.

Tang H, Shen DR, Han YH, Kong Y, Balimane P, Marino A, Gao M, Wu S, Xie D, Soars MG, O'Connell JC, Rodrigues AD, Zhang L, Cvijic ME.

J Biomol Screen. 2013 Oct;18(9):1072-83. doi: 10.1177/1087057113494807.

PMID:
24062352
49.

Timed artificial insemination programs during the summer in lactating dairy cows: comparison of the 5-d Cosynch protocol with an estrogen/progesterone-based protocol.

Pereira MH, Rodrigues AD, Martins T, Oliveira WV, Silveira PS, Wiltbank MC, Vasconcelos JL.

J Dairy Sci. 2013;96(11):6904-14. doi: 10.3168/jds.2012-6260. Epub 2013 Sep 18.

PMID:
24054286
50.

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