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MHC-mismatched mixed chimerism restores peripheral tolerance of noncross-reactive autoreactive T cells in NOD mice.

Zhang M, Racine JJ, Lin Q, Liu Y, Tang S, Qin Q, Qi T, Riggs AD, Zeng D.

Proc Natl Acad Sci U S A. 2018 Feb 20. pii: 201720169. doi: 10.1073/pnas.1720169115. [Epub ahead of print]


Analysis of high-resolution 3D intrachromosomal interactions aided by Bayesian network modeling.

Zhang X, Branciamore S, Gogoshin G, Rodin AS, Riggs AD.

Proc Natl Acad Sci U S A. 2017 Nov 28;114(48):E10359-E10368. doi: 10.1073/pnas.1620425114. Epub 2017 Nov 13.


Health Belief Model Offers Opportunities for Designing Weight Management Interventions for College Students.

McArthur LH, Riggs A, Uribe F, Spaulding TJ.

J Nutr Educ Behav. 2017 Oct 30. pii: S1499-4046(17)30893-X. doi: 10.1016/j.jneb.2017.09.010. [Epub ahead of print]


SAIC: an iterative clustering approach for analysis of single cell RNA-seq data.

Yang L, Liu J, Lu Q, Riggs AD, Wu X.

BMC Genomics. 2017 Oct 3;18(Suppl 6):689. doi: 10.1186/s12864-017-4019-5.


A Simple and Cost-Effective Approach for In Vitro Production of Sliced siRNAs as Potent Triggers for RNAi.

Sun G, Riggs AD.

Mol Ther Nucleic Acids. 2017 Sep 15;8:345-355. doi: 10.1016/j.omtn.2017.07.008. Epub 2017 Jul 13.


Symptom Distress Among Diverse Patients Referred for Community-Based Palliative Care: Sociodemographic and Medical Correlates.

Dhingra L, Barrett M, Knotkova H, Chen J, Riggs A, Lee B, Hiney B, McCarthy M, Portenoy R.

J Pain Symptom Manage. 2018 Feb;55(2):290-296. doi: 10.1016/j.jpainsymman.2017.08.015. Epub 2017 Aug 26.


Development and Field Test of an Audit Tool and Tracer Methodology for Clinician Assessment of Quality in End-of-Life Care.

Bookbinder M, Hugodot A, Freeman K, Homel P, Santiago E, Riggs A, Gavin M, Chu A, Brady E, Lesage P, Portenoy RK.

J Pain Symptom Manage. 2018 Feb;55(2):207-216.e2. doi: 10.1016/j.jpainsymman.2017.08.017. Epub 2017 Aug 26.


Hospice Enrollment After Referral to Community-Based, Specialist Palliative Care: Impact of Telephonic Outreach.

Riggs A, Breuer B, Dhingra L, Chen J, Portenoy RK, Knotkova H.

J Pain Symptom Manage. 2017 Aug;54(2):219-225. doi: 10.1016/j.jpainsymman.2017.03.007. Epub 2017 Apr 24.


m6A RNA Methylation Regulates the Self-Renewal and Tumorigenesis of Glioblastoma Stem Cells.

Cui Q, Shi H, Ye P, Li L, Qu Q, Sun G, Sun G, Lu Z, Huang Y, Yang CG, Riggs AD, He C, Shi Y.

Cell Rep. 2017 Mar 14;18(11):2622-2634. doi: 10.1016/j.celrep.2017.02.059.


Small-Molecule-Based Lineage Reprogramming Creates Functional Astrocytes.

Tian E, Sun G, Sun G, Chao J, Ye P, Warden C, Riggs AD, Shi Y.

Cell Rep. 2016 Jul 19;16(3):781-92. doi: 10.1016/j.celrep.2016.06.042. Epub 2016 Jul 7.


Developmental changes in children's normative reasoning across learning contexts and collaborative roles.

Riggs AE, Young AG.

Dev Psychol. 2016 Aug;52(8):1236-46. doi: 10.1037/dev0000119. Epub 2016 Jun 30.


In Vitro Colony Assays for Characterizing Tri-potent Progenitor Cells Isolated from the Adult Murine Pancreas.

Tremblay JR, LeBon JM, Luo A, Quijano JC, Wedeken L, Jou K, Riggs AD, Tirrell DA, Ku HT.

J Vis Exp. 2016 Jun 10;(112). doi: 10.3791/54016.


Hospice Enrollment After Referral to Community-Based, Specialist-Level Palliative Care: Incidence, Timing, and Predictors.

Riggs A, Breuer B, Dhingra L, Chen J, Hiney B, McCarthy M, Portenoy RK, Knotkova H.

J Pain Symptom Manage. 2016 Aug;52(2):170-7. doi: 10.1016/j.jpainsymman.2016.02.011. Epub 2016 May 18.


A High-Touch Model of Community-Based Specialist Palliative Care: Latent Class Analysis Identifies Distinct Patient Subgroups.

Dhingra L, Dieckmann NF, Knotkova H, Chen J, Riggs A, Breuer B, Hiney B, Lee B, McCarthy M, Portenoy R.

J Pain Symptom Manage. 2016 Aug;52(2):178-86. doi: 10.1016/j.jpainsymman.2016.04.001. Epub 2016 May 18.


Epigenomic profiling reveals an association between persistence of DNA methylation and metabolic memory in the DCCT/EDIC type 1 diabetes cohort.

Chen Z, Miao F, Paterson AD, Lachin JM, Zhang L, Schones DE, Wu X, Wang J, Tompkins JD, Genuth S, Braffett BH, Riggs AD; DCCT/EDIC Research Group, Natarajan R.

Proc Natl Acad Sci U S A. 2016 May 24;113(21):E3002-11. doi: 10.1073/pnas.1603712113. Epub 2016 May 9.


Mapping Human Pluripotent-to-Cardiomyocyte Differentiation: Methylomes, Transcriptomes, and Exon DNA Methylation "Memories".

Tompkins JD, Jung M, Chen CY, Lin Z, Ye J, Godatha S, Lizhar E, Wu X, Hsu D, Couture LA, Riggs AD.

EBioMedicine. 2016 Jan 19;4:74-85. doi: 10.1016/j.ebiom.2016.01.021. eCollection 2016 Feb.


The TLX-miR-219 cascade regulates neural stem cell proliferation in neurodevelopment and schizophrenia iPSC model.

Murai K, Sun G, Ye P, Tian E, Yang S, Cui Q, Sun G, Trinh D, Sun O, Hong T, Wen Z, Kalkum M, Riggs AD, Song H, Ming GL, Shi Y.

Nat Commun. 2016 Mar 11;7:10965. doi: 10.1038/ncomms10965.


Downregulation of TLX induces TET3 expression and inhibits glioblastoma stem cell self-renewal and tumorigenesis.

Cui Q, Yang S, Ye P, Tian E, Sun G, Zhou J, Sun G, Liu X, Chen C, Murai K, Zhao C, Azizian KT, Yang L, Warden C, Wu X, D'Apuzzo M, Brown C, Badie B, Peng L, Riggs AD, Rossi JJ, Shi Y.

Nat Commun. 2016 Feb 3;7:10637. doi: 10.1038/ncomms10637.


Growth factors and medium hyperglycemia induce Sox9+ ductal cell differentiation into ╬▓ cells in mice with reversal of diabetes.

Zhang M, Lin Q, Qi T, Wang T, Chen CC, Riggs AD, Zeng D.

Proc Natl Acad Sci U S A. 2016 Jan 19;113(3):650-5. doi: 10.1073/pnas.1524200113. Epub 2016 Jan 5.


Cells with surface expression of CD133highCD71low are enriched for tripotent colony-forming progenitor cells in the adult murine pancreas.

Jin L, Gao D, Feng T, Tremblay JR, Ghazalli N, Luo A, Rawson J, Quijano JC, Chai J, Wedeken L, Hsu J, LeBon J, Walker S, Shih HP, Mahdavi A, Tirrell DA, Riggs AD, Ku HT.

Stem Cell Res. 2016 Jan;16(1):40-53. doi: 10.1016/j.scr.2015.11.015. Epub 2015 Nov 30.


MHC-mismatched mixed chimerism augments thymic regulatory T-cell production and prevents relapse of EAE in mice.

Wu L, Li N, Zhang M, Xue SL, Cassady K, Lin Q, Riggs AD, Zeng D.

Proc Natl Acad Sci U S A. 2015 Dec 29;112(52):15994-9. doi: 10.1073/pnas.1521157112. Epub 2015 Dec 8.


SR4 Uncouples Mitochondrial Oxidative Phosphorylation, Modulates AMP-dependent Kinase (AMPK)-Mammalian Target of Rapamycin (mTOR) Signaling, and Inhibits Proliferation of HepG2 Hepatocarcinoma Cells.

Figarola JL, Singhal J, Tompkins JD, Rogers GW, Warden C, Horne D, Riggs AD, Awasthi S, Singhal SS.

J Biol Chem. 2015 Dec 18;290(51):30321-41. doi: 10.1074/jbc.M115.686352. Epub 2015 Nov 3.


Hyperparathyroidism Associated with Long-Term Proton Pump Inhibitors Independent of Concurrent Bisphosphonate Therapy in Elderly Adults.

Hinson AM, Wilkerson BM, Rothman-Fitts I, Riggs AT, Stack BC Jr, Bodenner DL.

J Am Geriatr Soc. 2015 Oct;63(10):2070-3. doi: 10.1111/jgs.13661. Epub 2015 Sep 29.


2'-Hydroxyflavanone: A promising molecule for kidney cancer prevention.

Singhal SS, Singhal J, Figarola JL, Riggs A, Horne D, Awasthi S.

Biochem Pharmacol. 2015 Aug 1;96(3):151-8. doi: 10.1016/j.bcp.2015.04.022. Epub 2015 May 6. Review.


Postnatal Pancreas of Mice Contains Tripotent Progenitors Capable of Giving Rise to Duct, Acinar, and Endocrine Cells In Vitro.

Ghazalli N, Mahdavi A, Feng T, Jin L, Kozlowski MT, Hsu J, Riggs AD, Tirrell DA, Ku HT.

Stem Cells Dev. 2015 Sep 1;24(17):1995-2008. doi: 10.1089/scd.2015.0007. Epub 2015 Jun 9.


Leave Her out of It: Person-Presentation of Strategies is Harmful for Transfer.

Riggs AE, Alibali MW, Kalish CW.

Cogn Sci. 2015 Nov;39(8):1965-78. doi: 10.1111/cogs.12224. Epub 2015 Mar 21.


Colony-forming progenitor cells in the postnatal mouse liver and pancreas give rise to morphologically distinct insulin-expressing colonies in 3D cultures.

Jin L, Feng T, Chai J, Ghazalli N, Gao D, Zerda R, Li Z, Hsu J, Mahdavi A, Tirrell DA, Riggs AD, Ku HT.

Rev Diabet Stud. 2014 Spring;11(1):35-50. doi: 10.1900/RDS.2014.11.35. Epub 2014 May 10.


Enhanced evolution by stochastically variable modification of epigenetic marks in the early embryo.

Branciamore S, Rodin AS, Riggs AD, Rodin SN.

Proc Natl Acad Sci U S A. 2014 Apr 29;111(17):6353-8. doi: 10.1073/pnas.1402585111. Epub 2014 Apr 14.


The self-association of the giant hemoglobin from the earthworm, Lumbricus terrestris.

Riggs AF, Riggs CK.

Biochim Biophys Acta. 2014 Jun;1844(6):1071-5. doi: 10.1016/j.bbapap.2014.03.004. Epub 2014 Mar 12.


When you've seen one, have you seen them all? Children's memory for general and specific learning episodes.

Riggs AE, Kalish CW, Alibali MW.

Dev Psychol. 2014 Jun;50(6):1653-9. doi: 10.1037/a0036130. Epub 2014 Mar 10.


Property content guides children's memory for social learning episodes.

Riggs AE, Kalish CW, Alibali MW.

Cognition. 2014 May;131(2):243-53. doi: 10.1016/j.cognition.2014.01.004. Epub 2014 Feb 19.


Evaluating the role of epigenetic histone modifications in the metabolic memory of type 1 diabetes.

Miao F, Chen Z, Genuth S, Paterson A, Zhang L, Wu X, Li SM, Cleary P, Riggs A, Harlan DM, Lorenzi G, Kolterman O, Sun W, Lachin JM, Natarajan R; DCCT/EDIC Research Group.

Diabetes. 2014 May;63(5):1748-62. doi: 10.2337/db13-1251. Epub 2014 Jan 23.


Calcium-dependent stoichiometries of the KCa2.2 (SK) intracellular domain/calmodulin complex in solution.

Halling DB, Kenrick SA, Riggs AF, Aldrich RW.

J Gen Physiol. 2014 Feb;143(2):231-52. doi: 10.1085/jgp.201311007. Epub 2014 Jan 13.


Vitamin D deficiency: a simple algorithm employing weekly administration of 50,000 IU of vitamin D.

Middleton L, Stack BC Jr, Riggs AT, Bodenner DL.

Am J Otolaryngol. 2014 Mar-Apr;35(2):85-8. doi: 10.1016/j.amjoto.2013.12.002. Epub 2013 Dec 12.


In vitro multilineage differentiation and self-renewal of single pancreatic colony-forming cells from adult C57BL/6 mice.

Jin L, Feng T, Zerda R, Chen CC, Riggs AD, Ku HT.

Stem Cells Dev. 2014 Apr 15;23(8):899-909. doi: 10.1089/scd.2013.0466. Epub 2014 Jan 4.


MicroRNA-26a targets ten eleven translocation enzymes and is regulated during pancreatic cell differentiation.

Fu X, Jin L, Wang X, Luo A, Hu J, Zheng X, Tsark WM, Riggs AD, Ku HT, Huang W.

Proc Natl Acad Sci U S A. 2013 Oct 29;110(44):17892-7. doi: 10.1073/pnas.1317397110. Epub 2013 Oct 10.


Regulation of adipose tissue T cell subsets by Stat3 is crucial for diet-induced obesity and insulin resistance.

Priceman SJ, Kujawski M, Shen S, Cherryholmes GA, Lee H, Zhang C, Kruper L, Mortimer J, Jove R, Riggs AD, Yu H.

Proc Natl Acad Sci U S A. 2013 Aug 6;110(32):13079-84. doi: 10.1073/pnas.1311557110. Epub 2013 Jul 22.


Conservative management of thyroglobulin-positive, nonlocalizable thyroid carcinoma.

Frank RW, Middleton L, Stack BC Jr, Spencer HJ, Riggs AT, Bodenner DL.

Head Neck. 2014 Feb;36(2):155-7. doi: 10.1002/hed.23272. Epub 2013 Jun 1.


Cardiopulmonary resuscitation requiring extracorporeal membrane oxygenation in the elderly: a review of the Extracorporeal Life Support Organization registry.

Mendiratta P, Wei JY, Gomez A, Podrazik P, Riggs AT, Rycus P, Gossett J, Prodhan P.

ASAIO J. 2013 May-Jun;59(3):211-5. doi: 10.1097/MAT.0b013e31828fd6e5.


COHCAP: an integrative genomic pipeline for single-nucleotide resolution DNA methylation analysis.

Warden CD, Lee H, Tompkins JD, Li X, Wang C, Riggs AD, Yu H, Jove R, Yuan YC.

Nucleic Acids Res. 2013 Jun;41(11):e117. doi: 10.1093/nar/gkt242. Epub 2013 Apr 17.


Colony-forming cells in the adult mouse pancreas are expandable in Matrigel and form endocrine/acinar colonies in laminin hydrogel.

Jin L, Feng T, Shih HP, Zerda R, Luo A, Hsu J, Mahdavi A, Sander M, Tirrell DA, Riggs AD, Ku HT.

Proc Natl Acad Sci U S A. 2013 Mar 5;110(10):3907-12. doi: 10.1073/pnas.1301889110. Epub 2013 Feb 19.


The histone methyltransferase KMT2B is required for RNA polymerase II association and protection from DNA methylation at the MagohB CpG island promoter.

Ladopoulos V, Hofemeister H, Hoogenkamp M, Riggs AD, Stewart AF, Bonifer C.

Mol Cell Biol. 2013 Apr;33(7):1383-93. doi: 10.1128/MCB.01721-12. Epub 2013 Jan 28.


Identification of Oct4-activating compounds that enhance reprogramming efficiency.

Li W, Tian E, Chen ZX, Sun G, Ye P, Yang S, Lu D, Xie J, Ho TV, Tsark WM, Wang C, Horne DA, Riggs AD, Yip ML, Shi Y.

Proc Natl Acad Sci U S A. 2012 Dec 18;109(51):20853-8. doi: 10.1073/pnas.1219181110. Epub 2012 Dec 3.


Epigenetic stability, adaptability, and reversibility in human embryonic stem cells.

Tompkins JD, Hall C, Chen VC, Li AX, Wu X, Hsu D, Couture LA, Riggs AD.

Proc Natl Acad Sci U S A. 2012 Jul 31;109(31):12544-9. doi: 10.1073/pnas.1209620109. Epub 2012 Jul 16.


Molecular and immunohistochemical diagnosis of Francisella noatunensis subsp. orientalis from formalin-fixed, paraffin-embedded tissues.

Soto E, Illanes O, Hilchie D, Morales JA, Sunyakumthorn P, Hawke JP, Goodwin AE, Riggs A, Yanong RP, Pouder DB, Francis-Floyd R, Arauz M, Bogdanovic L, Castillo-Alcala F.

J Vet Diagn Invest. 2012 Sep;24(5):840-5. doi: 10.1177/1040638712452108. Epub 2012 Jul 11.


Inhibition of S-phase kinase-associated protein 2 (Skp2) reprograms and converts diabetogenic T cells to Foxp3+ regulatory T cells.

Wang D, Qin H, Du W, Shen YW, Lee WH, Riggs AD, Liu CP.

Proc Natl Acad Sci U S A. 2012 Jun 12;109(24):9493-8. doi: 10.1073/pnas.1207293109. Epub 2012 May 29.


Ten questions: developmentally appropriate support for pediatric testing in young children--how you can help.

Riggs A.

Heart Rhythm. 2012 Sep;9(9):1519-21. doi: 10.1016/j.hrthm.2012.05.017. Epub 2012 May 24. No abstract available.


Acetylated STAT3 is crucial for methylation of tumor-suppressor gene promoters and inhibition by resveratrol results in demethylation.

Lee H, Zhang P, Herrmann A, Yang C, Xin H, Wang Z, Hoon DS, Forman SJ, Jove R, Riggs AD, Yu H.

Proc Natl Acad Sci U S A. 2012 May 15;109(20):7765-9. doi: 10.1073/pnas.1205132109. Epub 2012 Apr 30.


DNA methylation biomarkers for lung cancer.

Rauch TA, Wang Z, Wu X, Kernstine KH, Riggs AD, Pfeifer GP.

Tumour Biol. 2012 Apr;33(2):287-96. doi: 10.1007/s13277-011-0282-2. Epub 2011 Dec 6.


Recurrent meningitis associated with frontal sinus tuber encephalocele in a patient with tuberous sclerosis.

Elbabaa SK, Riggs AD, Saad AG.

J Neurosurg Pediatr. 2011 Jul;8(1):103-6. doi: 10.3171/2011.4.PEDS10308.


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