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Items: 48


Pilot study of safety and feasibility of DNA microseeding for treatment of spontaneous canine melanoma.

Zuleger CL, Kang C, Ranheim EA, Kurzman ID, Macklin MD, Newton MA, Wolchok JD, Vail DM, Eriksson E, Albertini MR.

Vet Med Sci. 2017 May 22;3(3):134-145. doi: 10.1002/vms3.65. eCollection 2017 Aug.


Integrating Enhancer Mechanisms to Establish a Hierarchical Blood Development Program.

Mehta C, Johnson KD, Gao X, Ong IM, Katsumura KR, McIver SC, Ranheim EA, Bresnick EH.

Cell Rep. 2017 Sep 19;20(12):2966-2979. doi: 10.1016/j.celrep.2017.08.090.


Dnmt3a haploinsufficiency cooperates with oncogenic Kras to promote an early-onset T-cell acute lymphoblastic leukemia.

Chang YI, Kong G, Ranheim EA, Tu PS, Yu YS, Zhang J.

Am J Transl Res. 2017 Mar 15;9(3):1326-1334. eCollection 2017.


Incorporation of autopsy case-based learning into PhD graduate education: a novel approach to bridging the "bench-to-bedside" gap.

Brooks EG, Thornton JM, Ranheim EA, Fabry Z.

Hum Pathol. 2017 Oct;68:1-6. doi: 10.1016/j.humpath.2017.03.006. Epub 2017 Mar 16.


Safety and Immunological Efficacy of a DNA Vaccine Encoding the Androgen Receptor Ligand-Binding Domain (AR-LBD).

Olson BM, Bradley ES, Sawicki T, Zhong W, Ranheim EA, Bloom JE, Colluru VT, Johnson LE, Rekoske BT, Eickhoff JC, McNeel DG.

Prostate. 2017 May;77(7):812-821. doi: 10.1002/pros.23321. Epub 2017 Feb 9.


Latent Membrane Protein 1 (LMP1) and LMP2A Collaborate To Promote Epstein-Barr Virus-Induced B Cell Lymphomas in a Cord Blood-Humanized Mouse Model but Are Not Essential.

Ma SD, Tsai MH, Romero-Masters JC, Ranheim EA, Huebner SM, Bristol JA, Delecluse HJ, Kenney SC.

J Virol. 2017 Mar 13;91(7). pii: e01928-16. doi: 10.1128/JVI.01928-16. Print 2017 Apr 1.


p53-/- synergizes with enhanced NrasG12D signaling to transform megakaryocyte-erythroid progenitors in acute myeloid leukemia.

Zhang J, Kong G, Rajagopalan A, Lu L, Song J, Hussaini M, Zhang X, Ranheim EA, Liu Y, Wang J, Gao X, Chang YI, Johnson KD, Zhou Y, Yang D, Bhatnagar B, Lucas DM, Bresnick EH, Zhong X, Padron E, Zhang J.

Blood. 2017 Jan 19;129(3):358-370. doi: 10.1182/blood-2016-06-719237. Epub 2016 Nov 4.


Phase I study to evaluate toxicity and feasibility of intratumoral injection of α-gal glycolipids in patients with advanced melanoma.

Albertini MR, Ranheim EA, Zuleger CL, Sondel PM, Hank JA, Bridges A, Newton MA, McFarland T, Collins J, Clements E, Henry MB, Neuman HB, Weber S, Whalen G, Galili U.

Cancer Immunol Immunother. 2016 Aug;65(8):897-907. doi: 10.1007/s00262-016-1846-1. Epub 2016 May 20.


The ability of endogenous Nras oncogenes to initiate leukemia is codon-dependent.

Kong G, Chang YI, You X, Ranheim EA, Zhou Y, Burd CE, Zhang J.

Leukemia. 2016 Sep;30(9):1935-8. doi: 10.1038/leu.2016.89. Epub 2016 Apr 25. No abstract available.


Loss of wild-type Kras promotes activation of all Ras isoforms in oncogenic Kras-induced leukemogenesis.

Kong G, Chang YI, Damnernsawad A, You X, Du J, Ranheim EA, Lee W, Ryu MJ, Zhou Y, Xing Y, Chang Q, Burd CE, Zhang J.

Leukemia. 2016 Jul;30(7):1542-51. doi: 10.1038/leu.2016.40. Epub 2016 Feb 29.


Enhancing preclinical year pathology exposure: the Angevine approach.

Brooks EG, Paus AM, Corliss RF, Ranheim EA.

Hum Pathol. 2016 Jul;53:58-62. doi: 10.1016/j.humpath.2016.02.006. Epub 2016 Mar 23.


Kras is Required for Adult Hematopoiesis.

Damnernsawad A, Kong G, Wen Z, Liu Y, Rajagopalan A, You X, Wang J, Zhou Y, Ranheim EA, Luo HR, Chang Q, Zhang J.

Stem Cells. 2016 Jul;34(7):1859-71. doi: 10.1002/stem.2355. Epub 2016 Mar 28.


GATA Factor-G-Protein-Coupled Receptor Circuit Suppresses Hematopoiesis.

Gao X, Wu T, Johnson KD, Lahvic JL, Ranheim EA, Zon LI, Bresnick EH.

Stem Cell Reports. 2016 Mar 8;6(3):368-82. doi: 10.1016/j.stemcr.2016.01.008. Epub 2016 Feb 18.


Cis-regulatory mechanisms governing stem and progenitor cell transitions.

Johnson KD, Kong G, Gao X, Chang YI, Hewitt KJ, Sanalkumar R, Prathibha R, Ranheim EA, Dewey CN, Zhang J, Bresnick EH.

Sci Adv. 2015 Sep 4;1(8):e1500503. doi: 10.1126/sciadv.1500503. eCollection 2015 Sep.


Deficiency of β Common Receptor Moderately Attenuates the Progression of Myeloproliferative Neoplasm in NrasG12D/+ Mice.

Zhang J, Ranheim EA, Du J, Liu Y, Wang J, Kong G, Zhang J.

J Biol Chem. 2015 Jul 31;290(31):19093-103. doi: 10.1074/jbc.M115.653154. Epub 2015 Jun 16.


Response-adapted therapy for aggressive non-Hodgkin's lymphomas based on early [18F] FDG-PET scanning: ECOG-ACRIN Cancer Research Group study (E3404).

Swinnen LJ, Li H, Quon A, Gascoyne R, Hong F, Ranheim EA, Habermann TM, Kahl BS, Horning SJ, Advani RH.

Br J Haematol. 2015 Jul;170(1):56-65. doi: 10.1111/bjh.13389. Epub 2015 Mar 30.


Loss of Dnmt3a and endogenous Kras(G12D/+) cooperate to regulate hematopoietic stem and progenitor cell functions in leukemogenesis.

Chang YI, You X, Kong G, Ranheim EA, Wang J, Du J, Liu Y, Zhou Y, Ryu MJ, Zhang J.

Leukemia. 2015 Sep;29(9):1847-56. doi: 10.1038/leu.2015.85. Epub 2015 Mar 24.


LMP1-deficient Epstein-Barr virus mutant requires T cells for lymphomagenesis.

Ma SD, Xu X, Plowshay J, Ranheim EA, Burlingham WJ, Jensen JL, Asimakopoulos F, Tang W, Gulley ML, Cesarman E, Gumperz JE, Kenney SC.

J Clin Invest. 2015 Jan;125(1):304-15. doi: 10.1172/JCI76357. Epub 2014 Dec 8.


Combined MEK and JAK inhibition abrogates murine myeloproliferative neoplasm.

Kong G, Wunderlich M, Yang D, Ranheim EA, Young KH, Wang J, Chang YI, Du J, Liu Y, Tey SR, Zhang X, Juckett M, Mattison R, Damnernsawad A, Zhang J, Mulloy JC, Zhang J.

J Clin Invest. 2014 Jun;124(6):2762-73. doi: 10.1172/JCI74182. Epub 2014 May 8.


Evaluation of allelic strength of human TET2 mutations and cooperation between Tet2 knockdown and oncogenic Nras mutation.

Chang YI, Damnernsawad A, Allen LK, Yang D, Ranheim EA, Young KH, Zhang J, Kong G, Wang J, Liu Y, Fu HY, Yang CS, Guo J, Song H, Zhang J.

Br J Haematol. 2014 Aug;166(3):461-5. doi: 10.1111/bjh.12871. Epub 2014 Apr 3. No abstract available.


A novel program for clinical pathology training for residents emphasizing high-impact and attending-level learning opportunities.

Ranheim EA.

Hum Pathol. 2014 Feb;45(2):206-12. doi: 10.1016/j.humpath.2013.08.012. Epub 2013 Nov 4.


A Unique "Composite" PTLD with Diffuse Large B-Cell and T/Anaplastic Large Cell Lymphoma Components Occurring 17 Years after Transplant.

La Fortune K, Zhang D, Raca G, Ranheim EA.

Case Rep Hematol. 2013;2013:386147. doi: 10.1155/2013/386147. Epub 2013 May 7.


Nras(G12D/+) promotes leukemogenesis by aberrantly regulating hematopoietic stem cell functions.

Wang J, Kong G, Liu Y, Du J, Chang YI, Tey SR, Zhang X, Ranheim EA, Saba-El-Leil MK, Meloche S, Damnernsawad A, Zhang J, Zhang J.

Blood. 2013 Jun 27;121(26):5203-7. doi: 10.1182/blood-2012-12-475863. Epub 2013 May 17.


Notch1 gene mutations target KRAS G12D-expressing CD8+ cells and contribute to their leukemogenic transformation.

Kong G, Du J, Liu Y, Meline B, Chang YI, Ranheim EA, Wang J, Zhang J.

J Biol Chem. 2013 Jun 21;288(25):18219-27. doi: 10.1074/jbc.M113.475376. Epub 2013 May 14. Erratum in: J Biol Chem. 2013 Dec 27;288(52):37368.


Intratumoral treatment of smaller mouse neuroblastoma tumors with a recombinant protein consisting of IL-2 linked to the hu14.18 antibody increases intratumoral CD8+ T and NK cells and improves survival.

Yang RK, Kalogriopoulos NA, Rakhmilevich AL, Ranheim EA, Seo S, Kim K, Alderson KL, Gan J, Reisfeld RA, Gillies SD, Hank JA, Sondel PM.

Cancer Immunol Immunother. 2013 Aug;62(8):1303-13. doi: 10.1007/s00262-013-1430-x. Epub 2013 May 10.


Leukocyte abnormalities associated with hyperthermia.

Ranheim EA.

Int J Hematol. 2013 May;97(5):545-6. doi: 10.1007/s12185-013-1310-3. Epub 2013 Mar 24. No abstract available.


Intratumoral hu14.18-IL-2 (IC) induces local and systemic antitumor effects that involve both activated T and NK cells as well as enhanced IC retention.

Yang RK, Kalogriopoulos NA, Rakhmilevich AL, Ranheim EA, Seo S, Kim K, Alderson KL, Gan J, Reisfeld RA, Gillies SD, Hank JA, Sondel PM.

J Immunol. 2012 Sep 1;189(5):2656-64. doi: 10.4049/jimmunol.1200934. Epub 2012 Jul 27.


Distinct requirements of hematopoietic stem cell activity and Nras G12D signaling in different cell types during leukemogenesis.

Wang J, Liu Y, Tan LX, Lo JC, Du J, Ryu MJ, Ranheim EA, Zhang J.

Cell Cycle. 2011 Sep 1;10(17):2836-9. Epub 2011 Sep 1.


Molecular characteristics of mantle cell lymphoma presenting with clonal plasma cell component.

Visco C, Hoeller S, Malik JT, Xu-Monette ZY, Wiggins ML, Liu J, Sanger WG, Liu Z, Chang J, Ranheim EA, Gradowski JF, Serrano S, Wang HY, Liu Q, Dave S, Olsen B, Gascoyne RD, Campo E, Swerdlow SH, Chan WC, Tzankov A, Young KH.

Am J Surg Pathol. 2011 Feb;35(2):177-89. doi: 10.1097/PAS.0b013e3182049a9c.


Characterization of zebrafish larval inflammatory macrophages.

Mathias JR, Dodd ME, Walters KB, Yoo SK, Ranheim EA, Huttenlocher A.

Dev Comp Immunol. 2009 Nov;33(11):1212-7. doi: 10.1016/j.dci.2009.07.003. Epub 2009 Jul 29.


Tumoricidal effects of activated macrophages in a mouse model of chronic lymphocytic leukemia.

Wu QL, Buhtoiarov IN, Sondel PM, Rakhmilevich AL, Ranheim EA.

J Immunol. 2009 Jun 1;182(11):6771-8. doi: 10.4049/jimmunol.0801847.


Naive mouse macrophages become activated following recognition of L5178Y lymphoma cells via concurrent ligation of CD40, NKG2D, and CD18 molecules.

Buhtoiarov IN, Rakhmilevich AL, Lanier LL, Ranheim EA, Sondel PM.

J Immunol. 2009 Feb 15;182(4):1940-53. doi: 10.4049/jimmunol.0800443.


Dysregulation of Frizzled 6 is a critical component of B-cell leukemogenesis in a mouse model of chronic lymphocytic leukemia.

Wu QL, Zierold C, Ranheim EA.

Blood. 2009 Mar 26;113(13):3031-9. doi: 10.1182/blood-2008-06-163303. Epub 2009 Jan 28.


Wnt1 expression induces short-range and long-range cell recruitments that modify mammary tumor development and are not induced by a cell-autonomous beta-catenin effector.

Kim YC, Clark RJ, Ranheim EA, Alexander CM.

Cancer Res. 2008 Dec 15;68(24):10145-53. doi: 10.1158/0008-5472.CAN-08-2992.


Juvenile syndecan-1 null mice are protected from carcinogen-induced tumor development.

McDermott SP, Ranheim EA, Leatherberry VS, Khwaja SS, Klos KS, Alexander CM.

Oncogene. 2007 Mar 1;26(10):1407-16. Epub 2006 Sep 4.


Selection of aberrant class II restricted CD8+ T cells in NOD mice expressing a glutamic acid decarboxylase (GAD)65-specific T cell receptor transgene.

Ranheim EA, Tarbell KV, Krogsgaard M, Mallet-Designe V, Teyton L, McDevitt HO, Weissman IL.

Autoimmunity. 2004 Dec;37(8):555-67.


Frizzled 9 knock-out mice have abnormal B-cell development.

Ranheim EA, Kwan HC, Reya T, Wang YK, Weissman IL, Francke U.

Blood. 2005 Mar 15;105(6):2487-94. Epub 2004 Nov 30.


The gene related to anergy in lymphocytes, an E3 ubiquitin ligase, is necessary for anergy induction in CD4 T cells.

Seroogy CM, Soares L, Ranheim EA, Su L, Holness C, Bloom D, Fathman CG.

J Immunol. 2004 Jul 1;173(1):79-85.


Variable hematopoietic graft rejection and graft-versus-host disease in MHC-matched strains of mice.

Cao TM, Lo B, Ranheim EA, Grumet FC, Shizuru JA.

Proc Natl Acad Sci U S A. 2003 Sep 30;100(20):11571-6. Epub 2003 Sep 22.


Ectopic prostate: case report of a presacral mass presenting with obstructive symptoms.

Fulton RS, Rouse RV, Ranheim EA.

Arch Pathol Lab Med. 2001 Feb;125(2):286-8.


Highly active antiretroviral therapy results in HIV type 1 suppression in lymph nodes, increased pools of naive T cells, decreased pools of activated T cells, and diminished frequencies of peripheral activated HIV type 1-specific CD8+ T cells.

Gray CM, Lawrence J, Ranheim EA, Vierra M, Zupancic M, Winters M, Altman J, Montoya J, Zolopa A, Schapiro J, Haase AT, Merigan TC.

AIDS Res Hum Retroviruses. 2000 Sep 20;16(14):1357-69.


Spontaneously relapsing clonal, mucosal cytotoxic T-cell lymphoproliferative disorder: case report and review of the literature.

Ranheim EA, Jones C, Zehnder JL, Warnke R, Yuen A.

Am J Surg Pathol. 2000 Feb;24(2):296-301. Review.


Expression of CD27 and its ligand, CD70, on chronic lymphocytic leukemia B cells.

Ranheim EA, Cantwell MJ, Kipps TJ.

Blood. 1995 Jun 15;85(12):3556-65.


Tumor suppressor genes and clonal evolution in B-CLL.

Kay NE, Ranheim EA, Peterson LC.

Leuk Lymphoma. 1995 Jun;18(1-2):41-9. Review.


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