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Rapid, ultra low coverage copy number profiling of cell-free DNA as a precision oncology screening strategy.

Hovelson DH, Liu CJ, Wang Y, Kang Q, Henderson J, Gursky A, Brockman S, Ramnath N, Krauss JC, Talpaz M, Kandarpa M, Chugh R, Tuck M, Herman K, Grasso CS, Quist MJ, Feng FY, Haakenson C, Langmore J, Kamberov E, Tesmer T, Husain H, Lonigro RJ, Robinson D, Smith DC, Alva AS, Hussain MH, Chinnaiyan AM, Tewari M, Mills RE, Morgan TM, Tomlins SA.

Oncotarget. 2017 Sep 22;8(52):89848-89866. doi: 10.18632/oncotarget.21163. eCollection 2017 Oct 27.


The "liquid biopsy" in non-small cell lung cancer - not quite ready for prime time use.

Qin A, Ramnath N.

Transl Cancer Res. 2016 Oct;5(Suppl 4):S632-S635. doi: 10.21037/tcr.2016.10.29. No abstract available.


Radiation-induced lung toxicity in non-small-cell lung cancer: Understanding the interactions of clinical factors and cytokines with the dose-toxicity relationship.

Hawkins PG, Boonstra PS, Hobson ST, Hearn JWD, Hayman JA, Ten Haken RK, Matuszak MM, Stanton P, Kalemkerian GP, Ramnath N, Lawrence TS, Schipper MJ, Spring Kong FM, Jolly S.

Radiother Oncol. 2017 Oct;125(1):66-72. doi: 10.1016/j.radonc.2017.09.005. Epub 2017 Sep 23.


Integrative clinical genomics of metastatic cancer.

Robinson DR, Wu YM, Lonigro RJ, Vats P, Cobain E, Everett J, Cao X, Rabban E, Kumar-Sinha C, Raymond V, Schuetze S, Alva A, Siddiqui J, Chugh R, Worden F, Zalupski MM, Innis J, Mody RJ, Tomlins SA, Lucas D, Baker LH, Ramnath N, Schott AF, Hayes DF, Vijai J, Offit K, Stoffel EM, Roberts JS, Smith DC, Kunju LP, Talpaz M, Cieślik M, Chinnaiyan AM.

Nature. 2017 Aug 17;548(7667):297-303. doi: 10.1038/nature23306. Epub 2017 Aug 2.


Poor Prognosis Indicated by Venous Circulating Tumor Cell Clusters in Early-Stage Lung Cancers.

Murlidhar V, Reddy RM, Fouladdel S, Zhao L, Ishikawa MK, Grabauskiene S, Zhang Z, Lin J, Chang AC, Carrott P, Lynch WR, Orringer MB, Kumar-Sinha C, Palanisamy N, Beer DG, Wicha MS, Ramnath N, Azizi E, Nagrath S.

Cancer Res. 2017 Sep 15;77(18):5194-5206. doi: 10.1158/0008-5472.CAN-16-2072. Epub 2017 Jul 17.


Effect of Midtreatment PET/CT-Adapted Radiation Therapy With Concurrent Chemotherapy in Patients With Locally Advanced Non-Small-Cell Lung Cancer: A Phase 2 Clinical Trial.

Kong FM, Ten Haken RK, Schipper M, Frey KA, Hayman J, Gross M, Ramnath N, Hassan KA, Matuszak M, Ritter T, Bi N, Wang W, Orringer M, Cease KB, Lawrence TS, Kalemkerian GP.

JAMA Oncol. 2017 Oct 1;3(10):1358-1365. doi: 10.1001/jamaoncol.2017.0982.


Clinical Determinants of Durable Clinical Benefit of Pembrolizumab in Veterans With Advanced Non-Small-Cell Lung Cancer.

Qin A, Street L, Cease K, Viglianti BL, Warren EH, Zhao L, Ramnath N.

Clin Lung Cancer. 2017 Sep;18(5):559-564. doi: 10.1016/j.cllc.2017.01.012. Epub 2017 Feb 9.


Oncogenic Potential of CYP24A1 in Lung Adenocarcinoma.

Shiratsuchi H, Wang Z, Chen G, Ray P, Lin J, Zhang Z, Zhao L, Beer D, Ray D, Ramnath N.

J Thorac Oncol. 2017 Feb;12(2):269-280. doi: 10.1016/j.jtho.2016.10.010. Epub 2016 Oct 26.


Expanded Circulating Tumor Cells from a Patient with ALK-Positive Lung Cancer Present with EML4-ALK Rearrangement Along with Resistance Mutation and Enable Drug Sensitivity Testing: A Case Study.

Zhang Z, Shiratsuchi H, Palanisamy N, Nagrath S, Ramnath N.

J Thorac Oncol. 2017 Feb;12(2):397-402. doi: 10.1016/j.jtho.2016.07.027. Epub 2016 Aug 6.


Mechanisms of immune evasion and current status of checkpoint inhibitors in non-small cell lung cancer.

Qin A, Coffey DG, Warren EH, Ramnath N.

Cancer Med. 2016 Sep;5(9):2567-78. doi: 10.1002/cam4.819. Epub 2016 Jul 15. Review.


Optimizing the Detection of Circulating Markers to Aid in Early Lung Cancer Detection.

Murlidhar V, Ramnath N, Nagrath S, Reddy RM.

Cancers (Basel). 2016 Jun 28;8(7). pii: E61. doi: 10.3390/cancers8070061. Review.


Impact of Staging With Positron-emission Tomography (PET) and Comorbidities on Management and Survival of American Veterans With Stage I-III Non-Small Cell Lung Cancer.

Raghunathan R, Cease K, Troeschel S, Zhao L, Gross M, Chen G, Chopra V, Ramnath N.

Am J Clin Oncol. 2016 Jun 17. [Epub ahead of print]


The VA Point-of-Care Precision Oncology Program: Balancing Access with Rapid Learning in Molecular Cancer Medicine.

Fiore LD, Brophy MT, Turek S, Kudesia V, Ramnath N, Shannon C, Ferguson R, Pyarajan S, Fiore MA, Hornberger J, Lavori P.

Biomark Cancer. 2016 Feb 29;8:9-16. doi: 10.4137/BIC.S37548. eCollection 2016.


Pulmonary venous blood sampling significantly increases the yield of circulating tumor cells in early-stage lung cancer.

Reddy RM, Murlidhar V, Zhao L, Grabauskiene S, Zhang Z, Ramnath N, Lin J, Chang AC, Carrott P, Lynch W, Orringer MB, Beer DG, Nagrath S.

J Thorac Cardiovasc Surg. 2016 Mar;151(3):852-858. doi: 10.1016/j.jtcvs.2015.09.126. Epub 2015 Oct 22.


Fibulin-4 deficiency increases TGF-β signalling in aortic smooth muscle cells due to elevated TGF-β2 levels.

Ramnath NW, Hawinkels LJ, van Heijningen PM, te Riet L, Paauwe M, Vermeij M, Danser AH, Kanaar R, ten Dijke P, Essers J.

Sci Rep. 2015 Nov 26;5:16872. doi: 10.1038/srep16872.


Current Status of CTCs as Liquid Biopsy in Lung Cancer and Future Directions.

Zhang Z, Ramnath N, Nagrath S.

Front Oncol. 2015 Sep 30;5:209. doi: 10.3389/fonc.2015.00209. eCollection 2015. Review.


Effects of selenomethionine on acute toxicities from concurrent chemoradiation for inoperable stage III non-small cell lung cancer.

Mix M, Ramnath N, Gomez J, de Groot C, Rajan S, Dibaj S, Tan W, Rustum Y, Jameson MB, Singh AK.

World J Clin Oncol. 2015 Oct 10;6(5):156-65. doi: 10.5306/wjco.v6.i5.156.


A Novel Serum 4-microRNA Signature for Lung Cancer Detection.

Nadal E, Truini A, Nakata A, Lin J, Reddy RM, Chang AC, Ramnath N, Gotoh N, Beer DG, Chen G.

Sci Rep. 2015 Jul 23;5:12464. doi: 10.1038/srep12464.


MAP3K3 expression in tumor cells and tumor-infiltrating lymphocytes is correlated with favorable patient survival in lung cancer.

He Y, Wang L, Liu W, Zhong J, Bai S, Wang Z, Thomas DG, Lin J, Reddy RM, Ramnath N, Carrott PW, Lynch WR, Orringer MB, Chang AC, Beer DG, Chen G.

Sci Rep. 2015 Jun 19;5:11471. doi: 10.1038/srep11471.


KRAS-G12C mutation is associated with poor outcome in surgically resected lung adenocarcinoma.

Nadal E, Beer DG, Ramnath N.

J Thorac Oncol. 2015 Feb;10(2):e9-10. doi: 10.1097/JTO.0000000000000438. No abstract available.


Expansion of CTCs from early stage lung cancer patients using a microfluidic co-culture model.

Zhang Z, Shiratsuchi H, Lin J, Chen G, Reddy RM, Azizi E, Fouladdel S, Chang AC, Lin L, Jiang H, Waghray M, Luker G, Simeone DM, Wicha MS, Beer DG, Ramnath N, Nagrath S.

Oncotarget. 2014 Dec 15;5(23):12383-97.


Extracellular matrix defects in aneurysmal Fibulin-4 mice predispose to lung emphysema.

Ramnath NW, van de Luijtgaarden KM, van der Pluijm I, van Nimwegen M, van Heijningen PM, Swagemakers SM, van Thiel BS, Ridwan RY, van Vliet N, Vermeij M, Hawinkels LJ, de Munck A, Dzyubachyk O, Meijering E, van der Spek P, Rottier R, Yanagisawa H, Hendriks RW, Kanaar R, Rouwet EV, Kleinjan A, Essers J.

PLoS One. 2014 Sep 25;9(9):e106054. doi: 10.1371/journal.pone.0106054. eCollection 2014.


KRAS-G12C mutation is associated with poor outcome in surgically resected lung adenocarcinoma.

Nadal E, Chen G, Prensner JR, Shiratsuchi H, Sam C, Zhao L, Kalemkerian GP, Brenner D, Lin J, Reddy RM, Chang AC, Capellà G, Cardenal F, Beer DG, Ramnath N.

J Thorac Oncol. 2014 Oct;9(10):1513-22. doi: 10.1097/JTO.0000000000000305.


A radial flow microfluidic device for ultra-high-throughput affinity-based isolation of circulating tumor cells.

Murlidhar V, Zeinali M, Grabauskiene S, Ghannad-Rezaie M, Wicha MS, Simeone DM, Ramnath N, Reddy RM, Nagrath S.

Small. 2014 Dec 10;10(23):4895-904. doi: 10.1002/smll.201400719. Epub 2014 Jul 29.


Effects of cigarette smoking on metabolism and effectiveness of systemic therapy for lung cancer.

O'Malley M, King AN, Conte M, Ellingrod VL, Ramnath N.

J Thorac Oncol. 2014 Jul;9(7):917-26. doi: 10.1097/JTO.0000000000000191. Review.


A MicroRNA cluster at 14q32 drives aggressive lung adenocarcinoma.

Nadal E, Zhong J, Lin J, Reddy RM, Ramnath N, Orringer MB, Chang AC, Beer DG, Chen G.

Clin Cancer Res. 2014 Jun 15;20(12):3107-17. doi: 10.1158/1078-0432.CCR-13-3348. Epub 2014 May 15.


Epigenetic regulation of vitamin D metabolism in human lung adenocarcinoma.

Ramnath N, Nadal E, Jeon CK, Sandoval J, Colacino J, Rozek LS, Christensen PJ, Esteller M, Beer DG, Kim SH.

J Thorac Oncol. 2014 Apr;9(4):473-82. doi: 10.1097/JTO.0000000000000114.


Phase II study of perioperative chemotherapy with cisplatin and pemetrexed in non-small-cell lung cancer.

Dy GK, Bogner PN, Tan W, Demmy TL, Farooq A, Chen H, Yendamuri SS, Nwogu CE, Bushunow PW, Gannon J, Adjei AA, Adjei AA, Ramnath N.

J Thorac Oncol. 2014 Feb;9(2):222-30. doi: 10.1097/JTO.0000000000000062.


Cigarette smoking and gemcitabine-induced neutropenia in advanced solid tumors.

O'Malley M, Healy P, Daignault S, Ramnath N.

Oncology. 2013;85(4):216-22. doi: 10.1159/000355107. Epub 2013 Sep 24.


Sensitive capture of circulating tumour cells by functionalized graphene oxide nanosheets.

Yoon HJ, Kim TH, Zhang Z, Azizi E, Pham TM, Paoletti C, Lin J, Ramnath N, Wicha MS, Hayes DF, Simeone DM, Nagrath S.

Nat Nanotechnol. 2013 Oct;8(10):735-41. doi: 10.1038/nnano.2013.194. Epub 2013 Sep 29.


Treatment of stage III non-small cell lung cancer: Diagnosis and management of lung cancer, 3rd ed: American College of Chest Physicians evidence-based clinical practice guidelines.

Ramnath N, Dilling TJ, Harris LJ, Kim AW, Michaud GC, Balekian AA, Diekemper R, Detterbeck FC, Arenberg DA.

Chest. 2013 May;143(5 Suppl):e314S-e340S. doi: 10.1378/chest.12-2360.


A phase I/II pharmacokinetic and pharmacogenomic study of calcitriol in combination with cisplatin and docetaxel in advanced non-small-cell lung cancer.

Ramnath N, Daignault-Newton S, Dy GK, Muindi JR, Adjei A, Elingrod VL, Kalemkerian GP, Cease KB, Stella PJ, Brenner DE, Troeschel S, Johnson CS, Trump DL.

Cancer Chemother Pharmacol. 2013 May;71(5):1173-82. doi: 10.1007/s00280-013-2109-x. Epub 2013 Feb 23.


Characterization of vitamin D receptor (VDR) in lung adenocarcinoma.

Kim SH, Chen G, King AN, Jeon CK, Christensen PJ, Zhao L, Simpson RU, Thomas DG, Giordano TJ, Brenner DE, Hollis B, Beer DG, Ramnath N.

Lung Cancer. 2012 Aug;77(2):265-71. doi: 10.1016/j.lungcan.2012.04.010. Epub 2012 May 6.


Changes in global function and regional ventilation and perfusion on SPECT during the course of radiotherapy in patients with non-small-cell lung cancer.

Yuan ST, Frey KA, Gross MD, Hayman JA, Arenberg D, Cai XW, Ramnath N, Hassan K, Moran J, Eisbruch A, Ten Haken RK, Kong FM.

Int J Radiat Oncol Biol Phys. 2012 Mar 15;82(4):e631-8. doi: 10.1016/j.ijrobp.2011.07.044. Epub 2011 Dec 22.


Impaired vascular contractility and aortic wall degeneration in fibulin-4 deficient mice: effect of angiotensin II type 1 (AT1) receptor blockade.

Moltzer E, te Riet L, Swagemakers SM, van Heijningen PM, Vermeij M, van Veghel R, Bouhuizen AM, van Esch JH, Lankhorst S, Ramnath NW, de Waard MC, Duncker DJ, van der Spek PJ, Rouwet EV, Danser AH, Essers J.

PLoS One. 2011;6(8):e23411. doi: 10.1371/journal.pone.0023411. Epub 2011 Aug 9.


Development and validation of a quantitative real-time polymerase chain reaction classifier for lung cancer prognosis.

Chen G, Kim S, Taylor JM, Wang Z, Lee O, Ramnath N, Reddy RM, Lin J, Chang AC, Orringer MB, Beer DG.

J Thorac Oncol. 2011 Sep;6(9):1481-7. doi: 10.1097/JTO.0b013e31822918bd.


Vitamin D and lung cancer.

Ramnath N, Kim S, Christensen PJ.

Expert Rev Respir Med. 2011 Jun;5(3):305-9. doi: 10.1586/ers.11.31. No abstract available.


Phase II trial of sunitinib maintenance therapy after platinum-based chemotherapy in patients with extensive-stage small cell lung cancer.

Schneider BJ, Gadgeel SM, Ramnath N, Wozniak AJ, Dy GK, Daignault S, Kalemkerian GP.

J Thorac Oncol. 2011 Jun;6(6):1117-20. doi: 10.1097/JTO.0b013e31821529c3.


CYP24A1 is an independent prognostic marker of survival in patients with lung adenocarcinoma.

Chen G, Kim SH, King AN, Zhao L, Simpson RU, Christensen PJ, Wang Z, Thomas DG, Giordano TJ, Lin L, Brenner DE, Beer DG, Ramnath N.

Clin Cancer Res. 2011 Feb 15;17(4):817-26. doi: 10.1158/1078-0432.CCR-10-1789. Epub 2010 Dec 17.


Semiquantification and classification of local pulmonary function by V/Q single photon emission computed tomography in patients with non-small cell lung cancer: potential indication for radiotherapy planning.

Yuan ST, Frey KA, Gross MD, Hayman JA, Arenberg D, Curtis JL, Cai XW, Ramnath N, Kalemkerian GP, Ten Haken RK, Eisbruch A, Kong FM.

J Thorac Oncol. 2011 Jan;6(1):71-8. doi: 10.1097/JTO.0b013e3181f77b40.


Phase II trial of imatinib maintenance therapy after irinotecan and cisplatin in patients with c-Kit-positive, extensive-stage small-cell lung cancer.

Schneider BJ, Kalemkerian GP, Ramnath N, Kraut MJ, Wozniak AJ, Worden FP, Ruckdeschel JC, Zhang X, Chen W, Gadgeel SM.

Clin Lung Cancer. 2010 Jul 1;11(4):223-7. doi: 10.3816/CLC.2010.n.028.


Multimodality imaging reveals a gradual increase in matrix metalloproteinase activity at aneurysmal lesions in live fibulin-4 mice.

Kaijzel EL, van Heijningen PM, Wielopolski PA, Vermeij M, Koning GA, van Cappellen WA, Que I, Chan A, Dijkstra J, Ramnath NW, Hawinkels LJ, Bernsen MR, Löwik CW, Essers J.

Circ Cardiovasc Imaging. 2010 Sep;3(5):567-77. doi: 10.1161/CIRCIMAGING.109.933093. Epub 2010 Jun 30.


EphA2 mutation in lung squamous cell carcinoma promotes increased cell survival, cell invasion, focal adhesions, and mammalian target of rapamycin activation.

Faoro L, Singleton PA, Cervantes GM, Lennon FE, Choong NW, Kanteti R, Ferguson BD, Husain AN, Tretiakova MS, Ramnath N, Vokes EE, Salgia R.

J Biol Chem. 2010 Jun 11;285(24):18575-85. doi: 10.1074/jbc.M109.075085. Epub 2010 Apr 1.


The vitamin D/CYP24A1 story in cancer.

King AN, Beer DG, Christensen PJ, Simpson RU, Ramnath N.

Anticancer Agents Med Chem. 2010 Mar;10(3):213-24. Review.


A phase II study of dasatinib in patients with chemosensitive relapsed small cell lung cancer (Cancer and Leukemia Group B 30602).

Miller AA, Pang H, Hodgson L, Ramnath N, Otterson GA, Kelley MJ, Kratzke RA, Vokes EE; Cancer and Leukemia Group B (CALGB).

J Thorac Oncol. 2010 Mar;5(3):380-4. doi: 10.1097/JTO.0b013e3181cee36e.


Semiquantitative visual approach to scoring lung cancer treatment response using computed tomography: a pilot study.

Gottlieb RH, Kumar P, Loud P, Klippenstein D, Raczyk C, Tan W, Lu J, Ramnath N.

J Comput Assist Tomogr. 2009 Sep-Oct;33(5):743-7. doi: 10.1097/RCT.0b013e3181963b14.


Ethnic differences and functional analysis of MET mutations in lung cancer.

Krishnaswamy S, Kanteti R, Duke-Cohan JS, Loganathan S, Liu W, Ma PC, Sattler M, Singleton PA, Ramnath N, Innocenti F, Nicolae DL, Ouyang Z, Liang J, Minna J, Kozloff MF, Ferguson MK, Natarajan V, Wang YC, Garcia JG, Vokes EE, Salgia R.

Clin Cancer Res. 2009 Sep 15;15(18):5714-23. doi: 10.1158/1078-0432.CCR-09-0070. Epub 2009 Sep 1.


Treatment outcomes of different prognostic groups of patients on cancer and leukemia group B trial 39801: induction chemotherapy followed by chemoradiotherapy compared with chemoradiotherapy alone for unresectable stage III non-small cell lung cancer.

Stinchcombe TE, Hodgson L, Herndon JE 2nd, Kelley MJ, Cicchetti MG, Ramnath N, Niell HB, Atkins JN, Akerley W, Green MR, Vokes EE; Cancer and Leukemia Group B.

J Thorac Oncol. 2009 Sep;4(9):1117-25. doi: 10.1097/JTO.0b013e3181b27b33.


Progress in the treatment of metastatic non-small-cell lung cancer: slow but steady!

Ramnath N, Govindan R.

Clin Lung Cancer. 2009 Jul;10(4):260-1. doi: 10.3816/CLC.2009.n.036. No abstract available.


Thoracoscopic organ suffusion for regional lung chemotherapy (preliminary results).

Demmy TL, Tomaszewski G, Dy GK, Yendamuri S, Nwogu C, Pendyala L, Ramnath N, Adjei AA.

Ann Thorac Surg. 2009 Aug;88(2):385-90; discussion 390-1. doi: 10.1016/j.athoracsur.2009.04.101.


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