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Probing biological activity through structural modelling of ligand-receptor interactions of 2,4-disubstituted thiazole retinoids.

Haffez H, Chisholm DR, Tatum NJ, Valentine R, Redfern C, Pohl E, Whiting A, Przyborski S.

Bioorg Med Chem. 2018 Feb 10. pii: S0968-0896(17)32036-9. doi: 10.1016/j.bmc.2018.02.002. [Epub ahead of print]


iPSC modeling of severe aplastic anemia reveals impaired differentiation and telomere shortening in blood progenitors.

Melguizo-Sanchis D, Xu Y, Taheem D, Yu M, Tilgner K, Barta T, Gassner K, Anyfantis G, Wan T, Elango R, Alharthi S, El-Harouni AA, Przyborski S, Adam S, Saretzki G, Samarasinghe S, Armstrong L, Lako M.

Cell Death Dis. 2018 Jan 26;9(2):128. doi: 10.1038/s41419-017-0141-1.


Innovative organotypic in vitro models for safety assessment: aligning with regulatory requirements and understanding models of the heart, skin, and liver as paradigms.

Pridgeon CS, Schlott C, Wong MW, Heringa MB, Heckel T, Leedale J, Launay L, Gryshkova V, Przyborski S, Bearon RN, Wilkinson EL, Ansari T, Greenman J, Hendriks DFG, Gibbs S, Sidaway J, Sison-Young RL, Walker P, Cross MJ, Park BK, Goldring CEP.

Arch Toxicol. 2018 Feb;92(2):557-569. doi: 10.1007/s00204-018-2152-9. Epub 2018 Jan 23. Review.


An Induced Pluripotent Stem Cell Patient Specific Model of Complement Factor H (Y402H) Polymorphism Displays Characteristic Features of Age-Related Macular Degeneration and Indicates a Beneficial Role for UV Light Exposure.

Hallam D, Collin J, Bojic S, Chichagova V, Buskin A, Xu Y, Lafage L, Otten EG, Anyfantis G, Mellough C, Przyborski S, Alharthi S, Korolchuk V, Lotery A, Saretzki G, McKibbin M, Armstrong L, Steel D, Kavanagh D, Lako M.

Stem Cells. 2017 Nov;35(11):2305-2320. doi: 10.1002/stem.2708. Epub 2017 Oct 9.


MicroRNAs in the skin: role in development, homoeostasis and regeneration.

Horsburgh S, Fullard N, Roger M, Degnan A, Todryk S, Przyborski S, O'Reilly S.

Clin Sci (Lond). 2017 Jul 13;131(15):1923-1940. doi: 10.1042/CS20170039. Print 2017 Aug 1. Review.


Systems modelling ageing: from single senescent cells to simple multi-cellular models.

Martinez Guimera A, Welsh C, Dalle Pezze P, Fullard N, Nelson G, Roger MF, Przyborski SA, Shanley DP.

Essays Biochem. 2017 Jul 11;61(3):369-377. doi: 10.1042/EBC20160087. Print 2017 Jul 15. Review.


Induced pluripotent stem cell modelling of HLHS underlines the contribution of dysfunctional NOTCH signalling to impaired cardiogenesis.

Yang C, Xu Y, Yu M, Lee D, Alharti S, Hellen N, Ahmad Shaik N, Banaganapalli B, Sheikh Ali Mohamoud H, Elango R, Przyborski S, Tenin G, Williams S, O'Sullivan J, Al-Radi OO, Atta J, Harding SE, Keavney B, Lako M, Armstrong L.

Hum Mol Genet. 2017 Aug 15;26(16):3031-3045. doi: 10.1093/hmg/ddx140.


Neurogenesis in Response to Synthetic Retinoids at Different Temporal Scales.

Haffez H, Khatib T, McCaffery P, Przyborski S, Redfern C, Whiting A.

Mol Neurobiol. 2018 Mar;55(3):1942-1950. doi: 10.1007/s12035-017-0440-7. Epub 2017 Feb 27.


A robust and reproducible human pluripotent stem cell derived model of neurite outgrowth in a three-dimensional culture system and its application to study neurite inhibition.

Clarke KE, Tams DM, Henderson AP, Roger MF, Whiting A, Przyborski SA.

Neurochem Int. 2017 Jun;106:74-84. doi: 10.1016/j.neuint.2016.12.009. Epub 2016 Dec 21.


Corrigendum: IL-13 mediates collagen deposition via STAT6 and microRNA-135b: a role for epigenetics.

O'Reilly S, Ciechomska M, Fullard N, Przyborski S, van Laar JM.

Sci Rep. 2016 Jun 10;6:27325. doi: 10.1038/srep27325. No abstract available.


IL-13 mediates collagen deposition via STAT6 and microRNA-135b: a role for epigenetics.

O'Reilly S, Ciechomska M, Fullard N, Przyborski S, van Laar JM.

Sci Rep. 2016 Apr 26;6:25066. doi: 10.1038/srep25066.


Histone Demethylation and Toll-like Receptor 8-Dependent Cross-Talk in Monocytes Promotes Transdifferentiation of Fibroblasts in Systemic Sclerosis Via Fra-2.

Ciechomska M, O'Reilly S, Przyborski S, Oakley F, Bogunia-Kubik K, van Laar JM.

Arthritis Rheumatol. 2016 Jun;68(6):1493-504. doi: 10.1002/art.39602.


Using Zinc Finger Nuclease Technology to Generate CRX-Reporter Human Embryonic Stem Cells as a Tool to Identify and Study the Emergence of Photoreceptors Precursors During Pluripotent Stem Cell Differentiation.

Collin J, Mellough CB, Dorgau B, Przyborski S, Moreno-Gimeno I, Lako M.

Stem Cells. 2016 Feb;34(2):311-21. doi: 10.1002/stem.2240. Epub 2015 Nov 26.


Neuronal-glial populations form functional networks in a biocompatible 3D scaffold.

Smith I, Haag M, Ugbode C, Tams D, Rattray M, Przyborski S, Bithell A, Whalley BJ.

Neurosci Lett. 2015 Nov 16;609:198-202. doi: 10.1016/j.neulet.2015.10.044. Epub 2015 Oct 19.


A Novel Fully Humanized 3D Skin Equivalent to Model Early Melanoma Invasion.

Hill DS, Robinson ND, Caley MP, Chen M, O'Toole EA, Armstrong JL, Przyborski S, Lovat PE.

Mol Cancer Ther. 2015 Nov;14(11):2665-73. doi: 10.1158/1535-7163.MCT-15-0394. Epub 2015 Sep 1.


Advances in 3D cell culture technologies enabling tissue-like structures to be created in vitro.

Knight E, Przyborski S.

J Anat. 2015 Dec;227(6):746-56. doi: 10.1111/joa.12257. Epub 2014 Nov 20. Review.


An induced pluripotent stem cell model of hypoplastic left heart syndrome (HLHS) reveals multiple expression and functional differences in HLHS-derived cardiac myocytes.

Jiang Y, Habibollah S, Tilgner K, Collin J, Barta T, Al-Aama JY, Tesarov L, Hussain R, Trafford AW, Kirkwood G, Sernagor E, Eleftheriou CG, Przyborski S, Stojković M, Lako M, Keavney B, Armstrong L.

Stem Cells Transl Med. 2014 Apr;3(4):416-23. doi: 10.5966/sctm.2013-0105. Epub 2014 Mar 3.


Application of synthetic photostable retinoids induces novel limb and facial phenotypes during chick embryogenesis in vivo.

Lopez-Real RE, Budge JJ, Marder TB, Whiting A, Hunt PN, Przyborski SA.

J Anat. 2014 Apr;224(4):392-411. doi: 10.1111/joa.12147. Epub 2013 Dec 4. Erratum in: J Anat. 2014 Apr;224(4):529. J Anat. 2014 Apr;224(4):529.


Acrylic-acid-functionalized PolyHIPE scaffolds for use in 3D cell culture.

Hayward AS, Sano N, Przyborski SA, Cameron NR.

Macromol Rapid Commun. 2013 Dec;34(23-24):1844-9. doi: 10.1002/marc.201300709. Epub 2013 Nov 14.


Galactose-functionalized polyHIPE scaffolds for use in routine three dimensional culture of mammalian hepatocytes.

Hayward AS, Eissa AM, Maltman DJ, Sano N, Przyborski SA, Cameron NR.

Biomacromolecules. 2013 Dec 9;14(12):4271-7. doi: 10.1021/bm401145x. Epub 2013 Nov 14.


Design and biological evaluation of synthetic retinoids: probing length vs. stability vs. activity.

Clemens G, Flower KR, Gardner P, Henderson AP, Knowles JP, Marder TB, Whiting A, Przyborski S.

Mol Biosyst. 2013 Dec;9(12):3124-34. doi: 10.1039/c3mb70273a. Epub 2013 Oct 9.


Recent advances in 2D and 3D in vitro systems using primary hepatocytes, alternative hepatocyte sources and non-parenchymal liver cells and their use in investigating mechanisms of hepatotoxicity, cell signaling and ADME.

Godoy P, Hewitt NJ, Albrecht U, Andersen ME, Ansari N, Bhattacharya S, Bode JG, Bolleyn J, Borner C, Böttger J, Braeuning A, Budinsky RA, Burkhardt B, Cameron NR, Camussi G, Cho CS, Choi YJ, Craig Rowlands J, Dahmen U, Damm G, Dirsch O, Donato MT, Dong J, Dooley S, Drasdo D, Eakins R, Ferreira KS, Fonsato V, Fraczek J, Gebhardt R, Gibson A, Glanemann M, Goldring CE, Gómez-Lechón MJ, Groothuis GM, Gustavsson L, Guyot C, Hallifax D, Hammad S, Hayward A, Häussinger D, Hellerbrand C, Hewitt P, Hoehme S, Holzhütter HG, Houston JB, Hrach J, Ito K, Jaeschke H, Keitel V, Kelm JM, Kevin Park B, Kordes C, Kullak-Ublick GA, LeCluyse EL, Lu P, Luebke-Wheeler J, Lutz A, Maltman DJ, Matz-Soja M, McMullen P, Merfort I, Messner S, Meyer C, Mwinyi J, Naisbitt DJ, Nussler AK, Olinga P, Pampaloni F, Pi J, Pluta L, Przyborski SA, Ramachandran A, Rogiers V, Rowe C, Schelcher C, Schmich K, Schwarz M, Singh B, Stelzer EH, Stieger B, Stöber R, Sugiyama Y, Tetta C, Thasler WE, Vanhaecke T, Vinken M, Weiss TS, Widera A, Woods CG, Xu JJ, Yarborough KM, Hengstler JG.

Arch Toxicol. 2013 Aug;87(8):1315-530. doi: 10.1007/s00204-013-1078-5. Epub 2013 Aug 23. Review.


Human mesenchymal stem cells creating an immunosuppressive environment and promote breast cancer in mice.

Ljujic B, Milovanovic M, Volarevic V, Murray B, Bugarski D, Przyborski S, Arsenijevic N, Lukic ML, Stojkovic M.

Sci Rep. 2013;3:2298. doi: 10.1038/srep02298.


Brief report: a human induced pluripotent stem cell model of cernunnos deficiency reveals an important role for XLF in the survival of the primitive hematopoietic progenitors.

Tilgner K, Neganova I, Singhapol C, Saretzki G, Al-Aama JY, Evans J, Gorbunova V, Gennery A, Przyborski S, Stojkovic M, Armstrong L, Jeggo P, Lako M.

Stem Cells. 2013 Sep;31(9):2015-23. doi: 10.1002/stem.1456.


A human iPSC model of Ligase IV deficiency reveals an important role for NHEJ-mediated-DSB repair in the survival and genomic stability of induced pluripotent stem cells and emerging haematopoietic progenitors.

Tilgner K, Neganova I, Moreno-Gimeno I, Al-Aama JY, Burks D, Yung S, Singhapol C, Saretzki G, Evans J, Gorbunova V, Gennery A, Przyborski S, Stojkovic M, Armstrong L, Jeggo P, Lako M.

Cell Death Differ. 2013 Aug;20(8):1089-100. doi: 10.1038/cdd.2013.44. Epub 2013 May 31.


A novel model of urinary tract differentiation, tissue regeneration, and disease: reprogramming human prostate and bladder cells into induced pluripotent stem cells.

Moad M, Pal D, Hepburn AC, Williamson SC, Wilson L, Lako M, Armstrong L, Hayward SW, Franco OE, Cates JM, Fordham SE, Przyborski S, Carr-Wilkinson J, Robson CN, Heer R.

Eur Urol. 2013 Nov;64(5):753-61. doi: 10.1016/j.eururo.2013.03.054. Epub 2013 Apr 6.


Synthesis and applications of 2,4-disubstituted thiazole derivatives as small molecule modulators of cellular development.

Zhou GL, Tams DM, Marder TB, Valentine R, Whiting A, Przyborski SA.

Org Biomol Chem. 2013 Apr 14;11(14):2323-34. doi: 10.1039/c3ob00005b.


The action of all-trans-retinoic acid (ATRA) and synthetic retinoid analogues (EC19 and EC23) on human pluripotent stem cells differentiation investigated using single cell infrared microspectroscopy.

Clemens G, Flower KR, Henderson AP, Whiting A, Przyborski SA, Jimenez-Hernandez M, Ball F, Bassan P, Cinque G, Gardner P.

Mol Biosyst. 2013 Apr 5;9(4):677-92. doi: 10.1039/c3mb25505k.


Brief report: human pluripotent stem cell models of fanconi anemia deficiency reveal an important role for fanconi anemia proteins in cellular reprogramming and survival of hematopoietic progenitors.

Yung SK, Tilgner K, Ledran MH, Habibollah S, Neganova I, Singhapol C, Saretzki G, Stojkovic M, Armstrong L, Przyborski S, Lako M.

Stem Cells. 2013 May;31(5):1022-9. doi: 10.1002/stem.1308.


Generation of proliferating human hepatocytes using Upcyte® technology: characterisation and applications in induction and cytotoxicity assays.

Burkard A, Dähn C, Heinz S, Zutavern A, Sonntag-Buck V, Maltman D, Przyborski S, Hewitt NJ, Braspenning J.

Xenobiotica. 2012 Oct;42(10):939-56. doi: 10.3109/00498254.2012.675093. Epub 2012 Apr 24.


Derivation and functional analysis of patient-specific induced pluripotent stem cells as an in vitro model of chronic granulomatous disease.

Jiang Y, Cowley SA, Siler U, Melguizo D, Tilgner K, Browne C, Dewilton A, Przyborski S, Saretzki G, James WS, Seger RA, Reichenbach J, Lako M, Armstrong L.

Stem Cells. 2012 Apr;30(4):599-611. doi: 10.1002/stem.1053.


Top-down label-free LC-MALDI analysis of the peptidome during neural progenitor cell differentiation reveals complexity in cytoskeletal protein dynamics and identifies progenitor cell markers.

Maltman DJ, Brand S, Belau E, Paape R, Suckau D, Przyborski SA.

Proteomics. 2011 Oct;11(20):3992-4006. doi: 10.1002/pmic.201100024. Epub 2011 Aug 31.


Novel silicon-containing analogues of the retinoid agonist bexarotene: syntheses and biological effects on human pluripotent stem cells.

Bauer JB, Lippert WP, Dörrich S, Tebbe D, Burschka C, Christie VB, Tams DM, Henderson AP, Murray BA, Marder TB, Przyborski SA, Tacke R.

ChemMedChem. 2011 Aug 1;6(8):1509-17. doi: 10.1002/cmdc.201100156. Epub 2011 Jul 1.


Role of mesenchymal stem cells in neurogenesis and nervous system repair.

Maltman DJ, Hardy SA, Przyborski SA.

Neurochem Int. 2011 Sep;59(3):347-56. doi: 10.1016/j.neuint.2011.06.008. Epub 2011 Jun 21. Review.


Rat primary hepatocytes show enhanced performance and sensitivity to acetaminophen during three-dimensional culture on a polystyrene scaffold designed for routine use.

Schutte M, Fox B, Baradez MO, Devonshire A, Minguez J, Bokhari M, Przyborski S, Marshall D.

Assay Drug Dev Technol. 2011 Oct;9(5):475-86. doi: 10.1089/adt.2011.0371. Epub 2011 Jun 15.


Mesenchymal differentiation propensity of a human embryonic stem cell line.

Pringle S, De Bari C, Dell'Accio F, Przyborski S, Cooke MJ, Minger SL, Grigoriadis AE.

Cell Prolif. 2011 Apr;44(2):120-7. doi: 10.1111/j.1365-2184.2011.00744.x.


Neuropharmacological properties of neurons derived from human stem cells.

Coyne L, Shan M, Przyborski SA, Hirakawa R, Halliwell RF.

Neurochem Int. 2011 Sep;59(3):404-12. doi: 10.1016/j.neuint.2011.01.022. Epub 2011 Feb 16.


Neurite formation by neurons derived from adult rat hippocampal progenitor cells is susceptible to myelin inhibition.

Mellough CB, Cho S, Wood A, Przyborski S.

Neurochem Int. 2011 Sep;59(3):333-40. doi: 10.1016/j.neuint.2011.01.015. Epub 2011 Jan 21.


Alvetex®: polystyrene scaffold technology for routine three dimensional cell culture.

Knight E, Murray B, Carnachan R, Przyborski S.

Methods Mol Biol. 2011;695:323-40. doi: 10.1007/978-1-60761-984-0_20.


Retinoid supplementation of differentiating human neural progenitors and embryonic stem cells leads to enhanced neurogenesis in vitro.

Christie VB, Maltman DJ, Henderson AP, Whiting A, Marder TB, Lako M, Przyborski SA.

J Neurosci Methods. 2010 Nov 30;193(2):239-45. doi: 10.1016/j.jneumeth.2010.08.022. Epub 2010 Sep 9.


Validation of reference gene stability for APAP hepatotoxicity studies in different in vitro systems and identification of novel potential toxicity biomarkers.

Fox BC, Devonshire AS, Schutte ME, Foy CA, Minguez J, Przyborski S, Maltman D, Bokhari M, Marshall D.

Toxicol In Vitro. 2010 Oct;24(7):1962-70. doi: 10.1016/j.tiv.2010.08.007. Epub 2010 Aug 21.


Developments in three-dimensional cell culture technology aimed at improving the accuracy of in vitro analyses.

Maltman DJ, Przyborski SA.

Biochem Soc Trans. 2010 Aug;38(4):1072-5. doi: 10.1042/BST0381072. Review.


Lamins as cancer biomarkers.

Foster CR, Przyborski SA, Wilson RG, Hutchison CJ.

Biochem Soc Trans. 2010 Feb;38(Pt 1):297-300. doi: 10.1042/BST0380297. Review.


Human induced pluripotent stem cell lines show stress defense mechanisms and mitochondrial regulation similar to those of human embryonic stem cells.

Armstrong L, Tilgner K, Saretzki G, Atkinson SP, Stojkovic M, Moreno R, Przyborski S, Lako M.

Stem Cells. 2010 Apr;28(4):661-73. doi: 10.1002/stem.307.


Synthetic retinoids: structure-activity relationships.

Barnard JH, Collings JC, Whiting A, Przyborski SA, Marder TB.

Chemistry. 2009 Nov 2;15(43):11430-42. doi: 10.1002/chem.200901952.


Neural differentiation regulated by biomimetic surfaces presenting motifs of extracellular matrix proteins.

Cooke MJ, Zahir T, Phillips SR, Shah DS, Athey D, Lakey JH, Shoichet MS, Przyborski SA.

J Biomed Mater Res A. 2010 Jun 1;93(3):824-32. doi: 10.1002/jbm.a.32585.


Clinically failed eggs as a source of normal human embryo stem cells.

De Sousa PA, Gardner J, Sneddon S, Pells S, Tye BJ, Dand P, Collins DM, Stewart K, Shaw L, Przyborski S, Cooke M, McLaughlin KJ, Kimber SJ, Lieberman BA, Wilmut I, Brison DR.

Stem Cell Res. 2009 May;2(3):188-97. doi: 10.1016/j.scr.2009.01.002. Epub 2009 Feb 6.


Proteomic profiling of the stem cell response to retinoic acid and synthetic retinoid analogues: identification of major retinoid-inducible proteins.

Maltman DJ, Christie VB, Collings JC, Barnard JH, Fenyk S, Marder TB, Whiting A, Przyborski SA.

Mol Biosyst. 2009 May;5(5):458-71. doi: 10.1039/b817912c. Epub 2009 Mar 12.


Mesenchymal stem cells expressing neural antigens instruct a neurogenic cell fate on neural stem cells.

Croft AP, Przyborski SA.

Exp Neurol. 2009 Apr;216(2):329-41. doi: 10.1016/j.expneurol.2008.12.010. Epub 2008 Dec 29.


A role for NANOG in G1 to S transition in human embryonic stem cells through direct binding of CDK6 and CDC25A.

Zhang X, Neganova I, Przyborski S, Yang C, Cooke M, Atkinson SP, Anyfantis G, Fenyk S, Keith WN, Hoare SF, Hughes O, Strachan T, Stojkovic M, Hinds PW, Armstrong L, Lako M.

J Cell Biol. 2009 Jan 12;184(1):67-82. doi: 10.1083/jcb.200801009.

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