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"Inverse Drug Discovery" Strategy To Identify Proteins That Are Targeted by Latent Electrophiles As Exemplified by Aryl Fluorosulfates.

Mortenson DE, Brighty GJ, Plate L, Bare G, Chen W, Li S, Wang H, Cravatt BF, Forli S, Powers ET, Sharpless KB, Wilson IA, Kelly JW.

J Am Chem Soc. 2018 Jan 10;140(1):200-210. doi: 10.1021/jacs.7b08366. Epub 2017 Dec 21.


Translation efficiency is maintained at elevated temperature in Escherichia coli.

Morgan GJ, Burkhardt DH, Kelly JW, Powers ET.

J Biol Chem. 2018 Jan 19;293(3):777-793. doi: 10.1074/jbc.RA117.000284. Epub 2017 Nov 28.


The eldercare landscape: Evidence from California.

McMillen DP, Powers ET.

Health Econ. 2017 Sep;26 Suppl 2:139-157. doi: 10.1002/hec.3567.


Peptide probes detect misfolded transthyretin oligomers in plasma of hereditary amyloidosis patients.

Schonhoft JD, Monteiro C, Plate L, Eisele YS, Kelly JM, Boland D, Parker CG, Cravatt BF, Teruya S, Helmke S, Maurer M, Berk J, Sekijima Y, Novais M, Coelho T, Powers ET, Kelly JW.

Sci Transl Med. 2017 Sep 13;9(407). pii: eaam7621. doi: 10.1126/scitranslmed.aam7621.


Using Cooperatively Folded Peptides To Measure Interaction Energies and Conformational Propensities.

Ardejani MS, Powers ET, Kelly JW.

Acc Chem Res. 2017 Aug 15;50(8):1875-1882. doi: 10.1021/acs.accounts.7b00195. Epub 2017 Jul 19.


The endoplasmic reticulum HSP40 co-chaperone ERdj3/DNAJB11 assembles and functions as a tetramer.

Chen KC, Qu S, Chowdhury S, Noxon IC, Schonhoft JD, Plate L, Powers ET, Kelly JW, Lander GC, Wiseman RL.

EMBO J. 2017 Aug 1;36(15):2296-2309. doi: 10.15252/embj.201695616. Epub 2017 Jun 27.


Semi-quantitative models for identifying potent and selective transthyretin amyloidogenesis inhibitors.

Connelly S, Mortenson DE, Choi S, Wilson IA, Powers ET, Kelly JW, Johnson SM.

Bioorg Med Chem Lett. 2017 Aug 1;27(15):3441-3449. doi: 10.1016/j.bmcl.2017.05.080. Epub 2017 May 26.


Ligand-promoted protein folding by biased kinetic partitioning.

Hingorani KS, Metcalf MC, Deming DT, Garman SC, Powers ET, Gierasch LM.

Nat Chem Biol. 2017 Apr;13(4):369-371. doi: 10.1038/nchembio.2303. Epub 2017 Feb 20.


Small molecule proteostasis regulators that reprogram the ER to reduce extracellular protein aggregation.

Plate L, Cooley CB, Chen JJ, Paxman RJ, Gallagher CM, Madoux F, Genereux JC, Dobbs W, Garza D, Spicer TP, Scampavia L, Brown SJ, Rosen H, Powers ET, Walter P, Hodder P, Wiseman RL, Kelly JW.

Elife. 2016 Jul 20;5. pii: e15550. doi: 10.7554/eLife.15550.


The Dependence of Carbohydrate-Aromatic Interaction Strengths on the Structure of the Carbohydrate.

Hsu CH, Park S, Mortenson DE, Foley BL, Wang X, Woods RJ, Case DA, Powers ET, Wong CH, Dyson HJ, Kelly JW.

J Am Chem Soc. 2016 Jun 22;138(24):7636-48. doi: 10.1021/jacs.6b02879. Epub 2016 Jun 14.


Arylfluorosulfates Inactivate Intracellular Lipid Binding Protein(s) through Chemoselective SuFEx Reaction with a Binding Site Tyr Residue.

Chen W, Dong J, Plate L, Mortenson DE, Brighty GJ, Li S, Liu Y, Galmozzi A, Lee PS, Hulce JJ, Cravatt BF, Saez E, Powers ET, Wilson IA, Sharpless KB, Kelly JW.

J Am Chem Soc. 2016 Jun 15;138(23):7353-64. doi: 10.1021/jacs.6b02960. Epub 2016 Jun 2.


Current and future treatment of amyloid diseases.

Ankarcrona M, Winblad B, Monteiro C, Fearns C, Powers ET, Johansson J, Westermark GT, Presto J, Ericzon BG, Kelly JW.

J Intern Med. 2016 Aug;280(2):177-202. doi: 10.1111/joim.12506. Epub 2016 May 10. Review.


Stabilizing the CH2 Domain of an Antibody by Engineering in an Enhanced Aromatic Sequon.

Chen W, Kong L, Connelly S, Dendle JM, Liu Y, Wilson IA, Powers ET, Kelly JW.

ACS Chem Biol. 2016 Jul 15;11(7):1852-61. doi: 10.1021/acschembio.5b01035. Epub 2016 Apr 29.


Targeting protein aggregation for the treatment of degenerative diseases.

Eisele YS, Monteiro C, Fearns C, Encalada SE, Wiseman RL, Powers ET, Kelly JW.

Nat Rev Drug Discov. 2015 Nov;14(11):759-80. doi: 10.1038/nrd4593. Epub 2015 Sep 4. Review.


Enhanced Aromatic Sequons Increase Oligosaccharyltransferase Glycosylation Efficiency and Glycan Homogeneity.

Murray AN, Chen W, Antonopoulos A, Hanson SR, Wiseman RL, Dell A, Haslam SM, Powers DL, Powers ET, Kelly JW.

Chem Biol. 2015 Aug 20;22(8):1052-62. doi: 10.1016/j.chembiol.2015.06.017. Epub 2015 Jul 16.


Individual and collective contributions of chaperoning and degradation to protein homeostasis in E. coli.

Cho Y, Zhang X, Pobre KF, Liu Y, Powers DL, Kelly JW, Gierasch LM, Powers ET.

Cell Rep. 2015 Apr 14;11(2):321-33. doi: 10.1016/j.celrep.2015.03.018. Epub 2015 Apr 2.


Translation: An O-GlcNAc stamp of approval.

Powers ET.

Nat Chem Biol. 2015 May;11(5):307-8. doi: 10.1038/nchembio.1777. Epub 2015 Mar 16. No abstract available.


The intrinsic and extrinsic effects of N-linked glycans on glycoproteostasis.

Hebert DN, Lamriben L, Powers ET, Kelly JW.

Nat Chem Biol. 2014 Nov;10(11):902-10. doi: 10.1038/nchembio.1651. Epub 2014 Oct 17. Review.


Characterizing the altered cellular proteome induced by the stress-independent activation of heat shock factor 1.

Ryno LM, Genereux JC, Naito T, Morimoto RI, Powers ET, Shoulders MD, Wiseman RL.

ACS Chem Biol. 2014 Jun 20;9(6):1273-83. doi: 10.1021/cb500062n. Epub 2014 Apr 16.


Quantification of transthyretin kinetic stability in human plasma using subunit exchange.

Rappley I, Monteiro C, Novais M, Baranczak A, Solis G, Wiseman RL, Helmke S, Maurer MS, Coelho T, Powers ET, Kelly JW.

Biochemistry. 2014 Apr 1;53(12):1993-2006. doi: 10.1021/bi500171j. Epub 2014 Mar 24.


Fluorogenic small molecules requiring reaction with a specific protein to create a fluorescent conjugate for biological imaging--what we know and what we need to learn.

Baranczak A, Connelly S, Liu Y, Choi S, Grimster NP, Powers ET, Wilson IA, Kelly JW.

Biopolymers. 2014 May;101(5):484-95. doi: 10.1002/bip.22407.


Aβ induces astrocytic glutamate release, extrasynaptic NMDA receptor activation, and synaptic loss.

Talantova M, Sanz-Blasco S, Zhang X, Xia P, Akhtar MW, Okamoto S, Dziewczapolski G, Nakamura T, Cao G, Pratt AE, Kang YJ, Tu S, Molokanova E, McKercher SR, Hires SA, Sason H, Stouffer DG, Buczynski MW, Solomon JP, Michael S, Powers ET, Kelly JW, Roberts A, Tong G, Fang-Newmeyer T, Parker J, Holland EA, Zhang D, Nakanishi N, Chen HS, Wolosker H, Wang Y, Parsons LH, Ambasudhan R, Masliah E, Heinemann SF, Piña-Crespo JC, Lipton SA.

Proc Natl Acad Sci U S A. 2013 Jul 2;110(27):E2518-27. doi: 10.1073/pnas.1306832110. Epub 2013 Jun 17. Erratum in: Proc Natl Acad Sci U S A. 2013 Aug 13;110(33):13691. Proc Natl Acad Sci U S A. 2015 Jul 7;112(27):E3630. Proc Natl Acad Sci U S A. 2015 Jul 14;112(28):E3751-2.


Structural and energetic basis of carbohydrate-aromatic packing interactions in proteins.

Chen W, Enck S, Price JL, Powers DL, Powers ET, Wong CH, Dyson HJ, Kelly JW.

J Am Chem Soc. 2013 Jul 3;135(26):9877-84. doi: 10.1021/ja4040472. Epub 2013 Jun 19.


AG10 inhibits amyloidogenesis and cellular toxicity of the familial amyloid cardiomyopathy-associated V122I transthyretin.

Penchala SC, Connelly S, Wang Y, Park MS, Zhao L, Baranczak A, Rappley I, Vogel H, Liedtke M, Witteles RM, Powers ET, Reixach N, Chan WK, Wilson IA, Kelly JW, Graef IA, Alhamadsheh MM.

Proc Natl Acad Sci U S A. 2013 Jun 11;110(24):9992-7. doi: 10.1073/pnas.1300761110. Epub 2013 May 28.


Diversity in the origins of proteostasis networks--a driver for protein function in evolution.

Powers ET, Balch WE.

Nat Rev Mol Cell Biol. 2013 Apr;14(4):237-48. doi: 10.1038/nrm3542. Epub 2013 Mar 6. Review.


Aromatic sulfonyl fluorides covalently kinetically stabilize transthyretin to prevent amyloidogenesis while affording a fluorescent conjugate.

Grimster NP, Connelly S, Baranczak A, Dong J, Krasnova LB, Sharpless KB, Powers ET, Wilson IA, Kelly JW.

J Am Chem Soc. 2013 Apr 17;135(15):5656-68. doi: 10.1021/ja311729d. Epub 2013 Feb 14.


N-glycosylation of enhanced aromatic sequons to increase glycoprotein stability.

Price JL, Culyba EK, Chen W, Murray AN, Hanson SR, Wong CH, Powers ET, Kelly JW.

Biopolymers. 2012;98(3):195-211. doi: 10.1002/bip.22030. Epub 2012 Feb 3.


Tafamidis, a potent and selective transthyretin kinetic stabilizer that inhibits the amyloid cascade.

Bulawa CE, Connelly S, Devit M, Wang L, Weigel C, Fleming JA, Packman J, Powers ET, Wiseman RL, Foss TR, Wilson IA, Kelly JW, Labaudinière R.

Proc Natl Acad Sci U S A. 2012 Jun 12;109(24):9629-34. doi: 10.1073/pnas.1121005109. Epub 2012 May 29.


FoldEco: a model for proteostasis in E. coli.

Powers ET, Powers DL, Gierasch LM.

Cell Rep. 2012 Mar 29;1(3):265-76.


Correction to Context-Dependent Effects of Asparagine Glycosylation on Pin WW Folding Kinetics and Thermodynamics.

Price JL, Shental-Bechor D, Dhar A, Turner MJ, Powers ET, Gruebele M, Levy Y, Kelly JW.

J Am Chem Soc. 2012 Mar 7;134(9):4450-4451. Epub 2012 Feb 27. No abstract available.


The transthyretin amyloidoses: from delineating the molecular mechanism of aggregation linked to pathology to a regulatory-agency-approved drug.

Johnson SM, Connelly S, Fearns C, Powers ET, Kelly JW.

J Mol Biol. 2012 Aug 10;421(2-3):185-203. doi: 10.1016/j.jmb.2011.12.060. Epub 2012 Jan 5. Review.


Binding of 3,4,5,6-tetrahydroxyazepanes to the acid-β-glucosidase active site: implications for pharmacological chaperone design for Gaucher disease.

Orwig SD, Tan YL, Grimster NP, Yu Z, Powers ET, Kelly JW, Lieberman RL.

Biochemistry. 2011 Dec 13;50(49):10647-57. doi: 10.1021/bi201619z. Epub 2011 Nov 14.


N-PEGylation of a reverse turn is stabilizing in multiple sequence contexts, unlike N-GlcNAcylation.

Price JL, Powers ET, Kelly JW.

ACS Chem Biol. 2011 Nov 18;6(11):1188-92. doi: 10.1021/cb200277u. Epub 2011 Sep 22.


Potent kinetic stabilizers that prevent transthyretin-mediated cardiomyocyte proteotoxicity.

Alhamadsheh MM, Connelly S, Cho A, Reixach N, Powers ET, Pan DW, Wilson IA, Kelly JW, Graef IA.

Sci Transl Med. 2011 Aug 24;3(97):97ra81. doi: 10.1126/scitranslmed.3002473.


Glycosylation of the enhanced aromatic sequon is similarly stabilizing in three distinct reverse turn contexts.

Price JL, Powers DL, Powers ET, Kelly JW.

Proc Natl Acad Sci U S A. 2011 Aug 23;108(34):14127-32. doi: 10.1073/pnas.1105880108. Epub 2011 Aug 8.


Amyloid-β forms fibrils by nucleated conformational conversion of oligomers.

Lee J, Culyba EK, Powers ET, Kelly JW.

Nat Chem Biol. 2011 Jul 31;7(9):602-9. doi: 10.1038/nchembio.624.


Thermodynamic stability and denaturation kinetics of a benign natural transthyretin mutant identified in a Danish kindred.

Groenning M, Campos RI, Fagerberg C, Rasmussen AA, Eriksen UH, Powers ET, Hammarström P.

Amyloid. 2011 Jun;18(2):35-46. doi: 10.3109/13506129.2011.560215. Epub 2011 Mar 16.


Protein folding: Protection from the outside.

Powers ET, Balch WE.

Nature. 2011 Mar 3;471(7336):42-3. doi: 10.1038/471042a. No abstract available.


Heparin binds 8 kDa gelsolin cross-β-sheet oligomers and accelerates amyloidogenesis by hastening fibril extension.

Solomon JP, Bourgault S, Powers ET, Kelly JW.

Biochemistry. 2011 Apr 5;50(13):2486-98. doi: 10.1021/bi101905n. Epub 2011 Mar 15.


Protein native-state stabilization by placing aromatic side chains in N-glycosylated reverse turns.

Culyba EK, Price JL, Hanson SR, Dhar A, Wong CH, Gruebele M, Powers ET, Kelly JW.

Science. 2011 Feb 4;331(6017):571-5. doi: 10.1126/science.1198461. Erratum in: Science. 2012 Mar 2;335(6072):1042.


Context-dependent effects of asparagine glycosylation on Pin WW folding kinetics and thermodynamics.

Price JL, Shental-Bechor D, Dhar A, Turner MJ, Powers ET, Gruebele M, Levy Y, Kelly JW.

J Am Chem Soc. 2010 Nov 3;132(43):15359-67. doi: 10.1021/ja106896t. Erratum in: J Am Chem Soc. 2012 Mar 7;134(9):4450-1.


The 8 and 5 kDa fragments of plasma gelsolin form amyloid fibrils by a nucleated polymerization mechanism, while the 68 kDa fragment is not amyloidogenic.

Solomon JP, Yonemoto IT, Murray AN, Price JL, Powers ET, Balch WE, Kelly JW.

Biochemistry. 2009 Dec 8;48(48):11370-80. doi: 10.1021/bi901368e.


Site-specific modification of Alzheimer's peptides by cholesterol oxidation products enhances aggregation energetics and neurotoxicity.

Usui K, Hulleman JD, Paulsson JF, Siegel SJ, Powers ET, Kelly JW.

Proc Natl Acad Sci U S A. 2009 Nov 3;106(44):18563-8. doi: 10.1073/pnas.0804758106. Epub 2009 Oct 19.


The proteostasis boundary in misfolding diseases of membrane traffic.

Hutt DM, Powers ET, Balch WE.

FEBS Lett. 2009 Aug 20;583(16):2639-46. Review.


Evaluating beta-turn mimics as beta-sheet folding nucleators.

Fuller AA, Du D, Liu F, Davoren JE, Bhabha G, Kroon G, Case DA, Dyson HJ, Powers ET, Wipf P, Gruebele M, Kelly JW.

Proc Natl Acad Sci U S A. 2009 Jul 7;106(27):11067-72. doi: 10.1073/pnas.0813012106. Epub 2009 Jun 18.


Localized thermodynamic coupling between hydrogen bonding and microenvironment polarity substantially stabilizes proteins.

Gao J, Bosco DA, Powers ET, Kelly JW.

Nat Struct Mol Biol. 2009 Jul;16(7):684-90. doi: 10.1038/nsmb.1610. Epub 2009 Jun 14.


Biological and chemical approaches to diseases of proteostasis deficiency.

Powers ET, Morimoto RI, Dillin A, Kelly JW, Balch WE.

Annu Rev Biochem. 2009;78:959-91. doi: 10.1146/annurev.biochem.052308.114844. Review.


The core trisaccharide of an N-linked glycoprotein intrinsically accelerates folding and enhances stability.

Hanson SR, Culyba EK, Hsu TL, Wong CH, Kelly JW, Powers ET.

Proc Natl Acad Sci U S A. 2009 Mar 3;106(9):3131-6. doi: 10.1073/pnas.0810318105. Epub 2009 Feb 9.


Understanding the mechanism of beta-sheet folding from a chemical and biological perspective.

Jager M, Deechongkit S, Koepf EK, Nguyen H, Gao J, Powers ET, Gruebele M, Kelly JW.

Biopolymers. 2008;90(6):751-8. doi: 10.1002/bip.21101. Review.


Costly mistakes: translational infidelity and protein homeostasis.

Powers ET, Balch WE.

Cell. 2008 Jul 25;134(2):204-6. doi: 10.1016/j.cell.2008.07.005.

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