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CaV 3.2 drives sustained burst-firing, which is critical for absence seizure propagation in reticular thalamic neurons.

Cain SM, Tyson JR, Choi HB, Ko R, Lin PJC, LeDue JM, Powell KL, Bernier LP, Rungta RL, Yang Y, Cullis PR, O'Brien TJ, MacVicar BA, Snutch TP.

Epilepsia. 2018 Feb 21. doi: 10.1111/epi.14018. [Epub ahead of print]


Gene therapy mediated seizure suppression in Genetic Generalised Epilepsy: Neuropeptide Y overexpression in a rat model.

Powell KL, Fitzgerald X, Shallue C, Jovanovska V, Klugmann M, Von Jonquieres G, O'Brien TJ, Morris MJ.

Neurobiol Dis. 2018 Jan 29;113:23-32. doi: 10.1016/j.nbd.2018.01.016. [Epub ahead of print]


Delayed myelination and neurodevelopment in male seizure-prone versus seizure-resistant rats.

Sharma P, Powell KL, Wlodek ME, O'Brien TJ, Gilby KL.

Epilepsia. 2018 Jan 28. doi: 10.1111/epi.14013. [Epub ahead of print]


Formyl peptide receptor-2 is decreased in foetal growth restriction and contributes to placental dysfunction.

Lappas M, McCracken S, McKelvey K, Lim R, James J, Roberts CT, Fournier T, Alfaidy N, Powell KL, Borg AJ, Morris JM, Leaw B, Singh H, Ebeling PR, Wallace EM, Parry LJ, Dimitriadis E, Murthi P.

Mol Hum Reprod. 2018 Feb 1;24(2):94-109. doi: 10.1093/molehr/gax067.


Analyzing Trophoblast Function Using Cell-Based Assays.

Powell KL, Ashton AW.

Methods Mol Biol. 2018;1710:233-246. doi: 10.1007/978-1-4939-7498-6_18.


Evaluating whole genome sequence data from the Genetic Absence Epilepsy Rat from Strasbourg and its related non-epileptic strain.

Casillas-Espinosa PM, Powell KL, Zhu M, Campbell CR, Maia JM, Ren Z, Jones NC, O'Brien TJ, Petrovski S.

PLoS One. 2017 Jul 14;12(7):e0179924. doi: 10.1371/journal.pone.0179924. eCollection 2017.


Differences in white matter structure between seizure prone (FAST) and seizure resistant (SLOW) rat strains.

Sharma P, Wright DK, Johnston LA, Powell KL, Wlodek ME, Shultz SR, O'Brien TJ, Gilby KL.

Neurobiol Dis. 2017 Aug;104:33-40. doi: 10.1016/j.nbd.2017.04.022. Epub 2017 May 1.


Inhibition of microglial activation with minocycline at the intrathecal level attenuates sympathoexcitatory and proarrhythmogenic changes in rats with chronic temporal lobe epilepsy.

Bhandare AM, Kapoor K, Powell KL, Braine E, Casillas-Espinosa P, O'Brien TJ, Farnham MMJ, Pilowsky PM.

Neuroscience. 2017 May 14;350:23-38. doi: 10.1016/j.neuroscience.2017.03.012. Epub 2017 Mar 18.


The pathophysiology of cardiac dysfunction in epilepsy.

Ravindran K, Powell KL, Todaro M, O'Brien TJ.

Epilepsy Res. 2016 Nov;127:19-29. doi: 10.1016/j.eplepsyres.2016.08.007. Epub 2016 Aug 11. Review.


Interleukin-1β has trophic effects in microglia and its release is mediated by P2X7R pore.

Monif M, Reid CA, Powell KL, Drummond KJ, O'Brien TJ, Williams DA.

J Neuroinflammation. 2016 Jun 30;13(1):173. doi: 10.1186/s12974-016-0621-8.


Role for the thromboxane A2 receptor β-isoform in the pathogenesis of intrauterine growth restriction.

Powell KL, Stevens V, Upton DH, McCracken SA, Simpson AM, Cheng Y, Tasevski V, Morris JM, Ashton AW.

Sci Rep. 2016 Jul 1;6:28811. doi: 10.1038/srep28811.


High maternal iron status, dietary iron intake and iron supplement use in pregnancy and risk of gestational diabetes mellitus: a prospective study and systematic review.

Khambalia AZ, Aimone A, Nagubandi P, Roberts CL, McElduff A, Morris JM, Powell KL, Tasevski V, Nassar N.

Diabet Med. 2016 Sep;33(9):1211-21. doi: 10.1111/dme.13056. Epub 2016 Jan 12. Review.


In response: LQT, HCN, and epilepsy model.

Powell KL, O'Brien TJ.

Epilepsia. 2015 Nov;56(11):1855-6. doi: 10.1111/epi.13206. No abstract available.


Iron deficiency in early pregnancy using serum ferritin and soluble transferrin receptor concentrations are associated with pregnancy and birth outcomes.

Khambalia AZ, Collins CE, Roberts CL, Morris JM, Powell KL, Tasevski V, Nassar N.

Eur J Clin Nutr. 2016 Mar;70(3):358-63. doi: 10.1038/ejcn.2015.157. Epub 2015 Sep 16.


Z944, a Novel Selective T-Type Calcium Channel Antagonist Delays the Progression of Seizures in the Amygdala Kindling Model.

Casillas-Espinosa PM, Hicks A, Jeffreys A, Snutch TP, O'Brien TJ, Powell KL.

PLoS One. 2015 Aug 14;10(8):e0130012. doi: 10.1371/journal.pone.0130012. eCollection 2015.


Exosomes: Mechanisms of Uptake.

McKelvey KJ, Powell KL, Ashton AW, Morris JM, McCracken SA.

J Circ Biomark. 2015 Jul 17;4:7. doi: 10.5772/61186. eCollection 2015 Jan-Dec. Review.


High maternal serum ferritin in early pregnancy and risk of spontaneous preterm birth.

Khambalia AZ, Collins CE, Roberts CL, Morris JM, Powell KL, Tasevski V, Nassar N.

Br J Nutr. 2015 Aug 14;114(3):455-61. doi: 10.1017/S0007114515001932. Epub 2015 Jul 6.


Development of a potent melanoma vaccine capable of stimulating CD8(+) T-cells independently of dendritic cells in a mouse model.

Powell KL, Stephens AS, Ralph SJ.

Cancer Immunol Immunother. 2015 Jul;64(7):861-72. doi: 10.1007/s00262-015-1695-3. Epub 2015 Apr 19.


Seizure expression, behavior, and brain morphology differences in colonies of Genetic Absence Epilepsy Rats from Strasbourg.

Powell KL, Tang H, Ng C, Guillemain I, Dieuset G, Dezsi G, Çarçak N, Onat F, Martin B, O'Brien TJ, Depaulis A, Jones NC.

Epilepsia. 2014 Dec;55(12):1959-68. doi: 10.1111/epi.12840. Epub 2014 Nov 6.


Are alterations in transmitter receptor and ion channel expression responsible for epilepsies?

Powell KL, Lukasiuk K, O'Brien TJ, Pitkänen A.

Adv Exp Med Biol. 2014;813:211-29. doi: 10.1007/978-94-017-8914-1_17. Review.


The effect of amygdala kindling on neuronal firing patterns in the lateral thalamus in the GAERS model of absence epilepsy.

Carçak N, Zheng T, Ali I, Abdullah A, French C, Powell KL, Jones NC, van Raay L, Rind G, Onat F, O'Brien TJ.

Epilepsia. 2014 May;55(5):654-65. doi: 10.1111/epi.12592. Epub 2014 Mar 27.


HCN channelopathy and cardiac electrophysiologic dysfunction in genetic and acquired rat epilepsy models.

Powell KL, Jones NC, Kennard JT, Ng C, Urmaliya V, Lau S, Tran A, Zheng T, Ozturk E, Dezsi G, Megatia I, Delbridge LM, Pinault D, Reid CA, White PJ, O'Brien TJ.

Epilepsia. 2014 Apr;55(4):609-20. doi: 10.1111/epi.12563. Epub 2014 Mar 4.


Long-term valproate treatment increases brain neuropeptide Y expression and decreases seizure expression in a genetic rat model of absence epilepsy.

Elms J, Powell KL, van Raay L, Dedeurwaerdere S, O'Brien TJ, Morris MJ.

PLoS One. 2013 Sep 9;8(9):e73505. doi: 10.1371/journal.pone.0073505. eCollection 2013.


Low threshold T-type calcium channels as targets for novel epilepsy treatments.

Powell KL, Cain SM, Snutch TP, O'Brien TJ.

Br J Clin Pharmacol. 2014 May;77(5):729-39. doi: 10.1111/bcp.12205. Review.


Ethosuximide reduces epileptogenesis and behavioral comorbidity in the GAERS model of genetic generalized epilepsy.

Dezsi G, Ozturk E, Stanic D, Powell KL, Blumenfeld H, O'Brien TJ, Jones NC.

Epilepsia. 2013 Apr;54(4):635-43. doi: 10.1111/epi.12118. Epub 2013 Mar 6.


Regulators of synaptic transmission: roles in the pathogenesis and treatment of epilepsy.

Casillas-Espinosa PM, Powell KL, O'Brien TJ.

Epilepsia. 2012 Dec;53 Suppl 9:41-58. doi: 10.1111/epi.12034. Review.


Sulforaphane induces phase II detoxication enzymes in mouse skin and prevents mutagenesis induced by a mustard gas analog.

Abel EL, Boulware S, Fields T, McIvor E, Powell KL, DiGiovanni J, Vasquez KM, MacLeod MC.

Toxicol Appl Pharmacol. 2013 Feb 1;266(3):439-42. doi: 10.1016/j.taap.2012.11.020. Epub 2012 Nov 30.


Glutamate is associated with a higher risk of seizures in patients with gliomas.

Yuen TI, Morokoff AP, Bjorksten A, D'Abaco G, Paradiso L, Finch S, Wong D, Reid CA, Powell KL, Drummond KJ, Rosenthal MA, Kaye AH, O'Brien TJ.

Neurology. 2012 Aug 28;79(9):883-9. doi: 10.1212/WNL.0b013e318266fa89. Epub 2012 Jul 25.


2,6-Dithiopurine, a nucleophilic scavenger, protects against mutagenesis in mouse skin treated in vivo with 2-(chloroethyl) ethyl sulfide, a mustard gas analog.

Boulware S, Fields T, McIvor E, Powell KL, Abel EL, Vasquez KM, MacLeod MC.

Toxicol Appl Pharmacol. 2012 Sep 1;263(2):203-9. doi: 10.1016/j.taap.2012.06.010. Epub 2012 Jun 23.


T-type calcium channel blockers that attenuate thalamic burst firing and suppress absence seizures.

Tringham E, Powell KL, Cain SM, Kuplast K, Mezeyova J, Weerapura M, Eduljee C, Jiang X, Smith P, Morrison JL, Jones NC, Braine E, Rind G, Fee-Maki M, Parker D, Pajouhesh H, Parmar M, O'Brien TJ, Snutch TP.

Sci Transl Med. 2012 Feb 15;4(121):121ra19. doi: 10.1126/scitranslmed.3003120.


Structures of respiratory syncytial virus nucleocapsid protein from two crystal forms: details of potential packing interactions in the native helical form.

El Omari K, Dhaliwal B, Ren J, Abrescia NG, Lockyer M, Powell KL, Hawkins AR, Stammers DK.

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2011 Oct 1;67(Pt 10):1179-83. doi: 10.1107/S1744309111029228. Epub 2011 Sep 24.


Pyocyanin-induced toxicity in A549 respiratory cells is causally linked to oxidative stress.

Gloyne LS, Grant GD, Perkins AV, Powell KL, McDermott CM, Johnson PV, Anderson GJ, Kiefel M, Anoopkumar-Dukie S.

Toxicol In Vitro. 2011 Oct;25(7):1353-8. doi: 10.1016/j.tiv.2011.05.004. Epub 2011 May 8.


Morphometric changes and molecular mechanisms in rat models of idiopathic generalized epilepsy with absence seizures.

Jones NC, O'Brien TJ, Powell KL.

Neurosci Lett. 2011 Jun 27;497(3):185-93. doi: 10.1016/j.neulet.2011.02.039. Epub 2011 Feb 24. Review.


Activation of the canonical Wnt/β-catenin pathway in ATF3-induced mammary tumors.

Yan L, Della Coletta L, Powell KL, Shen J, Thames H, Aldaz CM, MacLeod MC.

PLoS One. 2011 Jan 31;6(1):e16515. doi: 10.1371/journal.pone.0016515.


Stargazin and AMPA receptor membrane expression is increased in the somatosensory cortex of Genetic Absence Epilepsy Rats from Strasbourg.

Kennard JT, Barmanray R, Sampurno S, Ozturk E, Reid CA, Paradiso L, D'Abaco GM, Kaye AH, Foote SJ, O'Brien TJ, Powell KL.

Neurobiol Dis. 2011 Apr;42(1):48-54. doi: 10.1016/j.nbd.2011.01.003. Epub 2011 Jan 8.


Retargeting of adenovirus vectors through genetic fusion of a single-chain or single-domain antibody to capsid protein IX.

Poulin KL, Lanthier RM, Smith AC, Christou C, Risco Quiroz M, Powell KL, O'Meara RW, Kothary R, Lorimer IA, Parks RJ.

J Virol. 2010 Oct;84(19):10074-86. doi: 10.1128/JVI.02665-09. Epub 2010 Jul 14.


Detoxication of sulfur half-mustards by nucleophilic scavengers: robust activity of thiopurines.

Liu J, Powell KL, Thames HD, MacLeod MC.

Chem Res Toxicol. 2010 Mar 15;23(3):488-96. doi: 10.1021/tx900190j.


2,6-Dithiopurine blocks toxicity and mutagenesis in human skin cells exposed to sulfur mustard analogues, 2-chloroethyl ethyl sulfide and 2-chloroethyl methyl sulfide.

Powell KL, Boulware S, Thames H, Vasquez KM, MacLeod MC.

Chem Res Toxicol. 2010 Mar 15;23(3):497-503. doi: 10.1021/tx9001918.


The P2X7 receptor drives microglial activation and proliferation: a trophic role for P2X7R pore.

Monif M, Reid CA, Powell KL, Smart ML, Williams DA.

J Neurosci. 2009 Mar 25;29(12):3781-91. doi: 10.1523/JNEUROSCI.5512-08.2009.


A Cav3.2 T-type calcium channel point mutation has splice-variant-specific effects on function and segregates with seizure expression in a polygenic rat model of absence epilepsy.

Powell KL, Cain SM, Ng C, Sirdesai S, David LS, Kyi M, Garcia E, Tyson JR, Reid CA, Bahlo M, Foote SJ, Snutch TP, O'Brien TJ.

J Neurosci. 2009 Jan 14;29(2):371-80. doi: 10.1523/JNEUROSCI.5295-08.2009.


Crystallization and preliminary X-ray analysis of the human respiratory syncytial virus nucleocapsid protein.

El Omari K, Scott K, Dhaliwal B, Ren J, Abrescia NG, Budworth J, Lockyer M, Powell KL, Hawkins AR, Stammers DK.

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2008 Nov 1;64(Pt 11):1019-23. doi: 10.1107/S1744309108031059. Epub 2008 Oct 28.


Genetic absence epilepsy rats from Strasbourg have increased corticothalamic expression of stargazin.

Powell KL, Kyi M, Reid CA, Paradiso L, D'Abaco GM, Kaye AH, Foote SJ, O'Brien TJ.

Neurobiol Dis. 2008 Aug;31(2):261-5. doi: 10.1016/j.nbd.2008.04.012. Epub 2008 May 10.


Decreases in HCN mRNA expression in the hippocampus after kindling and status epilepticus in adult rats.

Powell KL, Ng C, O'Brien TJ, Xu SH, Williams DA, Foote SJ, Reid CA.

Epilepsia. 2008 Oct;49(10):1686-95. doi: 10.1111/j.1528-1167.2008.01593.x. Epub 2008 Apr 7.


Fructan supplementation and infection affect food intake, fever, and epithelial sloughing from Salmonella challenge in weanling puppies.

Apanavicius CJ, Powell KL, Vester BM, Karr-Lilienthal LK, Pope LL, Fastinger ND, Wallig MA, Tappenden KA, Swanson KS.

J Nutr. 2007 Aug;137(8):1923-30.


RSV604, a novel inhibitor of respiratory syncytial virus replication.

Chapman J, Abbott E, Alber DG, Baxter RC, Bithell SK, Henderson EA, Carter MC, Chambers P, Chubb A, Cockerill GS, Collins PL, Dowdell VC, Keegan SJ, Kelsey RD, Lockyer MJ, Luongo C, Najarro P, Pickles RJ, Simmonds M, Taylor D, Tyms S, Wilson LJ, Powell KL.

Antimicrob Agents Chemother. 2007 Sep;51(9):3346-53. Epub 2007 Jun 18.


1,4-benzodiazepines as inhibitors of respiratory syncytial virus. The identification of a clinical candidate.

Henderson EA, Alber DG, Baxter RC, Bithell SK, Budworth J, Carter MC, Chubb A, Cockerill GS, Dowdell VC, Fraser IJ, Harris RA, Keegan SJ, Kelsey RD, Lumley JA, Stables JN, Weerasekera N, Wilson LJ, Powell KL.

J Med Chem. 2007 Apr 5;50(7):1685-92. Epub 2007 Mar 7.


Dietary proteins as environmental modifiers of type 1 diabetes mellitus.

Lefebvre DE, Powell KL, Strom A, Scott FW.

Annu Rev Nutr. 2006;26:175-202. Review.


1,4-Benzodiazepines as inhibitors of respiratory syncytial virus.

Carter MC, Alber DG, Baxter RC, Bithell SK, Budworth J, Chubb A, Cockerill GS, Dowdell VC, Henderson EA, Keegan SJ, Kelsey RD, Lockyer MJ, Stables JN, Wilson LJ, Powell KL.

J Med Chem. 2006 Apr 6;49(7):2311-9.


Quantitative high-throughput measurement of gene expression with sub-zeptomole sensitivity by capillary electrophoresis.

Spyres L, Gaddis S, Bedford E, Arantes S, Liburd N, Powell KL, Thames H, Mitchell D, Walborg E, Rouabhia M, Aldaz CM, MacLeod MC.

Anal Biochem. 2005 Oct 15;345(2):284-95.


Coronary artery bypass grafting in patients with dialysis-dependent end stage renal disease: a prospective, nested case-control study.

Powell KL, Smith JM, Woods SE, Hendy MP, Engel AM, Hiratzka LF.

J Card Surg. 2004 Sep-Oct;19(5):449-52.


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