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Human expression patterns: qualitative and quantitative analysis of thrombospondin-1 under physiological and pathological conditions.

Zhao C, Isenberg JS, Popel AS.

J Cell Mol Med. 2018 Feb 14. doi: 10.1111/jcmm.13565. [Epub ahead of print] Review.


Biomimetic peptide display from a polymeric nanoparticle surface for targeting and antitumor activity to human triple-negative breast cancer cells.

Bressler EM, Kim J, Shmueli RB, Mirando AC, Bazzazi H, Lee E, Popel AS, Pandey NB, Green JJ.

J Biomed Mater Res A. 2018 Feb 9. doi: 10.1002/jbm.a.36360. [Epub ahead of print]


Deciphering microvascular changes after myocardial infarction through 3D fully automated image analysis.

Gkontra P, Norton KA, Żak MM, Clemente C, Agüero J, Ibáñez B, Santos A, Popel AS, Arroyo AG.

Sci Rep. 2018 Jan 30;8(1):1854. doi: 10.1038/s41598-018-19758-4.


Therapeutic potential of an anti-angiogenic multimodal biomimetic peptide in hepatocellular carcinoma.

Barbhuiya MA, Mirando AC, Simons BW, Lemtiri-Chlieh G, Green JJ, Popel AS, Pandey NB, Tran PT.

Oncotarget. 2017 Sep 21;8(60):101520-101534. doi: 10.18632/oncotarget.21148. eCollection 2017 Nov 24.


Crosstalk between stromal components and tumor cells of TNBC via secreted factors enhances tumor growth and metastasis.

Jin K, Pandey NB, Popel AS.

Oncotarget. 2017 Jul 21;8(36):60210-60222. doi: 10.18632/oncotarget.19417. eCollection 2017 Sep 1.


A computational multiscale agent-based model for simulating spatio-temporal tumour immune response to PD1 and PDL1 inhibition.

Gong C, Milberg O, Wang B, Vicini P, Narwal R, Roskos L, Popel AS.

J R Soc Interface. 2017 Sep;14(134). pii: 20170320. doi: 10.1098/rsif.2017.0320.


An agent-based model of triple-negative breast cancer: the interplay between chemokine receptor CCR5 expression, cancer stem cells, and hypoxia.

Norton KA, Wallace T, Pandey NB, Popel AS.

BMC Syst Biol. 2017 Jul 11;11(1):68. doi: 10.1186/s12918-017-0445-x.


Corrigendum: Inhibition of VEGFR2 Activation and Its Downstream Signaling to ERK1/2 and Calcium by Thrombospondin-1 (TSP1): In silico Investigation.

Bazzazi H, Isenberg JS, Popel AS.

Front Physiol. 2017 Mar 7;8:147. doi: 10.3389/fphys.2017.00147. eCollection 2017.


Inhibition of VEGFR2 Activation and Its Downstream Signaling to ERK1/2 and Calcium by Thrombospondin-1 (TSP1): In silico Investigation.

Bazzazi H, Isenberg JS, Popel AS.

Front Physiol. 2017 Feb 6;8:48. doi: 10.3389/fphys.2017.00048. eCollection 2017. Erratum in: Front Physiol. 2017 Mar 07;8:147.


Computational investigation of sphingosine kinase 1 (SphK1) and calcium dependent ERK1/2 activation downstream of VEGFR2 in endothelial cells.

Bazzazi H, Popel AS.

PLoS Comput Biol. 2017 Feb 8;13(2):e1005332. doi: 10.1371/journal.pcbi.1005332. eCollection 2017 Feb.


Tyrosine kinase blocking collagen IV-derived peptide suppresses ocular neovascularization and vascular leakage.

Silva RLE, Kanan Y, Mirando AC, Kim J, Shmueli RB, Lorenc VE, Fortmann SD, Sciamanna J, Pandey NB, Green JJ, Popel AS, Campochiaro PA.

Sci Transl Med. 2017 Jan 18;9(373). pii: eaai8030. doi: 10.1126/scitranslmed.aai8030.


Transcriptional and Post-Transcriptional Regulation of Thrombospondin-1 Expression: A Computational Model.

Zhao C, Isenberg JS, Popel AS.

PLoS Comput Biol. 2017 Jan 3;13(1):e1005272. doi: 10.1371/journal.pcbi.1005272. eCollection 2017 Jan.


The Angiogenic Secretome in VEGF overexpressing Breast Cancer Xenografts.

Dore-Savard L, Lee E, Kakkad S, Popel AS, Bhujwalla ZM.

Sci Rep. 2016 Dec 20;6:39460. doi: 10.1038/srep39460.


Gene delivery nanoparticles to modulate angiogenesis.

Kim J, Mirando AC, Popel AS, Green JJ.

Adv Drug Deliv Rev. 2017 Sep 15;119:20-43. doi: 10.1016/j.addr.2016.11.003. Epub 2016 Nov 30. Review.


A multiscale computational model predicts distribution of anti-angiogenic isoform VEGF165b in peripheral arterial disease in human and mouse.

Chu LH, Ganta VC, Choi MH, Chen G, Finley SD, Annex BH, Popel AS.

Sci Rep. 2016 Nov 17;6:37030. doi: 10.1038/srep37030.


Multi-scale Modeling in Clinical Oncology: Opportunities and Barriers to Success.

Yankeelov TE, An G, Saut O, Luebeck EG, Popel AS, Ribba B, Vicini P, Zhou X, Weis JA, Ye K, Genin GM.

Ann Biomed Eng. 2016 Sep;44(9):2626-41. doi: 10.1007/s10439-016-1691-6. Epub 2016 Jul 6. Review.


Endothelial cells decode VEGF-mediated Ca2+ signaling patterns to produce distinct functional responses.

Noren DP, Chou WH, Lee SH, Qutub AA, Warmflash A, Wagner DS, Popel AS, Levchenko A.

Sci Signal. 2016 Feb 23;9(416):ra20. doi: 10.1126/scisignal.aad3188.


Multiscale Modeling in the Clinic: Drug Design and Development.

Clancy CE, An G, Cannon WR, Liu Y, May EE, Ortoleva P, Popel AS, Sluka JP, Su J, Vicini P, Zhou X, Eckmann DM.

Ann Biomed Eng. 2016 Sep;44(9):2591-610. doi: 10.1007/s10439-016-1563-0. Epub 2016 Feb 17. Review.


Pharmacokinetics of Anti-VEGF Agent Aflibercept in Cancer Predicted by Data-Driven, Molecular-Detailed Model.

Finley SD, Angelikopoulos P, Koumoutsakos P, Popel AS.

CPT Pharmacometrics Syst Pharmacol. 2015 Nov;4(11):641-9. doi: 10.1002/psp4.12040. Epub 2015 Oct 9.


Computational Model of MicroRNA Control of HIF-VEGF Pathway: Insights into the Pathophysiology of Ischemic Vascular Disease and Cancer.

Zhao C, Popel AS.

PLoS Comput Biol. 2015 Nov 20;11(11):e1004612. doi: 10.1371/journal.pcbi.1004612. eCollection 2015 Nov.


Computational drug repositioning for peripheral arterial disease: prediction of anti-inflammatory and pro-angiogenic therapeutics.

Chu LH, Annex BH, Popel AS.

Front Pharmacol. 2015 Aug 25;6:179. doi: 10.3389/fphar.2015.00179. eCollection 2015.


Analysis of gene expression of secreted factors associated with breast cancer metastases in breast cancer subtypes.

Fertig EJ, Lee E, Pandey NB, Popel AS.

Sci Rep. 2015 Jul 15;5:12133. doi: 10.1038/srep12133.


Heterogeneity of chemokine cell-surface receptor expression in triple-negative breast cancer.

Norton KA, Popel AS, Pandey NB.

Am J Cancer Res. 2015 Mar 15;5(4):1295-307. eCollection 2015.


PADPIN: protein-protein interaction networks of angiogenesis, arteriogenesis, and inflammation in peripheral arterial disease.

Chu LH, Vijay CG, Annex BH, Bader JS, Popel AS.

Physiol Genomics. 2015 Aug;47(8):331-43. doi: 10.1152/physiolgenomics.00125.2014. Epub 2015 Jun 9.


Crosstalk between cancer cells and blood endothelial and lymphatic endothelial cells in tumour and organ microenvironment.

Lee E, Pandey NB, Popel AS.

Expert Rev Mol Med. 2015 Jan 30;17:e3. doi: 10.1017/erm.2015.2. Review.


Inhibition of breast cancer growth and metastasis by a biomimetic peptide.

Lee E, Lee SJ, Koskimaki JE, Han Z, Pandey NB, Popel AS.

Sci Rep. 2014 Nov 20;4:7139. doi: 10.1038/srep07139.


Vasculature-specific MRI reveals differential anti-angiogenic effects of a biomimetic peptide in an orthotopic breast cancer model.

Kim E, Lee E, Plummer C, Gil S, Popel AS, Pathak AP.

Angiogenesis. 2015 Apr;18(2):125-36. doi: 10.1007/s10456-014-9450-5. Epub 2014 Nov 19.


A biomimetic collagen derived peptide exhibits anti-angiogenic activity in triple negative breast cancer.

Rosca EV, Penet MF, Mori N, Koskimaki JE, Lee E, Pandey NB, Bhujwalla ZM, Popel AS.

PLoS One. 2014 Nov 10;9(11):e111901. doi: 10.1371/journal.pone.0111901. eCollection 2014.


Angiogenesis interactome and time course microarray data reveal the distinct activation patterns in endothelial cells.

Chu LH, Lee E, Bader JS, Popel AS.

PLoS One. 2014 Oct 16;9(10):e110871. doi: 10.1371/journal.pone.0110871. eCollection 2014.


Computational systems biology approaches to anti-angiogenic cancer therapeutics.

Finley SD, Chu LH, Popel AS.

Drug Discov Today. 2015 Feb;20(2):187-97. doi: 10.1016/j.drudis.2014.09.026. Epub 2014 Oct 5. Review.


Antiangiogenic cancer drug sunitinib exhibits unexpected proangiogenic effects on endothelial cells.

Norton KA, Han Z, Popel AS, Pandey NB.

Onco Targets Ther. 2014 Sep 9;7:1571-82. doi: 10.2147/OTT.S65055. eCollection 2014.


An agent-based model of cancer stem cell initiated avascular tumour growth and metastasis: the effect of seeding frequency and location.

Norton KA, Popel AS.

J R Soc Interface. 2014 Nov 6;11(100):20140640. doi: 10.1098/rsif.2014.0640.


Breast cancer cells condition lymphatic endothelial cells within pre-metastatic niches to promote metastasis.

Lee E, Fertig EJ, Jin K, Sukumar S, Pandey NB, Popel AS.

Nat Commun. 2014 Sep 2;5:4715. doi: 10.1038/ncomms5715.


Lymphatic endothelial cells support tumor growth in breast cancer.

Lee E, Pandey NB, Popel AS.

Sci Rep. 2014 Jul 28;4:5853. doi: 10.1038/srep05853.


Quantitative fluorescent profiling of VEGFRs reveals tumor cell and endothelial cell heterogeneity in breast cancer xenografts.

Imoukhuede PI, Popel AS.

Cancer Med. 2014 Apr;3(2):225-44. doi: 10.1002/cam4.188. Epub 2014 Jan 22.


A bioimage informatics based reconstruction of breast tumor microvasculature with computational blood flow predictions.

Stamatelos SK, Kim E, Pathak AP, Popel AS.

Microvasc Res. 2014 Jan;91:8-21. doi: 10.1016/j.mvr.2013.12.003. Epub 2013 Dec 14.


Extracellular regulation of VEGF: isoforms, proteolysis, and vascular patterning.

Vempati P, Popel AS, Mac Gabhann F.

Cytokine Growth Factor Rev. 2014 Feb;25(1):1-19. doi: 10.1016/j.cytogfr.2013.11.002. Epub 2013 Nov 27. Review.


A systems biology view of blood vessel growth and remodelling.

Logsdon EA, Finley SD, Popel AS, Mac Gabhann F.

J Cell Mol Med. 2014 Aug;18(8):1491-508. doi: 10.1111/jcmm.12164. Epub 2013 Nov 17. Review.


Computational model of VEGFR2 pathway to ERK activation and modulation through receptor trafficking.

Tan WH, Popel AS, Mac Gabhann F.

Cell Signal. 2013 Dec;25(12):2496-510. doi: 10.1016/j.cellsig.2013.08.015. Epub 2013 Aug 29.


Pre-treatment of mice with tumor-conditioned media accelerates metastasis to lymph nodes and lungs: a new spontaneous breast cancer metastasis model.

Lee E, Pandey NB, Popel AS.

Clin Exp Metastasis. 2014 Jan;31(1):67-79. doi: 10.1007/s10585-013-9610-9. Epub 2013 Aug 21.


Compartment model predicts VEGF secretion and investigates the effects of VEGF trap in tumor-bearing mice.

Finley SD, Dhar M, Popel AS.

Front Oncol. 2013 Jul 30;3:196. doi: 10.3389/fonc.2013.00196. eCollection 2013.


Long-term suppression of ocular neovascularization by intraocular injection of biodegradable polymeric particles containing a serpin-derived peptide.

Shmueli RB, Ohnaka M, Miki A, Pandey NB, Lima e Silva R, Koskimaki JE, Kim J, Popel AS, Campochiaro PA, Green JJ.

Biomaterials. 2013 Oct;34(30):7544-51. doi: 10.1016/j.biomaterials.2013.06.044. Epub 2013 Jul 10.


Computational Model of Gab1/2-Dependent VEGFR2 Pathway to Akt Activation.

Tan WH, Popel AS, Mac Gabhann F.

PLoS One. 2013 Jun 21;8(6):e67438. doi: 10.1371/journal.pone.0067438. Print 2013.


Effect of tumor microenvironment on tumor VEGF during anti-VEGF treatment: systems biology predictions.

Finley SD, Popel AS.

J Natl Cancer Inst. 2013 Jun 5;105(11):802-11. doi: 10.1093/jnci/djt093. Epub 2013 May 13.


Endothelial cell-by-cell profiling reveals the temporal dynamics of VEGFR1 and VEGFR2 membrane localization after murine hindlimb ischemia.

Imoukhuede PI, Dokun AO, Annex BH, Popel AS.

Am J Physiol Heart Circ Physiol. 2013 Apr 15;304(8):H1085-93. doi: 10.1152/ajpheart.00514.2012. Epub 2013 Feb 1.


Synergy between a collagen IV mimetic peptide and a somatotropin-domain derived peptide as angiogenesis and lymphangiogenesis inhibitors.

Koskimaki JE, Lee E, Chen W, Rivera CG, Rosca EV, Pandey NB, Popel AS.

Angiogenesis. 2013 Jan;16(1):159-70. doi: 10.1007/s10456-012-9308-7. Epub 2012 Sep 29.


Effects of fiber type and size on the heterogeneity of oxygen distribution in exercising skeletal muscle.

Liu G, Mac Gabhann F, Popel AS.

PLoS One. 2012;7(9):e44375. doi: 10.1371/journal.pone.0044375. Epub 2012 Sep 18.


Expression of VEGF receptors on endothelial cells in mouse skeletal muscle.

Imoukhuede PI, Popel AS.

PLoS One. 2012;7(9):e44791. doi: 10.1371/journal.pone.0044791. Epub 2012 Sep 12.

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