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Items: 20

1.

BAY 1125976, a selective allosteric AKT1/2 inhibitor, exhibits high efficacy on AKT signaling-dependent tumor growth in mouse models.

Politz O, Siegel F, Bärfacker L, Bömer U, Hägebarth A, Scott WJ, Michels M, Ince S, Neuhaus R, Meyer K, Fernández-Montalván AE, Liu N, von Nussbaum F, Mumberg D, Ziegelbauer K.

Int J Cancer. 2017 Jan 15;140(2):449-459. doi: 10.1002/ijc.30457. Epub 2016 Oct 20.

2.

AKT1 (E17K) mutation profiling in breast cancer: prevalence, concurrent oncogenic alterations, and blood-based detection.

Rudolph M, Anzeneder T, Schulz A, Beckmann G, Byrne AT, Jeffers M, Pena C, Politz O, Köchert K, Vonk R, Reischl J.

BMC Cancer. 2016 Aug 11;16:622. doi: 10.1186/s12885-016-2626-1.

3.

Novel DNA methylation markers with potential prognostic relevance in advanced malignant melanoma identified using COBRA assays.

Kaehler KC, Politz O, Henderson D, Ulbrich HF, Hauschild A, Mund C, Egberts F.

Melanoma Res. 2015 Jun;25(3):225-31. doi: 10.1097/CMR.0000000000000150.

PMID:
25919928
4.

Bay846, a new irreversible small molecule inhibitor of EGFR and Her2, is highly effective against malignant brain tumor models.

Longo SL, Padalino DJ, McGillis S, Petersen K, Schirok H, Politz O, Canute GW, Post DE.

Invest New Drugs. 2012 Dec;30(6):2161-72. doi: 10.1007/s10637-011-9784-4. Epub 2011 Dec 29.

PMID:
22203214
5.

MS-275, a potent orally available inhibitor of histone deacetylases--the development of an anticancer agent.

Hess-Stumpp H, Bracker TU, Henderson D, Politz O.

Int J Biochem Cell Biol. 2007;39(7-8):1388-405. Epub 2007 Feb 16. Review.

PMID:
17383217
6.

Androgen receptor function is modulated by the tissue-specific AR45 variant.

Ahrens-Fath I, Politz O, Geserick C, Haendler B.

FEBS J. 2005 Jan;272(1):74-84.

7.

Stabilin-1 and -2 constitute a novel family of fasciclin-like hyaluronan receptor homologues.

Politz O, Gratchev A, McCourt PA, Schledzewski K, Guillot P, Johansson S, Svineng G, Franke P, Kannicht C, Kzhyshkowska J, Longati P, Velten FW, Johansson S, Goerdt S.

Biochem J. 2002 Feb 15;362(Pt 1):155-64.

8.

Alternatively activated macrophages differentially express fibronectin and its splice variants and the extracellular matrix protein betaIG-H3.

Gratchev A, Guillot P, Hakiy N, Politz O, Orfanos CE, Schledzewski K, Goerdt S.

Scand J Immunol. 2001 Apr;53(4):386-92.

9.

[Alternative activation of antigen-presenting cells: concepts and clinical relevance].

Birk RW, Gratchev A, Hakiy N, Politz O, Schledzewski K, Guillot P, Orfanos CE, Goerdt S.

Hautarzt. 2001 Mar;52(3):193-200. Review. German.

PMID:
11284063
10.

A highly thermostable endo-(1,4)-beta-mannanase from the marine bacterium Rhodothermus marinus.

Politz O, Krah M, Thomsen KK, Borriss R.

Appl Microbiol Biotechnol. 2000 Jun;53(6):715-21.

PMID:
10919332
11.

Alternative versus classical activation of macrophages.

Goerdt S, Politz O, Schledzewski K, Birk R, Gratchev A, Guillot P, Hakiy N, Klemke CD, Dippel E, Kodelja V, Orfanos CE.

Pathobiology. 1999;67(5-6):222-6. Review.

PMID:
10725788
12.
13.

Langerhans cells do not express alternative macrophage activation-associated CC chemokine (AMAC)-1.

Kodelja V, Kraft S, Politz O, Hakij N, Treudler R, Orfanos CE, Bieber T, Goerdt S.

Res Immunol. 1998 Sep-Oct;149(7-8):633-7.

PMID:
9851514
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17.

Influence of Ca2+ on conformation and stability of three bacterial hybrid glucanases.

Welfle K, Misselwitz R, Welfle H, Politz O, Borriss R.

Eur J Biochem. 1995 May 1;229(3):726-35.

18.

Crystal structure and site-directed mutagenesis of Bacillus macerans endo-1,3-1,4-beta-glucanase.

Hahn M, Olsen O, Politz O, Borriss R, Heinemann U.

J Biol Chem. 1995 Feb 17;270(7):3081-8.

19.

Microcalorimetric determination of the thermostability of three hybrid (1-3,1-4)-beta-glucanases.

Welfle K, Misselwitz R, Welfle H, Simon O, Politz O, Borriss R.

J Biomol Struct Dyn. 1994 Jun;11(6):1417-24.

PMID:
7946082
20.

Determinants for the enhanced thermostability of hybrid (1-3,1-4)-beta-glucanases.

Politz O, Simon O, Olsen O, Borriss R.

Eur J Biochem. 1993 Sep 15;216(3):829-34.

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