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Items: 1 to 50 of 472

1.

The systemic response to surgery triggers the outgrowth of distant immune-controlled tumors in mouse models of dormancy.

Krall JA, Reinhardt F, Mercury OA, Pattabiraman DR, Brooks MW, Dougan M, Lambert AW, Bierie B, Ploegh HL, Dougan SK, Weinberg RA.

Sci Transl Med. 2018 Apr 11;10(436). pii: eaan3464. doi: 10.1126/scitranslmed.aan3464.

PMID:
29643230
2.

Anti-CTLA-4 therapy requires an Fc domain for efficacy.

Ingram JR, Blomberg OS, Rashidian M, Ali L, Garforth S, Fedorov E, Fedorov AA, Bonanno JB, Le Gall C, Crowley S, Espinosa C, Biary T, Keliher EJ, Weissleder R, Almo SC, Dougan SK, Ploegh HL, Dougan M.

Proc Natl Acad Sci U S A. 2018 Apr 10;115(15):3912-3917. doi: 10.1073/pnas.1801524115. Epub 2018 Mar 26.

3.

Phosphorylation of IRE1 at S729 regulates RIDD in B cells and antibody production after immunization.

Tang CH, Chang S, Paton AW, Paton JC, Gabrilovich DI, Ploegh HL, Del Valle JR, Hu CC.

J Cell Biol. 2018 Mar 6. pii: jcb.201709137. doi: 10.1083/jcb.201709137. [Epub ahead of print]

PMID:
29511123
4.

Exploiting Nanobodies' Singular Traits.

Ingram JR, Schmidt FI, Ploegh HL.

Annu Rev Immunol. 2018 Feb 28. doi: 10.1146/annurev-immunol-042617-053327. [Epub ahead of print]

PMID:
29490163
5.

Targeting Cytokine Therapy to the Pancreatic Tumor Microenvironment Using PD-L1-Specific VHHs.

Dougan M, Ingram JR, Jeong HJ, Mosaheb MM, Bruck PT, Ali L, Pishesha N, Blomberg O, Tyler PM, Servos MM, Rashidian M, Nguyen QD, von Andrian UH, Ploegh HL, Dougan SK.

Cancer Immunol Res. 2018 Apr;6(4):389-401. doi: 10.1158/2326-6066.CIR-17-0495. Epub 2018 Feb 19.

PMID:
29459478
6.

Identification of a Novel CD8 T Cell Epitope Derived from Plasmodium berghei Protective Liver-Stage Antigen.

Pichugin A, Zarling S, Perazzo L, Duffy PE, Ploegh HL, Krzych U.

Front Immunol. 2018 Jan 29;9:91. doi: 10.3389/fimmu.2018.00091. eCollection 2018.

7.

The activity of myeloid cell-specific VHH immunotoxins is target-, epitope-, subset- and organ dependent.

Bachran C, Schröder M, Conrad L, Cragnolini JJ, Tafesse FG, Helming L, Ploegh HL, Swee LK.

Sci Rep. 2017 Dec 20;7(1):17916. doi: 10.1038/s41598-017-17948-0.

8.

In vitro AMPylation Assays Using Purified, Recombinant Proteins.

Truttmann MC, Ploegh HL.

Bio Protoc. 2017 Jul 20;7(14). pii: e2416. doi: 10.21769/BioProtoc.2416.

9.

Targeted antigen delivery by an anti-class II MHC VHH elicits focused αMUC1(Tn) immunity.

Fang T, Van Elssen CHMJ, Duarte JN, Guzman JS, Chahal JS, Ling J, Ploegh HL.

Chem Sci. 2017 Aug 1;8(8):5591-5597. doi: 10.1039/c7sc00446j. Epub 2017 May 26.

10.

PD-L1 is an activation-independent marker of brown adipocytes.

Ingram JR, Dougan M, Rashidian M, Knoll M, Keliher EJ, Garrett S, Garforth S, Blomberg OS, Espinosa C, Bhan A, Almo SC, Weissleder R, Lodish H, Dougan SK, Ploegh HL.

Nat Commun. 2017 Sep 21;8(1):647. doi: 10.1038/s41467-017-00799-8.

11.

Localized CD47 blockade enhances immunotherapy for murine melanoma.

Ingram JR, Blomberg OS, Sockolosky JT, Ali L, Schmidt FI, Pishesha N, Espinosa C, Dougan SK, Garcia KC, Ploegh HL, Dougan M.

Proc Natl Acad Sci U S A. 2017 Sep 19;114(38):10184-10189. doi: 10.1073/pnas.1710776114. Epub 2017 Sep 5.

12.

Tissue-specific emergence of regulatory and intraepithelial T cells from a clonal T cell precursor.

Bilate AM, Bousbaine D, Mesin L, Agudelo M, Leube J, Kratzert A, Dougan SK, Victora GD, Ploegh HL.

Sci Immunol. 2016 Aug 26;1(2):eaaf7471. doi: 10.1126/sciimmunol.aaf7471. Epub 2016 Aug 26.

PMID:
28783695
13.

Site-Specific Protein Labeling via Sortase-Mediated Transpeptidation.

Antos JM, Ingram J, Fang T, Pishesha N, Truttmann MC, Ploegh HL.

Curr Protoc Protein Sci. 2017 Aug 1;89:15.3.1-15.3.19. doi: 10.1002/cpps.38.

PMID:
28762490
14.

Editorial: Crystal death: it's not always the inflammasome...

Schmidt FI, Ploegh HL.

J Leukoc Biol. 2017 Jul;102(1):1-4. doi: 10.1189/jlb.3CE0117-022R. No abstract available.

PMID:
28667083
15.

Predicting the response to CTLA-4 blockade by longitudinal noninvasive monitoring of CD8 T cells.

Rashidian M, Ingram JR, Dougan M, Dongre A, Whang KA, LeGall C, Cragnolini JJ, Bierie B, Gostissa M, Gorman J, Grotenbreg GM, Bhan A, Weinberg RA, Ploegh HL.

J Exp Med. 2017 Aug 7;214(8):2243-2255. doi: 10.1084/jem.20161950. Epub 2017 Jun 30.

16.

Monoclonal Invariant NKT (iNKT) Cell Mice Reveal a Role for Both Tissue of Origin and the TCR in Development of iNKT Functional Subsets.

Clancy-Thompson E, Chen GZ, Tyler PM, Servos MM, Barisa M, Brennan PJ, Ploegh HL, Dougan SK.

J Immunol. 2017 Jul 1;199(1):159-171. doi: 10.4049/jimmunol.1700214. Epub 2017 Jun 2.

PMID:
28576977
17.

rAMPing Up Stress Signaling: Protein AMPylation in Metazoans.

Truttmann MC, Ploegh HL.

Trends Cell Biol. 2017 Aug;27(8):608-620. doi: 10.1016/j.tcb.2017.03.004. Epub 2017 Apr 19. Review.

PMID:
28433487
18.

Epithelial-to-Mesenchymal Transition Contributes to Immunosuppression in Breast Carcinomas.

Dongre A, Rashidian M, Reinhardt F, Bagnato A, Keckesova Z, Ploegh HL, Weinberg RA.

Cancer Res. 2017 Aug 1;77(15):3982-3989. doi: 10.1158/0008-5472.CAN-16-3292. Epub 2017 Apr 20.

19.

Vesicular stomatitis virus N protein-specific single-domain antibody fragments inhibit replication.

Hanke L, Schmidt FI, Knockenhauer KE, Morin B, Whelan SP, Schwartz TU, Ploegh HL.

EMBO Rep. 2017 Jun;18(6):1027-1037. doi: 10.15252/embr.201643764. Epub 2017 Apr 10.

PMID:
28396572
20.

An RNA nanoparticle vaccine against Zika virus elicits antibody and CD8+ T cell responses in a mouse model.

Chahal JS, Fang T, Woodham AW, Khan OF, Ling J, Anderson DG, Ploegh HL.

Sci Rep. 2017 Mar 21;7(1):252. doi: 10.1038/s41598-017-00193-w.

21.

Engineered erythrocytes covalently linked to antigenic peptides can protect against autoimmune disease.

Pishesha N, Bilate AM, Wibowo MC, Huang NJ, Li Z, Deshycka R, Bousbaine D, Li H, Patterson HC, Dougan SK, Maruyama T, Lodish HF, Ploegh HL.

Proc Natl Acad Sci U S A. 2017 Mar 21;114(12):3157-3162. doi: 10.1073/pnas.1701746114. Epub 2017 Mar 7. Erratum in: Proc Natl Acad Sci U S A. 2017 Apr 25;114(17 ):E3583. Dhesycka, Rhogerry [corrected to Deshycka, Rhogerry].

22.

Noninvasive Imaging of Human Immune Responses in a Human Xenograft Model of Graft-Versus-Host Disease.

Van Elssen CHMJ, Rashidian M, Vrbanac V, Wucherpfennig KW, Habre ZE, Sticht J, Freund C, Jacobsen JT, Cragnolini J, Ingram J, Plaisier L, Spierings E, Tager AM, Ploegh HL.

J Nucl Med. 2017 Jun;58(6):1003-1008. doi: 10.2967/jnumed.116.186007. Epub 2017 Feb 16.

23.

Hepta-Mutant Staphylococcus aureus Sortase A (SrtA7m) as a Tool for in Vivo Protein Labeling in Caenorhabditis elegans.

Wu Q, Ploegh HL, Truttmann MC.

ACS Chem Biol. 2017 Mar 17;12(3):664-673. doi: 10.1021/acschembio.6b00998. Epub 2017 Jan 18.

24.

Enhanced Cell Capture on Functionalized Graphene Oxide Nanosheets through Oxygen Clustering.

Bardhan NM, Kumar PV, Li Z, Ploegh HL, Grossman JC, Belcher AM, Chen GY.

ACS Nano. 2017 Feb 28;11(2):1548-1558. doi: 10.1021/acsnano.6b06979. Epub 2017 Jan 24.

25.

Cocapture of cognate and bystander antigens can activate autoreactive B cells.

Sanderson NS, Zimmermann M, Eilinger L, Gubser C, Schaeren-Wiemers N, Lindberg RL, Dougan SK, Ploegh HL, Kappos L, Derfuss T.

Proc Natl Acad Sci U S A. 2017 Jan 24;114(4):734-739. doi: 10.1073/pnas.1614472114. Epub 2017 Jan 5.

26.

Unrestrained AMPylation targets cytosolic chaperones and activates the heat shock response.

Truttmann MC, Zheng X, Hanke L, Damon JR, Grootveld M, Krakowiak J, Pincus D, Ploegh HL.

Proc Natl Acad Sci U S A. 2017 Jan 10;114(2):E152-E160. doi: 10.1073/pnas.1619234114. Epub 2016 Dec 28.

27.

The Antiviral Mechanism of an Influenza A Virus Nucleoprotein-Specific Single-Domain Antibody Fragment.

Hanke L, Knockenhauer KE, Brewer RC, van Diest E, Schmidt FI, Schwartz TU, Ploegh HL.

MBio. 2016 Dec 13;7(6). pii: e01569-16. doi: 10.1128/mBio.01569-16.

28.

Peripheral self-reactivity regulates antigen-specific CD8 T-cell responses and cell division under physiological conditions.

Swee LK, Tan ZW, Sanecka A, Yoshida N, Patel H, Grotenbreg G, Frickel EM, Ploegh HL.

Open Biol. 2016 Nov;6(11). pii: 160293.

29.

Crystal Structure and Conformational Change Mechanism of a Bacterial Nramp-Family Divalent Metal Transporter.

Bozzi AT, Bane LB, Weihofen WA, Singharoy A, Guillen ER, Ploegh HL, Schulten K, Gaudet R.

Structure. 2016 Dec 6;24(12):2102-2114. doi: 10.1016/j.str.2016.09.017. Epub 2016 Nov 10.

30.

Generation of Immunity against Pathogens via Single-Domain Antibody-Antigen Constructs.

Duarte JN, Cragnolini JJ, Swee LK, Bilate AM, Bader J, Ingram JR, Rashidfarrokhi A, Fang T, Schiepers A, Hanke L, Ploegh HL.

J Immunol. 2016 Dec 15;197(12):4838-4847. Epub 2016 Nov 7.

31.

Rapid capture and labeling of cells on single domain antibodies-functionalized flow cell.

Chen GY, Li Z, Duarte JN, Esteban A, Cheloha RW, Theile CS, Fink GR, Ploegh HL.

Biosens Bioelectron. 2017 Mar 15;89(Pt 2):789-794. doi: 10.1016/j.bios.2016.10.015. Epub 2016 Oct 5.

32.

Phenotypic lentivirus screens to identify functional single domain antibodies.

Schmidt FI, Hanke L, Morin B, Brewer R, Brusic V, Whelan SP, Ploegh HL.

Nat Microbiol. 2016 Jun 20;1(8):16080. doi: 10.1038/nmicrobiol.2016.80.

33.

Posttranscriptional Regulation of Glycoprotein Quality Control in the Endoplasmic Reticulum Is Controlled by the E2 Ub-Conjugating Enzyme UBC6e.

Hagiwara M, Ling J, Koenig PA, Ploegh HL.

Mol Cell. 2016 Sep 1;63(5):753-67. doi: 10.1016/j.molcel.2016.07.014. Epub 2016 Aug 25.

34.

Thymic CD4 T cell selection requires attenuation of March8-mediated MHCII turnover in cortical epithelial cells through CD83.

von Rohrscheidt J, Petrozziello E, Nedjic J, Federle C, Krzyzak L, Ploegh HL, Ishido S, Steinkasserer A, Klein L.

J Exp Med. 2016 Aug 22;213(9):1685-94. doi: 10.1084/jem.20160316. Epub 2016 Aug 8.

35.

Structures of TorsinA and its disease-mutant complexed with an activator reveal the molecular basis for primary dystonia.

Demircioglu FE, Sosa BA, Ingram J, Ploegh HL, Schwartz TU.

Elife. 2016 Aug 4;5. pii: e17983. doi: 10.7554/eLife.17983.

36.

Dendrimer-RNA nanoparticles generate protective immunity against lethal Ebola, H1N1 influenza, and Toxoplasma gondii challenges with a single dose.

Chahal JS, Khan OF, Cooper CL, McPartlan JS, Tsosie JK, Tilley LD, Sidik SM, Lourido S, Langer R, Bavari S, Ploegh HL, Anderson DG.

Proc Natl Acad Sci U S A. 2016 Jul 19;113(29):E4133-42. doi: 10.1073/pnas.1600299113. Epub 2016 Jul 5. Erratum in: Proc Natl Acad Sci U S A. 2016 Aug 30;113(35):E5250.

37.

Recent advances in sortase-catalyzed ligation methodology.

Antos JM, Truttmann MC, Ploegh HL.

Curr Opin Struct Biol. 2016 Jun;38:111-8. doi: 10.1016/j.sbi.2016.05.021. Epub 2016 Jun 16. Review.

38.

Longitudinal multiparameter assay of lymphocyte interactions from onset by microfluidic cell pairing and culture.

Dura B, Servos MM, Barry RM, Ploegh HL, Dougan SK, Voldman J.

Proc Natl Acad Sci U S A. 2016 Jun 28;113(26):E3599-608. doi: 10.1073/pnas.1515364113. Epub 2016 Jun 14.

39.

The Caenorhabditis elegans Protein FIC-1 Is an AMPylase That Covalently Modifies Heat-Shock 70 Family Proteins, Translation Elongation Factors and Histones.

Truttmann MC, Cruz VE, Guo X, Engert C, Schwartz TU, Ploegh HL.

PLoS Genet. 2016 May 3;12(5):e1006023. doi: 10.1371/journal.pgen.1006023. eCollection 2016 May.

40.

Durable antitumor responses to CD47 blockade require adaptive immune stimulation.

Sockolosky JT, Dougan M, Ingram JR, Ho CC, Kauke MJ, Almo SC, Ploegh HL, Garcia KC.

Proc Natl Acad Sci U S A. 2016 May 10;113(19):E2646-54. doi: 10.1073/pnas.1604268113. Epub 2016 Apr 18.

41.

A single domain antibody fragment that recognizes the adaptor ASC defines the role of ASC domains in inflammasome assembly.

Schmidt FI, Lu A, Chen JW, Ruan J, Tang C, Wu H, Ploegh HL.

J Exp Med. 2016 May 2;213(5):771-90. doi: 10.1084/jem.20151790. Epub 2016 Apr 11.

42.

Molecular basis of caspase-1 polymerization and its inhibition by a new capping mechanism.

Lu A, Li Y, Schmidt FI, Yin Q, Chen S, Fu TM, Tong AB, Ploegh HL, Mao Y, Wu H.

Nat Struct Mol Biol. 2016 May;23(5):416-25. doi: 10.1038/nsmb.3199. Epub 2016 Apr 4.

43.

Corrigendum: CEACAM1 regulates TIM-3-mediated tolerance and exhaustion.

Huang YH, Zhu C, Kondo Y, Anderson AC, Gandhi A, Russell A, Dougan SK, Petersen BS, Melum E, Pertel T, Clayton KL, Raab M, Chen Q, Beauchemin N, Yazaki PJ, Pyzik M, Ostrowski MA, Glickman JN, Rudd CE, Ploegh HL, Franke A, Petsko GA, Kuchroo VK, Blumberg RS.

Nature. 2016 Aug 18;536(7616):359. doi: 10.1038/nature17421. Epub 2016 Mar 16. No abstract available.

44.

Corrigendum: Increasing the efficiency of precise genome editing with CRISPR-Cas9 by inhibition of nonhomologous end joining.

Maruyama T, Dougan SK, Truttmann MC, Bilate AM, Ingram JR, Ploegh HL.

Nat Biotechnol. 2016 Feb;34(2):210. doi: 10.1038/nbt0216-210c. No abstract available.

PMID:
26849523
45.

Structurally Defined αMHC-II Nanobody-Drug Conjugates: A Therapeutic and Imaging System for B-Cell Lymphoma.

Fang T, Duarte JN, Ling J, Li Z, Guzman JS, Ploegh HL.

Angew Chem Int Ed Engl. 2016 Feb 12;55(7):2416-20. doi: 10.1002/anie.201509432. Epub 2016 Jan 14.

46.

Usp12 stabilizes the T-cell receptor complex at the cell surface during signaling.

Jahan AS, Lestra M, Swee LK, Fan Y, Lamers MM, Tafesse FG, Theile CS, Spooner E, Bruzzone R, Ploegh HL, Sanyal S.

Proc Natl Acad Sci U S A. 2016 Feb 9;113(6):E705-14. doi: 10.1073/pnas.1521763113. Epub 2016 Jan 25.

47.

Graphene Oxide Nanosheets Modified with Single-Domain Antibodies for Rapid and Efficient Capture of Cells.

Chen GY, Li Z, Theile CS, Bardhan NM, Kumar PV, Duarte JN, Maruyama T, Rashidfarrokh A, Belcher AM, Ploegh HL.

Chemistry. 2015 Nov 23;21(48):17178-83. doi: 10.1002/chem.201503057. Epub 2015 Oct 16.

48.

Disruption of Sphingolipid Biosynthesis Blocks Phagocytosis of Candida albicans.

Tafesse FG, Rashidfarrokhi A, Schmidt FI, Freinkman E, Dougan S, Dougan M, Esteban A, Maruyama T, Strijbis K, Ploegh HL.

PLoS Pathog. 2015 Oct 2;11(10):e1005188. doi: 10.1371/journal.ppat.1005188. eCollection 2015 Oct.

49.

Allosteric activation of apicomplexan calcium-dependent protein kinases.

Ingram JR, Knockenhauer KE, Markus BM, Mandelbaum J, Ramek A, Shan Y, Shaw DE, Schwartz TU, Ploegh HL, Lourido S.

Proc Natl Acad Sci U S A. 2015 Sep 8;112(36):E4975-84. doi: 10.1073/pnas.1505914112. Epub 2015 Aug 24.

50.

Fluorophore-Conjugated Holliday Junctions for Generating Super-Bright Antibodies and Antibody Fragments.

Li Z, Theile CS, Chen GY, Bilate AM, Duarte JN, Avalos AM, Fang T, Barberena R, Sato S, Ploegh HL.

Angew Chem Int Ed Engl. 2015 Sep 28;54(40):11706-10. doi: 10.1002/anie.201505277. Epub 2015 Aug 7.

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