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Items: 1 to 50 of 182

1.

Inhibition of CD95/CD95L Signaling with APG101 Prevents Invasion and Enhances Radiation Therapy for Glioblastoma.

Blaes J, Thomé CM, Pfenning PN, Rübmann P, Sahm F, Wick A, Bunse T, Schmenger T, Sykora J, von Deimling A, Wiestler B, Merz C, Jugold M, Haberkorn U, Abdollahi A, Debus J, Gieffers C, Kunz C, Bendszus M, Kluge M, Platten M, Fricke H, Wick W, Lemke D.

Mol Cancer Res. 2018 Feb 16. pii: molcanres.0563.2017. doi: 10.1158/1541-7786.MCR-17-0563. [Epub ahead of print]

PMID:
29453321
2.

Off-label use of IV t-PA in patients with intracranial neoplasm and cavernoma.

Schwarzbach CJ, Ebert A, Hennerici MG, Neumaier-Probst E, Platten M, Fatar M.

Ther Adv Neurol Disord. 2018 Feb 5;11:1756285617753423. doi: 10.1177/1756285617753423. eCollection 2018.

3.

Spatiotemporal evolution of venous narrowing in acute MS lesions.

Eisele P, Szabo K, Ebert A, Brueck W, Platten M, Gass A.

Neurol Neuroimmunol Neuroinflamm. 2018 Jan 17;5(2):e440. doi: 10.1212/NXI.0000000000000440. eCollection 2018 Mar.

4.

Fourier Transform Infrared Microscopy Enables Guidance of Automated Mass Spectrometry Imaging to Predefined Tissue Morphologies.

Rabe JH, A Sammour D, Schulz S, Munteanu B, Ott M, Ochs K, Hohenberger P, Marx A, Platten M, Opitz CA, Ory DS, Hopf C.

Sci Rep. 2018 Jan 10;8(1):313. doi: 10.1038/s41598-017-18477-6.

5.

Iron Induces Anti-tumor Activity in Tumor-Associated Macrophages.

Costa da Silva M, Breckwoldt MO, Vinchi F, Correia MP, Stojanovic A, Thielmann CM, Meister M, Muley T, Warth A, Platten M, Hentze MW, Cerwenka A, Muckenthaler MU.

Front Immunol. 2017 Nov 8;8:1479. doi: 10.3389/fimmu.2017.01479. eCollection 2017.

6.

Feasibility of real-time molecular profiling for patients with newly diagnosed glioblastoma without MGMT promoter-hypermethylation - the NCT Neuro Master Match (N2M2) pilot study.

Pfaff E, Kessler T, Balasubramanian GP, Berberich A, Schrimpf D, Wick A, Debus J, Unterberg A, Bendszus M, Herold-Mende C, Capper D, Schenkel I, Eisenmenger A, Dettmer S, Brors B, Platten M, Pfister SM, von Deimling A, Jones DTW, Wick W, Sahm F.

Neuro Oncol. 2017 Nov 18. doi: 10.1093/neuonc/nox216. [Epub ahead of print]

PMID:
29165638
7.

Lomustine and Bevacizumab in Progressive Glioblastoma.

Wick W, Gorlia T, Bendszus M, Taphoorn M, Sahm F, Harting I, Brandes AA, Taal W, Domont J, Idbaih A, Campone M, Clement PM, Stupp R, Fabbro M, Le Rhun E, Dubois F, Weller M, von Deimling A, Golfinopoulos V, Bromberg JC, Platten M, Klein M, van den Bent MJ.

N Engl J Med. 2017 Nov 16;377(20):1954-1963. doi: 10.1056/NEJMoa1707358.

PMID:
29141164
8.

Synergy of vaccination and agonist OX40 treatment-toward a mechanism-driven combination of glioma immunotherapy.

Deumelandt K, Platten M, Ochs K.

Neuro Oncol. 2018 Jan 10;20(1):4-5. doi: 10.1093/neuonc/nox169. No abstract available.

PMID:
29092058
9.

Treatment of Early Syphilis.

Fätkenheuer G, Suarez I, Platten M, Fabri M, Lehmann C.

Clin Infect Dis. 2017 Oct 30;65(10):1767. doi: 10.1093/cid/cix591. No abstract available.

PMID:
29091229
10.

[Nontuberculous mycobacterial infections].

Nowag A, Platten M, Plum G, Hartmann P.

Z Rheumatol. 2017 Nov;76(9):752-760. doi: 10.1007/s00393-017-0392-3. Review. German.

PMID:
29071482
11.

EGFRvIII vaccine in glioblastoma-InACT-IVe or not ReACTive enough?

Platten M.

Neuro Oncol. 2017 Oct 19;19(11):1425-1426. doi: 10.1093/neuonc/nox167. No abstract available.

PMID:
29059447
12.

Radiologic progression of glioblastoma under therapy - an exploratory analysis of AVAglio.

Nowosielski M, Ellingson BM, Chinot OL, Garcia J, Revil C, Radbruch A, Nishikawa R, Mason WP, Henriksson R, Saran F, Kickingereder P, Platten M, Sandmann T, Abrey LE, Cloughesy TF, Bendszus M, Wick W.

Neuro Oncol. 2017 Sep 1. doi: 10.1093/neuonc/nox162. [Epub ahead of print]

PMID:
29016943
13.

Glioblastoma in elderly patients: solid conclusions built on shifting sand?

Wick A, Kessler T, Elia AEH, Winkler F, Batchelor TT, Platten M, Wick W.

Neuro Oncol. 2018 Jan 22;20(2):174-183. doi: 10.1093/neuonc/nox133.

PMID:
29016815
14.

Molecular differences in IDH wildtype glioblastoma according to MGMT promoter methylation.

Kessler T, Sahm F, Sadik A, Stichel D, Hertenstein A, Reifenberger G, Zacher A, Sabel M, Tabatabai G, Steinbach J, Sure U, Krex D, Grosu AL, Bewerunge-Hudler M, Jones D, Pfister SM, Weller M, Opitz C, Bendszus M, von Deimling A, Platten M, Wick W.

Neuro Oncol. 2018 Feb 19;20(3):367-379. doi: 10.1093/neuonc/nox160.

PMID:
29016808
15.

The promises of immunotherapy in gliomas.

Mildenberger I, Bunse L, Ochs K, Platten M.

Curr Opin Neurol. 2017 Dec;30(6):650-658. doi: 10.1097/WCO.0000000000000491.

PMID:
28984704
16.

Fully automated joint space width measurement and digital X-ray radiogrammetry in early RA.

Platten M, Kisten Y, Kälvesten J, Arnaud L, Forslind K, van Vollenhoven R.

RMD Open. 2017 Jun 29;3(1):e000369. doi: 10.1136/rmdopen-2016-000369. eCollection 2017.

17.

K27M-mutant histone-3 as a novel target for glioma immunotherapy.

Ochs K, Ott M, Bunse T, Sahm F, Bunse L, Deumelandt K, Sonner JK, Keil M, von Deimling A, Wick W, Platten M.

Oncoimmunology. 2017 May 12;6(7):e1328340. doi: 10.1080/2162402X.2017.1328340. eCollection 2017.

18.

Lack of T1 hyperintensity in the dentate nucleus after 15 administrations of a macrocyclic contrast agent in multiple sclerosis.

Eisele P, Szabo K, Alonso A, Ong M, Platten M, Schoenberg SO, Gass A.

J Neurol Neurosurg Psychiatry. 2018 Mar;89(3):324-326. doi: 10.1136/jnnp-2017-316102. Epub 2017 Jul 14. No abstract available.

PMID:
28710325
19.

HIV-Associated Cerebellar Dysfunction and Improvement with Aminopyridine Therapy: A Case Report.

Hoyer C, Alonso A, Schlotter-Weigel B, Platten M, Fatar M.

Case Rep Neurol. 2017 May 16;9(2):121-126. doi: 10.1159/000475544. eCollection 2017 May-Aug.

20.

Tweety-Homolog 1 Drives Brain Colonization of Gliomas.

Jung E, Osswald M, Blaes J, Wiestler B, Sahm F, Schmenger T, Solecki G, Deumelandt K, Kurz FT, Xie R, Weil S, Heil O, Thomé C, Gömmel M, Syed M, Häring P, Huber PE, Heiland S, Platten M, von Deimling A, Wick W, Winkler F.

J Neurosci. 2017 Jul 19;37(29):6837-6850. doi: 10.1523/JNEUROSCI.3532-16.2017. Epub 2017 Jun 12.

21.

Structural Basis for Aryl Hydrocarbon Receptor-Mediated Gene Activation.

Schulte KW, Green E, Wilz A, Platten M, Daumke O.

Structure. 2017 Jul 5;25(7):1025-1033.e3. doi: 10.1016/j.str.2017.05.008. Epub 2017 Jun 9.

PMID:
28602820
22.

Vaccine-based immunotherapeutic approaches to gliomas and beyond.

Weller M, Roth P, Preusser M, Wick W, Reardon DA, Platten M, Sampson JH.

Nat Rev Neurol. 2017 Jun;13(6):363-374. doi: 10.1038/nrneurol.2017.64. Epub 2017 May 12. Review.

PMID:
28497804
23.

Suppression of Th1 differentiation by tryptophan supplementation in vivo.

Lanz TV, Becker S, Mohapatra SR, Opitz CA, Wick W, Platten M.

Amino Acids. 2017 Jul;49(7):1169-1175. doi: 10.1007/s00726-017-2415-4. Epub 2017 Apr 18.

PMID:
28421297
24.

Suppression of indoleamine-2,3-dioxygenase 1 expression by promoter hypermethylation in ER-positive breast cancer.

Dewi DL, Mohapatra SR, Blanco Cabañes S, Adam I, Somarribas Patterson LF, Berdel B, Kahloon M, Thürmann L, Loth S, Heilmann K, Weichenhan D, Mücke O, Heiland I, Wimberger P, Kuhlmann JD, Kellner KH, Schott S, Plass C, Platten M, Gerhäuser C, Trump S, Opitz CA.

Oncoimmunology. 2017 Jan 3;6(2):e1274477. doi: 10.1080/2162402X.2016.1274477. eCollection 2017.

25.

DNA methylation-based classification and grading system for meningioma: a multicentre, retrospective analysis.

Sahm F, Schrimpf D, Stichel D, Jones DTW, Hielscher T, Schefzyk S, Okonechnikov K, Koelsche C, Reuss DE, Capper D, Sturm D, Wirsching HG, Berghoff AS, Baumgarten P, Kratz A, Huang K, Wefers AK, Hovestadt V, Sill M, Ellis HP, Kurian KM, Okuducu AF, Jungk C, Drueschler K, Schick M, Bewerunge-Hudler M, Mawrin C, Seiz-Rosenhagen M, Ketter R, Simon M, Westphal M, Lamszus K, Becker A, Koch A, Schittenhelm J, Rushing EJ, Collins VP, Brehmer S, Chavez L, Platten M, Hänggi D, Unterberg A, Paulus W, Wick W, Pfister SM, Mittelbronn M, Preusser M, Herold-Mende C, Weller M, von Deimling A.

Lancet Oncol. 2017 May;18(5):682-694. doi: 10.1016/S1470-2045(17)30155-9. Epub 2017 Mar 15.

26.

Synovial Fibroblasts Selectively Suppress Th1 Cell Responses through IDO1-Mediated Tryptophan Catabolism.

Tykocinski LO, Lauffer AM, Bohnen A, Kaul NC, Krienke S, Tretter T, Adam I, Mohapatra SR, Saikali P, Löhning M, Neidhart M, Gay S, Oezen I, Platten M, Opitz CA, Lorenz HM.

J Immunol. 2017 Apr 15;198(8):3109-3117. doi: 10.4049/jimmunol.1600600. Epub 2017 Mar 6.

PMID:
28264972
27.

[Interaction between heart and brain in sudden cardiac death].

Fatar M, Akin I, Borggrefe M, Platten M, Alonso A.

Herz. 2017 Apr;42(2):171-175. doi: 10.1007/s00059-017-4547-4. Review. German.

PMID:
28246702
28.

Pan-mutant IDH1 inhibitor BAY 1436032 for effective treatment of IDH1 mutant astrocytoma in vivo.

Pusch S, Krausert S, Fischer V, Balss J, Ott M, Schrimpf D, Capper D, Sahm F, Eisel J, Beck AC, Jugold M, Eichwald V, Kaulfuss S, Panknin O, Rehwinkel H, Zimmermann K, Hillig RC, Guenther J, Toschi L, Neuhaus R, Haegebart A, Hess-Stumpp H, Bauser M, Wick W, Unterberg A, Herold-Mende C, Platten M, von Deimling A.

Acta Neuropathol. 2017 Apr;133(4):629-644. doi: 10.1007/s00401-017-1677-y. Epub 2017 Jan 25.

PMID:
28124097
29.

The stress kinase GCN2 does not mediate suppression of antitumor T cell responses by tryptophan catabolism in experimental melanomas.

Sonner JK, Deumelandt K, Ott M, Thomé CM, Rauschenbach KJ, Schulz S, Munteanu B, Mohapatra S, Adam I, Hofer AC, Feuerer M, Opitz CA, Hopf C, Wick W, Platten M.

Oncoimmunology. 2016 Nov 15;5(12):e1240858. doi: 10.1080/2162402X.2016.1240858. eCollection 2016.

30.

Tryptophan-2,3-Dioxygenase (TDO) deficiency is associated with subclinical neuroprotection in a mouse model of multiple sclerosis.

Lanz TV, Williams SK, Stojic A, Iwantscheff S, Sonner JK, Grabitz C, Becker S, Böhler LI, Mohapatra SR, Sahm F, Küblbeck G, Nakamura T, Funakoshi H, Opitz CA, Wick W, Diem R, Platten M.

Sci Rep. 2017 Jan 24;7:41271. doi: 10.1038/srep41271.

31.

Gain of 12p encompassing CCND2 is associated with gemistocytic histology in IDH mutant astrocytomas.

Sahm F, Korshunov A, Schrimpf D, Stichel D, Jones DT, Capper D, Koelsche C, Reuss D, Kratz A, Huang K, Wefers AK, Schick M, Bewerunge-Hudler M, Mittelbronn M, Platten M, Hänggi D, Jeibmann A, Unterberg A, Herold-Mende C, Pfister SM, Brandner S, Wick W, von Deimling A.

Acta Neuropathol. 2017 Feb;133(2):325-327. doi: 10.1007/s00401-016-1657-7. Epub 2016 Dec 20. No abstract available.

PMID:
28000032
32.

Neurological sequelae of cancer immunotherapies and targeted therapies.

Wick W, Hertenstein A, Platten M.

Lancet Oncol. 2016 Dec;17(12):e529-e541. doi: 10.1016/S1470-2045(16)30571-X. Review.

PMID:
27924751
33.

Increasing the sensitivity of MRI for the detection of multiple sclerosis lesions by long axial coverage of the spinal cord: a prospective study in 119 patients.

Breckwoldt MO, Gradl J, Hähnel S, Hielscher T, Wildemann B, Diem R, Platten M, Wick W, Heiland S, Bendszus M.

J Neurol. 2017 Feb;264(2):341-349. doi: 10.1007/s00415-016-8353-3. Epub 2016 Dec 1.

PMID:
27909801
34.

Prognostic relevance of miRNA-155 methylation in anaplastic glioma.

Schliesser MG, Claus R, Hielscher T, Grimm C, Weichenhan D, Blaes J, Wiestler B, Hau P, Schramm J, Sahm F, Weiß EK, Weiler M, Baer C, Schmidt-Graf F, Schackert G, Westphal M, Hertenstein A, Roth P, Galldiks N, Hartmann C, Pietsch T, Felsberg J, Reifenberger G, Sabel MC, Winkler F, von Deimling A, Meisner C, Vajkoczy P, Platten M, Weller M, Plass C, Wick W.

Oncotarget. 2016 Dec 13;7(50):82028-82045. doi: 10.18632/oncotarget.13452.

35.

In vivo nanoparticle imaging of innate immune cells can serve as a marker of disease severity in a model of multiple sclerosis.

Kirschbaum K, Sonner JK, Zeller MW, Deumelandt K, Bode J, Sharma R, Krüwel T, Fischer M, Hoffmann A, Costa da Silva M, Muckenthaler MU, Wick W, Tews B, Chen JW, Heiland S, Bendszus M, Platten M, Breckwoldt MO.

Proc Natl Acad Sci U S A. 2016 Nov 15;113(46):13227-13232. Epub 2016 Oct 31.

36.

Highlights in Central Nervous System Tumors.

Hertenstein A, Platten M, Wick W.

JAMA Oncol. 2016 Dec 1;2(12):1535-1536. doi: 10.1001/jamaoncol.2016.3673. No abstract available.

PMID:
27658179
37.

Concepts in glioma immunotherapy.

Platten M, Bunse L, Wick W, Bunse T.

Cancer Immunol Immunother. 2016 Oct;65(10):1269-75. doi: 10.1007/s00262-016-1874-x. Epub 2016 Jul 26. Review.

PMID:
27460064
38.

Slowing down glioblastoma progression in mice by running or the anti-malarial drug dihydroartemisinin? Induction of oxidative stress in murine glioblastoma therapy.

Lemke D, Pledl HW, Zorn M, Jugold M, Green E, Blaes J, Löw S, Hertenstein A, Ott M, Sahm F, Steffen AC, Weiler M, Winkler F, Platten M, Dong Z, Wick W.

Oncotarget. 2016 Aug 30;7(35):56713-56725. doi: 10.18632/oncotarget.10723.

39.

Impact of tapering and discontinuation of bevacizumab in patients with progressive glioblastoma.

Hertenstein A, Hielscher T, Menn O, Wiestler B, Winkler F, Platten M, Wick W, Wick A.

J Neurooncol. 2016 Sep;129(3):533-539. doi: 10.1007/s11060-016-2206-x. Epub 2016 Jul 15.

PMID:
27422128
40.

General control non-derepressible 2 (GCN2) in T cells controls disease progression of autoimmune neuroinflammation.

Keil M, Sonner JK, Lanz TV, Oezen I, Bunse T, Bittner S, Meyer HV, Meuth SG, Wick W, Platten M.

J Neuroimmunol. 2016 Aug 15;297:117-26. doi: 10.1016/j.jneuroim.2016.05.014. Epub 2016 May 20.

PMID:
27397084
41.

Long-term analysis of the NOA-04 randomized phase III trial of sequential radiochemotherapy of anaplastic glioma with PCV or temozolomide.

Wick W, Roth P, Hartmann C, Hau P, Nakamura M, Stockhammer F, Sabel MC, Wick A, Koeppen S, Ketter R, Vajkoczy P, Eyupoglu I, Kalff R, Pietsch T, Happold C, Galldiks N, Schmidt-Graf F, Bamberg M, Reifenberger G, Platten M, von Deimling A, Meisner C, Wiestler B, Weller M; Neurooncology Working Group (NOA) of the German Cancer Society.

Neuro Oncol. 2016 Nov;18(11):1529-1537. Epub 2016 Jul 1. Erratum in: Neuro Oncol. 2016 Nov;18(11):e1.

42.

Adding Papillomacular Bundle Measurements to Standard Optical Coherence Tomography Does Not Increase Sensitivity to Detect Prior Optic Neuritis in Patients with Multiple Sclerosis.

Laible M, Jarius S, Mackensen F, Schmidt-Bacher A, Platten M, Haas J, Albrecht P, Wildemann B.

PLoS One. 2016 May 12;11(5):e0155322. doi: 10.1371/journal.pone.0155322. eCollection 2016.

43.

Phase II Study of Radiotherapy and Temsirolimus versus Radiochemotherapy with Temozolomide in Patients with Newly Diagnosed Glioblastoma without MGMT Promoter Hypermethylation (EORTC 26082).

Wick W, Gorlia T, Bady P, Platten M, van den Bent MJ, Taphoorn MJ, Steuve J, Brandes AA, Hamou MF, Wick A, Kosch M, Weller M, Stupp R, Roth P, Golfinopoulos V, Frenel JS, Campone M, Ricard D, Marosi C, Villa S, Weyerbrock A, Hopkins K, Homicsko K, Lhermitte B, Pesce G, Hegi ME.

Clin Cancer Res. 2016 Oct 1;22(19):4797-4806. Epub 2016 May 3.

44.

Autoantigen-specific immunosuppression with tolerogenic peripheral blood cells prevents relapses in a mouse model of relapsing-remitting multiple sclerosis.

Kleist C, Mohr E, Gaikwad S, Dittmar L, Kuerten S, Platten M, Mier W, Schmitt M, Opelz G, Terness P.

J Transl Med. 2016 May 1;14(1):99. doi: 10.1186/s12967-016-0860-6.

45.

Corrigendum: Viraemia suppressed in HIV-1-infected humans by broadly neutralizing antibody 3BNC117.

Caskey M, Klein F, Lorenzi JC, Seaman MS, West AP, Buckley N, Kremer G, Nogueira L, Braunschweig M, Scheid JF, Horwitz JA, Shimeliovich I, Ben-Avraham S, Witmer-Pack M, Platten M, Lehmann C, Burke LA, Hawthorne T, Gorelick RJ, Walker BD, Keler T, Gulick RM, Fätkenheuer G, Schlesinger SJ, Nussenzweig MC.

Nature. 2016 Jul 28;535(7613):580. doi: 10.1038/nature17642. Epub 2016 Mar 23. No abstract available.

PMID:
27007847
46.

Treatment of optic neuritis with erythropoietin (TONE): a randomised, double-blind, placebo-controlled trial-study protocol.

Diem R, Molnar F, Beisse F, Gross N, Drüschler K, Heinrich SP, Joachimsen L, Rauer S, Pielen A, Sühs KW, Linker RA, Huchzermeyer C, Albrecht P, Hassenstein A, Aktas O, Guthoff T, Tonagel F, Kernstock C, Hartmann K, Kümpfel T, Hein K, van Oterendorp C, Grotejohann B, Ihorst G, Maurer J, Müller M, Volkmann M, Wildemann B, Platten M, Wick W, Heesen C, Schiefer U, Wolf S, Lagrèze WA.

BMJ Open. 2016 Mar 1;6(3):e010956. doi: 10.1136/bmjopen-2015-010956.

47.

Correlated magnetic resonance imaging and ultramicroscopy (MR-UM) is a tool kit to assess the dynamics of glioma angiogenesis.

Breckwoldt MO, Bode J, Kurz FT, Hoffmann A, Ochs K, Ott M, Deumelandt K, Krüwel T, Schwarz D, Fischer M, Helluy X, Milford D, Kirschbaum K, Solecki G, Chiblak S, Abdollahi A, Winkler F, Wick W, Platten M, Heiland S, Bendszus M, Tews B.

Elife. 2016 Feb 2;5:e11712. doi: 10.7554/eLife.11712.

48.

Cytokine and Chemokine Signature in Elite Versus Viremic Controllers Infected with HIV.

Platten M, Jung N, Trapp S, Flossdorf P, Meyer-Olson D, Schulze Zur Wiesch J, Stephan C, Mauss S, Weiss V, von Bergwelt-Baildon M, Rockstroh J, Fätkenheuer G, Lehmann C.

AIDS Res Hum Retroviruses. 2016 Jun;32(6):579-87. doi: 10.1089/AID.2015.0226. Epub 2016 Feb 22.

PMID:
26751176
49.

Tryptophan-2,3-dioxygenase is regulated by prostaglandin E2 in malignant glioma via a positive signaling loop involving prostaglandin E receptor-4.

Ochs K, Ott M, Rauschenbach KJ, Deumelandt K, Sahm F, Opitz CA, von Deimling A, Wick W, Platten M.

J Neurochem. 2015 Dec 27. doi: 10.1111/jnc.13503. [Epub ahead of print]

50.

Next-generation sequencing in routine brain tumor diagnostics enables an integrated diagnosis and identifies actionable targets.

Sahm F, Schrimpf D, Jones DT, Meyer J, Kratz A, Reuss D, Capper D, Koelsche C, Korshunov A, Wiestler B, Buchhalter I, Milde T, Selt F, Sturm D, Kool M, Hummel M, Bewerunge-Hudler M, Mawrin C, Schüller U, Jungk C, Wick A, Witt O, Platten M, Herold-Mende C, Unterberg A, Pfister SM, Wick W, von Deimling A.

Acta Neuropathol. 2016 Jun;131(6):903-10. doi: 10.1007/s00401-015-1519-8. Epub 2015 Dec 15.

PMID:
26671409

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