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Items: 47

1.

New Pioglitazone Metabolites and Absence of Opened Ring Metabolites in New N-substituted Thiazolidinedione.

Campos ML, Cerqueira LB, Silva BCU, Franchin TB, Galdino-Pitta MR, Pitta IR, Peccinini RG, Pontarolo R Sr..

Drug Metab Dispos. 2018 Apr 4. pii: dmd.117.079012. doi: 10.1124/dmd.117.079012. [Epub ahead of print]

PMID:
29618574
2.

GQ-11: A new PPAR agonist improves obesity-induced metabolic alterations in LDLr-/- mice.

Silva JC, de Oliveira EM, Turato WM, Trossini GHG, Maltarollo VG, Pitta MGR, Pitta IR, de Las Heras B, Boscá L, Rudnicki M, Abdalla DSP.

Int J Obes (Lond). 2018 Jan 30. doi: 10.1038/s41366-018-0011-7. [Epub ahead of print]

PMID:
29453462
3.

Solid dispersions to enhance the delivery of a potential drug candidate LPSF/FZ4 for the treatment of schistosomiasis.

Schver GCRM, Sun DD, Costa SPM, Silva KER, Oliveira JF, Rolim LA, de Azevedo Albuquerque MCP, de Lima Aires A, Lima MDCA, Pitta IR, Lee PI, Rolim-Neto PJ.

Eur J Pharm Sci. 2018 Mar 30;115:270-285. doi: 10.1016/j.ejps.2018.01.014. Epub 2018 Jan 10.

PMID:
29331607
4.

IL-17 and related cytokines involved in systemic sclerosis: Perspectives.

Gonçalves RSG, Pereira MC, Dantas AT, Almeida AR, Marques CDL, Rego MJBM, Pitta IR, Duarte ALBP, Pitta MGR.

Autoimmunity. 2018 Feb;51(1):1-9. doi: 10.1080/08916934.2017.1416467. Epub 2017 Dec 19.

PMID:
29256263
5.

New thiazacridine agents: Synthesis, physical and chemical characterization, and in vitro anticancer evaluation.

Chagas M, Cordeiro N, Marques K, Rocha Pitta MG, Rêgo M, Lima M, Pitta M, Pitta IR.

Hum Exp Toxicol. 2017 Oct;36(10):1059-1070. doi: 10.1177/0960327116680274. Epub 2016 Nov 28.

PMID:
27895099
6.

GQ-16, a TZD-Derived Partial PPARγ Agonist, Induces the Expression of Thermogenesis-Related Genes in Brown Fat and Visceral White Fat and Decreases Visceral Adiposity in Obese and Hyperglycemic Mice.

Coelho MS, de Lima CL, Royer C, Silva JB, Oliveira FC, Christ CG, Pereira SA, Bao SN, Lima MC, Pitta MG, Pitta IR, Neves FA, Amato AA.

PLoS One. 2016 May 3;11(5):e0154310. doi: 10.1371/journal.pone.0154310. eCollection 2016.

7.

New thiazolidinediones affect endothelial cell activation and angiogenesis.

Rudnicki M, Tripodi GL, Ferrer R, Boscá L, Pitta MG, Pitta IR, Abdalla DS.

Eur J Pharmacol. 2016 Jul 5;782:98-106. doi: 10.1016/j.ejphar.2016.04.038. Epub 2016 Apr 21.

PMID:
27108791
8.

New PPARγ partial agonist improves obesity-induced metabolic alterations and atherosclerosis in LDLr(-/-) mice.

Silva JC, César FA, de Oliveira EM, Turato WM, Tripodi GL, Castilho G, Machado-Lima A, de Las Heras B, Boscá L, Rabello MM, Hernandes MZ, Pitta MG, Pitta IR, Passarelli M, Rudnicki M, Abdalla DS.

Pharmacol Res. 2016 Feb;104:49-60. doi: 10.1016/j.phrs.2015.12.010. Epub 2015 Dec 17.

PMID:
26706782
9.

Development and validation of a UHPLC-MS/MS bioanalytical method to quantify in plasma the analgesic candidate PT-31 following a preliminary pharmacokinetic study in rats.

Bessegato TC, Niehues M, Buqui GA, Lopes NP, Pitta IR, Galdino SL, Dalla Costa T.

Biomed Chromatogr. 2016 Jun;30(6):852-6. doi: 10.1002/bmc.3618. Epub 2015 Oct 28.

PMID:
26379109
10.

PPARγ partial agonist GQ-16 strongly represses a subset of genes in 3T3-L1 adipocytes.

Milton FA, Cvoro A, Amato AA, Sieglaff DH, Filgueira CS, Arumanayagam AS, de Lima Mdo C, Pitta IR, de Assis Rocha Neves F, Webb P.

Biochem Biophys Res Commun. 2015 Aug 28;464(3):718-23. doi: 10.1016/j.bbrc.2015.07.011. Epub 2015 Jul 10.

PMID:
26168725
11.

New indole-thiazolidine attenuates atherosclerosis in LDLr(-/-) mice.

César FA, Rudnicki M, de Las Heras B, Boscá L, Lima MC, Pitta IR, Abdalla DS.

Vascul Pharmacol. 2015 Aug;71:174-80. doi: 10.1016/j.vph.2015.03.009. Epub 2015 Apr 11.

PMID:
25869519
12.

Reduction of carrageenan-induced acute pulmonary inflammation in mice by novel thiazolidinedione derivative LPSF/RA-4.

Barbosa KP, Santos LA, Ribeiro EL, Fragoso IT, Rocha SW, Nunes AK, França ME, Silva BS, Silva AK, Donato MA, Gomes FO, Silva TG, Pitta IR, Pitta MR, Lima MC, Uchôa FD, Galdino SL, Peixoto CA.

Eur J Pharmacol. 2013 Oct 15;718(1-3):197-205. doi: 10.1016/j.ejphar.2013.08.033. Epub 2013 Sep 12.

PMID:
24036257
13.

Dimethyl 2-[(acridin-9-yl)methyl-idene]malonate.

de Almeida SM, Pitta IR, de Lima Mdo C, Mendonça Junior FJ, de Simone CA.

Acta Crystallogr Sect E Struct Rep Online. 2013 Feb 1;69(Pt 2):o224. doi: 10.1107/S1600536813000500. Epub 2013 Jan 12.

14.

SAR, QSAR and docking of anticancer flavonoids and variants: a review.

Scotti L, Bezerra Mendonça Junior FJ, Magalhaes Moreira DR, da Silva MS, Pitta IR, Scotti MT.

Curr Top Med Chem. 2012;12(24):2785-809. Review.

PMID:
23368103
15.

Chemical synthesis, docking studies and biological effects of a pan peroxisome proliferator-activated receptor agonist and cyclooxygenase inhibitor.

Santin JR, Uchôa FD, Lima Mdo C, Rabello MM, Machado ID, Hernandes MZ, Amato AA, Milton FA, Webb P, Neves Fde A, Galdino SL, Pitta IR, Farsky SH.

Eur J Pharm Sci. 2013 Mar 12;48(4-5):689-97. doi: 10.1016/j.ejps.2012.12.029. Epub 2013 Jan 7.

PMID:
23305993
16.

Photodynamic antimicrobial chemotherapy (PACT) using phenothiazine derivatives as photosensitizers against Leishmania braziliensis.

Barbosa AF, Sangiorgi BB, Galdino SL, Barral-Netto M, Pitta IR, Pinheiro AL.

Lasers Surg Med. 2012 Dec;44(10):850-5. doi: 10.1002/lsm.22099. Epub 2012 Nov 26.

PMID:
23184450
17.

Enhanced antiproliferative activity of the new anticancer candidate LPSF/AC04 in cyclodextrin inclusion complexes encapsulated into liposomes.

Mendonça EA, Lira MC, Rabello MM, Cavalcanti IM, Galdino SL, Pitta IR, Lima Mdo C, Pitta MG, Hernandes MZ, Santos-Magalhães NS.

AAPS PharmSciTech. 2012 Dec;13(4):1355-66. doi: 10.1208/s12249-012-9853-9. Epub 2012 Oct 2.

18.

Preliminary antifungal and cytotoxic evaluation of synthetic cycloalkyl[b]thiophene derivatives with PLS-DA analysis.

Souza BC, De Oliveira TB, Aquino TM, de Lima MC, Pitta IR, Galdino SL, Lima EO, Gonçalves-Silva T, Militão GC, Scotti L, Scotti MT, Mendonça FJ Jr.

Acta Pharm. 2012 Jun;62(2):221-36. doi: 10.2478/v10007-012-0017-y.

PMID:
22750820
19.

GQ-16, a novel peroxisome proliferator-activated receptor γ (PPARγ) ligand, promotes insulin sensitization without weight gain.

Amato AA, Rajagopalan S, Lin JZ, Carvalho BM, Figueira AC, Lu J, Ayers SD, Mottin M, Silveira RL, Souza PC, Mourão RH, Saad MJ, Togashi M, Simeoni LA, Abdalla DS, Skaf MS, Polikparpov I, Lima MC, Galdino SL, Brennan RG, Baxter JD, Pitta IR, Webb P, Phillips KJ, Neves FA.

J Biol Chem. 2012 Aug 10;287(33):28169-79. doi: 10.1074/jbc.M111.332106. Epub 2012 May 14.

20.

2-Amino-4,5,6,7-tetra-hydro-benzo[b]thio-phene-3-carbonitrile.

Silva WL, de Lima Mdo C, Galdino SL, Pitta IR, De Simone CA.

Acta Crystallogr Sect E Struct Rep Online. 2011 Dec 1;67(Pt 12):o3161. doi: 10.1107/S1600536811045338. Epub 2011 Nov 2.

21.

Anti-inflammatory and antioxidant properties of a new arylidene-thiazolidinedione in macrophages.

Faine LA, Rudnicki M, César FA, Heras BL, Boscá L, Souza ES, Hernandes MZ, Galdino SL, Lima MC, Pitta IR, Abdalla DS.

Curr Med Chem. 2011;18(22):3351-60.

PMID:
21728966
22.

Solid dispersions of imidazolidinedione by PEG and PVP polymers with potential antischistosomal activities.

Guedes FL, de Oliveira BG, Hernandes MZ, De Simone CA, Veiga FJ, de Lima Mdo C, Pitta IR, Galdino SL, Neto PJ.

AAPS PharmSciTech. 2011 Mar;12(1):401-10. doi: 10.1208/s12249-010-9556-z. Epub 2011 Mar 1.

23.

Development and validation of an HPLC/MS/MS method for determining the thiazolidinone PG15 in rat plasma.

Uchôa FD, Palma EC, Souza NF, Lima MC, Galdino SL, Pitta IR, Dalla Costa T.

J AOAC Int. 2010 Jul-Aug;93(4):1215-21.

PMID:
20922954
24.

Effect of chronic treatment with Rosiglitazone on Leydig cell steroidogenesis in rats: in vivo and ex vivo studies.

Couto JA, Saraiva KL, Barros CD, Udrisar DP, Peixoto CA, Vieira JS, Lima MC, Galdino SL, Pitta IR, Wanderley MI.

Reprod Biol Endocrinol. 2010 Feb 9;8:13. doi: 10.1186/1477-7827-8-13.

25.

2-(2-Nitro-anilino)-4,5,6,7-tetra-hydro-benzo[b]thio-phene-3-carbonitrile.

Mendonça Junior FJ, de Lima Mdo C, Galdino SL, Pitta IR, de Simone CA.

Acta Crystallogr Sect E Struct Rep Online. 2010 Sep 11;66(Pt 10):o2543. doi: 10.1107/S1600536810035439.

26.

2-(2-Nitro-anilino)-5,6,7,8-tetra-hydro-4H-cyclo-hepta-[b]thio-phene-3-carbonitrile.

de Lima Mdo C, Mendonça Junior FJ, Galdino SL, Pitta IR, de Simone CA.

Acta Crystallogr Sect E Struct Rep Online. 2010 May 15;66(Pt 6):o1350-1. doi: 10.1107/S1600536810017149.

27.

Interaction of morphine with a new alpha2-adrenoceptor agonist in mice.

Sudo RT, Calasans-Maia JA, Galdino SL, Lima MC, Zapata-Sudo G, Hernandes MZ, Pitta IR.

J Pain. 2010 Jan;11(1):71-8. doi: 10.1016/j.jpain.2009.08.001. Epub 2009 Oct 22.

PMID:
19853523
28.

A theoretical study of red-shifting and blue-shifting hydrogen bonds occurring between imidazolidine derivatives and PEG/PVP polymers.

Oliveira BG, Lima MC, Pitta IR, Galdino SL, Hernandes MZ.

J Mol Model. 2010 Jan;16(1):119-27. doi: 10.1007/s00894-009-0525-y. Epub 2009 Jun 12.

PMID:
19517145
29.

New imidazolidinic bioisosters: potential candidates for antischistosomal drugs.

Pitta MG, Silva AC, Neves JK, Silva PG, Irmão JI, Malagueño E, Santana JV, Lima MC, Galdino SL, Pitta IR, Albuquerque MC.

Mem Inst Oswaldo Cruz. 2006 Sep;101 Suppl 1:313-6.

30.

Synthesis and biological activity of novel acridinylidene and benzylidene thiazolidinediones.

Mourão RH, Silva TG, Soares AL, Vieira ES, Santos JN, Lima MC, Lima VL, Galdino SL, Barbe J, Pitta IR.

Eur J Med Chem. 2005 Nov;40(11):1129-33. Epub 2005 Aug 29.

PMID:
16040159
31.

Synthesis and schistosomicidal activity of new substituted thioxo-imidazolidine compounds.

Albuquerque MC, Silva TG, Pitta MG, Silva AC, Silva PG, Malagueño E, Santana JV, Wanderley AG, Lima MC, Galdino SL, Barbe J, Pitta IR.

Pharmazie. 2005 Jan;60(1):13-7.

PMID:
15700773
32.

Synthesis of 4-octyl-2H-1,4-benzo-thiazin-3-ones.

Guarda VL, Perrissin M, Thomasson F, Ximenes EA, Galdino SL, Pitta IR, Luu-Duc C, Barbe J.

Eur J Med Chem. 2003 Jul-Aug;38(7-8):769-73.

PMID:
12932908
33.

Synthesis and structural study of substituted thioxothiazolidinones and thioxoimidazolidinones.

Andrade AM, Lima WT, Rocha MP, Lima MC, Galdino SL, Barbosa Filho JM, Góes AJ, Pitta IR.

Boll Chim Farm. 2002 Nov-Dec;141(6):428-33.

PMID:
12577511
34.

[New substituted 4-thioxothiazolidin-2-one derivatives: synthesis and structural study].

Chantegrel J, Albuquerque JC, Guarda VL, Perrissin M, Lima MC, Galdino SL, Brandão SS, Thomasson F, Pitta IR, Luu-Duc C.

Ann Pharm Fr. 2002 Nov;60(6):403-9. French.

PMID:
12514507
35.

Synthesis and microbiological activity of some 4-butyl-2H-benzo[1,4]thiazin-3-one derivatives.

Guarda VL, Perrissin M, Thomasson F, Ximenes EA, Galdino SL, Pitta IR, Luu-Duc C.

Farmaco. 2001 Sep;56(9):689-93.

PMID:
11680813
36.

[Synthesis and structural study of substituted arylideneimidazolidines and arylidenebenzothiazines].

Brandão SS, Guarda VL, Pitta IR, Chantegrel J, Perrissin M, Souza VM, Galdino SL, Thomasson F, Lima MC, Leite LF, Luu-Duc C.

Boll Chim Farm. 2000 Mar-Apr;139(2):54-8. French.

PMID:
10920529
37.

[Substituted thiazolidinediones and thioxothiazolidinones: synthesis and structure].

Albuquerque JF, Andrade AM, Barros AL, Nascimento MR, Ximenes EA, Galdino SL, Pitta IR, Perrissin M.

Ann Pharm Fr. 1999 Sep;57(5):385-91. French.

PMID:
10520509
38.

Synthesis and antimicrobial activity of substituted imidazolidinediones and thioxoimidazolidinones.

Albuquerque JF, Rocha Filho JA, Brandao SS, Lima MC, Ximenes EA, Galdino SL, Pitta IR, Chantegrel J, Perrissin M, Luu-Duc C.

Farmaco. 1999 Jan-Feb;54(1-2):77-82.

PMID:
10321032
39.

[Synthesis and structure of substituted arylazo-imidazolidines and arylidenethiazolidines].

Brandão SS, Rocha Filho JA, Chantegrel J, Albuquerque JF, Ximenes EA, Galdino SL, Pitta IR, Perrissin M, Luu-Duc C.

Ann Pharm Fr. 1997;55(5):206-11. French.

PMID:
9406469
40.

[Substituted thio-arylidene thiazolidinones: synthesis and structural study].

Albuquerque JF, Galdino SL, Chantegrel J, Thomasson F, Pitta IR, Luu-Duc C.

Ann Pharm Fr. 1997;55(5):201-5. French.

PMID:
9406468
41.

Substituted thiazolidinediones and thio-imidazolidinones: synthesis, structural study and pharmacological activity.

Albuquerque JF, Albuquerque A, Azevedo CC, Thomasson F, Galdino LS, Chantegrel J, Catanho MT, Pitta IR, Luu-Duc C.

Pharmazie. 1995 Jun;50(6):387-9.

PMID:
7651975
42.

[Substituted imidazolidinediones and thiazolidinediones: synthesis, structure and cytotoxic activity].

Barros Costa DL, Chantegrel J, Alves de Lima MC, Cavalcanti Albuquerque JM, Correa Lima RM, Galdino SL, Pitta IR, Luu-Duc C.

J Pharm Belg. 1995 Jan-Feb;50(1):5-10. French.

PMID:
7602453
43.

[Synthesis and structural study of 5-arylidene thiazolidine-2,4-diones and 3-substituted-4-thio-imidazolidine-2-ones].

Albuquerque JF, Azevedo LC, Galdino SL, Chantegrel J, Pitta IR, Luu-Duc C.

Ann Pharm Fr. 1995;53(5):209-14. French.

PMID:
7503509
44.

[Synthesis and antimicrobial activity of chlorobenzyl benzylidene imidazolidinedione derivatives and substituted thiazolidinediones].

Lima MC, Costa DL, Goes AJ, Galdino SL, Pitta IR, Luu-Duc C.

Pharmazie. 1992 Mar;47(3):182-4. French.

PMID:
1615023
45.

[Synthesis and structure of substituted bromo and nitrobenzyl benzylidene imidazolidinediones and thiazolidinediones].

Amorim EL, Brandao SS, Cavalcanti CO, Galdino SL, Pitta IR, Luu-Duc C.

Ann Pharm Fr. 1992;50(2):103-11. French.

PMID:
1471825
46.

[Synthesis and antimicrobial activity of substituted fluorobenzyl benzylidenethiazolidinediones and imidazolidinediones].

Goes AJ, De Lima MC, Galdino SL, Pitta IR, Luu-Duc C.

J Pharm Belg. 1991 Jul-Aug;46(4):236-40. French.

PMID:
1795213
47.

[Benzylidene-5 pyrrolones, furanones and thiophenones. 2. Quantitative structure-activity relationship].

Galdino SL, Pitta IR, Luu-Duc C.

Farmaco Sci. 1986 Jan;41(1):59-68. French.

PMID:
3956721

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