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Items: 1 to 50 of 67

1.

MicroRNA and transcriptome analysis in periocular Sebaceous Gland Carcinoma.

Bladen JC, Wang J, Sangaralingam A, Moosajee M, Fitchett C, Chelala C, Beaconsfield M, O'Toole EA, Philpott MP, Ezra DG.

Sci Rep. 2018 May 14;8(1):7531. doi: 10.1038/s41598-018-25900-z.

2.

Culture of the human pilosebaceous unit, hair follicle and sebaceous gland.

Philpott MP.

Exp Dermatol. 2018 Apr 25. doi: 10.1111/exd.13669. [Epub ahead of print] Review.

PMID:
29693730
3.

Tissue stiffening promotes keratinocyte proliferation through activation of epidermal growth factor signaling.

Kenny FN, Drymoussi Z, Delaine-Smith R, Kao AP, Laly AC, Knight MM, Philpott MP, Connelly JT.

J Cell Sci. 2018 May 16;131(10). pii: jcs215780. doi: 10.1242/jcs.215780.

PMID:
29669739
4.

A Novel Mechanism for Activation of GLI1 by Nuclear SMO That Escapes Anti-SMO Inhibitors.

Rahman MM, Hazan A, Selway JL, Herath DS, Harwood CA, Pirzado MS, Atkar R, Kelsell DP, Linton KJ, Philpott MP, Neill GW.

Cancer Res. 2018 May 15;78(10):2577-2588. doi: 10.1158/0008-5472.CAN-17-2897. Epub 2018 Feb 20.

PMID:
29463581
5.

Analysis of hedgehog signaling in periocular sebaceous carcinoma.

Bladen JC, Moosajee M, Tracey-White D, Beaconsfield M, O'Toole EA, Philpott MP.

Graefes Arch Clin Exp Ophthalmol. 2018 Apr;256(4):853-860. doi: 10.1007/s00417-018-3900-5. Epub 2018 Feb 8.

6.

Can the skin make you fat? A role for the skin in regulating adipose tissue function and whole-body glucose and lipid homeostasis.

Caton PW, Evans EA, Philpott MP, Hannen RF.

Curr Opin Pharmacol. 2017 Dec;37:59-64. doi: 10.1016/j.coph.2017.08.011. Epub 2017 Oct 3. Review.

PMID:
28985599
7.

GLI2 Is a Regulator of β-Catenin and Is Associated with Loss of E-Cadherin, Cell Invasiveness, and Long-Term Epidermal Regeneration.

Pantazi E, Gemenetzidis E, Teh MT, Reddy SV, Warnes G, Evagora C, Trigiante G, Philpott MP.

J Invest Dermatol. 2017 Aug;137(8):1719-1730. doi: 10.1016/j.jid.2016.11.046. Epub 2017 Mar 11.

PMID:
28300597
8.

Meta-analysis identifies novel risk loci and yields systematic insights into the biology of male-pattern baldness.

Heilmann-Heimbach S, Herold C, Hochfeld LM, Hillmer AM, Nyholt DR, Hecker J, Javed A, Chew EG, Pechlivanis S, Drichel D, Heng XT, Del Rosario RC, Fier HL, Paus R, Rueedi R, Galesloot TE, Moebus S, Anhalt T, Prabhakar S, Li R, Kanoni S, Papanikolaou G, Kutalik Z, Deloukas P, Philpott MP, Waeber G, Spector TD, Vollenweider P, Kiemeney LA, Dedoussis G, Richards JB, Nothnagel M, Martin NG, Becker T, Hinds DA, Nöthen MM.

Nat Commun. 2017 Mar 8;8:14694. doi: 10.1038/ncomms14694.

9.

Retaining in-gel zymographic activity of cysteine proteases via a cysteine-supplemented running buffer.

Vootukuri Reddy S, Philpott MP, Trigiante G.

Electrophoresis. 2016 Oct;37(20):2644-2648. doi: 10.1002/elps.201600188. Epub 2016 Aug 23.

PMID:
27440471
10.

Differential Expression between Human Dermal Papilla Cells from Balding and Non-Balding Scalps Reveals New Candidate Genes for Androgenetic Alopecia.

Chew EG, Tan JH, Bahta AW, Ho BS, Liu X, Lim TC, Sia YY, Bigliardi PL, Heilmann S, Wan AC, Nöthen MM, Philpott MP, Hillmer AM.

J Invest Dermatol. 2016 Aug;136(8):1559-67. doi: 10.1016/j.jid.2016.03.032. Epub 2016 Apr 7.

11.

Constitutive Autophagy and Nucleophagy during Epidermal Differentiation.

Akinduro O, Sully K, Patel A, Robinson DJ, Chikh A, McPhail G, Braun KM, Philpott MP, Harwood CA, Byrne C, O'Shaughnessy RFL, Bergamaschi D.

J Invest Dermatol. 2016 Jul;136(7):1460-1470. doi: 10.1016/j.jid.2016.03.016. Epub 2016 Mar 25.

12.

Human hair follicle organ culture: theory, application and perspectives.

Langan EA, Philpott MP, Kloepper JE, Paus R.

Exp Dermatol. 2015 Dec;24(12):903-11. doi: 10.1111/exd.12836. Review.

PMID:
26284830
13.

Oxidative stress-associated senescence in dermal papilla cells of men with androgenetic alopecia.

Upton JH, Hannen RF, Bahta AW, Farjo N, Farjo B, Philpott MP.

J Invest Dermatol. 2015 May;135(5):1244-1252. doi: 10.1038/jid.2015.28. Epub 2015 Feb 3.

14.

GLI2 induces genomic instability in human keratinocytes by inhibiting apoptosis.

Pantazi E, Gemenetzidis E, Trigiante G, Warnes G, Shan L, Mao X, Ikram M, Teh MT, Lu YJ, Philpott MP.

Cell Death Dis. 2014 Jan 30;5:e1028. doi: 10.1038/cddis.2013.535.

15.

A meeting of two chronobiological systems: circadian proteins Period1 and BMAL1 modulate the human hair cycle clock.

Al-Nuaimi Y, Hardman JA, Bíró T, Haslam IS, Philpott MP, Tóth BI, Farjo N, Farjo B, Baier G, Watson REB, Grimaldi B, Kloepper JE, Paus R.

J Invest Dermatol. 2014 Mar;134(3):610-619. doi: 10.1038/jid.2013.366. Epub 2013 Sep 4.

16.

Cysteine proteases: mode of action and role in epidermal differentiation.

Brocklehurst K, Philpott MP.

Cell Tissue Res. 2013 Feb;351(2):237-44. doi: 10.1007/s00441-013-1557-2. Epub 2013 Jan 24. Review.

PMID:
23344364
17.

Isolating stem cells in the inter-follicular epidermis employing synchrotron radiation-based Fourier-transform infrared microspectroscopy and focal plane array imaging.

Patel II, Harrison WJ, Kerns JG, Filik J, Wehbe K, Carmichael PL, Scott AD, Philpott MP, Frogley MD, Cinque G, Martin FL.

Anal Bioanal Chem. 2012 Oct;404(6-7):1745-58. doi: 10.1007/s00216-012-6314-y. Epub 2012 Sep 4.

PMID:
22945554
18.

The mTOR inhibitor rapamycin opposes carcinogenic changes to epidermal Akt1/PKBα isoform signaling.

Sully K, Akinduro O, Philpott MP, Naeem AS, Harwood CA, Reeve VE, O'Shaughnessy RF, Byrne C.

Oncogene. 2013 Jul 4;32(27):3254-62. doi: 10.1038/onc.2012.338. Epub 2012 Aug 13.

PMID:
22890326
19.

iASPP/p63 autoregulatory feedback loop is required for the homeostasis of stratified epithelia.

Chikh A, Matin RN, Senatore V, Hufbauer M, Lavery D, Raimondi C, Ostano P, Mello-Grand M, Ghimenti C, Bahta A, Khalaf S, Akgül B, Braun KM, Chiorino G, Philpott MP, Harwood CA, Bergamaschi D.

EMBO J. 2011 Sep 6;30(20):4261-73. doi: 10.1038/emboj.2011.302.

20.

Spermidine promotes human hair growth and is a novel modulator of human epithelial stem cell functions.

Ramot Y, Tiede S, Bíró T, Abu Bakar MH, Sugawara K, Philpott MP, Harrison W, Pietilä M, Paus R.

PLoS One. 2011;6(7):e22564. doi: 10.1371/journal.pone.0022564. Epub 2011 Jul 27.

21.

GLI1 confers profound phenotypic changes upon LNCaP prostate cancer cells that include the acquisition of a hormone independent state.

Nadendla SK, Hazan A, Ward M, Harper LJ, Moutasim K, Bianchi LS, Naase M, Ghali L, Thomas GJ, Prowse DM, Philpott MP, Neill GW.

PLoS One. 2011;6(5):e20271. doi: 10.1371/journal.pone.0020271. Epub 2011 May 25.

22.

Delineating immune-mediated mechanisms underlying hair follicle destruction in the mouse mutant defolliculated.

Ruge F, Glavini A, Gallimore AM, Richards HE, Thomas CP, O'Donnell VB, Philpott MP, Porter RM.

J Invest Dermatol. 2011 Mar;131(3):572-9. doi: 10.1038/jid.2010.379. Epub 2010 Dec 16.

23.

Steroid synthesis by primary human keratinocytes; implications for skin disease.

Hannen RF, Michael AE, Jaulim A, Bhogal R, Burrin JM, Philpott MP.

Biochem Biophys Res Commun. 2011 Jan 7;404(1):62-7. doi: 10.1016/j.bbrc.2010.11.059. Epub 2010 Nov 19.

PMID:
21094146
24.

Upregulation of FOXM1 induces genomic instability in human epidermal keratinocytes.

Teh MT, Gemenetzidis E, Chaplin T, Young BD, Philpott MP.

Mol Cancer. 2010 Feb 26;9:45. doi: 10.1186/1476-4598-9-45.

25.

Neuronal differentiation in basal cell carcinoma: possible relationship to Hedgehog pathway activation?

Gore SM, Kasper M, Williams T, Regl G, Aberger F, Cerio R, Neill GW, Philpott MP.

J Pathol. 2009 Sep;219(1):61-8. doi: 10.1002/path.2568.

PMID:
19479712
26.

GLI1 repression of ERK activity correlates with colony formation and impaired migration in human epidermal keratinocytes.

Neill GW, Harrison WJ, Ikram MS, Williams TD, Bianchi LS, Nadendla SK, Green JL, Ghali L, Frischauf AM, O'Toole EA, Aberger F, Philpott MP.

Carcinogenesis. 2008 Apr;29(4):738-46. doi: 10.1093/carcin/bgn037. Epub 2008 Feb 14.

PMID:
18281251
27.

Functional role of beta 1 integrin-mediated signalling in the human hair follicle.

Kloepper JE, Hendrix S, Bodó E, Tiede S, Humphries MJ, Philpott MP, Fässler R, Paus R.

Exp Cell Res. 2008 Feb 1;314(3):498-508. Epub 2007 Nov 12.

PMID:
18155697
28.

Premature senescence of balding dermal papilla cells in vitro is associated with p16(INK4a) expression.

Bahta AW, Farjo N, Farjo B, Philpott MP.

J Invest Dermatol. 2008 May;128(5):1088-94. Epub 2007 Nov 8.

29.

Characterization of liver X receptor expression and function in human skin and the pilosebaceous unit.

Russell LE, Harrison WJ, Bahta AW, Zouboulis CC, Burrin JM, Philpott MP.

Exp Dermatol. 2007 Oct;16(10):844-52.

PMID:
17845217
30.

R-spondins in cutaneous biology: nails and cancer.

Blaydon DC, Philpott MP, Kelsell DP.

Cell Cycle. 2007 Apr 15;6(8):895-7. Epub 2007 Apr 9. Review.

PMID:
17426450
31.

Expression of lipogenic factors galectin-12, resistin, SREBP-1, and SCD in human sebaceous glands and cultured sebocytes.

Harrison WJ, Bull JJ, Seltmann H, Zouboulis CC, Philpott MP.

J Invest Dermatol. 2007 Jun;127(6):1309-17. Epub 2007 Mar 15.

32.

Role for WNT16B in human epidermal keratinocyte proliferation and differentiation.

Teh MT, Blaydon D, Ghali LR, Briggs V, Edmunds S, Pantazi E, Barnes MR, Leigh IM, Kelsell DP, Philpott MP.

J Cell Sci. 2007 Jan 15;120(Pt 2):330-9. Epub 2007 Jan 2. Erratum in: J Cell Sci. 2007 Mar 1;120(Pt 5):917. Briggs, Victoria [added].

33.

Selective modulation of Hedgehog/GLI target gene expression by epidermal growth factor signaling in human keratinocytes.

Kasper M, Schnidar H, Neill GW, Hanneder M, Klingler S, Blaas L, Schmid C, Hauser-Kronberger C, Regl G, Philpott MP, Aberger F.

Mol Cell Biol. 2006 Aug;26(16):6283-98.

34.

Genomewide single nucleotide polymorphism microarray mapping in basal cell carcinomas unveils uniparental disomy as a key somatic event.

Teh MT, Blaydon D, Chaplin T, Foot NJ, Skoulakis S, Raghavan M, Harwood CA, Proby CM, Philpott MP, Young BD, Kelsell DP.

Cancer Res. 2005 Oct 1;65(19):8597-603.

35.

Ectopic expression of c-Myc in the skin affects the hair growth cycle and causes an enlargement of the sebaceous gland.

Bull JJ, Pelengaris S, Hendrix S, Chronnell CM, Khan M, Philpott MP.

Br J Dermatol. 2005 Jun;152(6):1125-33.

PMID:
15948972
36.

Activation of the BCL2 promoter in response to Hedgehog/GLI signal transduction is predominantly mediated by GLI2.

Regl G, Kasper M, Schnidar H, Eichberger T, Neill GW, Philpott MP, Esterbauer H, Hauser-Kronberger C, Frischauf AM, Aberger F.

Cancer Res. 2004 Nov 1;64(21):7724-31.

37.

FOXE1, a new transcriptional target of GLI2 is expressed in human epidermis and basal cell carcinoma.

Eichberger T, Regl G, Ikram MS, Neill GW, Philpott MP, Aberger F, Frischauf AM.

J Invest Dermatol. 2004 May;122(5):1180-7.

38.

Epidermal and hair follicle progenitor cells express melanoma-associated chondroitin sulfate proteoglycan core protein.

Ghali L, Wong ST, Tidman N, Quinn A, Philpott MP, Leigh IM.

J Invest Dermatol. 2004 Feb;122(2):433-42.

39.

The zinc-finger transcription factor GLI2 antagonizes contact inhibition and differentiation of human epidermal cells.

Regl G, Kasper M, Schnidar H, Eichberger T, Neill GW, Ikram MS, Quinn AG, Philpott MP, Frischauf AM, Aberger F.

Oncogene. 2004 Feb 12;23(6):1263-74.

PMID:
14691458
40.

Defensins and acne.

Philpott MP.

Mol Immunol. 2003 Nov;40(7):457-62.

PMID:
14568392
41.

Loss of protein kinase Calpha expression may enhance the tumorigenic potential of Gli1 in basal cell carcinoma.

Neill GW, Ghali LR, Green JL, Ikram MS, Philpott MP, Quinn AG.

Cancer Res. 2003 Aug 1;63(15):4692-7.

42.

Animal and in vitro models for the study of hair follicles.

Randall VA, Sundberg JP, Philpott MP.

J Investig Dermatol Symp Proc. 2003 Jun;8(1):39-45. Review.

43.

Adrenomedullin: expression and possible role in human skin and hair growth.

Müller FB, Müller-Röver S, Korge BP, Kapas S, Hinson JP, Philpott MP.

Br J Dermatol. 2003 Jan;148(1):30-8.

PMID:
12534591
44.

FOXM1 is a downstream target of Gli1 in basal cell carcinomas.

Teh MT, Wong ST, Neill GW, Ghali LR, Philpott MP, Quinn AG.

Cancer Res. 2002 Aug 15;62(16):4773-80.

45.

Contrasting expression patterns of CCAAT/enhancer-binding protein transcription factors in the hair follicle and at different stages of the hair growth cycle.

Bull JJ, Müller-Röver S, Chronnell CM, Paus R, Philpott MP, McKay IA.

J Invest Dermatol. 2002 Jan;118(1):17-24.

46.

Human beta defensin-1 and -2 expression in human pilosebaceous units: upregulation in acne vulgaris lesions.

Chronnell CM, Ghali LR, Ali RS, Quinn AG, Holland DB, Bull JJ, Cunliffe WJ, McKay IA, Philpott MP, Müller-Röver S.

J Invest Dermatol. 2001 Nov;117(5):1120-5.

47.

Contrasting localization of c-Myc with other Myc superfamily transcription factors in the human hair follicle and during the hair growth cycle.

Bull JJ, Müller-Röver S, Patel SV, Chronnell CM, McKay IA, Philpott MP.

J Invest Dermatol. 2001 Apr;116(4):617-22.

48.

Cyclical changes in rat vibrissa follicles maintained In vitro.

Philpott MP, Kealey T.

J Invest Dermatol. 2000 Dec;115(6):1152-5.

49.

The role of IGF-I in human skin and its appendages: morphogen as well as mitogen?

Rudman SM, Philpott MP, Thomas GA, Kealey T.

J Invest Dermatol. 1997 Dec;109(6):770-7.

50.

Characterization of LHTric-1, a new monospecific monoclonal antibody to the trichocyte keratin Ha1.

Westgate GE, Tidman N, De Berker D, Blount MA, Philpott MP, Leigh IM.

Br J Dermatol. 1997 Jul;137(1):24-30.

PMID:
9274621

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