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Items: 44

1.

A high yield optimized method for the production of acylated ACPs enabling the analysis of enzymes involved in P. falciparum fatty acid biosynthesis.

Lauciello L, Lack G, Scapozza L, Perozzo R.

Biochem Biophys Rep. 2016 Oct 6;8:310-317. doi: 10.1016/j.bbrep.2016.09.017. eCollection 2016 Dec.

2.

Non-covalent modification of granulocyte-colony stimulating factor (G-CSF) by coiled-coil technology.

Reichert C, Perozzo R, Borchard G.

Int J Pharm. 2016 Sep 10;511(1):98-103. doi: 10.1016/j.ijpharm.2016.06.122. Epub 2016 Jun 27.

PMID:
27363936
3.

In Silico Driven Design and Synthesis of Rhodanine Derivatives as Novel Antibacterials Targeting the Enoyl Reductase InhA.

Slepikas L, Chiriano G, Perozzo R, Tardy S, Kranjc A, Patthey-Vuadens O, Ouertatani-Sakouhi H, Kicka S, Harrison CF, Scrignari T, Perron K, Hilbi H, Soldati T, Cosson P, Tarasevicius E, Scapozza L.

J Med Chem. 2016 Dec 22;59(24):10917-10928. doi: 10.1021/acs.jmedchem.5b01620. Epub 2016 Dec 9.

PMID:
26730986
4.

Chemical constituents from Waltheria indica exert in vitro activity against Trypanosoma brucei and T. cruzi.

Cretton S, Bréant L, Pourrez L, Ambuehl C, Perozzo R, Marcourt L, Kaiser M, Cuendet M, Christen P.

Fitoterapia. 2015 Sep;105:55-60. doi: 10.1016/j.fitote.2015.06.007. Epub 2015 Jun 11.

PMID:
26072041
5.

Synthesis of 3-azabicyclo[3.2.2]nonanes and their antiprotozoal activities.

Seebacher W, Wolkinger V, Faist J, Kaiser M, Brun R, Saf R, Bucar F, Gröblacher B, Brantner A, Merino V, Kalia Y, Scapozza L, Perozzo R, Weis R.

Bioorg Med Chem Lett. 2015 Apr 1;25(7):1390-3. doi: 10.1016/j.bmcl.2015.02.044. Epub 2015 Feb 28.

PMID:
25746816
6.

Antitrypanosomal quinoline alkaloids from the roots of Waltheria indica.

Cretton S, Breant L, Pourrez L, Ambuehl C, Marcourt L, Ebrahimi SN, Hamburger M, Perozzo R, Karimou S, Kaiser M, Cuendet M, Christen P.

J Nat Prod. 2014 Oct 24;77(10):2304-11. doi: 10.1021/np5006554. Epub 2014 Oct 14.

PMID:
25314007
7.

Purine metabolite and energy charge analysis of Trypanosoma brucei cells in different growth phases using an optimized ion-pair RP-HPLC/UV for the quantification of adenine and guanine pools.

Graven P, Tambalo M, Scapozza L, Perozzo R.

Exp Parasitol. 2014 Jun;141:28-38. doi: 10.1016/j.exppara.2014.03.006. Epub 2014 Mar 19.

PMID:
24657574
8.

Design, synthesis, and biological and crystallographic evaluation of novel inhibitors of Plasmodium falciparum enoyl-ACP-reductase (PfFabI).

Belluti F, Perozzo R, Lauciello L, Colizzi F, Kostrewa D, Bisi A, Gobbi S, Rampa A, Bolognesi ML, Recanatini M, Brun R, Scapozza L, Cavalli A.

J Med Chem. 2013 Oct 10;56(19):7516-26. doi: 10.1021/jm400637m. Epub 2013 Sep 25.

PMID:
24063369
9.

Inhibition of iPLA2 β and of stretch-activated channels by doxorubicin alters dystrophic muscle function.

Ismail HM, Dorchies OM, Perozzo R, Strosova MK, Scapozza L, Ruegg UT.

Br J Pharmacol. 2013 Aug;169(7):1537-50. doi: 10.1111/bph.12188.

10.

Potential of lichen secondary metabolites against Plasmodium liver stage parasites with FAS-II as the potential target.

Lauinger IL, Vivas L, Perozzo R, Stairiker C, Tarun A, Zloh M, Zhang X, Xu H, Tonge PJ, Franzblau SG, Pham DH, Esguerra CV, Crawford AD, Maes L, Tasdemir D.

J Nat Prod. 2013 Jun 28;76(6):1064-70. doi: 10.1021/np400083k. Epub 2013 Jun 19.

11.

Expression, purification and biochemical characterization of recombinant Ca-dependent protein kinase 2 of the malaria parasite Plasmodium falciparum.

Lauciello L, Kappes B, Scapozza L, Perozzo R.

Protein Expr Purif. 2013 Aug;90(2):170-7. doi: 10.1016/j.pep.2013.06.006. Epub 2013 Jun 18.

PMID:
23792132
12.

RNA pentaloop structures as effective targets of regulators belonging to the RsmA/CsrA protein family.

Lapouge K, Perozzo R, Iwaszkiewicz J, Bertelli C, Zoete V, Michielin O, Scapozza L, Haas D.

RNA Biol. 2013 Jun;10(6):1031-41. doi: 10.4161/rna.24771. Epub 2013 Apr 23.

13.

Naphthoquinone derivatives exert their antitrypanosomal activity via a multi-target mechanism.

Pieretti S, Haanstra JR, Mazet M, Perozzo R, Bergamini C, Prati F, Fato R, Lenaz G, Capranico G, Brun R, Bakker BM, Michels PA, Scapozza L, Bolognesi ML, Cavalli A.

PLoS Negl Trop Dis. 2013;7(1):e2012. doi: 10.1371/journal.pntd.0002012. Epub 2013 Jan 17.

14.

The pharmaceutical biochemistry group: where pharmaceutical chemistry meets biology and drug delivery.

Kalia YN, Perozzo R, Scapozza L.

Chimia (Aarau). 2012;66(5):313-9. doi: 10.2533/chimia.2012.313. Review.

PMID:
22867543
15.

Noninvasive transdermal iontophoretic delivery of biologically active human basic fibroblast growth factor.

Dubey S, Perozzo R, Scapozza L, Kalia YN.

Mol Pharm. 2011 Aug 1;8(4):1322-31. doi: 10.1021/mp200125j. Epub 2011 Jul 5.

PMID:
21696184
16.

Crystal structures of T. b. rhodesiense adenosine kinase complexed with inhibitor and activator: implications for catalysis and hyperactivation.

Kuettel S, Greenwald J, Kostrewa D, Ahmed S, Scapozza L, Perozzo R.

PLoS Negl Trop Dis. 2011 May;5(5):e1164. doi: 10.1371/journal.pntd.0001164. Epub 2011 May 24.

17.

Synthesis, crystal structure, and in vitro biological evaluation of C-6 pyrimidine derivatives: new lead structures for monitoring gene expression in vivo.

Martić M, Pernot L, Westermaier Y, Perozzo R, Kraljević TG, Krištafor S, Raić-Malić S, Scapozza L, Ametamey S.

Nucleosides Nucleotides Nucleic Acids. 2011 Apr;30(4):293-315. doi: 10.1080/15257770.2011.581258.

PMID:
21623543
18.

NADPH oxidase (NOX) isoforms are inhibited by celastrol with a dual mode of action.

Jaquet V, Marcoux J, Forest E, Leidal KG, McCormick S, Westermaier Y, Perozzo R, Plastre O, Fioraso-Cartier L, Diebold B, Scapozza L, Nauseef WM, Fieschi F, Krause KH, Bedard K.

Br J Pharmacol. 2011 Sep;164(2b):507-20. doi: 10.1111/j.1476-5381.2011.01439.x.

19.

2-Hexadecynoic acid inhibits plasmodial FAS-II enzymes and arrests erythrocytic and liver stage Plasmodium infections.

Tasdemir D, Sanabria D, Lauinger IL, Tarun A, Herman R, Perozzo R, Zloh M, Kappe SH, Brun R, Carballeira NM.

Bioorg Med Chem. 2010 Nov 1;18(21):7475-85. doi: 10.1016/j.bmc.2010.08.055. Epub 2010 Sep 18.

20.

Single-molecule pulling simulations can discern active from inactive enzyme inhibitors.

Colizzi F, Perozzo R, Scapozza L, Recanatini M, Cavalli A.

J Am Chem Soc. 2010 Jun 2;132(21):7361-71. doi: 10.1021/ja100259r.

PMID:
20462212
21.

Adenosine Kinase of T. b. Rhodesiense identified as the putative target of 4-[5-(4-phenoxyphenyl)-2H-pyrazol-3-yl]morpholine using chemical proteomics.

Kuettel S, Mosimann M, Mäser P, Kaiser M, Brun R, Scapozza L, Perozzo R.

PLoS Negl Trop Dis. 2009 Aug 25;3(8):e506. doi: 10.1371/journal.pntd.0000506.

22.

Inhibiting enoyl-ACP reductase (FabI) across pathogenic microorganisms by linear sesquiterpene lactones from Anthemis auriculata.

Karioti A, Skaltsa H, Zhang X, Tonge PJ, Perozzo R, Kaiser M, Franzblau SG, Tasdemir D.

Phytomedicine. 2008 Dec;15(12):1125-9. doi: 10.1016/j.phymed.2008.02.018.

PMID:
18424102
23.

Synthesis of a small library of 2-phenoxy-1,4-naphthoquinone and 2-phenoxy-1,4-anthraquinone derivatives bearing anti-trypanosomal and anti-leishmanial activity.

Bolognesi ML, Lizzi F, Perozzo R, Brun R, Cavalli A.

Bioorg Med Chem Lett. 2008 Apr 1;18(7):2272-6. doi: 10.1016/j.bmcl.2008.03.009. Epub 2008 Mar 7.

PMID:
18353643
24.

Caspase-8 is activated by cathepsin D initiating neutrophil apoptosis during the resolution of inflammation.

Conus S, Perozzo R, Reinheckel T, Peters C, Scapozza L, Yousefi S, Simon HU.

J Exp Med. 2008 Mar 17;205(3):685-98. doi: 10.1084/jem.20072152. Epub 2008 Feb 25.

25.

Synthesis and evaluation of antiparasitic activities of new 4-[5-(4-phenoxyphenyl)-2H-pyrazol-3-yl]morpholine derivatives.

Kuettel S, Zambon A, Kaiser M, Brun R, Scapozza L, Perozzo R.

J Med Chem. 2007 Nov 15;50(23):5833-9. Epub 2007 Oct 20.

PMID:
17949068
26.

Anthecularin: a novel sesquiterpene lactone from Anthemis auriculata with antiprotozoal activity.

Karioti A, Skaltsa H, Linden A, Perozzo R, Brun R, Tasdemir D.

J Org Chem. 2007 Oct 12;72(21):8103-6. Epub 2007 Sep 20.

PMID:
17880246
27.

Marine natural products from the Turkish sponge Agelas oroides that inhibit the enoyl reductases from Plasmodium falciparum, Mycobacterium tuberculosis and Escherichia coli.

Tasdemir D, Topaloglu B, Perozzo R, Brun R, O'Neill R, Carballeira NM, Zhang X, Tonge PJ, Linden A, Rüedi P.

Bioorg Med Chem. 2007 Nov 1;15(21):6834-45. Epub 2007 Aug 22.

PMID:
17765547
28.

Calpain-mediated cleavage of Atg5 switches autophagy to apoptosis.

Yousefi S, Perozzo R, Schmid I, Ziemiecki A, Schaffner T, Scapozza L, Brunner T, Simon HU.

Nat Cell Biol. 2006 Oct;8(10):1124-32. Epub 2006 Sep 24.

PMID:
16998475
29.

Inhibition of Plasmodium falciparum fatty acid biosynthesis: evaluation of FabG, FabZ, and FabI as drug targets for flavonoids.

Tasdemir D, Lack G, Brun R, Rüedi P, Scapozza L, Perozzo R.

J Med Chem. 2006 Jun 1;49(11):3345-53.

PMID:
16722653
30.

Turkish freshwater and marine macrophyte extracts show in vitro antiprotozoal activity and inhibit FabI, a key enzyme of Plasmodium falciparum fatty acid biosynthesis.

Orhan I, Sener B, Atici T, Brun R, Perozzo R, Tasdemir D.

Phytomedicine. 2006 Jun;13(6):388-93. Epub 2006 May 11.

PMID:
16697632
31.

High-level expression and purification of human thymidine kinase 1: quaternary structure, stability, and kinetics.

Birringer MS, Perozzo R, Kut E, Stillhart C, Surber W, Scapozza L, Folkers G.

Protein Expr Purif. 2006 Jun;47(2):506-15. Epub 2006 Jan 30.

PMID:
16473525
33.
34.

Evaluation of antiprotozoal and plasmodial enoyl-ACP reductase inhibition potential of turkish medicinal plants.

Tasdemir D, Brun R, Perozzo R, Dönmez AA.

Phytother Res. 2005 Feb;19(2):162-6.

PMID:
15852483
35.

Anti-protozoal and plasmodial FabI enzyme inhibiting metabolites of Scrophularia lepidota roots.

Tasdemir D, Güner ND, Perozzo R, Brun R, Dönmez AA, Calis I, Rüedi P.

Phytochemistry. 2005 Feb;66(3):355-62.

PMID:
15680992
36.

Thermodynamics of protein-ligand interactions: history, presence, and future aspects.

Perozzo R, Folkers G, Scapozza L.

J Recept Signal Transduct Res. 2004 Feb;24(1-2):1-52. Review.

PMID:
15344878
37.

Inhibiting activities of the secondary metabolites of Phlomis brunneogaleata against parasitic protozoa and plasmodial enoyl-ACP Reductase, a crucial enzyme in fatty acid biosynthesis.

Kirmizibekmez H, Calis I, Perozzo R, Brun R, Dönmez AA, Linden A, Rüedi P, Tasdemir D.

Planta Med. 2004 Aug;70(8):711-7.

PMID:
15326547
38.

Targeting tuberculosis and malaria through inhibition of Enoyl reductase: compound activity and structural data.

Kuo MR, Morbidoni HR, Alland D, Sneddon SF, Gourlie BB, Staveski MM, Leonard M, Gregory JS, Janjigian AD, Yee C, Musser JM, Kreiswirth B, Iwamoto H, Perozzo R, Jacobs WR Jr, Sacchettini JC, Fidock DA.

J Biol Chem. 2003 Jun 6;278(23):20851-9. Epub 2003 Feb 26.

39.

Structural elucidation of the specificity of the antibacterial agent triclosan for malarial enoyl acyl carrier protein reductase.

Perozzo R, Kuo M, Sidhu Ab, Valiyaveettil JT, Bittman R, Jacobs WR Jr, Fidock DA, Sacchettini JC.

J Biol Chem. 2002 Apr 12;277(15):13106-14. Epub 2002 Jan 15.

40.

Nucleoside binding site of herpes simplex type 1 thymidine kinase analyzed by X-ray crystallography.

Vogt J, Perozzo R, Pautsch A, Prota A, Schelling P, Pilger B, Folkers G, Scapozza L, Schulz GE.

Proteins. 2000 Dec 1;41(4):545-53.

PMID:
11056041
41.

Kinetics and crystal structure of the wild-type and the engineered Y101F mutant of Herpes simplex virus type 1 thymidine kinase interacting with (North)-methanocarba-thymidine.

Prota A, Vogt J, Pilger B, Perozzo R, Wurth C, Marquez VE, Russ P, Schulz GE, Folkers G, Scapozza L.

Biochemistry. 2000 Aug 8;39(31):9597-603.

PMID:
10924157
42.

Compulsory order of substrate binding to herpes simplex virus type 1 thymidine kinase. A calorimetric study.

Perozzo R, Jelesarov I, Bosshard HR, Folkers G, Scapozza L.

J Biol Chem. 2000 May 26;275(21):16139-45.

43.

Substrate diversity of herpes simplex virus thymidine kinase. Impact Of the kinematics of the enzyme.

Pilger BD, Perozzo R, Alber F, Wurth C, Folkers G, Scapozza L.

J Biol Chem. 1999 Nov 5;274(45):31967-73.

44.

The periplasmic domain of the histidine autokinase CitA functions as a highly specific citrate receptor.

Kaspar S, Perozzo R, Reinelt S, Meyer M, Pfister K, Scapozza L, Bott M.

Mol Microbiol. 1999 Aug;33(4):858-72.

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