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Items: 1 to 50 of 56

1.

The Factor Inhibiting HIF Asparaginyl Hydroxylase Regulates Oxidative Metabolism and Accelerates Metabolic Adaptation to Hypoxia.

Sim J, Cowburn AS, Palazon A, Madhu B, Tyrakis PA, Macías D, Bargiela DM, Pietsch S, Gralla M, Evans CE, Kittipassorn T, Chey YCJ, Branco CM, Rundqvist H, Peet DJ, Johnson RS.

Cell Metab. 2018 Apr 3;27(4):898-913.e7. doi: 10.1016/j.cmet.2018.02.020.

2.

HIF-2α Promotes Dissemination of Plasma Cells in Multiple Myeloma by Regulating CXCL12/CXCR4 and CCR1.

Vandyke K, Zeissig MN, Hewett DR, Martin SK, Mrozik KM, Cheong CM, Diamond P, To LB, Gronthos S, Peet DJ, Croucher PI, Zannettino ACW.

Cancer Res. 2017 Oct 15;77(20):5452-5463. doi: 10.1158/0008-5472.CAN-17-0115. Epub 2017 Aug 30.

PMID:
28855206
3.

Modulation of TRP Channel Activity by Hydroxylation and Its Therapeutic Potential.

Nagarajan Y, Rychkov GY, Peet DJ.

Pharmaceuticals (Basel). 2017 Mar 27;10(2). pii: E35. doi: 10.3390/ph10020035. Review.

4.

HIF signalling: The eyes have it.

Peet DJ, Kittipassorn T, Wood JP, Chidlow G, Casson RJ.

Exp Cell Res. 2017 Jul 15;356(2):136-140. doi: 10.1016/j.yexcr.2017.03.030. Epub 2017 Mar 16. Review.

PMID:
28315667
5.

Ankyrin Repeat Proteins of Orf Virus Influence the Cellular Hypoxia Response Pathway.

Chen DY, Fabrizio JA, Wilkins SE, Dave KA, Gorman JJ, Gleadle JM, Fleming SB, Peet DJ, Mercer AA.

J Virol. 2016 Dec 16;91(1). pii: e01430-16. Print 2017 Jan 1.

6.
7.

MAGED1 is a novel regulator of a select subset of bHLH PAS transcription factors.

Sullivan AE, Peet DJ, Whitelaw ML.

FEBS J. 2016 Sep;283(18):3488-502. doi: 10.1111/febs.13824. Epub 2016 Aug 18.

8.

M-Type Pyruvate Kinase Isoforms and Lactate Dehydrogenase A in the Mammalian Retina: Metabolic Implications.

Casson RJ, Wood JP, Han G, Kittipassorn T, Peet DJ, Chidlow G.

Invest Ophthalmol Vis Sci. 2016 Jan 1;57(1):66-80. doi: 10.1167/iovs.15-17962.

PMID:
26780311
9.

FIH Regulates Cellular Metabolism through Hydroxylation of the Deubiquitinase OTUB1.

Scholz CC, Rodriguez J, Pickel C, Burr S, Fabrizio JA, Nolan KA, Spielmann P, Cavadas MA, Crifo B, Halligan DN, Nathan JA, Peet DJ, Wenger RH, Von Kriegsheim A, Cummins EP, Taylor CT.

PLoS Biol. 2016 Jan 11;14(1):e1002347. doi: 10.1371/journal.pbio.1002347. eCollection 2016 Jan.

10.

Hypoxia inducible factor single nucleotide polymorphisms: exploring the role of HIF polymorphisms in retinal disease.

Kittipassorn T, Peet DJ.

Clin Exp Ophthalmol. 2015 Jan-Feb;43(1):1-2. doi: 10.1111/ceo.12493. No abstract available.

PMID:
25625895
11.

Oxygen-dependent hydroxylation by FIH regulates the TRPV3 ion channel.

Karttunen S, Duffield M, Scrimgeour NR, Squires L, Lim WL, Dallas ML, Scragg JL, Chicher J, Dave KA, Whitelaw ML, Peers C, Gorman JJ, Gleadle JM, Rychkov GY, Peet DJ.

J Cell Sci. 2015 Jan 15;128(2):225-31. doi: 10.1242/jcs.158451. Epub 2014 Nov 20.

12.

Cancer-like metabolism of the mammalian retina.

Ng SK, Wood JP, Chidlow G, Han G, Kittipassorn T, Peet DJ, Casson RJ.

Clin Exp Ophthalmol. 2015 May-Jun;43(4):367-76. doi: 10.1111/ceo.12462. Epub 2014 Nov 7. Review.

PMID:
25330055
13.

Potential adverse effects to the retina of cancer therapy targeting pyruvate kinase M2.

Ng SK, Wood JP, Chidlow G, Peet DJ, Casson RJ.

Acta Oncol. 2015 Jan;54(1):136-7. doi: 10.3109/0284186X.2014.922217. Epub 2014 May 26. No abstract available.

PMID:
24856372
14.

Characterization of human variants in obesity-related SIM1 protein identifies a hot-spot for dimerization with the partner protein ARNT2.

Sullivan AE, Raimondo A, Schwab TA, Bruning JB, Froguel P, Farooqi IS, Peet DJ, Whitelaw ML.

Biochem J. 2014 Aug 1;461(3):403-12. doi: 10.1042/BJ20131618.

PMID:
24814368
15.

Human variants in the neuronal basic helix-loop-helix/Per-Arnt-Sim (bHLH/PAS) transcription factor complex NPAS4/ARNT2 disrupt function.

Bersten DC, Bruning JB, Peet DJ, Whitelaw ML.

PLoS One. 2014 Jan 17;9(1):e85768. doi: 10.1371/journal.pone.0085768. eCollection 2014.

16.

Oxygen-regulated gene expression in murine cumulus cells.

Kind KL, Tam KK, Banwell KM, Gauld AD, Russell DL, Macpherson AM, Brown HM, Frank LA, Peet DJ, Thompson JG.

Reprod Fertil Dev. 2015 Jan;27(2):407-18. doi: 10.1071/RD13249.

PMID:
24388334
17.

Iodine-131 monitoring in sewage plant outflow.

McGowan DR, Pratt BE, Hinton PJ, Peet DJ, Crawley MT.

J Radiol Prot. 2014 Mar;34(1):1-14. doi: 10.1088/0952-4746/34/1/1. Epub 2013 Nov 22.

PMID:
24270089
18.

bHLH-PAS proteins in cancer.

Bersten DC, Sullivan AE, Peet DJ, Whitelaw ML.

Nat Rev Cancer. 2013 Dec;13(12):827-41. doi: 10.1038/nrc3621. Review.

PMID:
24263188
19.

Rare variants in single-minded 1 (SIM1) are associated with severe obesity.

Ramachandrappa S, Raimondo A, Cali AM, Keogh JM, Henning E, Saeed S, Thompson A, Garg S, Bochukova EG, Brage S, Trowse V, Wheeler E, Sullivan AE, Dattani M, Clayton PE, Datta V, Bruning JB, Wareham NJ, O'Rahilly S, Peet DJ, Barroso I, Whitelaw ML, Farooqi IS.

J Clin Invest. 2013 Jul;123(7):3042-50. doi: 10.1172/JCI68016. Epub 2013 Jun 17. Erratum in: J Clin Invest. 2013 Aug 1;123(8):3635. Datta, Vippan [corrected to Datta, Vipan].

20.

Loss-of-function mutations in SIM1 contribute to obesity and Prader-Willi-like features.

Bonnefond A, Raimondo A, Stutzmann F, Ghoussaini M, Ramachandrappa S, Bersten DC, Durand E, Vatin V, Balkau B, Lantieri O, Raverdy V, Pattou F, Van Hul W, Van Gaal L, Peet DJ, Weill J, Miller JL, Horber F, Goldstone AP, Driscoll DJ, Bruning JB, Meyre D, Whitelaw ML, Froguel P.

J Clin Invest. 2013 Jul;123(7):3037-41. doi: 10.1172/JCI68035. Epub 2013 Jun 17.

21.

Reciprocal regulation of the basic helix-loop-helix/Per-Arnt-Sim partner proteins, Arnt and Arnt2, during neuronal differentiation.

Hao N, Bhakti VL, Peet DJ, Whitelaw ML.

Nucleic Acids Res. 2013 Jun;41(11):5626-38. doi: 10.1093/nar/gkt206. Epub 2013 Apr 17.

22.

Hypoxic induction of the regulator of G-protein signalling 4 gene is mediated by the hypoxia-inducible factor pathway.

Olechnowicz SW, Fedele AO, Peet DJ.

PLoS One. 2012;7(9):e44564. doi: 10.1371/journal.pone.0044564. Epub 2012 Sep 7.

23.

The transcription factor encyclopedia.

Yusuf D, Butland SL, Swanson MI, Bolotin E, Ticoll A, Cheung WA, Zhang XY, Dickman CT, Fulton DL, Lim JS, Schnabl JM, Ramos OH, Vasseur-Cognet M, de Leeuw CN, Simpson EM, Ryffel GU, Lam EW, Kist R, Wilson MS, Marco-Ferreres R, Brosens JJ, Beccari LL, Bovolenta P, Benayoun BA, Monteiro LJ, Schwenen HD, Grontved L, Wederell E, Mandrup S, Veitia RA, Chakravarthy H, Hoodless PA, Mancarelli MM, Torbett BE, Banham AH, Reddy SP, Cullum RL, Liedtke M, Tschan MP, Vaz M, Rizzino A, Zannini M, Frietze S, Farnham PJ, Eijkelenboom A, Brown PJ, Laperrière D, Leprince D, de Cristofaro T, Prince KL, Putker M, del Peso L, Camenisch G, Wenger RH, Mikula M, Rozendaal M, Mader S, Ostrowski J, Rhodes SJ, Van Rechem C, Boulay G, Olechnowicz SW, Breslin MB, Lan MS, Nanan KK, Wegner M, Hou J, Mullen RD, Colvin SC, Noy PJ, Webb CF, Witek ME, Ferrell S, Daniel JM, Park J, Waldman SA, Peet DJ, Taggart M, Jayaraman PS, Karrich JJ, Blom B, Vesuna F, O'Geen H, Sun Y, Gronostajski RM, Woodcroft MW, Hough MR, Chen E, Europe-Finner GN, Karolczak-Bayatti M, Bailey J, Hankinson O, Raman V, LeBrun DP, Biswal S, Harvey CJ, DeBruyne JP, Hogenesch JB, Hevner RF, Héligon C, Luo XM, Blank MC, Millen KJ, Sharlin DS, Forrest D, Dahlman-Wright K, Zhao C, Mishima Y, Sinha S, Chakrabarti R, Portales-Casamar E, Sladek FM, Bradley PH, Wasserman WW.

Genome Biol. 2012;13(3):R24. doi: 10.1186/gb-2012-13-3-r24.

24.

Factor inhibiting HIF (FIH) recognizes distinct molecular features within hypoxia-inducible factor-α (HIF-α) versus ankyrin repeat substrates.

Wilkins SE, Karttunen S, Hampton-Smith RJ, Murchland I, Chapman-Smith A, Peet DJ.

J Biol Chem. 2012 Mar 16;287(12):8769-81. doi: 10.1074/jbc.M111.294678. Epub 2012 Jan 23.

25.

Radiation protection in fixed PET/CT facilities--design and operation.

Peet DJ, Morton R, Hussein M, Alsafi K, Spyrou N.

Br J Radiol. 2012 May;85(1013):643-6. doi: 10.1259/bjr/32969351. Epub 2011 Oct 5.

26.

The emerging role of hypoxia, HIF-1 and HIF-2 in multiple myeloma.

Martin SK, Diamond P, Gronthos S, Peet DJ, Zannettino AC.

Leukemia. 2011 Oct;25(10):1533-42. doi: 10.1038/leu.2011.122. Epub 2011 Jun 3. Review.

PMID:
21637285
27.

Consequences of IkappaB alpha hydroxylation by the factor inhibiting HIF (FIH).

Devries IL, Hampton-Smith RJ, Mulvihill MM, Alverdi V, Peet DJ, Komives EA.

FEBS Lett. 2010 Dec 1;584(23):4725-30. doi: 10.1016/j.febslet.2010.10.060. Epub 2010 Nov 5.

28.

Hormonally regulated follicle differentiation and luteinization in the mouse is associated with hypoxia inducible factor activity.

Tam KK, Russell DL, Peet DJ, Bracken CP, Rodgers RJ, Thompson JG, Kind KL.

Mol Cell Endocrinol. 2010 Oct 7;327(1-2):47-55. doi: 10.1016/j.mce.2010.06.008. Epub 2010 Jun 25.

PMID:
20600586
29.

The asparaginyl hydroxylase factor inhibiting HIF-1alpha is an essential regulator of metabolism.

Zhang N, Fu Z, Linke S, Chicher J, Gorman JJ, Visk D, Haddad GG, Poellinger L, Peet DJ, Powell F, Johnson RS.

Cell Metab. 2010 May 5;11(5):364-78. doi: 10.1016/j.cmet.2010.03.001. Epub 2010 Apr 15.

30.

Hypoxia-inducible factor-2 is a novel regulator of aberrant CXCL12 expression in multiple myeloma plasma cells.

Martin SK, Diamond P, Williams SA, To LB, Peet DJ, Fujii N, Gronthos S, Harris AL, Zannettino AC.

Haematologica. 2010 May;95(5):776-84. doi: 10.3324/haematol.2009.015628. Epub 2009 Dec 16.

31.

From polyps to people: a highly familiar response to hypoxia.

Hampton-Smith RJ, Peet DJ.

Ann N Y Acad Sci. 2009 Oct;1177:19-29. doi: 10.1111/j.1749-6632.2009.05035.x. Review.

PMID:
19845603
32.

Differences in hydroxylation and binding of Notch and HIF-1alpha demonstrate substrate selectivity for factor inhibiting HIF-1 (FIH-1).

Wilkins SE, Hyvärinen J, Chicher J, Gorman JJ, Peet DJ, Bilton RL, Koivunen P.

Int J Biochem Cell Biol. 2009 Jul;41(7):1563-71. doi: 10.1016/j.biocel.2009.01.005. Epub 2009 Jan 20.

PMID:
19401150
33.

Attenuation characteristics of MagnaDense high-density concrete at 6, 10 and 15 mv for use in radiotherapy bunker design.

Jones MR, Peet DJ, Horton PW.

Health Phys. 2009 Jan;96(1):67-75. doi: 10.1097/01.HP.0000327660.36130.ee.

PMID:
19066488
34.

Interaction with factor inhibiting HIF-1 defines an additional mode of cross-coupling between the Notch and hypoxia signaling pathways.

Zheng X, Linke S, Dias JM, Zheng X, Gradin K, Wallis TP, Hamilton BR, Gustafsson M, Ruas JL, Wilkins S, Bilton RL, Brismar K, Whitelaw ML, Pereira T, Gorman JJ, Ericson J, Peet DJ, Lendahl U, Poellinger L.

Proc Natl Acad Sci U S A. 2008 Mar 4;105(9):3368-73. doi: 10.1073/pnas.0711591105. Epub 2008 Feb 25.

35.

Turn me on: regulating HIF transcriptional activity.

Lisy K, Peet DJ.

Cell Death Differ. 2008 Apr;15(4):642-9. doi: 10.1038/sj.cdd.4402315. Epub 2008 Jan 18. Review. Erratum in: Cell Death Differ. 2008 Apr;15(4):805.

37.

Cell-specific regulation of hypoxia-inducible factor (HIF)-1alpha and HIF-2alpha stabilization and transactivation in a graded oxygen environment.

Bracken CP, Fedele AO, Linke S, Balrak W, Lisy K, Whitelaw ML, Peet DJ.

J Biol Chem. 2006 Aug 11;281(32):22575-85. Epub 2006 Jun 7.

38.

Activity of hypoxia-inducible factor 2alpha is regulated by association with the NF-kappaB essential modulator.

Bracken CP, Whitelaw ML, Peet DJ.

J Biol Chem. 2005 Apr 8;280(14):14240-51. Epub 2005 Jan 13.

39.

Oxygen-dependent asparagine hydroxylation.

Peet DJ, Lando D, Whelan DA, Whitelaw ML, Gorman JJ.

Methods Enzymol. 2004;381:467-87. No abstract available.

PMID:
15063693
40.

Regulation of gene expression by the hypoxia-inducible factors.

Fedele AO, Whitelaw ML, Peet DJ.

Mol Interv. 2002 Jul;2(4):229-43. Review.

PMID:
14993394
41.

Substrate requirements of the oxygen-sensing asparaginyl hydroxylase factor-inhibiting hypoxia-inducible factor.

Linke S, Stojkoski C, Kewley RJ, Booker GW, Whitelaw ML, Peet DJ.

J Biol Chem. 2004 Apr 2;279(14):14391-7. Epub 2004 Jan 20.

42.

The hypoxia-inducible factors: key transcriptional regulators of hypoxic responses.

Bracken CP, Whitelaw ML, Peet DJ.

Cell Mol Life Sci. 2003 Jul;60(7):1376-93. Review.

PMID:
12943226
43.

Defining the role for XAP2 in stabilization of the dioxin receptor.

Lees MJ, Peet DJ, Whitelaw ML.

J Biol Chem. 2003 Sep 19;278(38):35878-88. Epub 2003 Jul 1.

44.

Quantitative assessment of the radiation hazards and risks in sentinel node procedures.

Morton R, Horton PW, Peet DJ, Kissin MW.

Br J Radiol. 2003 Feb;76(902):117-22.

PMID:
12642280
45.

Oxygen-dependent regulation of hypoxia-inducible factors by prolyl and asparaginyl hydroxylation.

Lando D, Gorman JJ, Whitelaw ML, Peet DJ.

Eur J Biochem. 2003 Mar;270(5):781-90. Review.

46.

FIH-1 is an asparaginyl hydroxylase enzyme that regulates the transcriptional activity of hypoxia-inducible factor.

Lando D, Peet DJ, Gorman JJ, Whelan DA, Whitelaw ML, Bruick RK.

Genes Dev. 2002 Jun 15;16(12):1466-71.

47.

Mammalian two-hybrid assay showing redox control of HIF-like factor.

Lando D, Peet DJ, Pongratz I, Whitelaw ML.

Methods Enzymol. 2002;353:3-10. No abstract available.

PMID:
12078504
48.

Albumin recovery with centrifugal adsorption technology (CAT).

Peet DJ, Bisschops MA, van Hateren SH, van der Wielen LA.

Biotechnol Bioeng. 2002 May 5;78(3):237-50.

PMID:
11920440
49.

Asparagine hydroxylation of the HIF transactivation domain a hypoxic switch.

Lando D, Peet DJ, Whelan DA, Gorman JJ, Whitelaw ML.

Science. 2002 Feb 1;295(5556):858-61.

50.

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