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Items: 23


Identification of Pik3ca Mutation as a Genetic Driver of Prostate Cancer That Cooperates with Pten Loss to Accelerate Progression and Castration-Resistant Growth.

Pearson HB, Li J, Meniel VS, Fennell CM, Waring P, Montgomery KG, Rebello RJ, Macpherson AA, Koushyar S, Furic L, Cullinane C, Clarkson RW, Smalley MJ, Simpson KJ, Phesse TJ, Shepherd PR, Humbert PO, Sansom OJ, Phillips WA.

Cancer Discov. 2018 Mar 26. doi: 10.1158/2159-8290.CD-17-0867. [Epub ahead of print]


Mixtures of tritiated water, zinc and dissolved organic carbon: Assessing interactive bioaccumulation and genotoxic effects in marine mussels, Mytilus galloprovincialis.

Pearson HBC, Dallas LJ, Comber SDW, Braungardt CB, Worsfold PJ, Jha AN.

J Environ Radioact. 2018 Jul;187:133-143. doi: 10.1016/j.jenvrad.2017.12.018. Epub 2018 Feb 23.


[10]-gingerol induces apoptosis and inhibits metastatic dissemination of triple negative breast cancer in vivo.

Martin ACBM, Fuzer AM, Becceneri AB, da Silva JA, Tomasin R, Denoyer D, Kim SH, McIntyre KA, Pearson HB, Yeo B, Nagpal A, Ling X, Selistre-de-Araújo HS, Vieira PC, Cominetti MR, Pouliot N.

Oncotarget. 2017 Aug 10;8(42):72260-72271. doi: 10.18632/oncotarget.20139. eCollection 2017 Sep 22.


Intraoperative biomechanics of lumbar pedicle screw loosening following successful arthrodesis.

Pearson HB, Dobbs CJ, Grantham E, Niebur GL, Chappuis JL, Boerckel JD.

J Orthop Res. 2017 Dec;35(12):2673-2681. doi: 10.1002/jor.23575. Epub 2017 Jul 11.


Inhibiting the system xC-/glutathione axis selectively targets cancers with mutant-p53 accumulation.

Liu DS, Duong CP, Haupt S, Montgomery KG, House CM, Azar WJ, Pearson HB, Fisher OM, Read M, Guerra GR, Haupt Y, Cullinane C, Wiman KG, Abrahmsen L, Phillips WA, Clemons NJ.

Nat Commun. 2017 Mar 28;8:14844. doi: 10.1038/ncomms14844.


Predicting Copper Speciation in Estuarine Waters-Is Dissolved Organic Carbon a Good Proxy for the Presence of Organic Ligands?

Pearson HB, Comber SD, Braungardt C, Worsfold PJ.

Environ Sci Technol. 2017 Feb 21;51(4):2206-2216. doi: 10.1021/acs.est.6b05510. Epub 2017 Jan 31.


The Dual Inhibition of RNA Pol I Transcription and PIM Kinase as a New Therapeutic Approach to Treat Advanced Prostate Cancer.

Rebello RJ, Kusnadi E, Cameron DP, Pearson HB, Lesmana A, Devlin JR, Drygin D, Clark AK, Porter L, Pedersen J, Sandhu S, Risbridger GP, Pearson RB, Hannan RD, Furic L.

Clin Cancer Res. 2016 Nov 15;22(22):5539-5552. doi: 10.1158/1078-0432.CCR-16-0124. Epub 2016 Aug 2.


Copper as a target for prostate cancer therapeutics: copper-ionophore pharmacology and altering systemic copper distribution.

Denoyer D, Pearson HB, Clatworthy SA, Smith ZM, Francis PS, Llanos RM, Volitakis I, Phillips WA, Meggyesy PM, Masaldan S, Cater MA.

Oncotarget. 2016 Jun 14;7(24):37064-37080. doi: 10.18632/oncotarget.9245.


Absence of Gradients and Nernstian Equilibrium Stripping (AGNES) for the determination of [Zn(2+)] in estuarine waters.

Pearson HB, Galceran J, Companys E, Braungardt C, Worsfold P, Puy J, Comber S.

Anal Chim Acta. 2016 Mar 17;912:32-40. doi: 10.1016/j.aca.2016.01.035. Epub 2016 Jan 27.


A Chemical Screening Approach to Identify Novel Key Mediators of Erythroid Enucleation.

Wölwer CB, Pase LB, Pearson HB, Gödde NJ, Lackovic K, Huang DC, Russell SM, Humbert PO.

PLoS One. 2015 Nov 16;10(11):e0142655. doi: 10.1371/journal.pone.0142655. eCollection 2015.


The polarity protein Scrib mediates epidermal development and exerts a tumor suppressive function during skin carcinogenesis.

Pearson HB, McGlinn E, Phesse TJ, Schlüter H, Srikumar A, Gödde NJ, Woelwer CB, Ryan A, Phillips WA, Ernst M, Kaur P, Humbert P.

Mol Cancer. 2015 Sep 17;14:169. doi: 10.1186/s12943-015-0440-z.


Functional and molecular characterisation of EO771.LMB tumours, a new C57BL/6-mouse-derived model of spontaneously metastatic mammary cancer.

Johnstone CN, Smith YE, Cao Y, Burrows AD, Cross RS, Ling X, Redvers RP, Doherty JP, Eckhardt BL, Natoli AL, Restall CM, Lucas E, Pearson HB, Deb S, Britt KL, Rizzitelli A, Li J, Harmey JH, Pouliot N, Anderson RL.

Dis Model Mech. 2015 Mar;8(3):237-51. doi: 10.1242/dmm.017830. Epub 2015 Jan 29.


Estrogen receptor alpha drives proliferation in PTEN-deficient prostate carcinoma by stimulating survival signaling, MYC expression and altering glucose sensitivity.

Takizawa I, Lawrence MG, Balanathan P, Rebello R, Pearson HB, Garg E, Pedersen J, Pouliot N, Nadon R, Watt MJ, Taylor RA, Humbert P, Topisirovic I, Larsson O, Risbridger GP, Furic L.

Oncotarget. 2015 Jan 20;6(2):604-16.


Keratin 76 is required for tight junction function and maintenance of the skin barrier.

DiTommaso T, Cottle DL, Pearson HB, Schlüter H, Kaur P, Humbert PO, Smyth IM.

PLoS Genet. 2014 Oct 23;10(10):e1004706. doi: 10.1371/journal.pgen.1004706. eCollection 2014 Oct.


Partial inhibition of gp130-Jak-Stat3 signaling prevents Wnt-β-catenin-mediated intestinal tumor growth and regeneration.

Phesse TJ, Buchert M, Stuart E, Flanagan DJ, Faux M, Afshar-Sterle S, Walker F, Zhang HH, Nowell CJ, Jorissen R, Tan CW, Hirokawa Y, Eissmann MF, Poh AR, Malaterre J, Pearson HB, Kirsch DG, Provero P, Poli V, Ramsay RG, Sieber O, Burgess AW, Huszar D, Vincan E, Ernst M.

Sci Signal. 2014 Sep 30;7(345):ra92. doi: 10.1126/scisignal.2005411.


Dissecting the role of polarity regulators in cancer through the use of mouse models.

Gödde NJ, Pearson HB, Smith LK, Humbert PO.

Exp Cell Res. 2014 Nov 1;328(2):249-57. doi: 10.1016/j.yexcr.2014.08.036. Epub 2014 Aug 30. Review.


Scribble modulates the MAPK/Fra1 pathway to disrupt luminal and ductal integrity and suppress tumour formation in the mammary gland.

Godde NJ, Sheridan JM, Smith LK, Pearson HB, Britt KL, Galea RC, Yates LL, Visvader JE, Humbert PO.

PLoS Genet. 2014 May 22;10(5):e1004323. doi: 10.1371/journal.pgen.1004323. eCollection 2014 May.


Scrib heterozygosity predisposes to lung cancer and cooperates with KRas hyperactivation to accelerate lung cancer progression in vivo.

Elsum IA, Yates LL, Pearson HB, Phesse TJ, Long F, O'Donoghue R, Ernst M, Cullinane C, Humbert PO.

Oncogene. 2014 Nov 27;33(48):5523-33. doi: 10.1038/onc.2013.498. Epub 2013 Nov 25.


Increasing intracellular bioavailable copper selectively targets prostate cancer cells.

Cater MA, Pearson HB, Wolyniec K, Klaver P, Bilandzic M, Paterson BM, Bush AI, Humbert PO, La Fontaine S, Donnelly PS, Haupt Y.

ACS Chem Biol. 2013 Jul 19;8(7):1621-31. doi: 10.1021/cb400198p. Epub 2013 May 24.


SCRIB expression is deregulated in human prostate cancer, and its deficiency in mice promotes prostate neoplasia.

Pearson HB, Perez-Mancera PA, Dow LE, Ryan A, Tennstedt P, Bogani D, Elsum I, Greenfield A, Tuveson DA, Simon R, Humbert PO.

J Clin Invest. 2011 Nov;121(11):4257-67. doi: 10.1172/JCI58509. Epub 2011 Oct 3.


Lkb1 deficiency alters goblet and paneth cell differentiation in the small intestine.

Shorning BY, Zabkiewicz J, McCarthy A, Pearson HB, Winton DJ, Sansom OJ, Ashworth A, Clarke AR.

PLoS One. 2009;4(1):e4264. doi: 10.1371/journal.pone.0004264. Epub 2009 Jan 23. Erratum in: PLoS One.2009;4(2). doi: 10.1371/annotation/7750701a-2069-4810-820b-b0a02b674a06.


K-ras and Wnt signaling synergize to accelerate prostate tumorigenesis in the mouse.

Pearson HB, Phesse TJ, Clarke AR.

Cancer Res. 2009 Jan 1;69(1):94-101. doi: 10.1158/0008-5472.CAN-08-2895.


Lkb1 deficiency causes prostate neoplasia in the mouse.

Pearson HB, McCarthy A, Collins CM, Ashworth A, Clarke AR.

Cancer Res. 2008 Apr 1;68(7):2223-32. doi: 10.1158/0008-5472.CAN-07-5169.

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