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Structural basis for the interaction between the cell polarity proteins Par3 and Par6.

Renschler FA, Bruekner SR, Salomon PL, Mukherjee A, Kullmann L, Schütz-Stoffregen MC, Henzler C, Pawson T, Krahn MP, Wiesner S.

Sci Signal. 2018 Feb 13;11(517). pii: eaam9899. doi: 10.1126/scisignal.aam9899.


Native KCC2 interactome reveals PACSIN1 as a critical regulator of synaptic inhibition.

Mahadevan V, Khademullah CS, Dargaei Z, Chevrier J, Uvarov P, Kwan J, Bagshaw RD, Pawson T, Emili A, De Koninck Y, Anggono V, Airaksinen M, Woodin MA.

Elife. 2017 Oct 13;6. pii: e28270. doi: 10.7554/eLife.28270.


Grb2 regulates the proliferation of hematopoietic stem and progenitors cells.

Frelin C, Ofran Y, Ruston J, Hayun M, Derdikman Y, Khier Y, Rozales K, Brenner B, Iscove N, Pawson T, Louria-Hayon I.

Biochim Biophys Acta. 2017 Dec;1864(12):2449-2459. doi: 10.1016/j.bbamcr.2017.09.018. Epub 2017 Sep 28.


The Shc1 adaptor simultaneously balances Stat1 and Stat3 activity to promote breast cancer immune suppression.

Ahn R, Sabourin V, Bolt AM, Hébert S, Totten S, De Jay N, Festa MC, Young YK, Im YK, Pawson T, Koromilas AE, Muller WJ, Mann KK, Kleinman CL, Ursini-Siegel J.

Nat Commun. 2017 Mar 9;8:14638. doi: 10.1038/ncomms14638.


Mutational Analysis of Glycogen Synthase Kinase 3β Protein Kinase Together with Kinome-Wide Binding and Stability Studies Suggests Context-Dependent Recognition of Kinases by the Chaperone Heat Shock Protein 90.

Jin J, Tian R, Pasculescu A, Dai AY, Williton K, Taylor L, Savitski MM, Bantscheff M, Woodgett JR, Pawson T, Colwill K.

Mol Cell Biol. 2016 Jan 11;36(6):1007-18. doi: 10.1128/MCB.01045-15.


SMN and symmetric arginine dimethylation of RNA polymerase II C-terminal domain control termination.

Zhao DY, Gish G, Braunschweig U, Li Y, Ni Z, Schmitges FW, Zhong G, Liu K, Li W, Moffat J, Vedadi M, Min J, Pawson TJ, Blencowe BJ, Greenblatt JF.

Nature. 2016 Jan 7;529(7584):48-53. doi: 10.1038/nature16469. Epub 2015 Dec 23.


Phosphoinositide 3-kinase enables phagocytosis of large particles by terminating actin assembly through Rac/Cdc42 GTPase-activating proteins.

Schlam D, Bagshaw RD, Freeman SA, Collins RF, Pawson T, Fairn GD, Grinstein S.

Nat Commun. 2015 Oct 14;6:8623. doi: 10.1038/ncomms9623.


Selection of recombinant anti-SH3 domain antibodies by high-throughput phage display.

Huang H, Economopoulos NO, Liu BA, Uetrecht A, Gu J, Jarvik N, Nadeem V, Pawson T, Moffat J, Miersch S, Sidhu SS.

Protein Sci. 2015 Nov;24(11):1890-900. doi: 10.1002/pro.2799. Epub 2015 Sep 16.


A Rac/Cdc42 exchange factor complex promotes formation of lateral filopodia and blood vessel lumen morphogenesis.

Abraham S, Scarcia M, Bagshaw RD, McMahon K, Grant G, Harvey T, Yeo M, Esteves FO, Thygesen HH, Jones PF, Speirs V, Hanby AM, Selby PJ, Lorger M, Dear TN, Pawson T, Marshall CJ, Mavria G.

Nat Commun. 2015 Jul 1;6:7286. doi: 10.1038/ncomms8286.


Twisted amide electrophiles enable cyclic peptide sequencing.

Zaretsky S, Rai V, Gish G, Forbes MW, Kofler M, Yu JC, Tan J, Hickey JL, Pawson T, Yudin AK.

Org Biomol Chem. 2015 Jul 21;13(27):7384-8. doi: 10.1039/c5ob01050k.


Nck adaptor proteins modulate differentiation and effector function of T cells.

Lu KH, Keppler S, Leithäuser F, Mattfeldt T, Castello A, Kostezka U, Küblbeck G, Schmitt S, Klevenz A, Prokosch S, Pougialis G, Pawson T, Batista F, Tafuri A, Arnold B.

J Leukoc Biol. 2015 Sep;98(3):301-11. doi: 10.1189/jlb.1HI1114-565R. Epub 2015 May 20.


SELPHI: correlation-based identification of kinase-associated networks from global phospho-proteomics data sets.

Petsalaki E, Helbig AO, Gopal A, Pasculescu A, Roth FP, Pawson T.

Nucleic Acids Res. 2015 Jul 1;43(W1):W276-82. doi: 10.1093/nar/gkv459. Epub 2015 May 6.


Integrative analysis of kinase networks in TRAIL-induced apoptosis provides a source of potential targets for combination therapy.

So J, Pasculescu A, Dai AY, Williton K, James A, Nguyen V, Creixell P, Schoof EM, Sinclair J, Barrios-Rodiles M, Gu J, Krizus A, Williams R, Olhovsky M, Dennis JW, Wrana JL, Linding R, Jorgensen C, Pawson T, Colwill K.

Sci Signal. 2015 Apr 7;8(371):rs3. doi: 10.1126/scisignal.2005700.


Combinatorial proteomic analysis of intercellular signaling applied to the CD28 T-cell costimulatory receptor.

Tian R, Wang H, Gish GD, Petsalaki E, Pasculescu A, Shi Y, Mollenauer M, Bagshaw RD, Yosef N, Hunter T, Gingras AC, Weiss A, Pawson T.

Proc Natl Acad Sci U S A. 2015 Mar 31;112(13):E1594-603. doi: 10.1073/pnas.1503286112. Epub 2015 Mar 17.


Ankyrin repeats of ANKRA2 recognize a PxLPxL motif on the 3M syndrome protein CCDC8.

Nie J, Xu C, Jin J, Aka JA, Tempel W, Nguyen V, You L, Weist R, Min J, Pawson T, Yang XJ.

Structure. 2015 Apr 7;23(4):700-12. doi: 10.1016/j.str.2015.02.001. Epub 2015 Mar 5.


Phase transition of a disordered nuage protein generates environmentally responsive membraneless organelles.

Nott TJ, Petsalaki E, Farber P, Jervis D, Fussner E, Plochowietz A, Craggs TD, Bazett-Jones DP, Pawson T, Forman-Kay JD, Baldwin AJ.

Mol Cell. 2015 Mar 5;57(5):936-47. doi: 10.1016/j.molcel.2015.01.013.


SYK interaction with ITGβ4 suppressed by Epstein-Barr virus LMP2A modulates migration and invasion of nasopharyngeal carcinoma cells.

Zhou X, Matskova L, Rathje LS, Xiao X, Gish G, Werner M, Ignatyev I, Yu N, Zhao W, Tian F, Hou B, Zhang Z, Pawson T, Chen F, Ernberg I.

Oncogene. 2015 Aug 20;34(34):4491-9. doi: 10.1038/onc.2014.380. Epub 2014 Dec 22.


Src homology 2 domain containing protein 5 (SH2D5) binds the breakpoint cluster region protein, BCR, and regulates levels of Rac1-GTP.

Gray EJ, Petsalaki E, James DA, Bagshaw RD, Stacey MM, Rocks O, Gingras AC, Pawson T.

J Biol Chem. 2014 Dec 19;289(51):35397-408. doi: 10.1074/jbc.M114.615112. Epub 2014 Oct 20.


Albumin decrease is associated with spontaneous preterm delivery within 48 h in women with threatened preterm labor.

Heng YJ, Taylor L, Larsen BG, Chua HN, Pung SM, Lee MW, Tucholska M, Tate S, Kupchak P, Pennell CE, Pawson T, Lye SJ.

J Proteome Res. 2015 Jan 2;14(1):457-66. doi: 10.1021/pr500852p. Epub 2014 Oct 9.


Cell cycle-regulated oscillator coordinates core histone gene transcription through histone acetylation.

Kurat CF, Lambert JP, Petschnigg J, Friesen H, Pawson T, Rosebrock A, Gingras AC, Fillingham J, Andrews B.

Proc Natl Acad Sci U S A. 2014 Sep 30;111(39):14124-9. doi: 10.1073/pnas.1414024111. Epub 2014 Sep 16.


Directed network wiring identifies a key protein interaction in embryonic stem cell differentiation.

Yasui N, Findlay GM, Gish GD, Hsiung MS, Huang J, Tucholska M, Taylor L, Smith L, Boldridge WC, Koide A, Pawson T, Koide S.

Mol Cell. 2014 Jun 19;54(6):1034-41. doi: 10.1016/j.molcel.2014.05.002. Epub 2014 Jun 5.


The ShcA adaptor activates AKT signaling to potentiate breast tumor angiogenesis by stimulating VEGF mRNA translation in a 4E-BP-dependent manner.

Im YK, La Selva R, Gandin V, Ha JR, Sabourin V, Sonenberg N, Pawson T, Topisirovic I, Ursini-Siegel J.

Oncogene. 2015 Mar 26;34(13):1729-35. doi: 10.1038/onc.2014.110. Epub 2014 May 19.


The mammalian-membrane two-hybrid assay (MaMTH) for probing membrane-protein interactions in human cells.

Petschnigg J, Groisman B, Kotlyar M, Taipale M, Zheng Y, Kurat CF, Sayad A, Sierra JR, Mattiazzi Usaj M, Snider J, Nachman A, Krykbaeva I, Tsao MS, Moffat J, Pawson T, Lindquist S, Jurisica I, Stagljar I.

Nat Methods. 2014 May;11(5):585-92. doi: 10.1038/nmeth.2895. Epub 2014 Mar 23.


The adaptor protein p66Shc inhibits mTOR-dependent anabolic metabolism.

Soliman MA, Abdel Rahman AM, Lamming DW, Birsoy K, Pawling J, Frigolet ME, Lu H, Fantus IG, Pasculescu A, Zheng Y, Sabatini DM, Dennis JW, Pawson T.

Sci Signal. 2014 Feb 18;7(313):ra17. doi: 10.1126/scisignal.2004785. Erratum in: Sci Signal. 2014 Mar 4;7(315):er2. Lamming, Dudley A [corrected to Lamming, Dudley W].


Large-scale interaction profiling of PDZ domains through proteomic peptide-phage display using human and viral phage peptidomes.

Ivarsson Y, Arnold R, McLaughlin M, Nim S, Joshi R, Ray D, Liu B, Teyra J, Pawson T, Moffat J, Li SS, Sidhu SS, Kim PM.

Proc Natl Acad Sci U S A. 2014 Feb 18;111(7):2542-7. doi: 10.1073/pnas.1312296111. Epub 2014 Feb 3.


CoreFlow: a computational platform for integration, analysis and modeling of complex biological data.

Pasculescu A, Schoof EM, Creixell P, Zheng Y, Olhovsky M, Tian R, So J, Vanderlaan RD, Pawson T, Linding R, Colwill K.

J Proteomics. 2014 Apr 4;100:167-73. doi: 10.1016/j.jprot.2014.01.023. Epub 2014 Feb 3.


HDX-MS takes centre stage at unravelling kinase dynamics.

Lorenzen K, Pawson T.

Biochem Soc Trans. 2014 Feb;42(1):145-50. doi: 10.1042/BST20130250. Review.


Incorporating DNA shearing in standard affinity purification allows simultaneous identification of both soluble and chromatin-bound interaction partners.

Lambert JP, Tucholska M, Pawson T, Gingras AC.

J Proteomics. 2014 Apr 4;100:55-9. doi: 10.1016/j.jprot.2013.12.022. Epub 2014 Jan 9.


Lnk adaptor suppresses radiation resistance and radiation-induced B-cell malignancies by inhibiting IL-11 signaling.

Louria-Hayon I, Frelin C, Ruston J, Gish G, Jin J, Kofler MM, Lambert JP, Adissu HA, Milyavsky M, Herrington R, Minden MD, Dick JE, Gingras AC, Iscove NN, Pawson T.

Proc Natl Acad Sci U S A. 2013 Dec 17;110(51):20599-604. doi: 10.1073/pnas.1319665110. Epub 2013 Dec 2.


Molecular mechanisms of SH2- and PTB-domain-containing proteins in receptor tyrosine kinase signaling.

Wagner MJ, Stacey MM, Liu BA, Pawson T.

Cold Spring Harb Perspect Biol. 2013 Dec 1;5(12):a008987. doi: 10.1101/cshperspect.a008987. Review.


A quantitative liposome microarray to systematically characterize protein-lipid interactions.

Saliba AE, Vonkova I, Ceschia S, Findlay GM, Maeda K, Tischer C, Deghou S, van Noort V, Bork P, Pawson T, Ellenberg J, Gavin AC.

Nat Methods. 2014 Jan;11(1):47-50. doi: 10.1038/nmeth.2734. Epub 2013 Nov 24.


Protein interaction network of the mammalian Hippo pathway reveals mechanisms of kinase-phosphatase interactions.

Couzens AL, Knight JD, Kean MJ, Teo G, Weiss A, Dunham WH, Lin ZY, Bagshaw RD, Sicheri F, Pawson T, Wrana JL, Choi H, Gingras AC.

Sci Signal. 2013 Nov 19;6(302):rs15. doi: 10.1126/scisignal.2004712.


Identification of a novel protein interaction motif in the regulatory subunit of casein kinase 2.

Cao JY, Shire K, Landry C, Gish GD, Pawson T, Frappier L.

Mol Cell Biol. 2014 Jan;34(2):246-58. doi: 10.1128/MCB.00968-13. Epub 2013 Nov 11.


Mapping differential interactomes by affinity purification coupled with data-independent mass spectrometry acquisition.

Lambert JP, Ivosev G, Couzens AL, Larsen B, Taipale M, Lin ZY, Zhong Q, Lindquist S, Vidal M, Aebersold R, Pawson T, Bonner R, Tate S, Gingras AC.

Nat Methods. 2013 Dec;10(12):1239-45. doi: 10.1038/nmeth.2702. Epub 2013 Oct 27.


Conserved Asf1-importin β physical interaction in growth and sexual development in the ciliate Tetrahymena thermophila.

Garg J, Lambert JP, Karsou A, Marquez S, Nabeel-Shah S, Bertucci V, Retnasothie DV, Radovani E, Pawson T, Gingras AC, Pearlman RE, Fillingham JS.

J Proteomics. 2013 Dec 6;94:311-26. doi: 10.1016/j.jprot.2013.09.018. Epub 2013 Oct 11.


The CRAPome: a contaminant repository for affinity purification-mass spectrometry data.

Mellacheruvu D, Wright Z, Couzens AL, Lambert JP, St-Denis NA, Li T, Miteva YV, Hauri S, Sardiu ME, Low TY, Halim VA, Bagshaw RD, Hubner NC, Al-Hakim A, Bouchard A, Faubert D, Fermin D, Dunham WH, Goudreault M, Lin ZY, Badillo BG, Pawson T, Durocher D, Coulombe B, Aebersold R, Superti-Furga G, Colinge J, Heck AJ, Choi H, Gstaiger M, Mohammed S, Cristea IM, Bennett KL, Washburn MP, Raught B, Ewing RM, Gingras AC, Nesvizhskii AI.

Nat Methods. 2013 Aug;10(8):730-6. doi: 10.1038/nmeth.2557. Epub 2013 Jul 7.


Nck-mediated recruitment of BCAP to the BCR regulates the PI(3)K-Akt pathway in B cells.

Castello A, Gaya M, Tucholski J, Oellerich T, Lu KH, Tafuri A, Pawson T, Wienands J, Engelke M, Batista FD.

Nat Immunol. 2013 Sep;14(9):966-75. doi: 10.1038/ni.2685. Epub 2013 Aug 4.


Temporal regulation of EGF signalling networks by the scaffold protein Shc1.

Zheng Y, Zhang C, Croucher DR, Soliman MA, St-Denis N, Pasculescu A, Taylor L, Tate SA, Hardy WR, Colwill K, Dai AY, Bagshaw R, Dennis JW, Gingras AC, Daly RJ, Pawson T.

Nature. 2013 Jul 11;499(7457):166-71. doi: 10.1038/nature12308.


The ShcA PTB domain functions as a biological sensor of phosphotyrosine signaling during breast cancer progression.

Ahn R, Sabourin V, Ha JR, Cory S, Maric G, Im YK, Hardy WR, Zhao H, Park M, Hallett M, Siegel PM, Pawson T, Ursini-Siegel J.

Cancer Res. 2013 Jul 15;73(14):4521-32. doi: 10.1158/0008-5472.CAN-12-4178. Epub 2013 May 21.


Signalling change: signal transduction through the decades.

Hynes NE, Ingham PW, Lim WA, Marshall CJ, Massagué J, Pawson T.

Nat Rev Mol Cell Biol. 2013 Jun;14(6):393-8. doi: 10.1038/nrm3581. Epub 2013 May 2. Review.


Yap- and Cdc42-dependent nephrogenesis and morphogenesis during mouse kidney development.

Reginensi A, Scott RP, Gregorieff A, Bagherie-Lachidan M, Chung C, Lim DS, Pawson T, Wrana J, McNeill H.

PLoS Genet. 2013 Mar;9(3):e1003380. doi: 10.1371/journal.pgen.1003380. Epub 2013 Mar 21.


Construction of human activity-based phosphorylation networks.

Newman RH, Hu J, Rho HS, Xie Z, Woodard C, Neiswinger J, Cooper C, Shirley M, Clark HM, Hu S, Hwang W, Jeong JS, Wu G, Lin J, Gao X, Ni Q, Goel R, Xia S, Ji H, Dalby KN, Birnbaum MJ, Cole PA, Knapp S, Ryazanov AG, Zack DJ, Blackshaw S, Pawson T, Gingras AC, Desiderio S, Pandey A, Turk BE, Zhang J, Zhu H, Qian J.

Mol Syst Biol. 2013;9:655. doi: 10.1038/msb.2013.12.


Interaction domains of Sos1/Grb2 are finely tuned for cooperative control of embryonic stem cell fate.

Findlay GM, Smith MJ, Lanner F, Hsiung MS, Gish GD, Petsalaki E, Cockburn K, Kaneko T, Huang H, Bagshaw RD, Ketela T, Tucholska M, Taylor L, Bowtell DD, Moffat J, Ikura M, Li SS, Sidhu SS, Rossant J, Pawson T.

Cell. 2013 Feb 28;152(5):1008-20. doi: 10.1016/j.cell.2013.01.056.


Leukocyte-specific protein 1 links TNF receptor-associated factor 1 to survival signaling downstream of 4-1BB in T cells.

Sabbagh L, Andreeva D, Laramée GD, Oussa NA, Lew D, Bisson N, Soumounou Y, Pawson T, Watts TH.

J Leukoc Biol. 2013 May;93(5):713-21. doi: 10.1189/jlb.1112579. Epub 2013 Feb 27.


Rapid and sensitive MRM-based mass spectrometry approach for systematically exploring ganglioside-protein interactions.

Tian R, Jin J, Taylor L, Larsen B, Quaggin SE, Pawson T.

Proteomics. 2013 Apr;13(8):1334-8. doi: 10.1002/pmic.201200410. Epub 2013 Mar 12.


MERTK interactions with SH2-domain proteins in the retinal pigment epithelium.

Shelby SJ, Colwill K, Dhe-Paganon S, Pawson T, Thompson DA.

PLoS One. 2013;8(2):e53964. doi: 10.1371/journal.pone.0053964. Epub 2013 Feb 4.


Adipose vascular endothelial growth factor regulates metabolic homeostasis through angiogenesis.

Sung HK, Doh KO, Son JE, Park JG, Bae Y, Choi S, Nelson SM, Cowling R, Nagy K, Michael IP, Koh GY, Adamson SL, Pawson T, Nagy A.

Cell Metab. 2013 Jan 8;17(1):61-72. doi: 10.1016/j.cmet.2012.12.010.


Nck1 deficiency accelerates unloading-induced bone loss.

Aryal AC, Miyai K, Hayata T, Notomi T, Nakamoto T, Pawson T, Ezura Y, Noda M.

J Cell Physiol. 2013 Jul;228(7):1397-403. doi: 10.1002/jcp.24317.


Distinct phosphotyrosine-dependent functions of the ShcA adaptor protein are required for transforming growth factor β (TGFβ)-induced breast cancer cell migration, invasion, and metastasis.

Northey JJ, Dong Z, Ngan E, Kaplan A, Hardy WR, Pawson T, Siegel PM.

J Biol Chem. 2013 Feb 15;288(7):5210-22. doi: 10.1074/jbc.M112.424804. Epub 2012 Dec 31.


The adaptor protein Grb2 is not essential for the establishment of the glomerular filtration barrier.

Bisson N, Ruston J, Jeansson M, Vanderlaan R, Hardy WR, Du J, Hussein SM, Coward RJ, Quaggin SE, Pawson T.

PLoS One. 2012;7(11):e50996. doi: 10.1371/journal.pone.0050996. Epub 2012 Nov 30.

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