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Development of an Injectable Slow-Release Metformin Formulation and Evaluation of Its Potential Antitumor Effects.

Baldassari S, Solari A, Zuccari G, Drava G, Pastorino S, Fucile C, Marini V, Daga A, Pattarozzi A, Ratto A, Ferrari A, Mattioli F, Barbieri F, Caviglioli G, Florio T.

Sci Rep. 2018 Mar 2;8(1):3929. doi: 10.1038/s41598-018-22054-w.


Inhibition of the spindle assembly checkpoint kinase Mps-1 as a novel therapeutic strategy in malignant mesothelioma.

Szymiczek A, Carbone M, Pastorino S, Napolitano A, Tanji M, Minaai M, Pagano I, Mason JM, Pass HI, Bray MR, Mak TW, Yang H.

Oncogene. 2017 Nov 16;36(46):6501-6507. doi: 10.1038/onc.2017.266. Epub 2017 Jul 31.


Germline BAP1 mutations induce a Warburg effect.

Bononi A, Yang H, Giorgi C, Patergnani S, Pellegrini L, Su M, Xie G, Signorato V, Pastorino S, Morris P, Sakamoto G, Kuchay S, Gaudino G, Pass HI, Napolitano A, Pinton P, Jia W, Carbone M.

Cell Death Differ. 2017 Oct;24(10):1694-1704. doi: 10.1038/cdd.2017.95. Epub 2017 Jun 30.


BAP1 regulates IP3R3-mediated Ca2+ flux to mitochondria suppressing cell transformation.

Bononi A, Giorgi C, Patergnani S, Larson D, Verbruggen K, Tanji M, Pellegrini L, Signorato V, Olivetto F, Pastorino S, Nasu M, Napolitano A, Gaudino G, Morris P, Sakamoto G, Ferris LK, Danese A, Raimondi A, Tacchetti C, Kuchay S, Pass HI, Affar EB, Yang H, Pinton P, Carbone M.

Nature. 2017 Jun 22;546(7659):549-553. doi: 10.1038/nature22798. Epub 2017 Jun 14.


FTY720 inhibits mesothelioma growth in vitro and in a syngeneic mouse model.

Szymiczek A, Pastorino S, Larson D, Tanji M, Pellegrini L, Xue J, Li S, Giorgi C, Pinton P, Takinishi Y, Pass HI, Furuya H, Gaudino G, Napolitano A, Carbone M, Yang H.

J Transl Med. 2017 Mar 15;15(1):58. doi: 10.1186/s12967-017-1158-z.


HMGB1 targeting by ethyl pyruvate suppresses malignant phenotype of human mesothelioma.

Pellegrini L, Xue J, Larson D, Pastorino S, Jube S, Forest KH, Saad-Jube ZS, Napolitano A, Pagano I, Negi VS, Bianchi ME, Morris P, Pass HI, Gaudino G, Carbone M, Yang H.

Oncotarget. 2017 Apr 4;8(14):22649-22661. doi: 10.18632/oncotarget.15152.


Development and characterization of a mucoadhesive sublingual formulation for pain control: extemporaneous oxycodone films in personalized therapy.

Parodi B, Russo E, Baldassari S, Zuccari G, Pastorino S, Yan M, Neduri K, Caviglioli G.

Drug Dev Ind Pharm. 2017 Jun;43(6):917-924. doi: 10.1080/03639045.2017.1281290. Epub 2017 Jan 31.


High-density array-CGH with targeted NGS unmask multiple noncontiguous minute deletions on chromosome 3p21 in mesothelioma.

Yoshikawa Y, Emi M, Hashimoto-Tamaoki T, Ohmuraya M, Sato A, Tsujimura T, Hasegawa S, Nakano T, Nasu M, Pastorino S, Szymiczek A, Bononi A, Tanji M, Pagano I, Gaudino G, Napolitano A, Goparaju C, Pass HI, Yang H, Carbone M.

Proc Natl Acad Sci U S A. 2016 Nov 22;113(47):13432-13437. Epub 2016 Nov 9.


Investigating palygorskite's role in the development of mesothelioma in southern Nevada: Insights into fiber-induced carcinogenicity.

Larson D, Powers A, Ambrosi JP, Tanji M, Napolitano A, Flores EG, Baumann F, Pellegrini L, Jennings CJ, Buck BJ, McLaurin BT, Merkler D, Robinson C, Morris P, Dogan M, Dogan AU, Pass HI, Pastorino S, Carbone M, Yang H.

J Toxicol Environ Health B Crit Rev. 2016;19(5-6):213-230.


Positive nuclear BAP1 immunostaining helps differentiate non-small cell lung carcinomas from malignant mesothelioma.

Carbone M, Shimizu D, Napolitano A, Tanji M, Pass HI, Yang H, Pastorino S.

Oncotarget. 2016 Sep 13;7(37):59314-59321. doi: 10.18632/oncotarget.10653.


A high-fat, high-glycaemic index, low-fibre dietary pattern is prospectively associated with type 2 diabetes in a British birth cohort.

Pastorino S, Richards M, Pierce M, Ambrosini GL.

Br J Nutr. 2016 May;115(9):1632-42. doi: 10.1017/S0007114516000672.


HMGB1 and Its Hyperacetylated Isoform are Sensitive and Specific Serum Biomarkers to Detect Asbestos Exposure and to Identify Mesothelioma Patients.

Napolitano A, Antoine DJ, Pellegrini L, Baumann F, Pagano I, Pastorino S, Goparaju CM, Prokrym K, Canino C, Pass HI, Carbone M, Yang H.

Clin Cancer Res. 2016 Jun 15;22(12):3087-96. doi: 10.1158/1078-0432.CCR-15-1130. Epub 2016 Jan 5.


Combined Genetic and Genealogic Studies Uncover a Large BAP1 Cancer Syndrome Kindred Tracing Back Nine Generations to a Common Ancestor from the 1700s.

Carbone M, Flores EG, Emi M, Johnson TA, Tsunoda T, Behner D, Hoffman H, Hesdorffer M, Nasu M, Napolitano A, Powers A, Minaai M, Baumann F, Bryant-Greenwood P, Lauk O, Kirschner MB, Weder W, Opitz I, Pass HI, Gaudino G, Pastorino S, Yang H.

PLoS Genet. 2015 Dec 18;11(12):e1005633. doi: 10.1371/journal.pgen.1005633. eCollection 2015 Dec.


5-Fluorouracil, epirubicin and cyclophosphamide versus epirubicin and paclitaxel in node-positive early breast cancer: a phase-III randomized GONO-MIG5 trial.

Del Mastro L, Levaggi A, Michelotti A, Cavazzini G, Adami F, Scotto T, Piras M, Danese S, Garrone O, Durando A, Accortanzo V, Bighin C, Miglietta L, Pastorino S, Pronzato P, Castiglione F, Landucci E, Conte P, Bruzzi P.

Breast Cancer Res Treat. 2016 Jan;155(1):117-26. doi: 10.1007/s10549-015-3655-1. Epub 2015 Dec 10.


Multiple spatially related pharmacophores define small molecule inhibitors of OLIG2 in glioblastoma.

Tsigelny IF, Mukthavaram R, Kouznetsova VL, Chao Y, Babic I, Nurmemmedov E, Pastorino S, Jiang P, Calligaris D, Agar N, Scadeng M, Pingle SC, Wrasidlo W, Makale MT, Kesari S.

Oncotarget. 2017 Apr 4;8(14):22370-22384. doi: 10.18632/oncotarget.5633.


Pegfilgrastim administration after 24 or 72 or 96 h to allow dose-dense anthracycline- and taxane-based chemotherapy in breast cancer patients: a single-center experience within the GIM2 randomized phase III trial.

Lambertini M, Bruzzi P, Poggio F, Pastorino S, Gardin G, Clavarezza M, Bighin C, Pronzato P, Del Mastro L.

Support Care Cancer. 2016 Mar;24(3):1285-94. doi: 10.1007/s00520-015-2907-2. Epub 2015 Aug 27.


BAP1 hereditary cancer predisposition syndrome: a case report and review of literature.

Klebe S, Driml J, Nasu M, Pastorino S, Zangiabadi A, Henderson D, Carbone M.

Biomark Res. 2015 Jul 2;3:14. doi: 10.1186/s40364-015-0040-5. eCollection 2015.


Minimal asbestos exposure in germline BAP1 heterozygous mice is associated with deregulated inflammatory response and increased risk of mesothelioma.

Napolitano A, Pellegrini L, Dey A, Larson D, Tanji M, Flores EG, Kendrick B, Lapid D, Powers A, Kanodia S, Pastorino S, Pass HI, Dixit V, Yang H, Carbone M.

Oncogene. 2016 Apr 14;35(15):1996-2002. doi: 10.1038/onc.2015.243. Epub 2015 Jun 29.


Aspirin delays mesothelioma growth by inhibiting HMGB1-mediated tumor progression.

Yang H, Pellegrini L, Napolitano A, Giorgi C, Jube S, Preti A, Jennings CJ, De Marchis F, Flores EG, Larson D, Pagano I, Tanji M, Powers A, Kanodia S, Gaudino G, Pastorino S, Pass HI, Pinton P, Bianchi ME, Carbone M.

Cell Death Dis. 2015 Jun 11;6:e1786. doi: 10.1038/cddis.2015.153.


Hyaluronan expression in primary and secondary brain tumors.

Jadin L, Pastorino S, Symons R, Nomura N, Jiang P, Juarez T, Makale M, Kesari S.

Ann Transl Med. 2015 Apr;3(6):80. doi: 10.3978/j.issn.2305-5839.2015.04.07.


High Incidence of Somatic BAP1 alterations in sporadic malignant mesothelioma.

Nasu M, Emi M, Pastorino S, Tanji M, Powers A, Luk H, Baumann F, Zhang YA, Gazdar A, Kanodia S, Tiirikainen M, Flores E, Gaudino G, Becich MJ, Pass HI, Yang H, Carbone M.

J Thorac Oncol. 2015 Apr;10(4):565-76. doi: 10.1097/JTO.0000000000000471.


Mitochondrial p32 is upregulated in Myc expressing brain cancers and mediates glutamine addiction.

Fogal V, Babic I, Chao Y, Pastorino S, Mukthavaram R, Jiang P, Cho YJ, Pingle SC, Crawford JR, Piccioni DE, Kesari S.

Oncotarget. 2015 Jan 20;6(2):1157-70.


Evaluation of clonal origin of malignant mesothelioma.

Comertpay S, Pastorino S, Tanji M, Mezzapelle R, Strianese O, Napolitano A, Baumann F, Weigel T, Friedberg J, Sugarbaker P, Krausz T, Wang E, Powers A, Gaudino G, Kanodia S, Pass HI, Parsons BL, Yang H, Carbone M.

J Transl Med. 2014 Dec 4;12:301. doi: 10.1186/s12967-014-0301-3.


In vitro and in vivo anticancer effects of mevalonate pathway modulation on human cancer cells.

Jiang P, Mukthavaram R, Chao Y, Nomura N, Bharati IS, Fogal V, Pastorino S, Teng D, Cong X, Pingle SC, Kapoor S, Shetty K, Aggrawal A, Vali S, Abbasi T, Chien S, Kesari S.

Br J Cancer. 2014 Oct 14;111(8):1562-71. doi: 10.1038/bjc.2014.431. Epub 2014 Aug 5.


Validation of self-reported diagnosis of diabetes in the 1946 British birth cohort.

Pastorino S, Richards M, Hardy R, Abington J, Wills A, Kuh D, Pierce M; National Survey of Health and Development Scientific and Data Collection Teams.

Prim Care Diabetes. 2015 Oct;9(5):397-400. doi: 10.1016/j.pcd.2014.05.003. Epub 2014 Jul 15.


In silico modeling predicts drug sensitivity of patient-derived cancer cells.

Pingle SC, Sultana Z, Pastorino S, Jiang P, Mukthavaram R, Chao Y, Bharati IS, Nomura N, Makale M, Abbasi T, Kapoor S, Kumar A, Usmani S, Agrawal A, Vali S, Kesari S.

J Transl Med. 2014 May 21;12:128. doi: 10.1186/1479-5876-12-128.


Prostate specific membrane antigen (PSMA) expression in primary gliomas and breast cancer brain metastases.

Nomura N, Pastorino S, Jiang P, Lambert G, Crawford JR, Gymnopoulos M, Piccioni D, Juarez T, Pingle SC, Makale M, Kesari S.

Cancer Cell Int. 2014 Mar 20;14(1):26. doi: 10.1186/1475-2867-14-26.


Novel anti-glioblastoma agents and therapeutic combinations identified from a collection of FDA approved drugs.

Jiang P, Mukthavaram R, Chao Y, Bharati IS, Fogal V, Pastorino S, Cong X, Nomura N, Gallagher M, Abbasi T, Vali S, Pingle SC, Makale M, Kesari S.

J Transl Med. 2014 Jan 17;12:13. doi: 10.1186/1479-5876-12-13. Erratum in: J Transl Med. 2014;12:126. Mukthavavam, Rajesh [corrected to Mukthavaram, Rajesh].


High-efficiency liposomal encapsulation of a tyrosine kinase inhibitor leads to improved in vivo toxicity and tumor response profile.

Mukthavaram R, Jiang P, Saklecha R, Simberg D, Bharati IS, Nomura N, Chao Y, Pastorino S, Pingle SC, Fogal V, Wrasidlo W, Makale M, Kesari S.

Int J Nanomedicine. 2013;8:3991-4006. doi: 10.2147/IJN.S51949. Epub 2013 Oct 21.


Suicidal risk, depression, and religiosity: a study of women in a general hospital in Santiago de Chile.

Florenzano R, Rodríguez J, Sieverson C, Cataldo E, Pastorino S, Fernández L.

Asia Pac Psychiatry. 2014 Mar;6(1):23-7. doi: 10.1111/appy.12102. Epub 2013 Sep 5.


High-resolution mutational profiling suggests the genetic validity of glioblastoma patient-derived pre-clinical models.

Yost SE, Pastorino S, Rozenzhak S, Smith EN, Chao YS, Jiang P, Kesari S, Frazer KA, Harismendy O.

PLoS One. 2013;8(2):e56185. doi: 10.1371/journal.pone.0056185. Epub 2013 Feb 18.


MicroRNAs in cerebrospinal fluid identify glioblastoma and metastatic brain cancers and reflect disease activity.

Teplyuk NM, Mollenhauer B, Gabriely G, Giese A, Kim E, Smolsky M, Kim RY, Saria MG, Pastorino S, Kesari S, Krichevsky AM.

Neuro Oncol. 2012 Jun;14(6):689-700. doi: 10.1093/neuonc/nos074. Epub 2012 Apr 4.


Efficacy of normal saline versus heparinized saline solution for locking catheters of totally implantable long-term central vascular access devices in adult cancer patients.

Bertoglio S, Solari N, Meszaros P, Vassallo F, Bonvento M, Pastorino S, Bruzzi P.

Cancer Nurs. 2012 Jul-Aug;35(4):E35-42. doi: 10.1097/NCC.0b013e31823312b1.


Glioblastoma-derived epidermal growth factor receptor carboxyl-terminal deletion mutants are transforming and are sensitive to EGFR-directed therapies.

Cho J, Pastorino S, Zeng Q, Xu X, Johnson W, Vandenberg S, Verhaak R, Cherniack AD, Watanabe H, Dutt A, Kwon J, Chao YS, Onofrio RC, Chiang D, Yuza Y, Kesari S, Meyerson M.

Cancer Res. 2011 Dec 15;71(24):7587-96. doi: 10.1158/0008-5472.CAN-11-0821. Epub 2011 Oct 14.


Concurrent vs sequential adjuvant chemotherapy and hormone therapy in breast cancer: a multicenter randomized phase III trial.

Bedognetti D, Sertoli MR, Pronzato P, Del Mastro L, Venturini M, Taveggia P, Zanardi E, Siffredi G, Pastorino S, Queirolo P, Gardin G, Wang E, Monzeglio C, Boccardo F, Bruzzi P.

J Natl Cancer Inst. 2011 Oct 19;103(20):1529-39. doi: 10.1093/jnci/djr351. Epub 2011 Sep 15.


Corticosteroids in brain cancer patients: benefits and pitfalls.

Dietrich J, Rao K, Pastorino S, Kesari S.

Expert Rev Clin Pharmacol. 2011 Mar;4(2):233-42. doi: 10.1586/ecp.11.1. Review.


Transdifferentiation of glioblastoma cells into vascular endothelial cells.

Soda Y, Marumoto T, Friedmann-Morvinski D, Soda M, Liu F, Michiue H, Pastorino S, Yang M, Hoffman RM, Kesari S, Verma IM.

Proc Natl Acad Sci U S A. 2011 Mar 15;108(11):4274-80. doi: 10.1073/pnas.1016030108. Epub 2011 Jan 24.


The death effector domain protein PEA-15 negatively regulates T-cell receptor signaling.

Pastorino S, Renganathan H, Caliva MJ, Filbert EL, Opoku-Ansah J, Sulzmaier FJ, Gawecka JE, Werlen G, Shaw AS, Ramos JW.

FASEB J. 2010 Aug;24(8):2818-28. doi: 10.1096/fj.09-144295. Epub 2010 Mar 30.


Analysis and clinical relevance of human leukocyte antigen class I, heavy chain, and beta2-microglobulin downregulation in breast cancer.

Morabito A, Dozin B, Salvi S, Pasciucco G, Balbi G, Laurent S, Pastorino S, Carli F, Truini M, Bruzzi P, Del Mastro L, Pistillo MP.

Hum Immunol. 2009 Jul;70(7):492-5. doi: 10.1016/j.humimm.2009.04.029. Epub 2009 May 3.


Glycogen synthase kinase-3 inhibition induces glioma cell death through c-MYC, nuclear factor-kappaB, and glucose regulation.

Kotliarova S, Pastorino S, Kovell LC, Kotliarov Y, Song H, Zhang W, Bailey R, Maric D, Zenklusen JC, Lee J, Fine HA.

Cancer Res. 2008 Aug 15;68(16):6643-51. doi: 10.1158/0008-5472.CAN-08-0850.


Glioma: challenges and new insights in the development of effective therapies.

Pastorino S, Ramos JW.

Hawaii Med J. 2008 Jan;67(1):20-3, 25. Review. No abstract available.


The combination of granulocyte colony-stimulating factor and stem cell factor significantly increases the number of bone marrow-derived endothelial cells in brains of mice following cerebral ischemia.

Toth ZE, Leker RR, Shahar T, Pastorino S, Szalayova I, Asemenew B, Key S, Parmelee A, Mayer B, Nemeth K, Bratincsák A, Mezey E.

Blood. 2008 Jun 15;111(12):5544-52. doi: 10.1182/blood-2007-10-119073. Epub 2008 Feb 11.


ERK MAP kinase is targeted to RSK2 by the phosphoprotein PEA-15.

Vaidyanathan H, Opoku-Ansah J, Pastorino S, Renganathan H, Matter ML, Ramos JW.

Proc Natl Acad Sci U S A. 2007 Dec 11;104(50):19837-42. Epub 2007 Dec 6.


CD45-positive blood cells give rise to uterine epithelial cells in mice.

Bratincsák A, Brownstein MJ, Cassiani-Ingoni R, Pastorino S, Szalayova I, Tóth ZE, Key S, Németh K, Pickel J, Mezey E.

Stem Cells. 2007 Nov;25(11):2820-6. Epub 2007 Jul 26.


The 1p-encoded protein stathmin and resistance of malignant gliomas to nitrosoureas.

Ngo TT, Peng T, Liang XJ, Akeju O, Pastorino S, Zhang W, Kotliarov Y, Zenklusen JC, Fine HA, Maric D, Wen PY, De Girolami U, Black PM, Wu WW, Shen RF, Jeffries NO, Kang DW, Park JK.

J Natl Cancer Inst. 2007 Apr 18;99(8):639-52.


Hypoxia inhibits Moloney murine leukemia virus expression in activated macrophages.

Puppo M, Bosco MC, Federico M, Pastorino S, Varesio L.

J Leukoc Biol. 2007 Feb;81(2):528-38. Epub 2006 Oct 24.


Tumor stem cells derived from glioblastomas cultured in bFGF and EGF more closely mirror the phenotype and genotype of primary tumors than do serum-cultured cell lines.

Lee J, Kotliarova S, Kotliarov Y, Li A, Su Q, Donin NM, Pastorino S, Purow BW, Christopher N, Zhang W, Park JK, Fine HA.

Cancer Cell. 2006 May;9(5):391-403.


Neuronal and glioma-derived stem cell factor induces angiogenesis within the brain.

Sun L, Hui AM, Su Q, Vortmeyer A, Kotliarov Y, Pastorino S, Passaniti A, Menon J, Walling J, Bailey R, Rosenblum M, Mikkelsen T, Fine HA.

Cancer Cell. 2006 Apr;9(4):287-300.


Expression of Notch-1 and its ligands, Delta-like-1 and Jagged-1, is critical for glioma cell survival and proliferation.

Purow BW, Haque RM, Noel MW, Su Q, Burdick MJ, Lee J, Sundaresan T, Pastorino S, Park JK, Mikolaenko I, Maric D, Eberhart CG, Fine HA.

Cancer Res. 2005 Mar 15;65(6):2353-63.


Induction of apoptosis by flavopiridol in human neuroblastoma cells is enhanced under hypoxia and associated with N-myc proto-oncogene down-regulation.

Puppo M, Pastorino S, Melillo G, Pezzolo A, Varesio L, Bosco MC.

Clin Cancer Res. 2004 Dec 15;10(24):8704-19.

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