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Items: 18


High-throughput drug library screening identifies colchicine as a thyroid cancer inhibitor.

Zhang L, Yang Z, Granieri L, Pasculescu A, Datti A, Asa SL, Xu Z, Ezzat S.

Oncotarget. 2016 Apr 12;7(15):19948-59. doi: 10.18632/oncotarget.7890.


Mutational Analysis of Glycogen Synthase Kinase 3β Protein Kinase Together with Kinome-Wide Binding and Stability Studies Suggests Context-Dependent Recognition of Kinases by the Chaperone Heat Shock Protein 90.

Jin J, Tian R, Pasculescu A, Dai AY, Williton K, Taylor L, Savitski MM, Bantscheff M, Woodgett JR, Pawson T, Colwill K.

Mol Cell Biol. 2016 Jan 11;36(6):1007-18. doi: 10.1128/MCB.01045-15.


SELPHI: correlation-based identification of kinase-associated networks from global phospho-proteomics data sets.

Petsalaki E, Helbig AO, Gopal A, Pasculescu A, Roth FP, Pawson T.

Nucleic Acids Res. 2015 Jul 1;43(W1):W276-82. doi: 10.1093/nar/gkv459. Epub 2015 May 6.


Integrative analysis of kinase networks in TRAIL-induced apoptosis provides a source of potential targets for combination therapy.

So J, Pasculescu A, Dai AY, Williton K, James A, Nguyen V, Creixell P, Schoof EM, Sinclair J, Barrios-Rodiles M, Gu J, Krizus A, Williams R, Olhovsky M, Dennis JW, Wrana JL, Linding R, Jorgensen C, Pawson T, Colwill K.

Sci Signal. 2015 Apr 7;8(371):rs3. doi: 10.1126/scisignal.2005700.


Combinatorial proteomic analysis of intercellular signaling applied to the CD28 T-cell costimulatory receptor.

Tian R, Wang H, Gish GD, Petsalaki E, Pasculescu A, Shi Y, Mollenauer M, Bagshaw RD, Yosef N, Hunter T, Gingras AC, Weiss A, Pawson T.

Proc Natl Acad Sci U S A. 2015 Mar 31;112(13):E1594-603. doi: 10.1073/pnas.1503286112. Epub 2015 Mar 17.


A web-tool for visualizing quantitative protein-protein interaction data.

Knight JD, Liu G, Zhang JP, Pasculescu A, Choi H, Gingras AC.

Proteomics. 2015 Apr;15(8):1432-6. doi: 10.1002/pmic.201400429. Epub 2015 Jan 19.


The adaptor protein p66Shc inhibits mTOR-dependent anabolic metabolism.

Soliman MA, Abdel Rahman AM, Lamming DW, Birsoy K, Pawling J, Frigolet ME, Lu H, Fantus IG, Pasculescu A, Zheng Y, Sabatini DM, Dennis JW, Pawson T.

Sci Signal. 2014 Feb 18;7(313):ra17. doi: 10.1126/scisignal.2004785. Erratum in: Sci Signal. 2014 Mar 4;7(315):er2. Lamming, Dudley A [corrected to Lamming, Dudley W].


CoreFlow: a computational platform for integration, analysis and modeling of complex biological data.

Pasculescu A, Schoof EM, Creixell P, Zheng Y, Olhovsky M, Tian R, So J, Vanderlaan RD, Pawson T, Linding R, Colwill K.

J Proteomics. 2014 Apr 4;100:167-73. doi: 10.1016/j.jprot.2014.01.023. Epub 2014 Feb 3.


Temporal regulation of EGF signalling networks by the scaffold protein Shc1.

Zheng Y, Zhang C, Croucher DR, Soliman MA, St-Denis N, Pasculescu A, Taylor L, Tate SA, Hardy WR, Colwill K, Dai AY, Bagshaw R, Dennis JW, Gingras AC, Daly RJ, Pawson T.

Nature. 2013 Jul 11;499(7457):166-71. doi: 10.1038/nature12308.


OpenFreezer: a reagent information management software system.

Olhovsky M, Williton K, Dai AY, Pasculescu A, Lee JP, Goudreault M, Wells CD, Park JG, Gingras AC, Linding R, Pawson T, Colwill K.

Nat Methods. 2011 Jul 28;8(8):612-3. doi: 10.1038/nmeth.1658. No abstract available.


The ShcA phosphotyrosine docking protein uses distinct mechanisms to regulate myocyte and global heart function.

Vanderlaan RD, Hardy WR, Kabir MG, Pasculescu A, Jones N, deTombe PP, Backx PH, Pawson T.

Circ Res. 2011 Jan 21;108(2):184-93. doi: 10.1161/CIRCRESAHA.110.233924. Epub 2010 Dec 9.


ProHits: integrated software for mass spectrometry-based interaction proteomics.

Liu G, Zhang J, Larsen B, Stark C, Breitkreutz A, Lin ZY, Breitkreutz BJ, Ding Y, Colwill K, Pasculescu A, Pawson T, Wrana JL, Nesvizhskii AI, Raught B, Tyers M, Gingras AC.

Nat Biotechnol. 2010 Oct;28(10):1015-7. doi: 10.1038/nbt1010-1015. No abstract available.


Cell-specific information processing in segregating populations of Eph receptor ephrin-expressing cells.

Jørgensen C, Sherman A, Chen GI, Pasculescu A, Poliakov A, Hsiung M, Larsen B, Wilkinson DG, Linding R, Pawson T.

Science. 2009 Dec 11;326(5959):1502-9. doi: 10.1126/science.1176615.


Comparative analysis reveals conserved protein phosphorylation networks implicated in multiple diseases.

Tan CS, Bodenmiller B, Pasculescu A, Jovanovic M, Hengartner MO, Jørgensen C, Bader GD, Aebersold R, Pawson T, Linding R.

Sci Signal. 2009 Jul 28;2(81):ra39. doi: 10.1126/scisignal.2000316.


Positive selection of tyrosine loss in metazoan evolution.

Tan CS, Pasculescu A, Lim WA, Pawson T, Bader GD, Linding R.

Science. 2009 Sep 25;325(5948):1686-8. doi: 10.1126/science.1174301. Epub 2009 Jul 9.


Linear motif atlas for phosphorylation-dependent signaling.

Miller ML, Jensen LJ, Diella F, Jørgensen C, Tinti M, Li L, Hsiung M, Parker SA, Bordeaux J, Sicheritz-Ponten T, Olhovsky M, Pasculescu A, Alexander J, Knapp S, Blom N, Bork P, Li S, Cesareni G, Pawson T, Turk BE, Yaffe MB, Brunak S, Linding R.

Sci Signal. 2008 Sep 2;1(35):ra2. doi: 10.1126/scisignal.1159433.


NetworKIN: a resource for exploring cellular phosphorylation networks.

Linding R, Jensen LJ, Pasculescu A, Olhovsky M, Colwill K, Bork P, Yaffe MB, Pawson T.

Nucleic Acids Res. 2008 Jan;36(Database issue):D695-9. Epub 2007 Nov 2.


Systematic discovery of in vivo phosphorylation networks.

Linding R, Jensen LJ, Ostheimer GJ, van Vugt MA, Jørgensen C, Miron IM, Diella F, Colwill K, Taylor L, Elder K, Metalnikov P, Nguyen V, Pasculescu A, Jin J, Park JG, Samson LD, Woodgett JR, Russell RB, Bork P, Yaffe MB, Pawson T.

Cell. 2007 Jun 29;129(7):1415-26. Epub 2007 Jun 14.

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