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Items: 1 to 50 of 106

1.

Overexpression of PIK3CA in head and neck squamous cell carcinoma is associated with poor outcome and activation of the YAP pathway.

García-Escudero R, Segrelles C, Dueñas M, Pombo M, Ballestín C, Alonso-Riaño M, Nenclares P, Álvarez-Rodríguez R, Sánchez-Aniceto G, Ruíz-Alonso A, López-Cedrún JL, Paramio JM, Lorz C.

Oral Oncol. 2018 Apr;79:55-63. doi: 10.1016/j.oraloncology.2018.02.014. Epub 2018 Mar 3.

PMID:
29598951
2.

Ezh2-dependent therapies in bladder cancer: synthetic lethality.

Segovia C, Paramio JM.

Ann Transl Med. 2017 Dec;5(24):494. doi: 10.21037/atm.2017.10.08. No abstract available.

3.

Urothelial cancer proteomics provides both prognostic and functional information.

de Velasco G, Trilla-Fuertes L, Gamez-Pozo A, Urbanowicz M, Ruiz-Ares G, Sepúlveda JM, Prado-Vazquez G, Arevalillo JM, Zapater-Moros A, Navarro H, Lopez-Vacas R, Manneh R, Otero I, Villacampa F, Paramio JM, Vara JAF, Castellano D.

Sci Rep. 2017 Nov 17;7(1):15819. doi: 10.1038/s41598-017-15920-6.

4.

BMP4 Induces M2 Macrophage Polarization and Favors Tumor Progression in Bladder Cancer.

Martínez VG, Rubio C, Martínez-Fernández M, Segovia C, López-Calderón F, Garín MI, Teijeira A, Munera-Maravilla E, Varas A, Sacedón R, Guerrero F, Villacampa F, de la Rosa F, Castellano D, López-Collazo E, Paramio JM, Vicente Á, Dueñas M.

Clin Cancer Res. 2017 Dec 1;23(23):7388-7399. doi: 10.1158/1078-0432.CCR-17-1004. Epub 2017 Sep 19.

PMID:
28928159
5.

Correction: IKKα regulates the stratification and differentiation of the epidermis: implications for skin cancer development

Alameda JP, Navarro M, Ramírez Á, Page A, Suárez-Cabrera C, Moreno-Maldonado R, Paramio JM, del Carmen Fariña M, Fernández-Aceñero MJ, Bravo A.

Oncotarget. 2017 Aug 7;8(32):53887. doi: 10.18632/oncotarget.20002. eCollection 2017 Aug 8.

6.

Correction: Deciphering the role of nuclear and cytoplasmic IKKα in skin cancer.

Alameda JP, Gaspar M, Ramírez Á, Navarro M, Page A, Suárez-Cabrera C, Fernández MG, Mérida JR, Paramio JM, García-Fernández RA, Fernández-Aceñero MJ, Casanova ML.

Oncotarget. 2017 Aug 7;8(32):53886. doi: 10.18632/oncotarget.20001. eCollection 2017 Aug 8.

7.

Correction: Deregulation of the pRb-E2F4 axis alters epidermal homeostasis and favors tumor development.

Costa C, Santos M, Martínez-Fernández M, Lorz C, Lázaro S, Paramio JM.

Oncotarget. 2017 Jul 25;8(30):50324. doi: 10.18632/oncotarget.19511. No abstract available.

8.

Correction: Ablating all three retinoblastoma family members in mouse lung leads to neuroendocrine tumor formation.

Lázaro S, Pérez-Crespo M, Enguita AB, Hernández P, Martínez-Palacio J, Oteo M, Sage J, Paramio JM, Santos M.

Oncotarget. 2017 Jul 25;8(30):50323. doi: 10.18632/oncotarget.19510. No abstract available.

9.

IKKβ-Mediated Resistance to Skin Cancer Development Is Ink4a/Arf-Dependent.

Page A, Bravo A, Suarez-Cabrera C, Alameda JP, Casanova ML, Lorz C, Segrelles C, Segovia JC, Paramio JM, Navarro M, Ramirez A.

Mol Cancer Res. 2017 Sep;15(9):1255-1264. doi: 10.1158/1541-7786.MCR-17-0157. Epub 2017 Jun 5.

PMID:
28584022
10.

Novel potential predictive markers of sunitinib outcomes in long-term responders versus primary refractory patients with metastatic clear-cell renal cell carcinoma.

Puente J, Laínez N, Dueñas M, Méndez-Vidal MJ, Esteban E, Castellano D, Martinez-Fernández M, Basterretxea L, Juan-Fita MJ, Antón L, León L, Lambea J, Pérez-Valderrama B, Vázquez S, Suarez C, Del Muro XG, Gallardo E, Maroto JP, Samaniego ML, Suárez-Paniagua B, Sanz J, Paramio JM; SOGUG (Spanish Oncology Genitourinary Group).

Oncotarget. 2017 May 2;8(18):30410-30421. doi: 10.18632/oncotarget.16494.

11.

Correction: Protective role of p53 in skin cancer: Carcinogenesis studies in mice lacking epidermal p53.

Page A, Navarro M, Suarez-Cabrera C, Alameda JP, Casanova ML, Paramio JM, Bravo A, Ramirez A.

Oncotarget. 2017 Mar 28;8(13):22304. doi: 10.18632/oncotarget.16592. No abstract available.

12.

Clusterization in head and neck squamous carcinomas based on lncRNA expression: molecular and clinical correlates.

de Lena PG, Paz-Gallardo A, Paramio JM, García-Escudero R.

Clin Epigenetics. 2017 Apr 8;9:36. doi: 10.1186/s13148-017-0334-6. eCollection 2017.

13.

UroMark-a urinary biomarker assay for the detection of bladder cancer.

Feber A, Dhami P, Dong L, de Winter P, Tan WS, Martínez-Fernández M, Paul DS, Hynes-Allen A, Rezaee S, Gurung P, Rodney S, Mehmood A, Villacampa F, de la Rosa F, Jameson C, Cheng KK, Zeegers MP, Bryan RT, James ND, Paramio JM, Freeman A, Beck S, Kelly JD.

Clin Epigenetics. 2017 Jan 31;9:8. doi: 10.1186/s13148-016-0303-5. eCollection 2017.

14.

A Transposon-based Analysis Reveals RASA1 Is Involved in Triple-Negative Breast Cancer.

Suárez-Cabrera C, Quintana RM, Bravo A, Casanova ML, Page A, Alameda JP, Paramio JM, Maroto A, Salamanca J, Dupuy AJ, Ramírez A, Navarro M.

Cancer Res. 2017 Mar 15;77(6):1357-1368. doi: 10.1158/0008-5472.CAN-16-1586. Epub 2017 Jan 20.

15.

Opposing roles of PIK3CA gene alterations to EZH2 signaling in non-muscle invasive bladder cancer.

Segovia C, Martínez-Fernández M, Dueñas M, Rubio C, López-Calderón FF, Costa C, Saiz-Ladera C, Fernández-Grajera M, Duarte J, Muñoz HG, de la Rosa F, Villacampa F, Castellano D, Paramio JM.

Oncotarget. 2017 Feb 7;8(6):10531-10542. doi: 10.18632/oncotarget.14453.

16.

Ablating all three retinoblastoma family members in mouse lung leads to neuroendocrine tumor formation.

Lázaro S, Pérez-Crespo M, Enguita AB, Hernández P, Martínez-Palacio J, Oteo M, Sage J, Paramio JM, Santos M.

Oncotarget. 2017 Jan 17;8(3):4373-4386. doi: 10.18632/oncotarget.13875. Erratum in: Oncotarget. 2017 Jul 25;8(30):50323.

17.

IKKα regulates the stratification and differentiation of the epidermis: implications for skin cancer development.

Alameda JP, Navarro M, Ramírez Á, Page A, Suárez-Cabrera C, Moreno-Maldonado R, Paramio JM, del Carmen Fariña MR, Del Río M, Fernández-Aceñero MJ, Bravo A, de Los Llanos Casanova MR.

Oncotarget. 2016 Nov 22;7(47):76779-76792. doi: 10.18632/oncotarget.12527. Erratum in: Oncotarget. 2017 Aug 7;8(32):53887.

18.

Deregulation of the pRb-E2F4 axis alters epidermal homeostasis and favors tumor development.

Costa C, Santos M, Martínez-Fernández M, Lorz C, Lázaro S, Paramio JM.

Oncotarget. 2016 Nov 15;7(46):75712-75728. doi: 10.18632/oncotarget.12362. Erratum in: Oncotarget. 2017 Jul 25;8(30):50324.

19.

Deciphering the role of nuclear and cytoplasmic IKKα in skin cancer.

Alameda JP, Gaspar M, Ramírez Á, Navarro M, Page A, Suárez-Cabrera C, Fernández MG, Mérida JR, Paramio JM, García-Fernández RA, Fernández-Aceñero MJ, Casanova ML.

Oncotarget. 2016 May 17;7(20):29531-47. doi: 10.18632/oncotarget.8792. Erratum in: Oncotarget. 2017 Aug 7;8(32):53886.

20.

Protective role of p53 in skin cancer: Carcinogenesis studies in mice lacking epidermal p53.

Page A, Navarro M, Suarez-Cabrera C, Alameda JP, Casanova ML, Paramio JM, Bravo A, Ramirez A.

Oncotarget. 2016 Apr 12;7(15):20902-18. doi: 10.18632/oncotarget.7897. Erratum in: Oncotarget. 2017 Mar 28;8(13):22304.

21.

RNA Detection in Urine: From RNA Extraction to Good Normalizer Molecules.

Martínez-Fernández M, Paramio JM, Dueñas M.

J Mol Diagn. 2016 Jan;18(1):15-22. doi: 10.1016/j.jmoldx.2015.07.008. Epub 2015 Nov 14.

PMID:
26586227
22.

EZH2 in Bladder Cancer, a Promising Therapeutic Target.

Martínez-Fernández M, Rubio C, Segovia C, López-Calderón FF, Dueñas M, Paramio JM.

Int J Mol Sci. 2015 Nov 13;16(11):27107-32. doi: 10.3390/ijms161126000. Review.

23.

A Polycomb-mir200 loop regulates clinical outcome in bladder cancer.

Martínez-Fernández M, Dueñas M, Feber A, Segovia C, García-Escudero R, Rubio C, López-Calderón FF, Díaz-García C, Villacampa F, Duarte J, Gómez-Rodriguez MJ, Castellano D, Rodriguez-Peralto JL, de la Rosa F, Beck S, Paramio JM.

Oncotarget. 2015 Dec 8;6(39):42258-75. doi: 10.18632/oncotarget.5546.

24.

Analysis of the Polycomb-related lncRNAs HOTAIR and ANRIL in bladder cancer.

Martínez-Fernández M, Feber A, Dueñas M, Segovia C, Rubio C, Fernandez M, Villacampa F, Duarte J, López-Calderón FF, Gómez-Rodriguez MJ, Castellano D, Rodriguez-Peralto JL, de la Rosa F, Beck S, Paramio JM.

Clin Epigenetics. 2015 Oct 8;7:109. doi: 10.1186/s13148-015-0141-x. eCollection 2015.

25.

The downregulation of ΔNp63 in p53-deficient mouse epidermal tumors favors metastatic behavior.

Bornachea O, López-Calderón FF, Dueñas M, Segrelles C, Lorz C, Suárez-Cabrera C, Marañón M, Paradela-Dobarro B, Santos M, Paramio JM.

Oncotarget. 2015 Sep 15;6(27):24230-45.

26.

Combined deletion of p38γ and p38δ reduces skin inflammation and protects from carcinogenesis.

Zur R, Garcia-Ibanez L, Nunez-Buiza A, Aparicio N, Liappas G, Escós A, Risco A, Page A, Saiz-Ladera C, Alsina-Beauchamp D, Montans J, Paramio JM, Cuenda A.

Oncotarget. 2015 May 30;6(15):12920-35.

27.

The pluripotency factor NANOG promotes the formation of squamous cell carcinomas.

Palla AR, Piazzolla D, Alcazar N, Cañamero M, Graña O, Gómez-López G, Dominguez O, Dueñas M, Paramio JM, Serrano M.

Sci Rep. 2015 May 19;5:10205. doi: 10.1038/srep10205.

28.

Thyroid hormone signaling controls hair follicle stem cell function.

Contreras-Jurado C, Lorz C, García-Serrano L, Paramio JM, Aranda A.

Mol Biol Cell. 2015 Apr 1;26(7):1263-72. doi: 10.1091/mbc.E14-07-1251. Epub 2015 Feb 5.

29.

NOTCH pathway inactivation promotes bladder cancer progression.

Maraver A, Fernandez-Marcos PJ, Cash TP, Mendez-Pertuz M, Dueñas M, Maietta P, Martinelli P, Muñoz-Martin M, Martínez-Fernández M, Cañamero M, Roncador G, Martinez-Torrecuadrada JL, Grivas D, de la Pompa JL, Valencia A, Paramio JM, Real FX, Serrano M.

J Clin Invest. 2015 Feb;125(2):824-30. doi: 10.1172/JCI78185. Epub 2015 Jan 9.

30.

The PTEN/PI3K/AKT Pathway in vivo, Cancer Mouse Models.

Carnero A, Paramio JM.

Front Oncol. 2014 Sep 23;4:252. doi: 10.3389/fonc.2014.00252. eCollection 2014. Review.

31.

Impaired hair growth and wound healing in mice lacking thyroid hormone receptors.

Contreras-Jurado C, García-Serrano L, Martínez-Fernández M, Ruiz-Llorente L, Paramio JM, Aranda A.

PLoS One. 2014 Sep 25;9(9):e108137. doi: 10.1371/journal.pone.0108137. eCollection 2014.

32.

In vivo disruption of an Rb-E2F-Ezh2 signaling loop causes bladder cancer.

Santos M, Martínez-Fernández M, Dueñas M, García-Escudero R, Alfaya B, Villacampa F, Saiz-Ladera C, Costa C, Oteo M, Duarte J, Martínez V, Gómez-Rodriguez MJ, Martín ML, Fernández M, Viatour P, Morcillo MA, Sage J, Castellano D, Rodriguez-Peralto JL, de la Rosa F, Paramio JM.

Cancer Res. 2014 Nov 15;74(22):6565-6577. doi: 10.1158/0008-5472.CAN-14-1218. Epub 2014 Sep 24.

33.

Akt signaling leads to stem cell activation and promotes tumor development in epidermis.

Segrelles C, García-Escudero R, Garín MI, Aranda JF, Hernández P, Ariza JM, Santos M, Paramio JM, Lorz C.

Stem Cells. 2014 Jul;32(7):1917-28. doi: 10.1002/stem.1669.

34.

Skin Tumors Rb(eing) Uncovered.

Costa C, Paramio JM, Santos M.

Front Oncol. 2013 Dec 17;3:307. doi: 10.3389/fonc.2013.00307. Review.

35.

PIK3CA gene alterations in bladder cancer are frequent and associate with reduced recurrence in non-muscle invasive tumors.

Dueñas M, Martínez-Fernández M, García-Escudero R, Villacampa F, Marqués M, Saiz-Ladera C, Duarte J, Martínez V, Gómez MJ, Martín ML, Fernández M, Castellano D, Real FX, Rodriguez-Peralto JL, De La Rosa F, Paramio JM.

Mol Carcinog. 2015 Jul;54(7):566-76. doi: 10.1002/mc.22125. Epub 2013 Dec 18.

PMID:
24347284
36.

p21 suppresses inflammation and tumorigenesis on pRB-deficient stratified epithelia.

Saiz-Ladera C, Lara MF, Garín M, Ruiz S, Santos M, Lorz C, García-Escudero R, Martínez-Fernández M, Bravo A, Fernández-Capetillo O, Segrelles C, Paramio JM.

Oncogene. 2014 Sep 11;33(37):4599-4612. doi: 10.1038/onc.2013.417. Epub 2013 Oct 14.

37.

The Rho exchange factors Vav2 and Vav3 favor skin tumor initiation and promotion by engaging extracellular signaling loops.

Menacho-Márquez M, García-Escudero R, Ojeda V, Abad A, Delgado P, Costa C, Ruiz S, Alarcón B, Paramio JM, Bustelo XR.

PLoS Biol. 2013 Jul;11(7):e1001615. doi: 10.1371/journal.pbio.1001615. Epub 2013 Jul 23.

38.

A novel tumor suppressor network in squamous malignancies.

Costa C, Santos M, Segrelles C, Dueñas M, Lara MF, Agirre X, Prosper F, García-Escudero R, Paramio JM.

Sci Rep. 2012;2:828. doi: 10.1038/srep00828. Epub 2012 Nov 9.

39.

The rho exchange factors vav2 and vav3 control a lung metastasis-specific transcriptional program in breast cancer cells.

Citterio C, Menacho-Márquez M, García-Escudero R, Larive RM, Barreiro O, Sánchez-Madrid F, Paramio JM, Bustelo XR.

Sci Signal. 2012 Oct 2;5(244):ra71. doi: 10.1126/scisignal.2002962.

40.

Progeny of Lgr5-expressing hair follicle stem cell contributes to papillomavirus-induced tumor development in epidermis.

da Silva-Diz V, Solé-Sánchez S, Valdés-Gutiérrez A, Urpí M, Riba-Artés D, Penin RM, Pascual G, González-Suárez E, Casanovas O, Viñals F, Paramio JM, Batlle E, Muñoz P.

Oncogene. 2013 Aug 8;32(32):3732-43. doi: 10.1038/onc.2012.375. Epub 2012 Sep 3.

PMID:
22945646
41.

A humanized mouse model of HPV-associated pathology driven by E7 expression.

Buitrago-Pérez Á, Hachimi M, Dueñas M, Lloveras B, Santos A, Holguín A, Duarte B, Santiago JL, Akgül B, Rodríguez-Peralto JL, Storey A, Ribas C, Larcher F, del Rio M, Paramio JM, García-Escudero R.

PLoS One. 2012;7(7):e41743. doi: 10.1371/journal.pone.0041743. Epub 2012 Jul 23.

42.

E2F1 loss induces spontaneous tumour development in Rb-deficient epidermis.

Costa C, Santos M, Martínez-Fernández M, Dueñas M, Lorz C, García-Escudero R, Paramio JM.

Oncogene. 2013 Jun 13;32(24):2937-51. doi: 10.1038/onc.2012.316. Epub 2012 Aug 13.

PMID:
22890321
43.

Mouse p53-deficient cancer models as platforms for obtaining genomic predictors of human cancer clinical outcomes.

Dueñas M, Santos M, Aranda JF, Bielza C, Martínez-Cruz AB, Lorz C, Taron M, Ciruelos EM, Rodríguez-Peralto JL, Martín M, Larrañaga P, Dahabreh J, Stathopoulos GP, Rosell R, Paramio JM, García-Escudero R.

PLoS One. 2012;7(8):e42494. doi: 10.1371/journal.pone.0042494. Epub 2012 Aug 7.

44.

The orphan receptor GPR55 drives skin carcinogenesis and is upregulated in human squamous cell carcinomas.

Pérez-Gómez E, Andradas C, Flores JM, Quintanilla M, Paramio JM, Guzmán M, Sánchez C.

Oncogene. 2013 May 16;32(20):2534-42. doi: 10.1038/onc.2012.278. Epub 2012 Jul 2.

PMID:
22751111
45.

EMT and induction of miR-21 mediate metastasis development in Trp53-deficient tumours.

Bornachea O, Santos M, Martínez-Cruz AB, García-Escudero R, Dueñas M, Costa C, Segrelles C, Lorz C, Buitrago A, Saiz-Ladera C, Agirre X, Grande T, Paradela B, Maraver A, Ariza JM, Prosper F, Serrano M, Sánchez-Céspedes M, Paramio JM.

Sci Rep. 2012;2:434. doi: 10.1038/srep00434. Epub 2012 May 31.

46.

Genetic inactivation of Cdk7 leads to cell cycle arrest and induces premature aging due to adult stem cell exhaustion.

Ganuza M, Sáiz-Ladera C, Cañamero M, Gómez G, Schneider R, Blasco MA, Pisano D, Paramio JM, Santamaría D, Barbacid M.

EMBO J. 2012 May 30;31(11):2498-510. doi: 10.1038/emboj.2012.94. Epub 2012 Apr 13.

47.

p27Kip1 represses transcription by direct interaction with p130/E2F4 at the promoters of target genes.

Pippa R, Espinosa L, Gundem G, García-Escudero R, Dominguez A, Orlando S, Gallastegui E, Saiz C, Besson A, Pujol MJ, López-Bigas N, Paramio JM, Bigas A, Bachs O.

Oncogene. 2012 Sep 20;31(38):4207-20. doi: 10.1038/onc.2011.582. Epub 2011 Dec 19.

PMID:
22179826
48.

The thyroid hormone receptors modulate the skin response to retinoids.

García-Serrano L, Gomez-Ferrería MA, Contreras-Jurado C, Segrelles C, Paramio JM, Aranda A.

PLoS One. 2011;6(8):e23825. doi: 10.1371/journal.pone.0023825. Epub 2011 Aug 17.

49.

The thyroid hormone receptors as modulators of skin proliferation and inflammation.

Contreras-Jurado C, García-Serrano L, Gómez-Ferrería M, Costa C, Paramio JM, Aranda A.

J Biol Chem. 2011 Jul 8;286(27):24079-88. doi: 10.1074/jbc.M111.218487. Epub 2011 May 12.

50.

Establishment of a murine epidermal cell line suitable for in vitro and in vivo skin modelling.

Segrelles C, Holguín A, Hernández P, Ariza JM, Paramio JM, Lorz C.

BMC Dermatol. 2011 Apr 21;11:9. doi: 10.1186/1471-5945-11-9.

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