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Phosphorylation of the Transient Receptor Potential Ankyrin 1 by Cyclin-dependent Kinase 5 affects Chemo-nociception.

Hall BE, Prochazkova M, Sapio MR, Minetos P, Kurochkina N, Binukumar BK, Amin ND, Terse A, Joseph J, Raithel SJ, Mannes AJ, Pant HC, Chung MK, Iadarola MJ, Kulkarni AB.

Sci Rep. 2018 Jan 19;8(1):1177. doi: 10.1038/s41598-018-19532-6.


Curcumin Ameliorates Neuroinflammation, Neurodegeneration, and Memory Deficits in p25 Transgenic Mouse Model that Bears Hallmarks of Alzheimer's Disease.

Sundaram JR, Poore CP, Sulaimee NHB, Pareek T, Cheong WF, Wenk MR, Pant HC, Frautschy SA, Low CM, Kesavapany S.

J Alzheimers Dis. 2017;60(4):1429-1442. doi: 10.3233/JAD-170093.


Peripheral and orofacial pain sensation is unaffected by the loss of p39.

Prochazkova M, Hall B, Hu M, Okine T, Reukauf J, Binukumar BK, Amin ND, Roque E, Pant HC, Kulkarni A.

Mol Pain. 2017 Jan-Dec;13:1744806917737205. doi: 10.1177/1744806917737205.


Influence of a GSK3β phosphorylation site within the proximal C-terminus of Neurofilament-H on neurofilament dynamics.

Vohnoutka RB, Boumil EF, Liu Y, Uchida A, Pant HC, Shea TB.

Biol Open. 2017 Oct 15;6(10):1516-1527. doi: 10.1242/bio.028522.


TFP5, a Peptide Inhibitor of Aberrant and Hyperactive Cdk5/p25, Attenuates Pathological Phenotypes and Restores Synaptic Function in CK-p25Tg Mice.

Shukla V, Seo J, Binukumar BK, Amin ND, Reddy P, Grant P, Kuntz S, Kesavapany S, Steiner J, Mishra SK, Tsai LH, Pant HC.

J Alzheimers Dis. 2017;56(1):335-349. doi: 10.3233/JAD-160916.


The interaction of Munc 18 (p67) with the p10 domain of p35 protects in vivo Cdk5/p35 activity from inhibition by TFP5, a peptide derived from p35.

Amin ND, Zheng Y, Bk B, Shukla V, Skuntz S, Grant P, Steiner J, Bhaskar M, Pant HC.

Mol Biol Cell. 2016 Nov 1;27(21):3221-3232. Epub 2016 Sep 14.


Profiling of p5, a 24 Amino Acid Inhibitory Peptide Derived from the CDK5 Activator, p35 CDKR1 Against 70 Protein Kinases.

Binukumar BK, Pelech SL, Sutter C, Shukla V, Amin ND, Grant P, Bhaskar M, Skuntz S, Steiner J, Pant HC.

J Alzheimers Dis. 2016 Sep 6;54(2):525-33. doi: 10.3233/JAD-160458.


Computational study of the inhibitory mechanism of the kinase CDK5 hyperactivity by peptide p5 and derivation of a pharmacophore.

Cardone A, Brady M, Sriram R, Pant HC, Hassan SA.

J Comput Aided Mol Des. 2016 Jun;30(6):513-21. doi: 10.1007/s10822-016-9922-3. Epub 2016 Jul 8.


TFP5/TP5 peptide provides neuroprotection in the MPTP model of Parkinson's disease.

Binukumar BK, Pant HC.

Neural Regen Res. 2016 May;11(5):698-701. doi: 10.4103/1673-5374.182681. Review.


Squid Giant Axon Contains Neurofilament Protein mRNA but does not Synthesize Neurofilament Proteins.

Gainer H, House S, Kim DS, Chin H, Pant HC.

Cell Mol Neurobiol. 2017 Apr;37(3):475-486. doi: 10.1007/s10571-016-0382-z. Epub 2016 May 20.


Compartment-Specific Phosphorylation of Squid Neurofilaments.

Grant P, Pant HC.

Methods Enzymol. 2016;568:615-33. doi: 10.1016/bs.mie.2015.09.033. Epub 2015 Nov 3.


Analysis of the Inhibitory Elements in the p5 Peptide Fragment of the CDK5 Activator, p35, CDKR1 Protein.

Binukumar BK, Shukla V, Amin ND, Bhaskar M, Skuntz S, Steiner J, Winkler D, Pelech SL, Pant HC.

J Alzheimers Dis. 2015;48(4):1009-17. doi: 10.3233/JAD-150412.


Peptide TFP5/TP5 derived from Cdk5 activator P35 provides neuroprotection in the MPTP model of Parkinson's disease.

Binukumar BK, Shukla V, Amin ND, Grant P, Bhaskar M, Skuntz S, Steiner J, Pant HC.

Mol Biol Cell. 2015 Dec 1;26(24):4478-91. doi: 10.1091/mbc.E15-06-0415. Epub 2015 Sep 23.


The homeodomain transcription factor Phox2 in the stellate ganglion of the squid Loligo pealei.

Burbach JP, Hellemons AJ, Grant P, Pant HC.

Biol Open. 2015 Jun 26;4(8):954-60. doi: 10.1242/bio.012476.


Acute and chronic stress differentially regulate cyclin-dependent kinase 5 in mouse brain: implications to glucocorticoid actions and major depression.

Papadopoulou A, Siamatras T, Delgado-Morales R, Amin ND, Shukla V, Zheng YL, Pant HC, Almeida OF, Kino T.

Transl Psychiatry. 2015 Jun 9;5:e578. doi: 10.1038/tp.2015.72.


Detection and characterization of nonspecific, sparsely populated binding modes in the early stages of complexation.

Cardone A, Bornstein A, Pant HC, Brady M, Sriram R, Hassan SA.

J Comput Chem. 2015 May 15;36(13):983-95. doi: 10.1002/jcc.23883. Epub 2015 Mar 18.


Use of multilayer targets for achieving off-Hugoniot states.

Aliverdiev AA, Batani D, Antonelli L, Jakubowska K, Dezulian R, Amirova AA, Gajiev GM, Khan M, Pant HC.

Phys Rev E Stat Nonlin Soft Matter Phys. 2014 May;89(5):053101. Epub 2014 May 12. Erratum in: Phys Rev E Stat Nonlin Soft Matter Phys. 2014 May;89(5):059902.


Divergent and convergent roles for kinases and phosphatases in neurofilament dynamics.

Lee S, Pant HC, Shea TB.

J Cell Sci. 2014 Sep 15;127(Pt 18):4064-77. doi: 10.1242/jcs.153346. Epub 2014 Jul 11.


Searching for novel Cdk5 substrates in brain by comparative phosphoproteomics of wild type and Cdk5-/- mice.

Contreras-Vallejos E, Utreras E, Bórquez DA, Prochazkova M, Terse A, Jaffe H, Toledo A, Arruti C, Pant HC, Kulkarni AB, González-Billault C.

PLoS One. 2014 Mar 21;9(3):e90363. doi: 10.1371/journal.pone.0090363. eCollection 2014.


Activation of cyclin-dependent kinase 5 mediates orofacial mechanical hyperalgesia.

Prochazkova M, Terse A, Amin ND, Hall B, Utreras E, Pant HC, Kulkarni AB.

Mol Pain. 2013 Dec 21;9:66. doi: 10.1186/1744-8069-9-66.


TFP5, a peptide derived from p35, a Cdk5 neuronal activator, rescues cortical neurons from glucose toxicity.

Binukumar BK, Zheng YL, Shukla V, Amin ND, Grant P, Pant HC.

J Alzheimers Dis. 2014;39(4):899-909. doi: 10.3233/JAD-131784.


Differential expression of the FMRF gene in adult and hatchling stellate ganglia of the squid Loligo pealei.

Burbach JP, Grant P, Hellemons AJ, Degiorgis JA, Li KW, Pant HC.

Biol Open. 2014 Jan 15;3(1):50-8. doi: 10.1242/bio.20136890.


Cdk5 inhibitory peptide (CIP) inhibits Cdk5/p25 activity induced by high glucose in pancreatic beta cells and recovers insulin secretion from p25 damage.

Zheng YL, Li C, Hu YF, Cao L, Wang H, Li B, Lu XH, Bao L, Luo HY, Shukla V, Amin ND, Pant HC.

PLoS One. 2013 Sep 5;8(9):e63332. doi: 10.1371/journal.pone.0063332. eCollection 2013.


Impaired neurogenesis and neurite outgrowth in an HIV-gp120 transgenic model is reversed by exercise via BDNF production and Cdk5 regulation.

Lee MH, Amin ND, Venkatesan A, Wang T, Tyagi R, Pant HC, Nath A.

J Neurovirol. 2013 Oct;19(5):418-31. doi: 10.1007/s13365-013-0194-6. Epub 2013 Aug 27.


Topographic regulation of neuronal intermediate filaments by phosphorylation, role of peptidyl-prolyl isomerase 1: significance in neurodegeneration.

Binukumar BK, Shukla V, Amin ND, Reddy P, Skuntz S, Grant P, Pant HC.

Histochem Cell Biol. 2013 Jul;140(1):23-32. doi: 10.1007/s00418-013-1108-7. Epub 2013 Jun 23. Review.


Specific inhibition of p25/Cdk5 activity by the Cdk5 inhibitory peptide reduces neurodegeneration in vivo.

Sundaram JR, Poore CP, Sulaimee NH, Pareek T, Asad AB, Rajkumar R, Cheong WF, Wenk MR, Dawe GS, Chuang KH, Pant HC, Kesavapany S.

J Neurosci. 2013 Jan 2;33(1):334-43. doi: 10.1523/JNEUROSCI.3593-12.2013.


Deregulated Cdk5 activity is involved in inducing Alzheimer's disease.

Shukla V, Skuntz S, Pant HC.

Arch Med Res. 2012 Nov;43(8):655-62. doi: 10.1016/j.arcmed.2012.10.015. Epub 2012 Nov 7. Review.


A truncated peptide from p35, a Cdk5 activator, prevents Alzheimer's disease phenotypes in model mice.

Shukla V, Zheng YL, Mishra SK, Amin ND, Steiner J, Grant P, Kesavapany S, Pant HC.

FASEB J. 2013 Jan;27(1):174-86. doi: 10.1096/fj.12-217497. Epub 2012 Oct 4.


Achaete-scute homologue-1 (ASH1) stimulates migration of lung cancer cells through Cdk5/p35 pathway.

Demelash A, Rudrabhatla P, Pant HC, Wang X, Amin ND, McWhite CD, Naizhen X, Linnoila RI.

Mol Biol Cell. 2012 Aug;23(15):2856-66. doi: 10.1091/mbc.E10-12-1010. Epub 2012 Jun 13.


Cyclin-dependent kinase 5 regulates E2F transcription factor through phosphorylation of Rb protein in neurons.

Futatsugi A, Utreras E, Rudrabhatla P, Jaffe H, Pant HC, Kulkarni AB.

Cell Cycle. 2012 Apr 15;11(8):1603-10. doi: 10.4161/cc.20009. Epub 2012 Apr 15.


Oxidative stress in neurodegeneration.

Shukla V, Mishra SK, Pant HC.

Adv Pharmacol Sci. 2011;2011:572634. doi: 10.1155/2011/572634. Epub 2011 Sep 21.


Direct evidence of phosphorylated neuronal intermediate filament proteins in neurofibrillary tangles (NFTs): phosphoproteomics of Alzheimer's NFTs.

Rudrabhatla P, Jaffe H, Pant HC.

FASEB J. 2011 Nov;25(11):3896-905. doi: 10.1096/fj.11-181297. Epub 2011 Aug 9.


Role of protein phosphatase 2A in Alzheimer's disease.

Rudrabhatla P, Pant HC.

Curr Alzheimer Res. 2011 Sep;8(6):623-32. Review.


Overexpression of p35 in Min6 pancreatic beta cells induces a stressed neuron-like apoptosis.

Zheng YL, Hu YF, Zhang A, Wang W, Li B, Amin N, Grant P, Pant HC.

J Neurol Sci. 2010 Dec 15;299(1-2):101-7. doi: 10.1016/j.jns.2010.08.067.


Phosphorylation of p27Kip1 at Thr187 by cyclin-dependent kinase 5 modulates neural stem cell differentiation.

Zheng YL, Li BS, Rudrabhatla P, Shukla V, Amin ND, Maric D, Kesavapany S, Kanungo J, Pareek TK, Takahashi S, Grant P, Kulkarni AB, Pant HC.

Mol Biol Cell. 2010 Oct 15;21(20):3601-14. doi: 10.1091/mbc.E10-01-0054. Epub 2010 Sep 1.


A 24-residue peptide (p5), derived from p35, the Cdk5 neuronal activator, specifically inhibits Cdk5-p25 hyperactivity and tau hyperphosphorylation.

Zheng YL, Amin ND, Hu YF, Rudrabhatla P, Shukla V, Kanungo J, Kesavapany S, Grant P, Albers W, Pant HC.

J Biol Chem. 2010 Oct 29;285(44):34202-12. doi: 10.1074/jbc.M110.134643. Epub 2010 Aug 18.


Quantitative phosphoproteomic analysis of neuronal intermediate filament proteins (NF-M/H) in Alzheimer's disease by iTRAQ.

Rudrabhatla P, Grant P, Jaffe H, Strong MJ, Pant HC.

FASEB J. 2010 Nov;24(11):4396-407. doi: 10.1096/fj.10-157859. Epub 2010 Jul 12.


Structural and dynamic determinants of ligand binding and regulation of cyclin-dependent kinase 5 by pathological activator p25 and inhibitory peptide CIP.

Cardone A, Hassan SA, Albers RW, Sriram RD, Pant HC.

J Mol Biol. 2010 Aug 20;401(3):478-92. doi: 10.1016/j.jmb.2010.06.040. Epub 2010 Jun 25.


Cdk5-mediated phosphorylation of delta-catenin regulates its localization and GluR2-mediated synaptic activity.

Poore CP, Sundaram JR, Pareek TK, Fu A, Amin N, Mohamed NE, Zheng YL, Goh AX, Lai MK, Ip NY, Pant HC, Kesavapany S.

J Neurosci. 2010 Jun 23;30(25):8457-67. doi: 10.1523/JNEUROSCI.6062-09.2010.


Evaluation of the interaction of cyclin-dependent kinase 5 with activator p25 and with p25-derived inhibitor CIP.

Cardone A, Albers RW, Sriram RD, Pant HC.

J Comput Biol. 2010 May;17(5):707-21. doi: 10.1089/cmb.2009.0202.


Cyclin-dependent kinase 5 modulates the transcriptional activity of the mineralocorticoid receptor and regulates expression of brain-derived neurotrophic factor.

Kino T, Jaffe H, Amin ND, Chakrabarti M, Zheng YL, Chrousos GP, Pant HC.

Mol Endocrinol. 2010 May;24(5):941-52. doi: 10.1210/me.2009-0395. Epub 2010 Mar 31.


Phosphorylation-specific peptidyl-prolyl isomerization of neuronal cytoskeletal proteins by Pin1: implications for therapeutics in neurodegeneration.

Rudrabhatla P, Pant HC.

J Alzheimers Dis. 2010;19(2):389-403. doi: 10.3233/JAD-2010-1243. Review.


Declining phosphatases underlie aging-related hyperphosphorylation of neurofilaments.

Veeranna, Yang DS, Lee JH, Vinod KY, Stavrides P, Amin ND, Pant HC, Nixon RA.

Neurobiol Aging. 2011 Nov;32(11):2016-29. doi: 10.1016/j.neurobiolaging.2009.12.001. Epub 2009 Dec 23.


Peptidyl-prolyl isomerase 1 regulates protein phosphatase 2A-mediated topographic phosphorylation of neurofilament proteins.

Rudrabhatla P, Albers W, Pant HC.

J Neurosci. 2009 Nov 25;29(47):14869-80. doi: 10.1523/JNEUROSCI.4469-09.2009.


Specific inhibition of cyclin-dependent kinase 5 activity induces motor neuron development in vivo.

Kanungo J, Zheng YL, Amin ND, Kaur S, Ramchandran R, Pant HC.

Biochem Biophys Res Commun. 2009 Aug 14;386(1):263-7. doi: 10.1016/j.bbrc.2009.06.038. Epub 2009 Jun 11.


Targeting Cdk5 activity in neuronal degeneration and regeneration.

Kanungo J, Zheng YL, Amin ND, Pant HC.

Cell Mol Neurobiol. 2009 Dec;29(8):1073-80. doi: 10.1007/s10571-009-9410-6.


Zebrafish Rohon-Beard neuron development: cdk5 in the midst.

Kanungo J, Zheng YL, Mishra B, Pant HC.

Neurochem Res. 2009 Jun;34(6):1129-37. doi: 10.1007/s11064-008-9885-4. Epub 2008 Dec 9. Review.


Tumor necrosis factor-alpha regulates cyclin-dependent kinase 5 activity during pain signaling through transcriptional activation of p35.

Utreras E, Futatsugi A, Rudrabhatla P, Keller J, Iadarola MJ, Pant HC, Kulkarni AB.

J Biol Chem. 2009 Jan 23;284(4):2275-84. doi: 10.1074/jbc.M805052200. Epub 2008 Dec 2.


Neurofilament tail phosphorylation: identity of the RT-97 phosphoepitope and regulation in neurons by cross-talk among proline-directed kinases.

Veeranna, Lee JH, Pareek TK, Jaffee H, Boland B, Vinod KY, Amin N, Kulkarni AB, Pant HC, Nixon RA.

J Neurochem. 2008 Oct;107(1):35-49. doi: 10.1111/j.1471-4159.2008.05547.x. Epub 2008 Jul 4.


The Notch signaling inhibitor DAPT down-regulates cdk5 activity and modulates the distribution of neuronal cytoskeletal proteins.

Kanungo J, Zheng YL, Amin ND, Pant HC.

J Neurochem. 2008 Sep;106(5):2236-48. doi: 10.1111/j.1471-4159.2008.05551.x. Epub 2008 Jul 4.

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