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Items: 34

1.

rIgG1 Fc Hexamer Inhibits Antibody-Mediated Autoimmune Disease via Effects on Complement and FcγRs.

Spirig R, Campbell IK, Koernig S, Chen CG, Lewis BJB, Butcher R, Muir I, Taylor S, Chia J, Leong D, Simmonds J, Scotney P, Schmidt P, Fabri L, Hofmann A, Jordi M, Spycher MO, Cattepoel S, Brasseit J, Panousis C, Rowe T, Branch DR, Baz Morelli A, Käsermann F, Zuercher AW.

J Immunol. 2018 Apr 15;200(8):2542-2553. doi: 10.4049/jimmunol.1701171. Epub 2018 Mar 12.

2.

High-Throughput IgG Reformatting and Expression.

Chen CG, Sansome G, Wilson MJ, Panousis C.

Methods Mol Biol. 2018;1701:447-461. doi: 10.1007/978-1-4939-7447-4_25.

PMID:
29116521
3.

Antihistone Properties of C1 Esterase Inhibitor Protect against Lung Injury.

Wygrecka M, Kosanovic D, Wujak L, Reppe K, Henneke I, Frey H, Didiasova M, Kwapiszewska G, Marsh LM, Baal N, Hackstein H, Zakrzewicz D, Müller-Redetzky HC, de Maat S, Maas C, Nolte MW, Panousis C, Schermuly RT, Seeger W, Witzenrath M, Schaefer L, Markart P.

Am J Respir Crit Care Med. 2017 Jul 15;196(2):186-199. doi: 10.1164/rccm.201604-0712OC.

PMID:
28005404
4.

Therapeutic Targeting of the G-CSF Receptor Reduces Neutrophil Trafficking and Joint Inflammation in Antibody-Mediated Inflammatory Arthritis.

Campbell IK, Leong D, Edwards KM, Rayzman V, Ng M, Goldberg GL, Wilson NJ, Scalzo-Inguanti K, Mackenzie-Kludas C, Lawlor KE, Wicks IP, Brown LE, Baz Morelli A, Panousis C, Wilson MJ, Nash AD, McKenzie BS, Andrews AE.

J Immunol. 2016 Dec 1;197(11):4392-4402. Epub 2016 Nov 2.

5.

Blood coagulation factor XII drives adaptive immunity during neuroinflammation via CD87-mediated modulation of dendritic cells.

Göbel K, Pankratz S, Asaridou CM, Herrmann AM, Bittner S, Merker M, Ruck T, Glumm S, Langhauser F, Kraft P, Krug TF, Breuer J, Herold M, Gross CC, Beckmann D, Korb-Pap A, Schuhmann MK, Kuerten S, Mitroulis I, Ruppert C, Nolte MW, Panousis C, Klotz L, Kehrel B, Korn T, Langer HF, Pap T, Nieswandt B, Wiendl H, Chavakis T, Kleinschnitz C, Meuth SG.

Nat Commun. 2016 May 18;7:11626. doi: 10.1038/ncomms11626.

6.

FXIIa inhibitor rHA-Infestin-4: Safe thromboprotection in experimental venous, arterial and foreign surface-induced thrombosis.

May F, Krupka J, Fries M, Thielmann I, Pragst I, Weimer T, Panousis C, Nieswandt B, Stoll G, Dickneite G, Schulte S, Nolte MW.

Br J Haematol. 2016 Jun;173(5):769-78. doi: 10.1111/bjh.13990. Epub 2016 Mar 27.

PMID:
27018425
7.

The Coagulation Factor XIIa Inhibitor rHA-Infestin-4 Improves Outcome after Cerebral Ischemia/Reperfusion Injury in Rats.

Krupka J, May F, Weimer T, Pragst I, Kleinschnitz C, Stoll G, Panousis C, Dickneite G, Nolte MW.

PLoS One. 2016 Jan 27;11(1):e0146783. doi: 10.1371/journal.pone.0146783. eCollection 2016.

8.

CSL311, a novel, potent, therapeutic monoclonal antibody for the treatment of diseases mediated by the common β chain of the IL-3, GM-CSF and IL-5 receptors.

Panousis C, Dhagat U, Edwards KM, Rayzman V, Hardy MP, Braley H, Gauvreau GM, Hercus TR, Smith S, Sehmi R, McMillan L, Dottore M, McClure BJ, Fabri LJ, Vairo G, Lopez AF, Parker MW, Nash AD, Wilson NJ, Wilson MJ, Owczarek CM.

MAbs. 2016;8(3):436-53. doi: 10.1080/19420862.2015.1119352. Epub 2015 Dec 14.

9.

Frequency of Antiretroviral Resistance Mutations among Infants Exposed to Single-Dose Nevirapine and Short Course Maternal Antiretroviral Regimens: ACTG A5207.

Hitti J, Halvas EK, Zheng L, Panousis CG, Kabanda J, Taulo F, Kumarasamy N, Pape JW, Lalloo U, Sprenger H, Klingman KL, Chan ES, McMahon D, Mellors JW.

J AIDS Clin Res. 2014 Nov;5(11). pii: 371. Epub 2014 Nov 9.

10.

Defective glycosylation of coagulation factor XII underlies hereditary angioedema type III.

Björkqvist J, de Maat S, Lewandrowski U, Di Gennaro A, Oschatz C, Schönig K, Nöthen MM, Drouet C, Braley H, Nolte MW, Sickmann A, Panousis C, Maas C, Renné T.

J Clin Invest. 2015 Aug 3;125(8):3132-46. doi: 10.1172/JCI77139. Epub 2015 Jul 20.

11.

Targeting of acute myeloid leukemia in vitro and in vivo with an anti-CD123 mAb engineered for optimal ADCC.

Busfield SJ, Biondo M, Wong M, Ramshaw HS, Lee EM, Ghosh S, Braley H, Panousis C, Roberts AW, He SZ, Thomas D, Fabri L, Vairo G, Lock RB, Lopez AF, Nash AD.

Leukemia. 2014 Nov;28(11):2213-21. doi: 10.1038/leu.2014.128. Epub 2014 Apr 7.

PMID:
24705479
12.

Identification of potent antagonist antibodies against mouse IL-13Rα1 using novel bioassays.

Edwards KM, Huynh H, Prasad R, McDonald A, Hardy MP, Scotney P, Owczarek CM, Busfield SJ, Panousis C, Wilson NJ.

J Immunol Methods. 2014 May;407:48-57. doi: 10.1016/j.jim.2014.03.019. Epub 2014 Apr 3.

PMID:
24704819
13.

A factor XIIa inhibitory antibody provides thromboprotection in extracorporeal circulation without increasing bleeding risk.

Larsson M, Rayzman V, Nolte MW, Nickel KF, Björkqvist J, Jämsä A, Hardy MP, Fries M, Schmidbauer S, Hedenqvist P, Broomé M, Pragst I, Dickneite G, Wilson MJ, Nash AD, Panousis C, Renné T.

Sci Transl Med. 2014 Feb 5;6(222):222ra17. doi: 10.1126/scitranslmed.3006804.

14.

One-step zero-background IgG reformatting of phage-displayed antibody fragments enabling rapid and high-throughput lead identification.

Chen CG, Fabri LJ, Wilson MJ, Panousis C.

Nucleic Acids Res. 2014 Feb;42(4):e26. doi: 10.1093/nar/gkt1142. Epub 2013 Nov 18.

15.

G protein-coupled receptor transmembrane binding pockets and their applications in GPCR research and drug discovery: a survey.

Kratochwil NA, Gatti-McArthur S, Hoener MC, Lindemann L, Christ AD, Green LG, Guba W, Martin RE, Malherbe P, Porter RH, Slack JP, Winnig M, Dehmlow H, Grether U, Hertel C, Narquizian R, Panousis CG, Kolczewski S, Steward L.

Curr Top Med Chem. 2011;11(15):1902-24.

PMID:
21470172
16.

Pyrido pyrimidinones as selective agonists of the high affinity niacin receptor GPR109A: optimization of in vitro activity.

Peters JU, Kühne H, Dehmlow H, Grether U, Conte A, Hainzl D, Hertel C, Kratochwil NA, Otteneder M, Narquizian R, Panousis CG, Ricklin F, Röver S.

Bioorg Med Chem Lett. 2010 Sep 15;20(18):5426-30. doi: 10.1016/j.bmcl.2010.07.108. Epub 2010 Jul 29.

PMID:
20724150
17.

Engineering and characterisation of chimeric monoclonal antibody 806 (ch806) for targeted immunotherapy of tumours expressing de2-7 EGFR or amplified EGFR.

Panousis C, Rayzman VM, Johns TG, Renner C, Liu Z, Cartwright G, Lee FT, Wang D, Gan H, Cao D, Kypridis A, Smyth FE, Brechbiel MW, Burgess AW, Old LJ, Scott AM.

Br J Cancer. 2005 Mar 28;92(6):1069-77.

18.

Targeted bioactivity of membrane-anchored TNF by an antibody-derived TNF fusion protein.

Bauer S, Adrian N, Williamson B, Panousis C, Fadle N, Smerd J, Fettah I, Scott AM, Pfreundschuh M, Renner C.

J Immunol. 2004 Mar 15;172(6):3930-9.

19.

Generation of anti-idiotype antibodies for application in clinical immunotherapy laboratory analyses.

Liu Z, Panousis C, Smyth FE, Murphy R, Wirth V, Cartwright G, Johns TG, Scott AM.

Hybrid Hybridomics. 2003 Aug;22(4):219-28.

PMID:
14511567
20.

Interferon-gamma-mediated downregulation of cholesterol efflux and ABC1 expression is by the Stat1 pathway.

Wang XQ, Panousis CG, Alfaro ML, Evans GF, Zuckerman SH.

Arterioscler Thromb Vasc Biol. 2002 May 1;22(5):e5-9.

21.
22.

TGF-beta reduced binding of high-density lipoproteins in murine macrophages and macrophage-derived foam cells.

Zuckerman SH, Panousis C, Evans G.

Atherosclerosis. 2001 Mar;155(1):79-85.

PMID:
11223429
23.
24.
25.

Interstrand cross-linking by adriamycin in nuclear and mitochondrial DNA of MCF-7 cells.

Cullinane C, Cutts SM, Panousis C, Phillips DR.

Nucleic Acids Res. 2000 Feb 15;28(4):1019-25.

26.
27.

Monoclonal antibody-directed cytotoxic therapy: potential in malignant diseases of aging.

Panousis C, Pietersz GA.

Drugs Aging. 1999 Jul;15(1):1-13. Review.

PMID:
10459728
29.

Neutrophil-mediated activation of mitoxantrone to metabolites which form adducts with DNA.

Panousis C, Kettle AJ, Phillips DR.

Cancer Lett. 1997 Feb 26;113(1-2):173-8.

PMID:
9065819
30.

An oligonucleotide crosslinking assay for the analysis of individual drug-binding sites.

Cutts SM, Panousis C, Masta A, Phillips DR.

Methods Mol Biol. 1997;90:107-15. Review. No abstract available.

PMID:
9407530
31.

A gel mobility shift assay for probing the effect of drug-DNA adducts on DNA-binding proteins.

Cutts SM, Masta A, Panousis C, Parsons PG, Sturm RA, Phillips DR.

Methods Mol Biol. 1997;90:95-106. Review. No abstract available.

PMID:
9407529
32.

Myeloperoxidase oxidizes mitoxantrone to metabolites which bind covalently to DNA and RNA.

Panousis C, Kettle AJ, Phillips DR.

Anticancer Drug Des. 1995 Dec;10(8):593-605.

PMID:
8595120
33.

Oxidative metabolism of mitoxantrone by the human neutrophil enzyme myeloperoxidase.

Panousis C, Kettle AJ, Phillips DR.

Biochem Pharmacol. 1994 Dec 16;48(12):2223-30.

PMID:
7811304
34.

DNA sequence specificity of mitoxantrone.

Panousis C, Phillips DR.

Nucleic Acids Res. 1994 Apr 25;22(8):1342-5.

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