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Items: 1 to 50 of 351

1.

Chemical Control over T-Cell Activation in Vivo Using Deprotection of trans-Cyclooctene-Modified Epitopes.

van der Gracht AMF, de Geus MAR, Camps MGM, Ruckwardt TJ, Sarris AJC, Bremmers J, Maurits E, Pawlak JB, Posthoorn MM, Bonger KM, Filippov DV, Overkleeft HS, Robillard MS, Ossendorp F, van Kasteren SI.

ACS Chem Biol. 2018 May 11. doi: 10.1021/acschembio.8b00155. [Epub ahead of print]

PMID:
29733186
2.

Quantification of Bioorthogonal Stability in Immune Phagocytes Using Flow Cytometry Reveals Rapid Degradation of Strained Alkynes.

Bakkum T, van Leeuwen T, Sarris AJC, van Elsland DM, Poulcharidis D, Overkleeft HS, van Kasteren SI.

ACS Chem Biol. 2018 May 18;13(5):1173-1179. doi: 10.1021/acschembio.8b00355. Epub 2018 Apr 30.

PMID:
29693370
3.

Nicotiana benthamiana α-galactosidase A1.1 can functionally complement human α-galactosidase A deficiency associated with Fabry disease.

Kytidou K, Beekwilder J, Artola M, van Meel E, Wilbers RHP, Moolenaar GF, Goosen N, Ferraz MJ, Katzy R, Voskamp P, Florea BI, Hokke CH, Overkleeft HS, Schots A, Bosch D, Pannu N, Aerts JMFG.

J Biol Chem. 2018 Apr 19. pii: jbc.RA118.001774. doi: 10.1074/jbc.RA118.001774. [Epub ahead of print]

4.

Mapping the Relationship between Glycosyl Acceptor Reactivity and Glycosylation Stereoselectivity.

van der Vorm S, van Hengst JMA, Bakker M, Overkleeft HS, van der Marel GA, Codée JDC.

Angew Chem Int Ed Engl. 2018 Mar 30. doi: 10.1002/anie.201802899. [Epub ahead of print]

PMID:
29603532
5.

Gluco-1 H-imidazole: A New Class of Azole-Type β-Glucosidase Inhibitor.

Schröder SP, Wu L, Artola M, Hansen T, Offen WA, Ferraz MJ, Li KY, Aerts JMFG, van der Marel GA, Codée JDC, Davies GJ, Overkleeft HS.

J Am Chem Soc. 2018 Apr 18;140(15):5045-5048. doi: 10.1021/jacs.8b02399. Epub 2018 Apr 4.

6.

Mapping in vivo target interaction profiles of covalent inhibitors using chemical proteomics with label-free quantification.

van Rooden EJ, Florea BI, Deng H, Baggelaar MP, van Esbroeck ACM, Zhou J, Overkleeft HS, van der Stelt M.

Nat Protoc. 2018 Apr;13(4):752-767. doi: 10.1038/nprot.2017.159. Epub 2018 Mar 22.

PMID:
29565900
7.

Multiplex Fluorescent, Activity-Based Protein Profiling Identifies Active α-Glycosidases and Other Hydrolases in Plants.

Husaini AM, Morimoto K, Chandrasekar B, Kelly S, Kaschani F, Palmero D, Jiang J, Kaiser M, Ahrazem O, Overkleeft HS, van der Hoorn RAL.

Plant Physiol. 2018 May;177(1):24-37. doi: 10.1104/pp.18.00250. Epub 2018 Mar 19.

8.

Reagent Controlled Stereoselective Synthesis of α-Glucans.

Wang L, Overkleeft HS, van der Marel GA, Codée JDC.

J Am Chem Soc. 2018 Apr 4;140(13):4632-4638. doi: 10.1021/jacs.8b00669. Epub 2018 Mar 23.

9.

Selective Photoaffinity Probe That Enables Assessment of Cannabinoid CB2 Receptor Expression and Ligand Engagement in Human Cells.

Soethoudt M, Stolze SC, Westphal MV, van Stralen L, Martella A, van Rooden EJ, Guba W, Varga ZV, Deng H, van Kasteren SI, Grether U, IJzerman AP, Pacher P, Carreira EM, Overkleeft HS, Ioan-Facsinay A, Heitman LH, van der Stelt M.

J Am Chem Soc. 2018 May 16;140(19):6067-6075. doi: 10.1021/jacs.7b11281. Epub 2018 Feb 16.

PMID:
29420021
10.

Streamlined Synthesis and Evaluation of Teichoic Acid Fragments.

van der Es D, Berni F, Hogendorf WFJ, Meeuwenoord N, Laverde D, van Diepen A, Overkleeft HS, Filippov DV, Hokke CH, Huebner J, van der Marel GA, Codée JDC.

Chemistry. 2018 Mar 15;24(16):4014-4018. doi: 10.1002/chem.201800153. Epub 2018 Feb 19.

11.

Activity-Based Probes for Glycosidases: Profiling and Other Applications.

Kuo CL, van Meel E, Kytidou K, Kallemeijn WW, Witte M, Overkleeft HS, Artola ME, Aerts JM.

Methods Enzymol. 2018;598:217-235. doi: 10.1016/bs.mie.2017.06.039. Epub 2017 Dec 8.

PMID:
29306436
12.

Milder degenerative effects of Carfilzomib vs. Bortezomib in the Drosophila model: a link to clinical adverse events.

Tsakiri EN, Terpos E, Papanagnou ED, Kastritis E, Brieudes V, Halabalaki M, Bagratuni T, Florea BI, Overkleeft HS, Scorrano L, Skaltsounis AL, Dimopoulos MA, Trougakos IP.

Sci Rep. 2017 Dec 19;7(1):17802. doi: 10.1038/s41598-017-17596-4.

13.

A General Approach Towards Triazole-Linked Adenosine Diphosphate Ribosylated Peptides and Proteins.

Liu Q, Kistemaker HAV, Bhogaraju S, Dikic I, Overkleeft HS, van der Marel GA, Ovaa H, van der Heden van Noort GJ, Filippov DV.

Angew Chem Int Ed Engl. 2018 Feb 5;57(6):1659-1662. doi: 10.1002/anie.201710527. Epub 2018 Jan 8.

PMID:
29215186
14.

Identification of new quorum sensing autoinducer binding partners in Pseudomonas aeruginosa using photoaffinity probes.

Baker YR, Hodgkinson JT, Florea BI, Alza E, Galloway WRJD, Grimm L, Geddis SM, Overkleeft HS, Welch M, Spring DR.

Chem Sci. 2017 Nov 1;8(11):7403-7411. doi: 10.1039/c7sc01270e. Epub 2017 Aug 29.

15.

Cyanopivaloyl Ester in the Automated Solid-Phase Synthesis of Oligorhamnans.

Geert Volbeda A, van Mechelen J, Meeuwenoord N, Overkleeft HS, van der Marel GA, Codée JDC.

J Org Chem. 2017 Dec 15;82(24):12992-13002. doi: 10.1021/acs.joc.7b02511. Epub 2017 Dec 1.

16.

Towards broad spectrum activity-based glycosidase probes: synthesis and evaluation of deoxygenated cyclophellitol aziridines.

Schröder SP, van de Sande JW, Kallemeijn WW, Kuo CL, Artola M, van Rooden EJ, Jiang J, Beenakker TJM, Florea BI, Offen WA, Davies GJ, Minnaard AJ, Aerts JMFG, Codée JDC, van der Marel GA, Overkleeft HS.

Chem Commun (Camb). 2017 Nov 21;53(93):12528-12531. doi: 10.1039/c7cc07730k.

PMID:
29116266
17.

Novel activity-based probes for N-acylethanolamine acid amidase.

Petracca R, Romeo E, Baggelaar MP, Artola M, Pontis S, Ponzano S, Overkleeft HS, van der Stelt M, Piomelli D.

Chem Commun (Camb). 2017 Aug 22;53(86):11810-11813. doi: 10.1039/c7cc06838g.

PMID:
29035406
18.

Amelioration of autoimmunity with an inhibitor selectively targeting all active centres of the immunoproteasome.

Basler M, Maurits E, de Bruin G, Koerner J, Overkleeft HS, Groettrup M.

Br J Pharmacol. 2018 Jan;175(1):38-52. doi: 10.1111/bph.14069. Epub 2017 Nov 29.

PMID:
29034459
19.

In situ visualization of glucocerebrosidase in human skin tissue: zymography versus activity-based probe labeling.

van Smeden J, Dijkhoff IM, Helder RWJ, Al-Khakany H, Boer DEC, Schreuder A, Kallemeijn WW, Absalah S, Overkleeft HS, Aerts JMFG, Bouwstra JA.

J Lipid Res. 2017 Dec;58(12):2299-2309. doi: 10.1194/jlr.M079376. Epub 2017 Oct 12.

PMID:
29025868
20.

Intertwined Precursor Supply during Biosynthesis of the Catecholate-Hydroxamate Siderophores Qinichelins in Streptomyces sp. MBT76.

Gubbens J, Wu C, Zhu H, Filippov DV, Florea BI, Rigali S, Overkleeft HS, van Wezel GP.

ACS Chem Biol. 2017 Nov 17;12(11):2756-2766. doi: 10.1021/acschembio.7b00597. Epub 2017 Oct 2.

21.

A Fluorescence Polarization Activity-Based Protein Profiling Assay in the Discovery of Potent, Selective Inhibitors for Human Nonlysosomal Glucosylceramidase.

Lahav D, Liu B, van den Berg RJBHN, van den Nieuwendijk AMCH, Wennekes T, Ghisaidoobe AT, Breen I, Ferraz MJ, Kuo CL, Wu L, Geurink PP, Ovaa H, van der Marel GA, van der Stelt M, Boot RG, Davies GJ, Aerts JMFG, Overkleeft HS.

J Am Chem Soc. 2017 Oct 11;139(40):14192-14197. doi: 10.1021/jacs.7b07352. Epub 2017 Sep 29.

22.

Synthetic zwitterionic polysaccharides.

Zhang Q, Overkleeft HS, van der Marel GA, Codée JD.

Curr Opin Chem Biol. 2017 Oct;40:95-101. doi: 10.1016/j.cbpa.2017.07.010. Epub 2017 Sep 7. Review.

PMID:
28888143
23.

Chemoenzymatic Synthesis of Glycans and Glycoconjugates.

Overkleeft HS, Seeberger PH.

In: Varki A, Cummings RD, Esko JD, Stanley P, Hart GW, Aebi M, Darvill AG, Kinoshita T, Packer NH, Prestegard JH, Schnaar RL, Seeberger PH, editors. Essentials of Glycobiology [Internet]. 3rd edition. Cold Spring Harbor (NY): Cold Spring Harbor Laboratory Press; 2015-2017. Chapter 54.
2017.

24.

Chemical Synthesis of Glycans and Glycoconjugates.

Seeberger PH, Overkleeft HS.

In: Varki A, Cummings RD, Esko JD, Stanley P, Hart GW, Aebi M, Darvill AG, Kinoshita T, Packer NH, Prestegard JH, Schnaar RL, Seeberger PH, editors. Essentials of Glycobiology [Internet]. 3rd edition. Cold Spring Harbor (NY): Cold Spring Harbor Laboratory Press; 2015-2017. Chapter 53.
2017.

25.

Synthesis of ribosyl-ribosyl-adenosine-5',5'',5'''(triphosphate)-the naturally occurring branched fragment of poly(ADP ribose).

Liu Q, Kistemaker HAV, Overkleeft HS, van der Marel GA, Filippov DV.

Chem Commun (Camb). 2017 Sep 14;53(74):10255-10258. doi: 10.1039/c7cc05755e.

PMID:
28868552
26.

Proteasome activity regulates CD8+ T lymphocyte metabolism and fate specification.

Widjaja CE, Olvera JG, Metz PJ, Phan AT, Savas JN, de Bruin G, Leestemaker Y, Berkers CR, de Jong A, Florea BI, Fisch K, Lopez J, Kim SH, Garcia DA, Searles S, Bui JD, Chang AN, Yates JR 3rd, Goldrath AW, Overkleeft HS, Ovaa H, Chang JT.

J Clin Invest. 2017 Oct 2;127(10):3609-3623. doi: 10.1172/JCI90895. Epub 2017 Aug 28.

27.

Chemical synthesis of guanosine diphosphate mannuronic acid (GDP-ManA) and its C-4-O-methyl and C-4-deoxy congeners.

Zhang Q, Howell PL, Overkleeft HS, Filippov DV, van der Marel GA, Codée JDC.

Carbohydr Res. 2017 Oct 10;450:12-18. doi: 10.1016/j.carres.2017.08.005. Epub 2017 Aug 11.

PMID:
28822279
28.

1,6-Cyclophellitol Cyclosulfates: A New Class of Irreversible Glycosidase Inhibitor.

Artola M, Wu L, Ferraz MJ, Kuo CL, Raich L, Breen IZ, Offen WA, Codée JDC, van der Marel GA, Rovira C, Aerts JMFG, Davies GJ, Overkleeft HS.

ACS Cent Sci. 2017 Jul 26;3(7):784-793. doi: 10.1021/acscentsci.7b00214. Epub 2017 Jul 13.

29.

Piperidine and octahydropyrano[3,4-c] pyridine scaffolds for drug-like molecular libraries of the European Lead Factory.

Narhe BD, Breman AC, Padwal J, Vandenput DAL, Scheidt JM, Benningshof JCJ, van der Marel GA, Overkleeft HS, van der Stelt M, Filippov DV.

Bioorg Med Chem. 2017 Oct 1;25(19):5160-5170. doi: 10.1016/j.bmc.2017.07.016. Epub 2017 Jul 10.

30.

Correction to "Detection of Active Mammalian GH31 α-Glucosidases in Health and Disease Using In-Class, Broad-Spectrum Activity-Based Probes".

Jiang J, Kuo CL, Wu L, Franke C, Kallemeijn WW, Florea BI, van Meel E, van der Marel GA, Codée JDC, Boot RG, Davies GJ, Overkleeft HS, Aerts JMFG.

ACS Cent Sci. 2017 Jun 28;3(6):673. doi: 10.1021/acscentsci.7b00185. Epub 2017 May 18.

31.

Human Alpha Galactosidases Transiently Produced in Nicotiana benthamiana Leaves: New Insights in Substrate Specificities with Relevance for Fabry Disease.

Kytidou K, Beenakker TJM, Westerhof LB, Hokke CH, Moolenaar GF, Goosen N, Mirzaian M, Ferraz MJ, de Geus M, Kallemeijn WW, Overkleeft HS, Boot RG, Schots A, Bosch D, Aerts JMFG.

Front Plant Sci. 2017 Jun 21;8:1026. doi: 10.3389/fpls.2017.01026. eCollection 2017.

32.

Carfilzomib resistance due to ABCB1/MDR1 overexpression is overcome by nelfinavir and lopinavir in multiple myeloma.

Besse A, Stolze SC, Rasche L, Weinhold N, Morgan GJ, Kraus M, Bader J, Overkleeft HS, Besse L, Driessen C.

Leukemia. 2018 Feb;32(2):391-401. doi: 10.1038/leu.2017.212. Epub 2017 Jul 5.

33.

Identification of glucose kinase-dependent and -independent pathways for carbon control of primary metabolism, development and antibiotic production in Streptomyces coelicolor by quantitative proteomics.

Gubbens J, Janus MM, Florea BI, Overkleeft HS, van Wezel GP.

Mol Microbiol. 2017 Jul;105(1):175. doi: 10.1111/mmi.13714. Epub 2017 Jun 2. No abstract available.

PMID:
28631385
34.

Activity-based protein profiling reveals off-target proteins of the FAAH inhibitor BIA 10-2474.

van Esbroeck ACM, Janssen APA, Cognetta AB 3rd, Ogasawara D, Shpak G, van der Kroeg M, Kantae V, Baggelaar MP, de Vrij FMS, Deng H, Allarà M, Fezza F, Lin Z, van der Wel T, Soethoudt M, Mock ED, den Dulk H, Baak IL, Florea BI, Hendriks G, De Petrocellis L, Overkleeft HS, Hankemeier T, De Zeeuw CI, Di Marzo V, Maccarrone M, Cravatt BF, Kushner SA, van der Stelt M.

Science. 2017 Jun 9;356(6342):1084-1087. doi: 10.1126/science.aaf7497.

PMID:
28596366
35.

Activity-based probes for functional interrogation of retaining β-glucuronidases.

Wu L, Jiang J, Jin Y, Kallemeijn WW, Kuo CL, Artola M, Dai W, van Elk C, van Eijk M, van der Marel GA, Codée JDC, Florea BI, Aerts JMFG, Overkleeft HS, Davies GJ.

Nat Chem Biol. 2017 Aug;13(8):867-873. doi: 10.1038/nchembio.2395. Epub 2017 Jun 5.

PMID:
28581485
36.

The influence of acceptor nucleophilicity on the glycosylation reaction mechanism.

van der Vorm S, Hansen T, Overkleeft HS, van der Marel GA, Codée JDC.

Chem Sci. 2017 Mar 1;8(3):1867-1875. doi: 10.1039/c6sc04638j. Epub 2016 Nov 9.

37.

Stabilization of Glucocerebrosidase by Active Site Occupancy.

Ben Bdira F, Kallemeijn WW, Oussoren SV, Scheij S, Bleijlevens B, Florea BI, van Roomen CPAA, Ottenhoff R, van Kooten MJFM, Walvoort MTC, Witte MD, Boot RG, Ubbink M, Overkleeft HS, Aerts JMFG.

ACS Chem Biol. 2017 Jul 21;12(7):1830-1841. doi: 10.1021/acschembio.7b00276. Epub 2017 May 22.

38.

Synthesis of the Staphylococcus aureus Strain M Capsular Polysaccharide Repeating Unit.

Hagen B, van Dijk JHM, Zhang Q, Overkleeft HS, van der Marel GA, Codée JDC.

Org Lett. 2017 May 19;19(10):2514-2517. doi: 10.1021/acs.orglett.7b00747. Epub 2017 May 9.

39.

Correlative light and electron microscopy reveals discrepancy between gold and fluorescence labelling.

VAN Elsland DM, Bos E, Pawlak JB, Overkleeft HS, Koster AJ, VAN Kasteren SI.

J Microsc. 2017 Sep;267(3):309-317. doi: 10.1111/jmi.12567. Epub 2017 May 4.

PMID:
28470743
40.

Carba-cyclophellitols Are Neutral Retaining-Glucosidase Inhibitors.

Beenakker TJM, Wander DPA, Offen WA, Artola M, Raich L, Ferraz MJ, Li KY, Houben JHPM, van Rijssel ER, Hansen T, van der Marel GA, Codée JDC, Aerts JMFG, Rovira C, Davies GJ, Overkleeft HS.

J Am Chem Soc. 2017 May 17;139(19):6534-6537. doi: 10.1021/jacs.7b01773. Epub 2017 May 5.

41.

Stereoselectivity of Conformationally Restricted Glucosazide Donors.

van der Vorm S, Overkleeft HS, van der Marel GA, Codée JDC.

J Org Chem. 2017 May 5;82(9):4793-4811. doi: 10.1021/acs.joc.7b00470. Epub 2017 Apr 25.

42.

Conformational Behaviour of Azasugars Based on Mannuronic Acid.

van Rijssel ER, Janssen APA, Males A, Davies GJ, van der Marel GA, Overkleeft HS, Codée JDC.

Chembiochem. 2017 Jul 4;18(13):1297-1304. doi: 10.1002/cbic.201700080. Epub 2017 Apr 18.

PMID:
28256791
43.

Proteasome Activity Profiling Uncovers Alteration of Catalytic β2 and β5 Subunits of the Stress-Induced Proteasome during Salinity Stress in Tomato Roots.

Kovács J, Poór P, Kaschani F, Chandrasekar B, Hong TN, Misas-Villamil JC, Xin BT, Kaiser M, Overkleeft HS, Tari I, van der Hoorn RA.

Front Plant Sci. 2017 Feb 3;8:107. doi: 10.3389/fpls.2017.00107. eCollection 2017.

44.

Investigations on therapeutic glucocerebrosidases through paired detection with fluorescent activity-based probes.

Kallemeijn WW, Scheij S, Hoogendoorn S, Witte MD, Herrera Moro Chao D, van Roomen CP, Ottenhoff R, Overkleeft HS, Boot RG, Aerts JM.

PLoS One. 2017 Feb 16;12(2):e0170268. doi: 10.1371/journal.pone.0170268. eCollection 2017.

45.

Combined Phosphoramidite-Phosphodiester Reagents for the Synthesis of Methylene Bisphosphonates.

Engelsma SB, Meeuwenoord NJ, Overkleeft HS, van der Marel GA, Filippov DV.

Angew Chem Int Ed Engl. 2017 Mar 6;56(11):2955-2959. doi: 10.1002/anie.201611878. Epub 2017 Feb 7.

PMID:
28170152
46.

Inhibition of the Proteasome β2 Site Sensitizes Triple-Negative Breast Cancer Cells to β5 Inhibitors and Suppresses Nrf1 Activation.

Weyburne ES, Wilkins OM, Sha Z, Williams DA, Pletnev AA, de Bruin G, Overkleeft HS, Goldberg AL, Cole MD, Kisselev AF.

Cell Chem Biol. 2017 Feb 16;24(2):218-230. doi: 10.1016/j.chembiol.2016.12.016. Epub 2017 Jan 26.

47.

Subunit-selective proteasome activity profiling uncovers uncoupled proteasome subunit activities during bacterial infections.

Misas-Villamil JC, van der Burgh AM, Grosse-Holz F, Bach-Pages M, Kovács J, Kaschani F, Schilasky S, Emon AE, Ruben M, Kaiser M, Overkleeft HS, van der Hoorn RA.

Plant J. 2017 Apr;90(2):418-430. doi: 10.1111/tpj.13494. Epub 2017 Mar 14.

48.

Chemical Proteomics Maps Brain Region Specific Activity of Endocannabinoid Hydrolases.

Baggelaar MP, van Esbroeck AC, van Rooden EJ, Florea BI, Overkleeft HS, Marsicano G, Chaouloff F, van der Stelt M.

ACS Chem Biol. 2017 Mar 17;12(3):852-861. doi: 10.1021/acschembio.6b01052. Epub 2017 Feb 13.

PMID:
28106377
49.

Simultaneous quantitation of sphingoid bases by UPLC-ESI-MS/MS with identical 13C-encoded internal standards.

Mirzaian M, Wisse P, Ferraz MJ, Marques ARA, Gaspar P, Oussoren SV, Kytidou K, Codée JDC, van der Marel G, Overkleeft HS, Aerts JM.

Clin Chim Acta. 2017 Mar;466:178-184. doi: 10.1016/j.cca.2017.01.014. Epub 2017 Jan 13.

PMID:
28089753
50.

Mapping the Reactivity and Selectivity of 2-Azidofucosyl Donors for the Assembly of N-Acetylfucosamine-Containing Bacterial Oligosaccharides.

Hagen B, Ali S, Overkleeft HS, van der Marel GA, Codée JD.

J Org Chem. 2017 Jan 20;82(2):848-868. doi: 10.1021/acs.joc.6b02593. Epub 2017 Jan 10.

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