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mTOR Kinase Inhibition Effectively Decreases Progression of a Subset of Neuroendocrine Tumors that Progress on Rapalog Therapy and Delays Cardiac Impairment.

Orr-Asman MA, Chu Z, Jiang M, Worley M, LaSance K, Koch SE, Carreira VS, Dahche HM, Plas DR, Komurov K, Qi X, Mercer CA, Anthony LB, Rubinstein J, Thomas HE.

Mol Cancer Ther. 2017 Nov;16(11):2432-2441. doi: 10.1158/1535-7163.MCT-17-0058. Epub 2017 Sep 1.


Hedgehog signaling regulates E-cadherin expression for the maintenance of the actin cytoskeleton and tight junctions.

Xiao C, Ogle SA, Schumacher MA, Schilling N, Tokhunts RA, Orr-Asman MA, Miller ML, Robbins DJ, Hollande F, Zavros Y.

Am J Physiol Gastrointest Liver Physiol. 2010 Dec;299(6):G1252-65. doi: 10.1152/ajpgi.00512.2009. Epub 2010 Sep 16.


Loss of parietal cell expression of Sonic hedgehog induces hypergastrinemia and hyperproliferation of surface mucous cells.

Xiao C, Ogle SA, Schumacher MA, Orr-Asman MA, Miller ML, Lertkowit N, Varro A, Hollande F, Zavros Y.

Gastroenterology. 2010 Feb;138(2):550-61, 561.e1-8. doi: 10.1053/j.gastro.2009.11.002. Epub 2009 Nov 10.

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