Sort by
Items per page

Send to

Choose Destination

Search results

Items: 26


Superenhancer Analysis Defines Novel Epigenomic Subtypes of Non-APL AML, Including an RARα Dependency Targetable by SY-1425, a Potent and Selective RARα Agonist.

McKeown MR, Corces MR, Eaton ML, Fiore C, Lee E, Lopez JT, Chen MW, Smith D, Chan SM, Koenig JL, Austgen K, Guenther MG, Orlando DA, Lovén J, Fritz CC, Majeti R.

Cancer Discov. 2017 Oct;7(10):1136-1153. doi: 10.1158/2159-8290.CD-17-0399. Epub 2017 Jul 20.


Quantitative ChIP-Seq normalization reveals global modulation of the epigenome.

Orlando DA, Chen MW, Brown VE, Solanki S, Choi YJ, Olson ER, Fritz CC, Bradner JE, Guenther MG.

Cell Rep. 2014 Nov 6;9(3):1163-70. doi: 10.1016/j.celrep.2014.10.018. Epub 2014 Oct 30.


Multiple structural maintenance of chromosome complexes at transcriptional regulatory elements.

Dowen JM, Bilodeau S, Orlando DA, Hübner MR, Abraham BJ, Spector DL, Young RA.

Stem Cell Reports. 2013 Oct 24;1(5):371-8. doi: 10.1016/j.stemcr.2013.09.002. eCollection 2013.


Global transcriptional and translational repression in human-embryonic-stem-cell-derived Rett syndrome neurons.

Li Y, Wang H, Muffat J, Cheng AW, Orlando DA, Lovén J, Kwok SM, Feldman DA, Bateup HS, Gao Q, Hockemeyer D, Mitalipova M, Lewis CA, Vander Heiden MG, Sur M, Young RA, Jaenisch R.

Cell Stem Cell. 2013 Oct 3;13(4):446-58. doi: 10.1016/j.stem.2013.09.001.


Selective inhibition of tumor oncogenes by disruption of super-enhancers.

Lovén J, Hoke HA, Lin CY, Lau A, Orlando DA, Vakoc CR, Bradner JE, Lee TI, Young RA.

Cell. 2013 Apr 11;153(2):320-34. doi: 10.1016/j.cell.2013.03.036.


Master transcription factors and mediator establish super-enhancers at key cell identity genes.

Whyte WA, Orlando DA, Hnisz D, Abraham BJ, Lin CY, Kagey MH, Rahl PB, Lee TI, Young RA.

Cell. 2013 Apr 11;153(2):307-19. doi: 10.1016/j.cell.2013.03.035.


Branching process deconvolution algorithm reveals a detailed cell-cycle transcription program.

Guo X, Bernard A, Orlando DA, Haase SB, Hartemink AJ.

Proc Natl Acad Sci U S A. 2013 Mar 5;110(10):E968-77. doi: 10.1073/pnas.1120991110. Epub 2013 Feb 6.


Divergent transcription of long noncoding RNA/mRNA gene pairs in embryonic stem cells.

Sigova AA, Mullen AC, Molinie B, Gupta S, Orlando DA, Guenther MG, Almada AE, Lin C, Sharp PA, Giallourakis CC, Young RA.

Proc Natl Acad Sci U S A. 2013 Feb 19;110(8):2876-81. doi: 10.1073/pnas.1221904110. Epub 2013 Feb 4.


Revisiting global gene expression analysis.

Lovén J, Orlando DA, Sigova AA, Lin CY, Rahl PB, Burge CB, Levens DL, Lee TI, Young RA.

Cell. 2012 Oct 26;151(3):476-82. doi: 10.1016/j.cell.2012.10.012. Review.


CpG island structure and trithorax/polycomb chromatin domains in human cells.

Orlando DA, Guenther MG, Frampton GM, Young RA.

Genomics. 2012 Nov;100(5):320-6. doi: 10.1016/j.ygeno.2012.07.006. Epub 2012 Jul 20.


Cyclin-dependent kinases are regulators and effectors of oscillations driven by a transcription factor network.

Simmons Kovacs LA, Mayhew MB, Orlando DA, Jin Y, Li Q, Huang C, Reed SI, Mukherjee S, Haase SB.

Mol Cell. 2012 Mar 9;45(5):669-79. doi: 10.1016/j.molcel.2011.12.033. Epub 2012 Feb 2. Erratum in: Mol Cell. 2013 Mar 28;49(6):1177-9.


Enhancer decommissioning by LSD1 during embryonic stem cell differentiation.

Whyte WA, Bilodeau S, Orlando DA, Hoke HA, Frampton GM, Foster CT, Cowley SM, Young RA.

Nature. 2012 Feb 1;482(7384):221-5. doi: 10.1038/nature10805.


Master transcription factors determine cell-type-specific responses to TGF-β signaling.

Mullen AC, Orlando DA, Newman JJ, Lovén J, Kumar RM, Bilodeau S, Reddy J, Guenther MG, DeKoter RP, Young RA.

Cell. 2011 Oct 28;147(3):565-76. doi: 10.1016/j.cell.2011.08.050.


The histone methyltransferase SETDB1 is recurrently amplified in melanoma and accelerates its onset.

Ceol CJ, Houvras Y, Jane-Valbuena J, Bilodeau S, Orlando DA, Battisti V, Fritsch L, Lin WM, Hollmann TJ, Ferré F, Bourque C, Burke CJ, Turner L, Uong A, Johnson LA, Beroukhim R, Mermel CH, Loda M, Ait-Si-Ali S, Garraway LA, Young RA, Zon LI.

Nature. 2011 Mar 24;471(7339):513-7. doi: 10.1038/nature09806.


Mediator and cohesin connect gene expression and chromatin architecture.

Kagey MH, Newman JJ, Bilodeau S, Zhan Y, Orlando DA, van Berkum NL, Ebmeier CC, Goossens J, Rahl PB, Levine SS, Taatjes DJ, Dekker J, Young RA.

Nature. 2010 Sep 23;467(7314):430-5. doi: 10.1038/nature09380. Epub 2010 Aug 18. Erratum in: Nature. 2011 Apr 14;472(7342):247.


Detecting separate time scales in genetic expression data.

Orlando DA, Brady SM, Fink TM, Benfey PN, Ahnert SE.

BMC Genomics. 2010 Jun 16;11:381. doi: 10.1186/1471-2164-11-381.


Reconstructing spatiotemporal gene expression data from partial observations.

Cartwright DA, Brady SM, Orlando DA, Sturmfels B, Benfey PN.

Bioinformatics. 2009 Oct 1;25(19):2581-7. doi: 10.1093/bioinformatics/btp437. Epub 2009 Jul 16.


Manipulating large-scale Arabidopsis microarray expression data: identifying dominant expression patterns and biological process enrichment.

Orlando DA, Brady SM, Koch JD, Dinneny JR, Benfey PN.

Methods Mol Biol. 2009;553:57-77. doi: 10.1007/978-1-60327-563-7_4. Review.


Molecular dissection of the checkpoint kinase Hsl1p.

Crutchley J, King KM, Keaton MA, Szkotnicki L, Orlando DA, Zyla TR, Bardes ES, Lew DJ.

Mol Biol Cell. 2009 Apr;20(7):1926-36. doi: 10.1091/mbc.E08-08-0848. Epub 2009 Feb 11.


A branching process model for flow cytometry and budding index measurements in cell synchrony experiments.

Orlando DA, Iversen ES Jr, Hartemink AJ, Haase SB.

Ann Appl Stat. 2009 Winter;3(4):1521-1541.


Transcription networks and cyclin/CDKs: the yin and yang of cell cycle oscillators.

Simmons Kovacs LA, Orlando DA, Haase SB.

Cell Cycle. 2008 Sep 1;7(17):2626-9. Epub 2008 Sep 26. Review.


Protonophore- and pH-insensitive glucose and sucrose accumulation detected by FRET nanosensors in Arabidopsis root tips.

Chaudhuri B, Hörmann F, Lalonde S, Brady SM, Orlando DA, Benfey P, Frommer WB.

Plant J. 2008 Dec;56(6):948-62. doi: 10.1111/j.1365-313X.2008.03652.x. Epub 2008 Sep 18.


Global control of cell-cycle transcription by coupled CDK and network oscillators.

Orlando DA, Lin CY, Bernard A, Wang JY, Socolar JE, Iversen ES, Hartemink AJ, Haase SB.

Nature. 2008 Jun 12;453(7197):944-7. doi: 10.1038/nature06955. Epub 2008 May 7.


A high-resolution root spatiotemporal map reveals dominant expression patterns.

Brady SM, Orlando DA, Lee JY, Wang JY, Koch J, Dinneny JR, Mace D, Ohler U, Benfey PN.

Science. 2007 Nov 2;318(5851):801-6.


A probabilistic model for cell cycle distributions in synchrony experiments.

Orlando DA, Lin CY, Bernard A, Iversen ES, Hartemink AJ, Haase SB.

Cell Cycle. 2007 Feb 15;6(4):478-88. Epub 2007 Feb 12.


Reproductive capacities of control bobwhite quail (Colinus virginianus) during one-generation reproduction studies.

Piccirillo VJ, Orlando DA.

J Environ Pathol Toxicol Oncol. 1985 Sep-Oct;6(1):79-84.


Supplemental Content

Loading ...
Support Center