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Items: 41


Respiratory syncytial virus infection of newborn CX3CR1-deficent mice induces a pathogenic pulmonary innate immune response.

Das S, Raundhal M, Chen J, Oriss TB, Huff R, Williams JV, Ray A, Ray P.

JCI Insight. 2017 Sep 7;2(17). pii: 94605. doi: 10.1172/jci.insight.94605. [Epub ahead of print]


mTOR regulates metabolic adaptation of APCs in the lung and controls the outcome of allergic inflammation.

Sinclair C, Bommakanti G, Gardinassi L, Loebbermann J, Johnson MJ, Hakimpour P, Hagan T, Benitez L, Todor A, Machiah D, Oriss T, Ray A, Bosinger S, Ravindran R, Li S, Pulendran B.

Science. 2017 Sep 8;357(6355):1014-1021. doi: 10.1126/science.aaj2155. Epub 2017 Aug 10.


Severe asthma in humans and mouse model suggests a CXCL10 signature underlies corticosteroid-resistant Th1 bias.

Gauthier M, Chakraborty K, Oriss TB, Raundhal M, Das S, Chen J, Huff R, Sinha A, Fajt M, Ray P, Wenzel SE, Ray A.

JCI Insight. 2017 Jul 6;2(13). pii: 94580. doi: 10.1172/jci.insight.94580. [Epub ahead of print]


IRF5 distinguishes severe asthma in humans and drives Th1 phenotype and airway hyperreactivity in mice.

Oriss TB, Raundhal M, Morse C, Huff RE, Das S, Hannum R, Gauthier MC, Scholl KL, Chakraborty K, Nouraie SM, Wenzel SE, Ray P, Ray A.

JCI Insight. 2017 May 18;2(10). pii: 91019. doi: 10.1172/jci.insight.91019. [Epub ahead of print]


The mito-DAMP cardiolipin blocks IL-10 production causing persistent inflammation during bacterial pneumonia.

Chakraborty K, Raundhal M, Chen BB, Morse C, Tyurina YY, Khare A, Oriss TB, Huff R, Lee JS, St Croix CM, Watkins S, Mallampalli RK, Kagan VE, Ray A, Ray P.

Nat Commun. 2017 Jan 11;8:13944. doi: 10.1038/ncomms13944.


Current concepts of severe asthma.

Ray A, Raundhal M, Oriss TB, Ray P, Wenzel SE.

J Clin Invest. 2016 Jul 1;126(7):2394-403. doi: 10.1172/JCI84144. Epub 2016 Jul 1. Review.


Mitochondrial H2O2 in Lung Antigen-Presenting Cells Blocks NF-κB Activation to Prevent Unwarranted Immune Activation.

Khare A, Raundhal M, Chakraborty K, Das S, Corey C, Kamga CK, Quesnelle K, St Croix C, Watkins SC, Morse C, Oriss TB, Huff R, Hannum R, Ray P, Shiva S, Ray A.

Cell Rep. 2016 May 24;15(8):1700-14. doi: 10.1016/j.celrep.2016.04.060. Epub 2016 May 12.


High IFN-γ and low SLPI mark severe asthma in mice and humans.

Raundhal M, Morse C, Khare A, Oriss TB, Milosevic J, Trudeau J, Huff R, Pilewski J, Holguin F, Kolls J, Wenzel S, Ray P, Ray A.

J Clin Invest. 2015 Aug 3;125(8):3037-50. doi: 10.1172/JCI80911. Epub 2015 Jun 29.


Emerging molecular phenotypes of asthma.

Ray A, Oriss TB, Wenzel SE.

Am J Physiol Lung Cell Mol Physiol. 2015 Jan 15;308(2):L130-40. doi: 10.1152/ajplung.00070.2014. Epub 2014 Oct 17. Review.


Cutting Edge: MMP-9 inhibits IL-23p19 expression in dendritic cells by targeting membrane stem cell factor affecting lung IL-17 response.

Oriss TB, Krishnamoorthy N, Raundhal M, Morse C, Chakraborty K, Khare A, Huff R, Ray P, Ray A.

J Immunol. 2014 Jun 15;192(12):5471-5475. doi: 10.4049/jimmunol.1303183. Epub 2014 May 14.


Dendritic cell c-kit signaling and adaptive immunity: implications for the upper airways.

Oriss TB, Krishnamoorthy N, Ray P, Ray A.

Curr Opin Allergy Clin Immunol. 2014 Feb;14(1):7-12. doi: 10.1097/ACI.0000000000000019. Review.


Thrombospondin-1 triggers macrophage IL-10 production and promotes resolution of experimental lung injury.

Zhao Y, Xiong Z, Lechner EJ, Klenotic PA, Hamburg BJ, Hulver M, Khare A, Oriss T, Mangalmurti N, Chan Y, Zhang Y, Ross MA, Stolz DB, Rosengart MR, Pilewski J, Ray P, Ray A, Silverstein RL, Lee JS.

Mucosal Immunol. 2014 Mar;7(2):440-8. doi: 10.1038/mi.2013.63. Epub 2013 Sep 18.


Cutting edge: inhaled antigen upregulates retinaldehyde dehydrogenase in lung CD103+ but not plasmacytoid dendritic cells to induce Foxp3 de novo in CD4+ T cells and promote airway tolerance.

Khare A, Krishnamoorthy N, Oriss TB, Fei M, Ray P, Ray A.

J Immunol. 2013 Jul 1;191(1):25-9. doi: 10.4049/jimmunol.1300193. Epub 2013 Jun 3.


The relationship between the severity of hemolysis, clinical manifestations and risk of death in 415 patients with sickle cell anemia in the US and Europe.

Nouraie M, Lee JS, Zhang Y, Kanias T, Zhao X, Xiong Z, Oriss TB, Zeng Q, Kato GJ, Gibbs JS, Hildesheim ME, Sachdev V, Barst RJ, Machado RF, Hassell KL, Little JA, Schraufnagel DE, Krishnamurti L, Novelli E, Girgis RE, Morris CR, Rosenzweig EB, Badesch DB, Lanzkron S, Castro OL, Goldsmith JC, Gordeuk VR, Gladwin MT; Walk-PHASST Investigators and Patients.

Haematologica. 2013 Mar;98(3):464-72. doi: 10.3324/haematol.2012.068965. Epub 2012 Sep 14.


Early infection with respiratory syncytial virus impairs regulatory T cell function and increases susceptibility to allergic asthma.

Krishnamoorthy N, Khare A, Oriss TB, Raundhal M, Morse C, Yarlagadda M, Wenzel SE, Moore ML, Peebles RS Jr, Ray A, Ray P.

Nat Med. 2012 Oct;18(10):1525-30. doi: 10.1038/nm.2896. Epub 2012 Sep 9.


STAT1-regulated lung MDSC-like cells produce IL-10 and efferocytose apoptotic neutrophils with relevance in resolution of bacterial pneumonia.

Poe SL, Arora M, Oriss TB, Yarlagadda M, Isse K, Khare A, Levy DE, Lee JS, Mallampalli RK, Chan YR, Ray A, Ray P.

Mucosal Immunol. 2013 Jan;6(1):189-99. doi: 10.1038/mi.2012.62. Epub 2012 Jul 11.


Red cell microparticle enumeration: validation of a flow cytometric approach.

Xiong Z, Oriss TB, Cavaretta JP, Rosengart MR, Lee JS.

Vox Sang. 2012 Jul;103(1):42-8. doi: 10.1111/j.1423-0410.2011.01577.x. Epub 2012 Jan 11.


TNF-alpha from inflammatory dendritic cells (DCs) regulates lung IL-17A/IL-5 levels and neutrophilia versus eosinophilia during persistent fungal infection.

Fei M, Bhatia S, Oriss TB, Yarlagadda M, Khare A, Akira S, Saijo S, Iwakura Y, Fallert Junecko BA, Reinhart TA, Foreman O, Ray P, Kolls J, Ray A.

Proc Natl Acad Sci U S A. 2011 Mar 29;108(13):5360-5. doi: 10.1073/pnas.1015476108. Epub 2011 Mar 14.


TLR4/MyD88-induced CD11b+Gr-1 int F4/80+ non-migratory myeloid cells suppress Th2 effector function in the lung.

Arora M, Poe SL, Oriss TB, Krishnamoorthy N, Yarlagadda M, Wenzel SE, Billiar TR, Ray A, Ray P.

Mucosal Immunol. 2010 Nov;3(6):578-93. doi: 10.1038/mi.2010.41. Epub 2010 Jul 21. Erratum in: Mucosal Immunol. 2011 Jan;4(1):124.


Signaling of c-kit in dendritic cells influences adaptive immunity.

Ray P, Krishnamoorthy N, Oriss TB, Ray A.

Ann N Y Acad Sci. 2010 Jan;1183:104-22. doi: 10.1111/j.1749-6632.2009.05122.x. Review.


Macrophages: regulators of sex differences in asthma?

Melgert BN, Oriss TB, Qi Z, Dixon-McCarthy B, Geerlings M, Hylkema MN, Ray A.

Am J Respir Cell Mol Biol. 2010 May;42(5):595-603. doi: 10.1165/rcmb.2009-0016OC. Epub 2009 Jul 2.


STAT6 activation confers upon T helper cells resistance to suppression by regulatory T cells.

Pillemer BB, Qi Z, Melgert B, Oriss TB, Ray P, Ray A.

J Immunol. 2009 Jul 1;183(1):155-63. doi: 10.4049/jimmunol.0803733. Epub 2009 Jun 17.


WNT5A is a regulator of fibroblast proliferation and resistance to apoptosis.

Vuga LJ, Ben-Yehudah A, Kovkarova-Naumovski E, Oriss T, Gibson KF, Feghali-Bostwick C, Kaminski N.

Am J Respir Cell Mol Biol. 2009 Nov;41(5):583-9. doi: 10.1165/rcmb.2008-0201OC. Epub 2009 Feb 27.


Loss of red cell chemokine scavenging promotes transfusion-related lung inflammation.

Mangalmurti NS, Xiong Z, Hulver M, Ranganathan M, Liu XH, Oriss T, Fitzpatrick M, Rubin M, Triulzi D, Choi A, Lee JS.

Blood. 2009 Jan 29;113(5):1158-66. doi: 10.1182/blood-2008-07-166264. Epub 2008 Dec 8.


Activation of c-Kit in dendritic cells regulates T helper cell differentiation and allergic asthma.

Krishnamoorthy N, Oriss TB, Paglia M, Fei M, Yarlagadda M, Vanhaesebroeck B, Ray A, Ray P.

Nat Med. 2008 May;14(5):565-73. doi: 10.1038/nm1766. Epub 2008 May 4.


Indoleamine 2,3-dioxygenase in lung dendritic cells promotes Th2 responses and allergic inflammation.

Xu H, Oriss TB, Fei M, Henry AC, Melgert BN, Chen L, Mellor AL, Munn DH, Irvin CG, Ray P, Ray A.

Proc Natl Acad Sci U S A. 2008 May 6;105(18):6690-5. doi: 10.1073/pnas.0708809105. Epub 2008 Apr 24.


Species-specific immune responses generated by histidyl-tRNA synthetase immunization are associated with muscle and lung inflammation.

Katsumata Y, Ridgway WM, Oriss T, Gu X, Chin D, Wu Y, Fertig N, Oury T, Vandersteen D, Clemens P, Camacho CJ, Weinberg A, Ascherman DP.

J Autoimmun. 2007 Sep-Nov;29(2-3):174-86.


Deficient SOCS3 expression in CD4+CD25+FoxP3+ regulatory T cells and SOCS3-mediated suppression of Treg function.

Pillemer BB, Xu H, Oriss TB, Qi Z, Ray A.

Eur J Immunol. 2007 Aug;37(8):2082-9.


Distinct responses of lung and spleen dendritic cells to the TLR9 agonist CpG oligodeoxynucleotide.

Chen L, Arora M, Yarlagadda M, Oriss TB, Krishnamoorthy N, Ray A, Ray P.

J Immunol. 2006 Aug 15;177(4):2373-83.


Treg-mediated immunosuppression involves activation of the Notch-HES1 axis by membrane-bound TGF-beta.

Ostroukhova M, Qi Z, Oriss TB, Dixon-McCarthy B, Ray P, Ray A.

J Clin Invest. 2006 Apr;116(4):996-1004. Epub 2006 Mar 16.


T cell Ig and mucin 1 (TIM-1) is expressed on in vivo-activated T cells and provides a costimulatory signal for T cell activation.

de Souza AJ, Oriss TB, O'malley KJ, Ray A, Kane LP.

Proc Natl Acad Sci U S A. 2005 Nov 22;102(47):17113-8. Epub 2005 Nov 11.


Dynamics of dendritic cell phenotype and interactions with CD4+ T cells in airway inflammation and tolerance.

Oriss TB, Ostroukhova M, Seguin-Devaux C, Dixon-McCarthy B, Stolz DB, Watkins SC, Pillemer B, Ray P, Ray A.

J Immunol. 2005 Jan 15;174(2):854-63.


Tolerance induced by inhaled antigen involves CD4(+) T cells expressing membrane-bound TGF-beta and FOXP3.

Ostroukhova M, Seguin-Devaux C, Oriss TB, Dixon-McCarthy B, Yang L, Ameredes BT, Corcoran TE, Ray A.

J Clin Invest. 2004 Jul;114(1):28-38.


Transforming growth factor beta blocks Tec kinase phosphorylation, Ca2+ influx, and NFATc translocation causing inhibition of T cell differentiation.

Chen CH, Seguin-Devaux C, Burke NA, Oriss TB, Watkins SC, Clipstone N, Ray A.

J Exp Med. 2003 Jun 16;197(12):1689-99.


Crossregulation between Th1 and Th2 cells.

Morel PA, Oriss TB.

Crit Rev Immunol. 1998;18(4):275-303. Review.


Modeling the proliferative response of T cells to IL-2 and IL-4.

Burke MA, Morel BF, Oriss TB, Bray J, McCarthy SA, Morel PA.

Cell Immunol. 1997 May 25;178(1):42-52.


Crossregulation between T helper cell (Th)1 and Th2: inhibition of Th2 proliferation by IFN-gamma involves interference with IL-1.

Oriss TB, McCarthy SA, Morel BF, Campana MA, Morel PA.

J Immunol. 1997 Apr 15;158(8):3666-72.


Generation of DC from mouse spleen cell cultures in response to GM-CSF: immunophenotypic and functional analyses.

Lu L, Hsieh M, Oriss TB, Morel PA, Starzl TE, Rao AS, Thomson AW.

Immunology. 1995 Jan;84(1):127-34.

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