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Items: 1 to 50 of 202

1.

Gut metabolome meets microbiome: A methodological perspective to understand the relationship between host and microbe.

Lamichhane S, Sen P, Dickens AM, Orešič M, Bertram HC.

Methods. 2018 Apr 30. pii: S1046-2023(17)30437-1. doi: 10.1016/j.ymeth.2018.04.029. [Epub ahead of print] Review.

PMID:
29715508
2.

Perspectives on Systems Modeling of Human Peripheral Blood Mononuclear Cells.

Sen P, Kemppainen E, Orešič M.

Front Mol Biosci. 2018 Jan 9;4:96. doi: 10.3389/fmolb.2017.00096. eCollection 2017. Review.

3.

Targeted Serum Metabolite Profiling Identifies Metabolic Signatures in Patients with Alzheimer's Disease, Normal Pressure Hydrocephalus and Brain Tumor.

Orešič M, Anderson G, Mattila I, Manoucheri M, Soininen H, Hyötyläinen T, Basignani C.

Front Neurosci. 2018 Jan 9;11:747. doi: 10.3389/fnins.2017.00747. eCollection 2017.

4.

Platform for systems medicine research and diagnostic applications in psychotic disorders-The METSY project.

Frank E, Maier D, Pajula J, Suvitaival T, Borgan F, Butz-Ostendorf M, Fischer A, Hietala J, Howes O, Hyötyläinen T, Janssen J, Laurikainen H, Moreno C, Suvisaari J, Van Gils M, Orešič M.

Eur Psychiatry. 2018 Apr;50:40-46. doi: 10.1016/j.eurpsy.2017.12.001. Epub 2018 Feb 1.

PMID:
29361398
5.

PPARγ Modulates Long Chain Fatty Acid Processing in the Intestinal Epithelium.

Duszka K, Oresic M, Le May C, König J, Wahli W.

Int J Mol Sci. 2017 Nov 28;18(12). pii: E2559. doi: 10.3390/ijms18122559.

6.

Use of Blood Biomarkers in the Assessment of Sports-Related Concussion-A Systematic Review in the Context of Their Biological Significance.

OʼConnell B, Kelly ÁM, Mockler D, Orešič M, Denvir K, Farrell G, Janigro D, Wilson F.

Clin J Sport Med. 2017 Oct 12. doi: 10.1097/JSM.0000000000000478. [Epub ahead of print]

PMID:
29035978
7.

Harmonizing lipidomics: NIST interlaboratory comparison exercise for lipidomics using SRM 1950-Metabolites in Frozen Human Plasma.

Bowden JA, Heckert A, Ulmer CZ, Jones CM, Koelmel JP, Abdullah L, Ahonen L, Alnouti Y, Armando AM, Asara JM, Bamba T, Barr JR, Bergquist J, Borchers CH, Brandsma J, Breitkopf SB, Cajka T, Cazenave-Gassiot A, Checa A, Cinel MA, Colas RA, Cremers S, Dennis EA, Evans JE, Fauland A, Fiehn O, Gardner MS, Garrett TJ, Gotlinger KH, Han J, Huang Y, Neo AH, Hyötyläinen T, Izumi Y, Jiang H, Jiang H, Jiang J, Kachman M, Kiyonami R, Klavins K, Klose C, Köfeler HC, Kolmert J, Koal T, Koster G, Kuklenyik Z, Kurland IJ, Leadley M, Lin K, Maddipati KR, McDougall D, Meikle PJ, Mellett NA, Monnin C, Moseley MA, Nandakumar R, Oresic M, Patterson R, Peake D, Pierce JS, Post M, Postle AD, Pugh R, Qiu Y, Quehenberger O, Ramrup P, Rees J, Rembiesa B, Reynaud D, Roth MR, Sales S, Schuhmann K, Schwartzman ML, Serhan CN, Shevchenko A, Somerville SE, St John-Williams L, Surma MA, Takeda H, Thakare R, Thompson JW, Torta F, Triebl A, Trötzmüller M, Ubhayasekera SJK, Vuckovic D, Weir JM, Welti R, Wenk MR, Wheelock CE, Yao L, Yuan M, Zhao XH, Zhou S.

J Lipid Res. 2017 Dec;58(12):2275-2288. doi: 10.1194/jlr.M079012. Epub 2017 Oct 6.

PMID:
28986437
8.

Identification of a plasma signature of psychotic disorder in children and adolescents from the Avon Longitudinal Study of Parents and Children (ALSPAC) cohort.

O'Gorman A, Suvitaival T, Ahonen L, Cannon M, Zammit S, Lewis G, Roche HM, Mattila I, Hyotylainen T, Oresic M, Brennan L, Cotter DR.

Transl Psychiatry. 2017 Sep 26;7(9):e1240. doi: 10.1038/tp.2017.211.

9.

Lipidome as a predictive tool in progression to type 2 diabetes in Finnish men.

Suvitaival T, Bondia-Pons I, Yetukuri L, Pöhö P, Nolan JJ, Hyötyläinen T, Kuusisto J, Orešič M.

Metabolism. 2018 Jan;78:1-12. doi: 10.1016/j.metabol.2017.08.014. Epub 2017 Sep 20.

10.

Metabolomics Profiling As a Diagnostic Tool in Severe Traumatic Brain Injury.

Posti JP, Dickens AM, Orešič M, Hyötyläinen T, Tenovuo O.

Front Neurol. 2017 Aug 18;8:398. doi: 10.3389/fneur.2017.00398. eCollection 2017. Review.

11.

Hypothalamic AMPK-ER Stress-JNK1 Axis Mediates the Central Actions of Thyroid Hormones on Energy Balance.

Martínez-Sánchez N, Seoane-Collazo P, Contreras C, Varela L, Villarroya J, Rial-Pensado E, Buqué X, Aurrekoetxea I, Delgado TC, Vázquez-Martínez R, González-García I, Roa J, Whittle AJ, Gomez-Santos B, Velagapudi V, Tung YCL, Morgan DA, Voshol PJ, Martínez de Morentin PB, López-González T, Liñares-Pose L, Gonzalez F, Chatterjee K, Sobrino T, Medina-Gómez G, Davis RJ, Casals N, Orešič M, Coll AP, Vidal-Puig A, Mittag J, Tena-Sempere M, Malagón MM, Diéguez C, Martínez-Chantar ML, Aspichueta P, Rahmouni K, Nogueiras R, Sabio G, Villarroya F, López M.

Cell Metab. 2017 Jul 5;26(1):212-229.e12. doi: 10.1016/j.cmet.2017.06.014.

12.

Analysis of microbiota in first episode psychosis identifies preliminary associations with symptom severity and treatment response.

Schwarz E, Maukonen J, Hyytiäinen T, Kieseppä T, Orešič M, Sabunciyan S, Mantere O, Saarela M, Yolken R, Suvisaari J.

Schizophr Res. 2018 Feb;192:398-403. doi: 10.1016/j.schres.2017.04.017. Epub 2017 Apr 22.

PMID:
28442250
13.

Lipidomics in biomedical research-practical considerations.

Hyötyläinen T, Ahonen L, Pöhö P, Orešič M.

Biochim Biophys Acta. 2017 Aug;1862(8):800-803. doi: 10.1016/j.bbalip.2017.04.002. Epub 2017 Apr 10. Review.

PMID:
28408341
14.

Impaired hepatic lipid synthesis from polyunsaturated fatty acids in TM6SF2 E167K variant carriers with NAFLD.

Luukkonen PK, Zhou Y, Nidhina Haridas PA, Dwivedi OP, Hyötyläinen T, Ali A, Juuti A, Leivonen M, Tukiainen T, Ahonen L, Scott E, Palmer JM, Arola J, Orho-Melander M, Vikman P, Anstee QM, Olkkonen VM, Orešič M, Groop L, Yki-Järvinen H.

J Hepatol. 2017 Jul;67(1):128-136. doi: 10.1016/j.jhep.2017.02.014. Epub 2017 Feb 22.

PMID:
28235613
15.

Sphingolipids and glycerophospholipids - The "ying and yang" of lipotoxicity in metabolic diseases.

Rodriguez-Cuenca S, Pellegrinelli V, Campbell M, Oresic M, Vidal-Puig A.

Prog Lipid Res. 2017 Apr;66:14-29. doi: 10.1016/j.plipres.2017.01.002. Epub 2017 Jan 16. Review.

PMID:
28104532
16.

Serum metabolite profile associates with the development of metabolic co-morbidities in first-episode psychosis.

Suvitaival T, Mantere O, Kieseppä T, Mattila I, Pöhö P, Hyötyläinen T, Suvisaari J, Orešič M.

Transl Psychiatry. 2016 Nov 15;6(11):e951. doi: 10.1038/tp.2016.222.

17.

Human Serum Metabolites Associate With Severity and Patient Outcomes in Traumatic Brain Injury.

Orešič M, Posti JP, Kamstrup-Nielsen MH, Takala RSK, Lingsma HF, Mattila I, Jäntti S, Katila AJ, Carpenter KLH, Ala-Seppälä H, Kyllönen A, Maanpää HR, Tallus J, Coles JP, Heino I, Frantzén J, Hutchinson PJ, Menon DK, Tenovuo O, Hyötyläinen T.

EBioMedicine. 2016 Oct;12:118-126. doi: 10.1016/j.ebiom.2016.07.015. Epub 2016 Jul 15.

18.

Metabolomics enables precision medicine: "A White Paper, Community Perspective".

Beger RD, Dunn W, Schmidt MA, Gross SS, Kirwan JA, Cascante M, Brennan L, Wishart DS, Oresic M, Hankemeier T, Broadhurst DI, Lane AN, Suhre K, Kastenmüller G, Sumner SJ, Thiele I, Fiehn O, Kaddurah-Daouk R; for “Precision Medicine and Pharmacometabolomics Task Group”-Metabolomics Society Initiative.

Metabolomics. 2016;12(10):149. Epub 2016 Sep 2.

19.

The MBOAT7 variant rs641738 alters hepatic phosphatidylinositols and increases severity of non-alcoholic fatty liver disease in humans.

Luukkonen PK, Zhou Y, Hyötyläinen T, Leivonen M, Arola J, Orho-Melander M, Orešič M, Yki-Järvinen H.

J Hepatol. 2016 Dec;65(6):1263-1265. doi: 10.1016/j.jhep.2016.07.045. Epub 2016 Aug 9. No abstract available.

PMID:
27520876
20.

Imbalance of plasma amino acids, metabolites and lipids in patients with lysinuric protein intolerance (LPI).

Kurko J, Tringham M, Tanner L, Näntö-Salonen K, Vähä-Mäkilä M, Nygren H, Pöhö P, Lietzen N, Mattila I, Olkku A, Hyötyläinen T, Orešič M, Simell O, Niinikoski H, Mykkänen J.

Metabolism. 2016 Sep;65(9):1361-75. doi: 10.1016/j.metabol.2016.05.012. Epub 2016 May 27.

PMID:
27506743
21.

Human gut microbes impact host serum metabolome and insulin sensitivity.

Pedersen HK, Gudmundsdottir V, Nielsen HB, Hyotylainen T, Nielsen T, Jensen BA, Forslund K, Hildebrand F, Prifti E, Falony G, Le Chatelier E, Levenez F, Doré J, Mattila I, Plichta DR, Pöhö P, Hellgren LI, Arumugam M, Sunagawa S, Vieira-Silva S, Jørgensen T, Holm JB, Trošt K; MetaHIT Consortium, Kristiansen K, Brix S, Raes J, Wang J, Hansen T, Bork P, Brunak S, Oresic M, Ehrlich SD, Pedersen O.

Nature. 2016 Jul 21;535(7612):376-81. Epub 2016 Jul 13.

PMID:
27409811
22.

Noninvasive Detection of Nonalcoholic Steatohepatitis Using Clinical Markers and Circulating Levels of Lipids and Metabolites.

Zhou Y, Orešič M, Leivonen M, Gopalacharyulu P, Hyysalo J, Arola J, Verrijken A, Francque S, Van Gaal L, Hyötyläinen T, Yki-Järvinen H.

Clin Gastroenterol Hepatol. 2016 Oct;14(10):1463-1472.e6. doi: 10.1016/j.cgh.2016.05.046. Epub 2016 Jun 16.

PMID:
27317851
23.

Metabolic transformations of dietary polyphenols: comparison between in vitro colonic and hepatic models and in vivo urinary metabolites.

Vetrani C, Rivellese AA, Annuzzi G, Adiels M, Borén J, Mattila I, Orešič M, Aura AM.

J Nutr Biochem. 2016 Jul;33:111-8. doi: 10.1016/j.jnutbio.2016.03.007. Epub 2016 Mar 29.

PMID:
27155917
24.

Prolonged sleep restriction induces changes in pathways involved in cholesterol metabolism and inflammatory responses.

Aho V, Ollila HM, Kronholm E, Bondia-Pons I, Soininen P, Kangas AJ, Hilvo M, Seppälä I, Kettunen J, Oikonen M, Raitoharju E, Hyötyläinen T, Kähönen M, Viikari JS, Härmä M, Sallinen M, Olkkonen VM, Alenius H, Jauhiainen M, Paunio T, Lehtimäki T, Salomaa V, Orešič M, Raitakari OT, Ala-Korpela M, Porkka-Heiskanen T.

Sci Rep. 2016 Apr 22;6:24828. doi: 10.1038/srep24828.

25.

A Healthy Nordic Diet Alters the Plasma Lipidomic Profile in Adults with Features of Metabolic Syndrome in a Multicenter Randomized Dietary Intervention.

Lankinen M, Schwab U, Kolehmainen M, Paananen J, Nygren H, Seppänen-Laakso T, Poutanen K, Hyötyläinen T, Risérus U, Savolainen MJ, Hukkanen J, Brader L, Marklund M, Rosqvist F, Hermansen K, Cloetens L, Önning G, Thorsdottir I, Gunnarsdottir I, Åkesson B, Dragsted LO, Uusitupa M, Orešič M.

J Nutr. 2016 Mar 9. pii: jn220459. [Epub ahead of print]

PMID:
26962194
26.

Bioanalytical techniques in nontargeted clinical lipidomics.

Hyötyläinen T, Orešič M.

Bioanalysis. 2016 Feb;8(4):351-64. doi: 10.4155/bio.15.244. Epub 2016 Feb 9. Review.

PMID:
26856187
27.

Genome-scale study reveals reduced metabolic adaptability in patients with non-alcoholic fatty liver disease.

Hyötyläinen T, Jerby L, Petäjä EM, Mattila I, Jäntti S, Auvinen P, Gastaldelli A, Yki-Järvinen H, Ruppin E, Orešič M.

Nat Commun. 2016 Feb 3;7:8994. doi: 10.1038/ncomms9994.

28.

Longitudinal plasma metabolic profiles, infant feeding, and islet autoimmunity in the MIDIA study.

Jørgenrud B, Stene LC, Tapia G, Bøås H, Pepaj M, Berg JP, Thorsby PM, Orešič M, Hyötyläinen T, Rønningen KS.

Pediatr Diabetes. 2017 Mar;18(2):111-119. doi: 10.1111/pedi.12360. Epub 2016 Jan 21.

PMID:
26791677
29.

Interaction between dietary lipids and gut microbiota regulates hepatic cholesterol metabolism.

Caesar R, Nygren H, Orešič M, Bäckhed F.

J Lipid Res. 2016 Mar;57(3):474-81. doi: 10.1194/jlr.M065847. Epub 2016 Jan 18.

30.

Hepatic ceramides dissociate steatosis and insulin resistance in patients with non-alcoholic fatty liver disease.

Luukkonen PK, Zhou Y, Sädevirta S, Leivonen M, Arola J, Orešič M, Hyötyläinen T, Yki-Järvinen H.

J Hepatol. 2016 May;64(5):1167-1175. doi: 10.1016/j.jhep.2016.01.002. Epub 2016 Jan 11.

PMID:
26780287
31.

Data standards can boost metabolomics research, and if there is a will, there is a way.

Rocca-Serra P, Salek RM, Arita M, Correa E, Dayalan S, Gonzalez-Beltran A, Ebbels T, Goodacre R, Hastings J, Haug K, Koulman A, Nikolski M, Oresic M, Sansone SA, Schober D, Smith J, Steinbeck C, Viant MR, Neumann S.

Metabolomics. 2016;12:14. doi: 10.1007/s11306-015-0879-3. Epub 2015 Nov 17. Review.

32.

COordination of Standards in MetabOlomicS (COSMOS): facilitating integrated metabolomics data access.

Salek RM, Neumann S, Schober D, Hummel J, Billiau K, Kopka J, Correa E, Reijmers T, Rosato A, Tenori L, Turano P, Marin S, Deborde C, Jacob D, Rolin D, Dartigues B, Conesa P, Haug K, Rocca-Serra P, O'Hagan S, Hao J, van Vliet M, Sysi-Aho M, Ludwig C, Bouwman J, Cascante M, Ebbels T, Griffin JL, Moing A, Nikolski M, Oresic M, Sansone SA, Viant MR, Goodacre R, Günther UL, Hankemeier T, Luchinat C, Walther D, Steinbeck C.

Metabolomics. 2015;11(6):1587-1597. Epub 2015 May 26.

33.

Analytical Lipidomics in Metabolic and Clinical Research.

Hyötyläinen T, Orešič M.

Trends Endocrinol Metab. 2015 Dec;26(12):671-673. doi: 10.1016/j.tem.2015.08.006. Epub 2015 Oct 1.

PMID:
26439978
34.

Modeling strategies to study metabolic pathways in progression to type 1 diabetes--Challenges and opportunities.

Marinković T, Orešič M.

Arch Biochem Biophys. 2016 Jan 1;589:131-7. doi: 10.1016/j.abb.2015.08.011. Epub 2015 Aug 24. Review.

PMID:
26314918
35.

Serum Lipid and Serum Metabolite Components in relation to anthropometric parameters in EPIC-Potsdam participants.

Foerster J, Hyötyläinen T, Oresic M, Nygren H, Boeing H.

Metabolism. 2015 Oct;64(10):1348-58. doi: 10.1016/j.metabol.2015.07.004. Epub 2015 Jul 11.

PMID:
26271139
36.

The Metabolome in Finnish Carriers of the MYBPC3-Q1061X Mutation for Hypertrophic Cardiomyopathy.

Jørgenrud B, Jalanko M, Heliö T, Jääskeläinen P, Laine M, Hilvo M, Nieminen MS, Laakso M, Hyötyläinen T, Orešič M, Kuusisto J.

PLoS One. 2015 Aug 12;10(8):e0134184. doi: 10.1371/journal.pone.0134184. eCollection 2015.

37.

The effect of atorvastatin treatment on serum oxysterol concentrations and cytochrome P450 3A4 activity.

Hukkanen J, Puurunen J, Hyötyläinen T, Savolainen MJ, Ruokonen A, Morin-Papunen L, Orešič M, Piltonen T, Tapanainen JS.

Br J Clin Pharmacol. 2015 Sep;80(3):473-9. doi: 10.1111/bcp.12701. Epub 2015 Jul 22.

38.

The influence of sample collection methodology and sample preprocessing on the blood metabolic profile.

Jørgenrud B, Jäntti S, Mattila I, Pöhö P, Rønningen KS, Yki-Järvinen H, Orešič M, Hyötyläinen T.

Bioanalysis. 2015;7(8):991-1006. doi: 10.4155/bio.15.16.

PMID:
25966010
39.

Roux-en-Y Gastric Bypass Surgery Induces Early Plasma Metabolomic and Lipidomic Alterations in Humans Associated with Diabetes Remission.

Arora T, Velagapudi V, Pournaras DJ, Welbourn R, le Roux CW, Orešič M, Bäckhed F.

PLoS One. 2015 May 6;10(5):e0126401. doi: 10.1371/journal.pone.0126401. eCollection 2015.

40.

Optimizing the lipidomics workflow for clinical studies--practical considerations.

Hyötyläinen T, Orešič M.

Anal Bioanal Chem. 2015 Jul;407(17):4973-93. doi: 10.1007/s00216-015-8633-2. Epub 2015 Apr 9. Review.

PMID:
25855150
41.

The dynamics of the human infant gut microbiome in development and in progression toward type 1 diabetes.

Kostic AD, Gevers D, Siljander H, Vatanen T, Hyötyläinen T, Hämäläinen AM, Peet A, Tillmann V, Pöhö P, Mattila I, Lähdesmäki H, Franzosa EA, Vaarala O, de Goffau M, Harmsen H, Ilonen J, Virtanen SM, Clish CB, Orešič M, Huttenhower C, Knip M; DIABIMMUNE Study Group, Xavier RJ.

Cell Host Microbe. 2015 Feb 11;17(2):260-73. doi: 10.1016/j.chom.2015.01.001. Epub 2015 Feb 5.

42.

High-dose simvastatin exhibits enhanced lipid-lowering effects relative to simvastatin/ezetimibe combination therapy.

Snowden SG, Grapov D, Settergren M, D'Alexandri FL, Haeggström JZ, Fiehn O, Hyötyläinen T, Pedersen TL, Newman JW, Orešič M, Pernow J, Wheelock CE.

Circ Cardiovasc Genet. 2014 Dec;7(6):955-964. doi: 10.1161/CIRCGENETICS.114.000606.

43.

Circulating triacylglycerol signatures and insulin sensitivity in NAFLD associated with the E167K variant in TM6SF2.

Zhou Y, Llauradó G, Orešič M, Hyötyläinen T, Orho-Melander M, Yki-Järvinen H.

J Hepatol. 2015 Mar;62(3):657-63. doi: 10.1016/j.jhep.2014.10.010. Epub 2014 Oct 19.

PMID:
25457209
44.

The gut microbiota modulates glycaemic control and serum metabolite profiles in non-obese diabetic mice.

Greiner TU, Hyötyläinen T, Knip M, Bäckhed F, Orešič M.

PLoS One. 2014 Nov 12;9(11):e110359. doi: 10.1371/journal.pone.0110359. eCollection 2014.

45.

Quantitative profiling of bile acids in blood, adipose tissue, intestine, and gall bladder samples using ultra high performance liquid chromatography-tandem mass spectrometry.

Jäntti SE, Kivilompolo M, Ohrnberg L, Pietiläinen KH, Nygren H, Orešič M, Hyötyläinen T.

Anal Bioanal Chem. 2014 Dec;406(30):7799-815. doi: 10.1007/s00216-014-8230-9. Epub 2014 Nov 12.

PMID:
25384335
46.

Increased dihydroceramide/ceramide ratio mediated by defective expression of degs1 impairs adipocyte differentiation and function.

Barbarroja N, Rodriguez-Cuenca S, Nygren H, Camargo A, Pirraco A, Relat J, Cuadrado I, Pellegrinelli V, Medina-Gomez G, Lopez-Pedrera C, Tinahones FJ, Symons JD, Summers SA, Oresic M, Vidal-Puig A.

Diabetes. 2015 Apr;64(4):1180-92. doi: 10.2337/db14-0359. Epub 2014 Oct 28.

47.

The DEXLIFE study methods: identifying novel candidate biomarkers that predict progression to type 2 diabetes in high risk individuals.

Andersen GS, Thybo T, Cederberg H, Orešič M, Esteller M, Zorzano A, Carr B, Walker M, Cobb J, Clissmann C, O'Gorman DJ, Nolan JJ; DEXLIFE Consortium.

Diabetes Res Clin Pract. 2014 Nov;106(2):383-9. doi: 10.1016/j.diabres.2014.07.025. Epub 2014 Jul 27.

PMID:
25125339
48.

Overexpression of PPARγ specifically in pancreatic β-cells exacerbates obesity-induced glucose intolerance, reduces β-cell mass, and alters islet lipid metabolism in male mice.

Hogh KL, Craig MN, Uy CE, Nygren H, Asadi A, Speck M, Fraser JD, Rudecki AP, Baker RK, Orešič M, Gray SL.

Endocrinology. 2014 Oct;155(10):3843-52. doi: 10.1210/en.2014-1076. Epub 2014 Jul 22.

PMID:
25051434
49.

Systems biology strategies to study lipidomes in health and disease.

Hyötyläinen T, Orešič M.

Prog Lipid Res. 2014 Jul;55:43-60. doi: 10.1016/j.plipres.2014.06.001. Epub 2014 Jul 1. Review.

PMID:
24995945
50.

Isoenergetic diets differing in their n-3 fatty acid and polyphenol content reflect different plasma and HDL-fraction lipidomic profiles in subjects at high cardiovascular risk.

Bondia-Pons I, Pöhö P, Bozzetto L, Vetrani C, Patti L, Aura AM, Annuzzi G, Hyötyläinen T, Rivellese AA, Orešič M.

Mol Nutr Food Res. 2014 Sep;58(9):1873-82. doi: 10.1002/mnfr.201400155. Epub 2014 Jun 24.

PMID:
24961394

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