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Items: 23


RhoE Is a Pro-Survival p53 Target Gene that Inhibits ROCK I-Mediated Apoptosis in Response to Genotoxic Stress.

Ongusaha PP, Kim HG, Boswell SA, Ridley AJ, Der CJ, Dotto GP, Kim YB, Aaronson SA, Lee SW.

Curr Biol. 2016 Aug 22;26(16):2221-2222. doi: 10.1016/j.cub.2016.07.072. No abstract available.


Folliculin, the product of the Birt-Hogg-Dube tumor suppressor gene, interacts with the adherens junction protein p0071 to regulate cell-cell adhesion.

Medvetz DA, Khabibullin D, Hariharan V, Ongusaha PP, Goncharova EA, Schlechter T, Darling TN, Hofmann I, Krymskaya VP, Liao JK, Huang H, Henske EP.

PLoS One. 2012;7(11):e47842. doi: 10.1371/journal.pone.0047842. Epub 2012 Nov 6.


Rho-associated coiled-coil-containing kinase 2 deficiency in bone marrow-derived cells leads to increased cholesterol efflux and decreased atherosclerosis.

Zhou Q, Mei Y, Shoji T, Han X, Kaminski K, Oh GT, Ongusaha PP, Zhang K, Schmitt H, Moser M, Bode C, Liao JK.

Circulation. 2012 Oct 30;126(18):2236-47. doi: 10.1161/CIRCULATIONAHA.111.086041. Epub 2012 Sep 25.


ROCK1 & 2 perform overlapping and unique roles in angiogenesis and angiosarcoma tumor progression.

Montalvo J, Spencer C, Hackathorn A, Masterjohn K, Perkins A, Doty C, Arumugam A, Ongusaha PP, Lakshmanaswamy R, Liao JK, Mitchell DC, Bryan BA.

Curr Mol Med. 2013 Jan;13(1):205-19.


Histone H4K20/H3K9 demethylase PHF8 regulates zebrafish brain and craniofacial development.

Qi HH, Sarkissian M, Hu GQ, Wang Z, Bhattacharjee A, Gordon DB, Gonzales M, Lan F, Ongusaha PP, Huarte M, Yaghi NK, Lim H, Garcia BA, Brizuela L, Zhao K, Roberts TM, Shi Y.

Nature. 2010 Jul 22;466(7305):503-7. doi: 10.1038/nature09261. Epub 2010 Jul 11.


GAMT, a p53-inducible modulator of apoptosis, is critical for the adaptive response to nutrient stress.

Ide T, Brown-Endres L, Chu K, Ongusaha PP, Ohtsuka T, El-Deiry WS, Aaronson SA, Lee SW.

Mol Cell. 2009 Nov 13;36(3):379-92. doi: 10.1016/j.molcel.2009.09.031. Retraction in: Mol Cell. 2013 Aug 22;51(4):552.


Maximizing tumor cell invasion.

Ongusaha PP, Lee SW.

Pigment Cell Melanoma Res. 2009 Apr;22(2):148-9. doi: 10.1111/j.1755-148X.2009.00542.x. Epub 2009 Jan 27. No abstract available.


Identification of ROCK1 as an upstream activator of the JIP-3 to JNK signaling axis in response to UVB damage.

Ongusaha PP, Qi HH, Raj L, Kim YB, Aaronson SA, Davis RJ, Shi Y, Liao JK, Lee SW.

Sci Signal. 2008 Nov 25;1(47):ra14. doi: 10.1126/scisignal.1161938.


Prolyl 4-hydroxylation regulates Argonaute 2 stability.

Qi HH, Ongusaha PP, Myllyharju J, Cheng D, Pakkanen O, Shi Y, Lee SW, Peng J, Shi Y.

Nature. 2008 Sep 18;455(7211):421-4. doi: 10.1038/nature07186. Epub 2008 Aug 6.


Phosphoinositide signalling links O-GlcNAc transferase to insulin resistance.

Yang X, Ongusaha PP, Miles PD, Havstad JC, Zhang F, So WV, Kudlow JE, Michell RH, Olefsky JM, Field SJ, Evans RM.

Nature. 2008 Feb 21;451(7181):964-9. doi: 10.1038/nature06668.


CDIP, a novel pro-apoptotic gene, regulates TNFalpha-mediated apoptosis in a p53-dependent manner.

Brown L, Ongusaha PP, Kim HG, Nuti S, Mandinova A, Lee JW, Khosravi-Far R, Aaronson SA, Lee SW.

EMBO J. 2007 Jul 25;26(14):3410-22. Epub 2007 Jun 28.


RhoE is a pro-survival p53 target gene that inhibits ROCK I-mediated apoptosis in response to genotoxic stress.

Ongusaha PP, Kim HG, Boswell SA, Ridley AJ, Der CJ, Dotto GP, Kim YB, Aaronson SA, Lee SW.

Curr Biol. 2006 Dec 19;16(24):2466-72. Erratum in: Curr Biol. 2012 Nov 20;22(22):2186-7.


The protective role of a small GTPase RhoE against UVB-induced DNA damage in keratinocytes.

Boswell SA, Ongusaha PP, Nghiem P, Lee SW.

J Biol Chem. 2007 Feb 16;282(7):4850-8. Epub 2006 Dec 14.


HB-EGF is a potent inducer of tumor growth and angiogenesis.

Ongusaha PP, Kwak JC, Zwible AJ, Macip S, Higashiyama S, Taniguchi N, Fang L, Lee SW.

Cancer Res. 2004 Aug 1;64(15):5283-90.


Function of Drg1/Rit42 in p53-dependent mitotic spindle checkpoint.

Kim KT, Ongusaha PP, Hong YK, Kurdistani SK, Nakamura M, Lu KP, Lee SW.

J Biol Chem. 2004 Sep 10;279(37):38597-602. Epub 2004 Jul 9.


BRCA1 phosphorylation by Aurora-A in the regulation of G2 to M transition.

Ouchi M, Fujiuchi N, Sasai K, Katayama H, Minamishima YA, Ongusaha PP, Deng C, Sen S, Lee SW, Ouchi T.

J Biol Chem. 2004 May 7;279(19):19643-8. Epub 2004 Feb 27. Retraction in: J Biol Chem. 2015 Sep 4;290(36):22311.


IFI16 as a negative regulator in the regulation of p53 and p21(Waf1).

Kwak JC, Ongusaha PP, Ouchi T, Lee SW.

J Biol Chem. 2003 Oct 17;278(42):40899-904. Epub 2003 Aug 18.


BRCA1 shifts p53-mediated cellular outcomes towards irreversible growth arrest.

Ongusaha PP, Ouchi T, Kim KT, Nytko E, Kwak JC, Duda RB, Deng CX, Lee SW.

Oncogene. 2003 Jun 12;22(24):3749-58.


p53 induction and activation of DDR1 kinase counteract p53-mediated apoptosis and influence p53 regulation through a positive feedback loop.

Ongusaha PP, Kim JI, Fang L, Wong TW, Yancopoulos GD, Aaronson SA, Lee SW.

EMBO J. 2003 Mar 17;22(6):1289-301.


P53-mediated induction of Cox-2 counteracts p53- or genotoxic stress-induced apoptosis.

Han JA, Kim JI, Ongusaha PP, Hwang DH, Ballou LR, Mahale A, Aaronson SA, Lee SW.

EMBO J. 2002 Nov 1;21(21):5635-44.


Inositol hexakisphosphate in Schizosaccharomyces pombe: synthesis from Ins(1,4,5)P3 and osmotic regulation.

Ongusaha PP, Hughes PJ, Davey J, Michell RH.

Biochem J. 1998 Nov 1;335 ( Pt 3):671-9.


The inositol 1,4,5-trisphosphate 6-kinase of Schizosaccharomyces pombe.

Ongusaha PP, Hughes PJ, Hirata M, Davey J, Michell RH.

Biochem Soc Trans. 1997 Feb;25(1):105S. No abstract available.


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