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Items: 1 to 50 of 643

1.

Stac proteins associate with the critical domain for excitation-contraction coupling in the II-III loop of CaV1.1.

Polster A, Nelson BR, Papadopoulos S, Olson EN, Beam KG.

J Gen Physiol. 2018 Feb 21. pii: jgp.201711917. doi: 10.1085/jgp.201711917. [Epub ahead of print]

PMID:
29467163
2.

Correction of diverse muscular dystrophy mutations in human engineered heart muscle by single-site genome editing.

Long C, Li H, Tiburcy M, Rodriguez-Caycedo C, Kyrychenko V, Zhou H, Zhang Y, Min YL, Shelton JM, Mammen PPA, Liaw NY, Zimmermann WH, Bassel-Duby R, Schneider JW, Olson EN.

Sci Adv. 2018 Jan 31;4(1):eaap9004. doi: 10.1126/sciadv.aap9004. eCollection 2018 Jan.

3.

Single-cut genome editing restores dystrophin expression in a new mouse model of muscular dystrophy.

Amoasii L, Long C, Li H, Mireault AA, Shelton JM, Sanchez-Ortiz E, McAnally JR, Bhattacharyya S, Schmidt F, Grimm D, Hauschka SD, Bassel-Duby R, Olson EN.

Sci Transl Med. 2017 Nov 29;9(418). pii: eaan8081. doi: 10.1126/scitranslmed.aan8081. Erratum in: Sci Transl Med. 2018 Jan 24;10 (425):.

4.

Requirement of the fusogenic micropeptide myomixer for muscle formation in zebrafish.

Shi J, Bi P, Pei J, Li H, Grishin NV, Bassel-Duby R, Chen EH, Olson EN.

Proc Natl Acad Sci U S A. 2017 Nov 7;114(45):11950-11955. doi: 10.1073/pnas.1715229114. Epub 2017 Oct 23.

PMID:
29078404
5.

Considerations for Cardiac CRISPR.

Carroll KJ, Olson EN.

Circ Res. 2017 Oct 27;121(10):1111-1112. doi: 10.1161/CIRCRESAHA.117.311974. No abstract available.

PMID:
29074525
6.

ZNF281 enhances cardiac reprogramming by modulating cardiac and inflammatory gene expression.

Zhou H, Morales MG, Hashimoto H, Dickson ME, Song K, Ye W, Kim MS, Niederstrasser H, Wang Z, Chen B, Posner BA, Bassel-Duby R, Olson EN.

Genes Dev. 2017 Sep 1;31(17):1770-1783. doi: 10.1101/gad.305482.117.

PMID:
28982760
7.

Functional correction of dystrophin actin binding domain mutations by genome editing.

Kyrychenko V, Kyrychenko S, Tiburcy M, Shelton JM, Long C, Schneider JW, Zimmermann WH, Bassel-Duby R, Olson EN.

JCI Insight. 2017 Sep 21;2(18). pii: 95918. doi: 10.1172/jci.insight.95918. [Epub ahead of print]

8.

Deficiency in Kelch protein Klhl31 causes congenital myopathy in mice.

Papizan JB, Garry GA, Brezprozvannaya S, McAnally JR, Bassel-Duby R, Liu N, Olson EN.

J Clin Invest. 2017 Oct 2;127(10):3730-3740. doi: 10.1172/JCI93445. Epub 2017 Sep 5.

9.

KLHL41 stabilizes skeletal muscle sarcomeres by nonproteolytic ubiquitination.

Ramirez-Martinez A, Cenik BK, Bezprozvannaya S, Chen B, Bassel-Duby R, Liu N, Olson EN.

Elife. 2017 Aug 9;6. pii: e26439. doi: 10.7554/eLife.26439.

10.

MED12 regulates a transcriptional network of calcium-handling genes in the heart.

Baskin KK, Makarewich CA, DeLeon SM, Ye W, Chen B, Beetz N, Schrewe H, Bassel-Duby R, Olson EN.

JCI Insight. 2017 Jul 20;2(14). pii: 91920. doi: 10.1172/jci.insight.91920. [Epub ahead of print]

11.

A defect in myoblast fusion underlies Carey-Fineman-Ziter syndrome.

Di Gioia SA, Connors S, Matsunami N, Cannavino J, Rose MF, Gilette NM, Artoni P, de Macena Sobreira NL, Chan WM, Webb BD, Robson CD, Cheng L, Van Ryzin C, Ramirez-Martinez A, Mohassel P, Leppert M, Scholand MB, Grunseich C, Ferreira CR, Hartman T, Hayes IM, Morgan T, Markie DM, Fagiolini M, Swift A, Chines PS, Speck-Martins CE, Collins FS, Jabs EW, Bönnemann CG, Olson EN; Moebius Syndrome Research Consortium, Carey JC, Robertson SP, Manoli I, Engle EC.

Nat Commun. 2017 Jul 6;8:16077. doi: 10.1038/ncomms16077.

12.

Mining for Micropeptides.

Makarewich CA, Olson EN.

Trends Cell Biol. 2017 Sep;27(9):685-696. doi: 10.1016/j.tcb.2017.04.006. Epub 2017 May 18. Review.

PMID:
28528987
13.

CRISPR-Cpf1 correction of muscular dystrophy mutations in human cardiomyocytes and mice.

Zhang Y, Long C, Li H, McAnally JR, Baskin KK, Shelton JM, Bassel-Duby R, Olson EN.

Sci Adv. 2017 Apr 12;3(4):e1602814. doi: 10.1126/sciadv.1602814. eCollection 2017 Apr.

14.

Control of Muscle Metabolism by the Mediator Complex.

Amoasii L, Olson EN, Bassel-Duby R.

Cold Spring Harb Perspect Med. 2018 Feb 1;8(2). pii: a029843. doi: 10.1101/cshperspect.a029843. Review.

15.

Control of muscle formation by the fusogenic micropeptide myomixer.

Bi P, Ramirez-Martinez A, Li H, Cannavino J, McAnally JR, Shelton JM, Sánchez-Ortiz E, Bassel-Duby R, Olson EN.

Science. 2017 Apr 21;356(6335):323-327. doi: 10.1126/science.aam9361. Epub 2017 Apr 6.

16.

Notch Inhibition Enhances Cardiac Reprogramming by Increasing MEF2C Transcriptional Activity.

Abad M, Hashimoto H, Zhou H, Morales MG, Chen B, Bassel-Duby R, Olson EN.

Stem Cell Reports. 2017 Mar 14;8(3):548-560. doi: 10.1016/j.stemcr.2017.01.025. Epub 2017 Mar 2.

17.

A Twist2-dependent progenitor cell contributes to adult skeletal muscle.

Liu N, Garry GA, Li S, Bezprozvannaya S, Sanchez-Ortiz E, Chen B, Shelton JM, Jaichander P, Bassel-Duby R, Olson EN.

Nat Cell Biol. 2017 Mar;19(3):202-213. doi: 10.1038/ncb3477. Epub 2017 Feb 20.

18.

Blockade to pathological remodeling of infarcted heart tissue using a porcupine antagonist.

Moon J, Zhou H, Zhang LS, Tan W, Liu Y, Zhang S, Morlock LK, Bao X, Palecek SP, Feng JQ, Williams NS, Amatruda JF, Olson EN, Bassel-Duby R, Lum L.

Proc Natl Acad Sci U S A. 2017 Feb 14;114(7):1649-1654. doi: 10.1073/pnas.1621346114. Epub 2017 Jan 31.

19.

Insulin Regulates Astrocytic Glucose Handling Through Cooperation With IGF-I.

Fernandez AM, Hernandez-Garzón E, Perez-Domper P, Perez-Alvarez A, Mederos S, Matsui T, Santi A, Trueba-Saiz A, García-Guerra L, Pose-Utrilla J, Fielitz J, Olson EN, Fernandez de la Rosa R, Garcia Garcia L, Pozo MA, Iglesias T, Araque A, Soya H, Perea G, Martin ED, Torres Aleman I.

Diabetes. 2017 Jan;66(1):64-74. doi: 10.2337/db16-0861. Epub 2016 Oct 10.

20.

Widespread control of calcium signaling by a family of SERCA-inhibiting micropeptides.

Anderson DM, Makarewich CA, Anderson KM, Shelton JM, Bezprozvannaya S, Bassel-Duby R, Olson EN.

Sci Signal. 2016 Dec 6;9(457):ra119.

21.

Transcription of the non-coding RNA upperhand controls Hand2 expression and heart development.

Anderson KM, Anderson DM, McAnally JR, Shelton JM, Bassel-Duby R, Olson EN.

Nature. 2016 Nov 17;539(7629):433-436. doi: 10.1038/nature20128. Epub 2016 Oct 26.

22.

Mutations in the Histone Modifier PRDM6 Are Associated with Isolated Nonsyndromic Patent Ductus Arteriosus.

Li N, Subrahmanyan L, Smith E, Yu X, Zaidi S, Choi M, Mane S, Nelson-Williams C, Behjati M, Kazemi M, Hashemi M, Fathzadeh M, Narayanan A, Tian L, Montazeri F, Mani M, Begleiter ML, Coon BG, Lynch HT, Olson EN, Zhao H, Ruland J, Lifton RP, Mani A.

Am J Hum Genet. 2016 Oct 6;99(4):1000. doi: 10.1016/j.ajhg.2016.09.003. No abstract available.

23.

Genome Editing of Monogenic Neuromuscular Diseases: A Systematic Review.

Long C, Amoasii L, Bassel-Duby R, Olson EN.

JAMA Neurol. 2016 Nov 1;73(11):1349-1355. doi: 10.1001/jamaneurol.2016.3388. Review.

24.

Stac3 has a direct role in skeletal muscle-type excitation-contraction coupling that is disrupted by a myopathy-causing mutation.

Polster A, Nelson BR, Olson EN, Beam KG.

Proc Natl Acad Sci U S A. 2016 Sep 27;113(39):10986-91. doi: 10.1073/pnas.1612441113. Epub 2016 Sep 12.

25.

Muscle RING-finger 2 and 3 maintain striated-muscle structure and function.

Lodka D, Pahuja A, Geers-Knörr C, Scheibe RJ, Nowak M, Hamati J, Köhncke C, Purfürst B, Kanashova T, Schmidt S, Glass DJ, Morano I, Heuser A, Kraft T, Bassel-Duby R, Olson EN, Dittmar G, Sommer T, Fielitz J.

J Cachexia Sarcopenia Muscle. 2016 May;7(2):165-80. doi: 10.1002/jcsm.12057. Epub 2015 Sep 7.

26.

Severe muscle wasting and denervation in mice lacking the RNA-binding protein ZFP106.

Anderson DM, Cannavino J, Li H, Anderson KM, Nelson BR, McAnally J, Bezprozvannaya S, Liu Y, Lin W, Liu N, Bassel-Duby R, Olson EN.

Proc Natl Acad Sci U S A. 2016 Aug 2;113(31):E4494-503. doi: 10.1073/pnas.1608423113. Epub 2016 Jul 14.

27.

Myocardin-related transcription factors are required for skeletal muscle development.

Cenik BK, Liu N, Chen B, Bezprozvannaya S, Olson EN, Bassel-Duby R.

Development. 2016 Aug 1;143(15):2853-61. doi: 10.1242/dev.135855. Epub 2016 Jul 6.

28.

LATS-YAP/TAZ controls lineage specification by regulating TGFβ signaling and Hnf4α expression during liver development.

Lee DH, Park JO, Kim TS, Kim SK, Kim TH, Kim MC, Park GS, Kim JH, Kuninaka S, Olson EN, Saya H, Kim SY, Lee H, Lim DS.

Nat Commun. 2016 Jun 30;7:11961. doi: 10.1038/ncomms11961.

29.

Hdac3 Interaction with p300 Histone Acetyltransferase Regulates the Oligodendrocyte and Astrocyte Lineage Fate Switch.

Zhang L, He X, Liu L, Jiang M, Zhao C, Wang H, He D, Zheng T, Zhou X, Hassan A, Ma Z, Xin M, Sun Z, Lazar MA, Goldman SA, Olson EN, Richard Lu Q.

Dev Cell. 2016 Jun 20;37(6):582. doi: 10.1016/j.devcel.2016.06.004. No abstract available.

30.

Pitx2 promotes heart repair by activating the antioxidant response after cardiac injury.

Tao G, Kahr PC, Morikawa Y, Zhang M, Rahmani M, Heallen TR, Li L, Sun Z, Olson EN, Amendt BA, Martin JF.

Nature. 2016 Jun 2;534(7605):119-23. doi: 10.1038/nature17959. Epub 2016 May 25.

31.

Mutations in the Histone Modifier PRDM6 Are Associated with Isolated Nonsyndromic Patent Ductus Arteriosus.

Li N, Subrahmanyan L, Smith E, Yu X, Zaidi S, Choi M, Mane S, Nelson-Williams C, Behjati M, Kazemi M, Hashemi M, Fathzadeh M, Narayanan A, Tian L, Montazeri F, Mani M, Begleiter ML, Coon BG, Lynch HT, Olson EN, Zhao H, Ruland J, Lifton RP, Mani A.

Am J Hum Genet. 2016 Jun 2;98(6):1082-1091. doi: 10.1016/j.ajhg.2016.03.022. Epub 2016 May 12. Erratum in: Am J Hum Genet. 2016 Oct 6;99(4):1000.

32.

Hippo Signaling Mediators Yap and Taz Are Required in the Epicardium for Coronary Vasculature Development.

Singh A, Ramesh S, Cibi DM, Yun LS, Li J, Li L, Manderfield LJ, Olson EN, Epstein JA, Singh MK.

Cell Rep. 2016 May 17;15(7):1384-1393. doi: 10.1016/j.celrep.2016.04.027. Epub 2016 May 5.

33.

Bone and Muscle Endocrine Functions: Unexpected Paradigms of Inter-organ Communication.

Karsenty G, Olson EN.

Cell. 2016 Mar 10;164(6):1248-1256. doi: 10.1016/j.cell.2016.02.043. Review.

34.

Hypothalamic leptin action is mediated by histone deacetylase 5.

Kabra DG, Pfuhlmann K, García-Cáceres C, Schriever SC, Casquero García V, Kebede AF, Fuente-Martin E, Trivedi C, Heppner K, Uhlenhaut NH, Legutko B, Kabra UD, Gao Y, Yi CX, Quarta C, Clemmensen C, Finan B, Müller TD, Meyer CW, Paez-Pereda M, Stemmer K, Woods SC, Perez-Tilve D, Schneider R, Olson EN, Tschöp MH, Pfluger PT.

Nat Commun. 2016 Feb 29;7:10782. doi: 10.1038/ncomms10782.

35.

A MED13-dependent skeletal muscle gene program controls systemic glucose homeostasis and hepatic metabolism.

Amoasii L, Holland W, Sanchez-Ortiz E, Baskin KK, Pearson M, Burgess SC, Nelson BR, Bassel-Duby R, Olson EN.

Genes Dev. 2016 Feb 15;30(4):434-46. doi: 10.1101/gad.273128.115.

36.

Hdac3 Interaction with p300 Histone Acetyltransferase Regulates the Oligodendrocyte and Astrocyte Lineage Fate Switch.

Zhang L, He X, Liu L, Jiang M, Zhao C, Wang H, He D, Zheng T, Zhou X, Hassan A, Ma Z, Xin M, Sun Z, Lazar MA, Goldman SA, Olson EN, Lu QR.

Dev Cell. 2016 Feb 8;36(3):316-30. doi: 10.1016/j.devcel.2016.01.002.

37.

Structure-function analysis of myomaker domains required for myoblast fusion.

Millay DP, Gamage DG, Quinn ME, Min YL, Mitani Y, Bassel-Duby R, Olson EN.

Proc Natl Acad Sci U S A. 2016 Feb 23;113(8):2116-21. doi: 10.1073/pnas.1600101113. Epub 2016 Feb 8.

38.

A peptide encoded by a transcript annotated as long noncoding RNA enhances SERCA activity in muscle.

Nelson BR, Makarewich CA, Anderson DM, Winders BR, Troupes CD, Wu F, Reese AL, McAnally JR, Chen X, Kavalali ET, Cannon SC, Houser SR, Bassel-Duby R, Olson EN.

Science. 2016 Jan 15;351(6270):271-5. doi: 10.1126/science.aad4076.

39.

Postnatal genome editing partially restores dystrophin expression in a mouse model of muscular dystrophy.

Long C, Amoasii L, Mireault AA, McAnally JR, Li H, Sanchez-Ortiz E, Bhattacharyya S, Shelton JM, Bassel-Duby R, Olson EN.

Science. 2016 Jan 22;351(6271):400-3. doi: 10.1126/science.aad5725. Epub 2015 Dec 31.

40.

A mouse model for adult cardiac-specific gene deletion with CRISPR/Cas9.

Carroll KJ, Makarewich CA, McAnally J, Anderson DM, Zentilin L, Liu N, Giacca M, Bassel-Duby R, Olson EN.

Proc Natl Acad Sci U S A. 2016 Jan 12;113(2):338-43. doi: 10.1073/pnas.1523918113. Epub 2015 Dec 30.

41.

Yap and Taz play a crucial role in neural crest-derived craniofacial development.

Wang J, Xiao Y, Hsu CW, Martinez-Traverso IM, Zhang M, Bai Y, Ishii M, Maxson RE, Olson EN, Dickinson ME, Wythe JD, Martin JF.

Development. 2016 Feb 1;143(3):504-15. doi: 10.1242/dev.126920. Epub 2015 Dec 30.

42.

Myocardin-related transcription factors are required for cardiac development and function.

Mokalled MH, Carroll KJ, Cenik BK, Chen B, Liu N, Olson EN, Bassel-Duby R.

Dev Biol. 2015 Oct 15;406(2):109-16. doi: 10.1016/j.ydbio.2015.09.006. Epub 2015 Sep 16.

43.

Overexpression and knockout of miR-126 both promote leukemogenesis.

Li Z, Chen P, Su R, Li Y, Hu C, Wang Y, Arnovitz S, He M, Gurbuxani S, Zuo Z, Elkahloun AG, Li S, Weng H, Huang H, Neilly MB, Wang S, Olson EN, Larson RA, Le Beau MM, Zhang J, Jiang X, Wei M, Jin J, Liu PP, Chen J.

Blood. 2015 Oct 22;126(17):2005-15. doi: 10.1182/blood-2015-04-639062. Epub 2015 Sep 11.

44.

Akt1/protein kinase B enhances transcriptional reprogramming of fibroblasts to functional cardiomyocytes.

Zhou H, Dickson ME, Kim MS, Bassel-Duby R, Olson EN.

Proc Natl Acad Sci U S A. 2015 Sep 22;112(38):11864-9. doi: 10.1073/pnas.1516237112. Epub 2015 Sep 9.

45.

C-terminal variable AGES domain of Thymosin β4: the molecule's primary contribution in support of post-ischemic cardiac function and repair.

Hinkel R, Ball HL, DiMaio JM, Shrivastava S, Thatcher JE, Singh AN, Sun X, Faskerti G, Olson EN, Kupatt C, Bock-Marquette I.

J Mol Cell Cardiol. 2015 Oct;87:113-25. doi: 10.1016/j.yjmcc.2015.07.004. Epub 2015 Aug 5.

PMID:
26255251
46.

Hippo signaling is required for Notch-dependent smooth muscle differentiation of neural crest.

Manderfield LJ, Aghajanian H, Engleka KA, Lim LY, Liu F, Jain R, Li L, Olson EN, Epstein JA.

Development. 2015 Sep 1;142(17):2962-71. doi: 10.1242/dev.125807. Epub 2015 Aug 7.

47.

Endothelial depletion of murine SRF/MRTF provokes intracerebral hemorrhagic stroke.

Weinl C, Castaneda Vega S, Riehle H, Stritt C, Calaminus C, Wolburg H, Mauel S, Breithaupt A, Gruber AD, Wasylyk B, Olson EN, Adams RH, Pichler BJ, Nordheim A.

Proc Natl Acad Sci U S A. 2015 Aug 11;112(32):9914-9. doi: 10.1073/pnas.1509047112. Epub 2015 Jul 28.

48.

Angiotensin II Induces Skeletal Muscle Atrophy by Activating TFEB-Mediated MuRF1 Expression.

Du Bois P, Pablo Tortola C, Lodka D, Kny M, Schmidt F, Song K, Schmidt S, Bassel-Duby R, Olson EN, Fielitz J.

Circ Res. 2015 Aug 14;117(5):424-36. doi: 10.1161/CIRCRESAHA.114.305393. Epub 2015 Jul 2.

49.

hnRNP U protein is required for normal pre-mRNA splicing and postnatal heart development and function.

Ye J, Beetz N, O'Keeffe S, Tapia JC, Macpherson L, Chen WV, Bassel-Duby R, Olson EN, Maniatis T.

Proc Natl Acad Sci U S A. 2015 Jun 9;112(23):E3020-9. doi: 10.1073/pnas.1508461112. Epub 2015 May 26.

50.

Severe myopathy in mice lacking the MEF2/SRF-dependent gene leiomodin-3.

Cenik BK, Garg A, McAnally JR, Shelton JM, Richardson JA, Bassel-Duby R, Olson EN, Liu N.

J Clin Invest. 2015 Apr;125(4):1569-78. doi: 10.1172/JCI80115. Epub 2015 Mar 16.

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