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Items: 1 to 50 of 232

1.

Characterization of P-glycoprotein Humanized Mice Generated by Chromosome Engineering Technology: Its Utility for Prediction of Drug Distribution to the Brain in Humans.

Yamasaki Y, Kobayashi K, Okuya F, Kajitani N, Kazuki K, Abe S, Takehara S, Ito S, Ogata S, Uemura T, Ohtsuki S, Minegishi G, Akita H, Chiba K, Oshimura M, Kazuki Y.

Drug Metab Dispos. 2018 May 18. pii: dmd.118.081216. doi: 10.1124/dmd.118.081216. [Epub ahead of print]

PMID:
29777024
2.

Gene therapy for Glut1-deficient mouse using an adeno-associated virus vector with the human intrinsic GLUT1 promoter.

Nakamura S, Muramatsu SI, Takino N, Ito M, Jimbo EF, Shimazaki K, Onaka T, Ohtsuki S, Terasaki T, Yamagata T, Osaka H.

J Gene Med. 2018 Apr;20(4):e3013. doi: 10.1002/jgm.3013. Epub 2018 Apr 6.

PMID:
29624790
3.

Identification of blood biomarkers in glioblastoma by SWATH mass spectrometry and quantitative targeted absolute proteomics.

Miyauchi E, Furuta T, Ohtsuki S, Tachikawa M, Uchida Y, Sabit H, Obuchi W, Baba T, Watanabe M, Terasaki T, Nakada M.

PLoS One. 2018 Mar 7;13(3):e0193799. doi: 10.1371/journal.pone.0193799. eCollection 2018.

4.

Impact of Cardiac Progenitor Cells on Heart Failure and Survival in Single Ventricle Congenital Heart Disease.

Sano T, Ousaka D, Goto T, Ishigami S, Hirai K, Kasahara S, Ohtsuki S, Sano S, Oh H.

Circ Res. 2018 Mar 30;122(7):994-1005. doi: 10.1161/CIRCRESAHA.117.312311. Epub 2018 Jan 24.

PMID:
29367212
5.

Reduction in hepatic secondary bile acids caused by short-term antibiotic-induced dysbiosis decreases mouse serum glucose and triglyceride levels.

Kuno T, Hirayama-Kurogi M, Ito S, Ohtsuki S.

Sci Rep. 2018 Jan 19;8(1):1253. doi: 10.1038/s41598-018-19545-1.

6.

ATP-Binding Cassette Transporter A Subfamily 8 Is a Sinusoidal Efflux Transporter for Cholesterol and Taurocholate in Mouse and Human Liver.

Sasaki K, Tachikawa M, Uchida Y, Hirano S, Kadowaki F, Watanabe M, Ohtsuki S, Terasaki T.

Mol Pharm. 2018 Feb 5;15(2):343-355. doi: 10.1021/acs.molpharmaceut.7b00679. Epub 2018 Jan 24.

PMID:
29300488
7.

Formation of the Periotic Space During the Early Fetal Period in Humans.

Ishikawa A, Ohtsuki S, Yamada S, Uwabe C, Imai H, Matsuda T, Takakuwa T.

Anat Rec (Hoboken). 2018 Apr;301(4):563-570. doi: 10.1002/ar.23764. Epub 2018 Jan 18.

PMID:
29293291
8.

Morphogenesis of the Middle Ear during Fetal Development as Observed Via Magnetic Resonance Imaging.

Ohtsuki S, Ishikawa A, Yamada S, Imai H, Matsuda T, Takakuwa T.

Anat Rec (Hoboken). 2018 May;301(5):757-764. doi: 10.1002/ar.23760. Epub 2018 Jan 23.

PMID:
29266805
9.

Transcoronary cell infusion with the stop-flow technique in children with single-ventricle physiology.

Eitoku T, Baba K, Kondou M, Kurita Y, Fukushima Y, Hirai K, Ohtsuki S, Ishigami S, Sano S, Oh H.

Pediatr Int. 2018 Mar;60(3):240-246. doi: 10.1111/ped.13485.

PMID:
29266671
10.

High Expression of UGT1A1/1A6 in Monkey Small Intestine: Comparison of Protein Expression Levels of Cytochromes P450, UDP-Glucuronosyltransferases, and Transporters in Small Intestine of Cynomolgus Monkey and Human.

Akazawa T, Uchida Y, Miyauchi E, Tachikawa M, Ohtsuki S, Terasaki T.

Mol Pharm. 2018 Jan 2;15(1):127-140. doi: 10.1021/acs.molpharmaceut.7b00772. Epub 2017 Dec 5.

PMID:
29140712
11.

Reconstruction of Toll-like receptor 9-mediated responses in HEK-Blue hTLR9 cells by transfection of human macrophage scavenger receptor 1 gene.

Ohtsuki S, Takahashi Y, Inoue T, Takakura Y, Nishikawa M.

Sci Rep. 2017 Oct 20;7(1):13661. doi: 10.1038/s41598-017-13890-3.

12.

A simplified and sensitive method to identify Alzheimer's disease biomarker candidates using patient-derived induced pluripotent stem cells (iPSCs).

Shirotani K, Matsuo K, Ohtsuki S, Masuda T, Asai M, Kutoku Y, Ohsawa Y, Sunada Y, Kondo T, Inoue H, Iwata N.

J Biochem. 2017 Dec 1;162(6):391-394. doi: 10.1093/jb/mvx058.

PMID:
28992104
13.

DNA nanotechnology-based composite-type gold nanoparticle-immunostimulatory DNA hydrogel for tumor photothermal immunotherapy.

Yata T, Takahashi Y, Tan M, Nakatsuji H, Ohtsuki S, Murakami T, Imahori H, Umeki Y, Shiomi T, Takakura Y, Nishikawa M.

Biomaterials. 2017 Nov;146:136-145. doi: 10.1016/j.biomaterials.2017.09.014. Epub 2017 Sep 9.

PMID:
28918263
14.

Multi-laboratory assessment of reproducibility, qualitative and quantitative performance of SWATH-mass spectrometry.

Collins BC, Hunter CL, Liu Y, Schilling B, Rosenberger G, Bader SL, Chan DW, Gibson BW, Gingras AC, Held JM, Hirayama-Kurogi M, Hou G, Krisp C, Larsen B, Lin L, Liu S, Molloy MP, Moritz RL, Ohtsuki S, Schlapbach R, Selevsek N, Thomas SN, Tzeng SC, Zhang H, Aebersold R.

Nat Commun. 2017 Aug 21;8(1):291. doi: 10.1038/s41467-017-00249-5.

15.

Combining Genomics To Identify the Pathways of Post-Transcriptional Nongenotoxic Signaling and Energy Homeostasis in Livers of Rats Treated with the Pregnane X Receptor Agonist, Pregnenolone Carbonitrile.

Nagahori H, Nakamura K, Sumida K, Ito S, Ohtsuki S.

J Proteome Res. 2017 Oct 6;16(10):3634-3645. doi: 10.1021/acs.jproteome.7b00364. Epub 2017 Sep 6.

PMID:
28825834
16.

Elucidation of the Mechanism of Increased Activity of Immunostimulatory DNA by the Formation of Polypod-like Structure.

Mohri K, Nagata K, Ohtsuki S, Toyama S, Nonomura M, Takahashi Y, Takakura Y, Nishikawa M, Sakuma S.

Pharm Res. 2017 Nov;34(11):2362-2370. doi: 10.1007/s11095-017-2243-y. Epub 2017 Aug 8.

PMID:
28791533
17.

Identification of cyclic peptides for facilitation of transcellular transport of phages across intestinal epithelium in vitro and in vivo.

Yamaguchi S, Ito S, Kurogi-Hirayama M, Ohtsuki S.

J Control Release. 2017 Sep 28;262:232-238. doi: 10.1016/j.jconrel.2017.07.037. Epub 2017 Jul 27.

PMID:
28757359
18.

Regulation of Tight-Junction Integrity by Insulin in an In Vitro Model of Human Blood-Brain Barrier.

Ito S, Yanai M, Yamaguchi S, Couraud PO, Ohtsuki S.

J Pharm Sci. 2017 Sep;106(9):2599-2605. doi: 10.1016/j.xphs.2017.04.036. Epub 2017 Apr 26.

PMID:
28456720
19.

Scrambled Internal Standard Method for High-Throughput Protein Quantification by Matrix-Assisted Laser Desorption Ionization Tandem Mass Spectrometry.

Yoneyama T, Ohtsuki S, Tachikawa M, Uchida Y, Terasaki T.

J Proteome Res. 2017 Apr 7;16(4):1556-1565. doi: 10.1021/acs.jproteome.6b00941. Epub 2017 Mar 28.

PMID:
28317378
20.

Application of Quantitative Targeted Absolute Proteomics to Profile Protein Expression Changes of Hepatic Transporters and Metabolizing Enzymes During Cholic Acid-Promoted Liver Regeneration.

Miura T, Tachikawa M, Ohtsuka H, Fukase K, Nakayama S, Sakata N, Motoi F, Naitoh T, Katayose Y, Uchida Y, Ohtsuki S, Terasaki T, Unno M.

J Pharm Sci. 2017 Sep;106(9):2499-2508. doi: 10.1016/j.xphs.2017.02.018. Epub 2017 Feb 27.

PMID:
28249806
21.

All-trans retinoic acid enhances gemcitabine cytotoxicity in human pancreatic cancer cell line AsPC-1 by up-regulating protein expression of deoxycytidine kinase.

Kuroda H, Tachikawa M, Uchida Y, Inoue K, Ohtsuka H, Ohtsuki S, Unno M, Terasaki T.

Eur J Pharm Sci. 2017 May 30;103:116-121. doi: 10.1016/j.ejps.2017.02.021. Epub 2017 Feb 12.

PMID:
28215943
22.

Downregulation of GNA13-ERK network in prefrontal cortex of schizophrenia brain identified by combined focused and targeted quantitative proteomics.

Hirayama-Kurogi M, Takizawa Y, Kunii Y, Matsumoto J, Wada A, Hino M, Akatsu H, Hashizume Y, Yamamoto S, Kondo T, Ito S, Tachikawa M, Niwa SI, Yabe H, Terasaki T, Setou M, Ohtsuki S.

J Proteomics. 2017 Mar 31;158:31-42. doi: 10.1016/j.jprot.2017.02.009. Epub 2017 Feb 16.

PMID:
28214564
23.

[A Case of a-Fetoprotein Producing Gastric Cancer with Lymph Node Recurrence after Endoscopic Submucosal Dissection].

Gokita K, Inokuchi M, Ohtsuki S, Tanioka T, Okuno K, Tomii C, Murase H, Kojima K.

Gan To Kagaku Ryoho. 2016 Nov;43(12):1872-1874. Japanese.

PMID:
28133160
24.

Gene therapy for a mouse model of glucose transporter-1 deficiency syndrome.

Nakamura S, Osaka H, Muramatsu SI, Takino N, Ito M, Aoki S, Jimbo EF, Shimazaki K, Onaka T, Ohtsuki S, Terasaki T, Yamagata T.

Mol Genet Metab Rep. 2017 Jan 15;10:67-74. doi: 10.1016/j.ymgmr.2016.12.008. eCollection 2017 Mar.

25.

Actin filament-associated protein 1 (AFAP-1) is a key mediator in inflammatory signaling-induced rapid attenuation of intrinsic P-gp function in human brain capillary endothelial cells.

Hoshi Y, Uchida Y, Tachikawa M, Ohtsuki S, Terasaki T.

J Neurochem. 2017 Apr;141(2):247-262. doi: 10.1111/jnc.13960. Epub 2017 Mar 6.

26.

Intracoronary Cardiac Progenitor Cells in Single Ventricle Physiology: The PERSEUS (Cardiac Progenitor Cell Infusion to Treat Univentricular Heart Disease) Randomized Phase 2 Trial.

Ishigami S, Ohtsuki S, Eitoku T, Ousaka D, Kondo M, Kurita Y, Hirai K, Fukushima Y, Baba K, Goto T, Horio N, Kobayashi J, Kuroko Y, Kotani Y, Arai S, Iwasaki T, Sato S, Kasahara S, Sano S, Oh H.

Circ Res. 2017 Mar 31;120(7):1162-1173. doi: 10.1161/CIRCRESAHA.116.310253. Epub 2017 Jan 4.

27.

Abnormal N-Glycosylation of a Novel Missense Creatine Transporter Mutant, G561R, Associated with Cerebral Creatine Deficiency Syndromes Alters Transporter Activity and Localization.

Uemura T, Ito S, Ohta Y, Tachikawa M, Wada T, Terasaki T, Ohtsuki S.

Biol Pharm Bull. 2017;40(1):49-55. doi: 10.1248/bpb.b16-00582.

28.

The blood-brain barrier fatty acid transport protein 1 (FATP1/SLC27A1) supplies docosahexaenoic acid to the brain, and insulin facilitates transport.

Ochiai Y, Uchida Y, Ohtsuki S, Tachikawa M, Aizawa S, Terasaki T.

J Neurochem. 2017 May;141(3):400-412. doi: 10.1111/jnc.13943. Epub 2017 Mar 30.

29.

Identification of IGFBP2 and IGFBP3 As Compensatory Biomarkers for CA19-9 in Early-Stage Pancreatic Cancer Using a Combination of Antibody-Based and LC-MS/MS-Based Proteomics.

Yoneyama T, Ohtsuki S, Honda K, Kobayashi M, Iwasaki M, Uchida Y, Okusaka T, Nakamori S, Shimahara M, Ueno T, Tsuchida A, Sata N, Ioka T, Yasunami Y, Kosuge T, Kaneda T, Kato T, Yagihara K, Fujita S, Huang W, Yamada T, Tachikawa M, Terasaki T.

PLoS One. 2016 Aug 31;11(8):e0161009. doi: 10.1371/journal.pone.0161009. eCollection 2016.

30.

Effect of Intestinal Flora on Protein Expression of Drug-Metabolizing Enzymes and Transporters in the Liver and Kidney of Germ-Free and Antibiotics-Treated Mice.

Kuno T, Hirayama-Kurogi M, Ito S, Ohtsuki S.

Mol Pharm. 2016 Aug 1;13(8):2691-701. doi: 10.1021/acs.molpharmaceut.6b00259. Epub 2016 Jul 20.

PMID:
27376980
31.

Quantitative Targeted Absolute Proteomics of Transporters and Pharmacoproteomics-Based Reconstruction of P-Glycoprotein Function in Mouse Small Intestine.

Akazawa T, Uchida Y, Tachikawa M, Ohtsuki S, Terasaki T.

Mol Pharm. 2016 Jul 5;13(7):2443-56. doi: 10.1021/acs.molpharmaceut.6b00196. Epub 2016 Jun 17.

PMID:
27276518
32.

Large-scale multiplex absolute protein quantification of drug-metabolizing enzymes and transporters in human intestine, liver, and kidney microsomes by SWATH-MS: Comparison with MRM/SRM and HR-MRM/PRM.

Nakamura K, Hirayama-Kurogi M, Ito S, Kuno T, Yoneyama T, Obuchi W, Terasaki T, Ohtsuki S.

Proteomics. 2016 Aug;16(15-16):2106-17. doi: 10.1002/pmic.201500433. Epub 2016 Jul 8.

PMID:
27197958
33.

Quantitative Targeted Absolute Proteomics for 28 Transporters in Brush-Border and Basolateral Membrane Fractions of Rat Kidney.

Uchida Y, Toyohara T, Ohtsuki S, Moriyama Y, Abe T, Terasaki T.

J Pharm Sci. 2016 Feb;105(2):1011-1016. doi: 10.1002/jps.24645. Epub 2016 Jan 11.

PMID:
26367854
34.

Self-assembling DNA hydrogel-based delivery of immunoinhibitory nucleic acids to immune cells.

Nishida Y, Ohtsuki S, Araie Y, Umeki Y, Endo M, Emura T, Hidaka K, Sugiyama H, Takahashi Y, Takakura Y, Nishikawa M.

Nanomedicine. 2016 Jan;12(1):123-30. doi: 10.1016/j.nano.2015.08.004. Epub 2015 Sep 11.

PMID:
26364795
35.

Quantitative Targeted Proteomics of Pancreatic Cancer: Deoxycytidine Kinase Protein Level Correlates to Progression-Free Survival of Patients Receiving Gemcitabine Treatment.

Ohmine K, Kawaguchi K, Ohtsuki S, Motoi F, Ohtsuka H, Kamiie J, Abe T, Unno M, Terasaki T.

Mol Pharm. 2015 Sep 8;12(9):3282-91. doi: 10.1021/acs.molpharmaceut.5b00282. Epub 2015 Aug 25.

PMID:
26280109
36.

Transcoronary infusion of cardiac progenitor cells in hypoplastic left heart syndrome: Three-year follow-up of the Transcoronary Infusion of Cardiac Progenitor Cells in Patients With Single-Ventricle Physiology (TICAP) trial.

Tarui S, Ishigami S, Ousaka D, Kasahara S, Ohtsuki S, Sano S, Oh H.

J Thorac Cardiovasc Surg. 2015 Nov;150(5):1198-1207, 1208.e1-2. doi: 10.1016/j.jtcvs.2015.06.076. Epub 2015 Jul 8.

37.

Optimal Arrangement of Four Short DNA Strands for Delivery of Immunostimulatory Nucleic Acids to Immune Cells.

Ohtsuki S, Matsuzaki N, Mohri K, Endo M, Emura T, Hidaka K, Sugiyama H, Takahashi Y, Ishiyama K, Kadowaki N, Takakura Y, Nishikawa M.

Nucleic Acid Ther. 2015 Oct;25(5):245-53. doi: 10.1089/nat.2014.0524. Epub 2015 Jul 29.

PMID:
26222130
38.

Design and synthesis of a novel pre-column derivatization reagent with a 6-methoxy-4-quinolone moiety for fluorescence and tandem mass spectrometric detection and its application to chiral amino acid analysis.

Oyama T, Negishi E, Onigahara H, Kusano N, Miyoshi Y, Mita M, Nakazono M, Ohtsuki S, Ojida A, Lindner W, Hamase K.

J Pharm Biomed Anal. 2015 Dec 10;116:71-9. doi: 10.1016/j.jpba.2015.05.039. Epub 2015 Jun 17.

PMID:
26166005
39.

Left Ventricular Myxoma Occluding the Suprarenal Abdominal Aorta in an Infant.

Kawabata T, Kasahara S, Ohtsuki S, Kuroko Y, Kotani Y, Fujii Y, Yoshizumi K, Arai S, Sano S.

Ann Thorac Surg. 2015 Jul;100(1):309-11. doi: 10.1016/j.athoracsur.2014.08.066.

PMID:
26140776
40.

Preoperative administration of polysaccharide Kureha and reduced plasma transforming growth factor-╬▓ in patients with advanced gastric cancer: A randomized clinical trial.

Yamashita K, Sakuramoto S, Mieno H, Nemoto M, Shibata T, Katada N, Ohtsuki S, Sakamoto Y, Hoshi K, Wang G, Hemmi O, Satoh T, Kikuchi S, Watanabe M.

Mol Clin Oncol. 2015 May;3(3):471-478. Epub 2015 Jan 19.

41.

Major involvement of Na(+) -dependent multivitamin transporter (SLC5A6/SMVT) in uptake of biotin and pantothenic acid by human brain capillary endothelial cells.

Uchida Y, Ito K, Ohtsuki S, Kubo Y, Suzuki T, Terasaki T.

J Neurochem. 2015 Jul;134(1):97-112. doi: 10.1111/jnc.13092. Epub 2015 Apr 8.

42.

Self-assembling DNA dendrimer for effective delivery of immunostimulatory CpG DNA to immune cells.

Mohri K, Kusuki E, Ohtsuki S, Takahashi N, Endo M, Hidaka K, Sugiyama H, Takahashi Y, Takakura Y, Nishikawa M.

Biomacromolecules. 2015 Apr 13;16(4):1095-101. doi: 10.1021/bm501731f. Epub 2015 Mar 27.

PMID:
25775113
43.

Quantitative targeted absolute proteomics for 28 human transporters in plasma membrane of Caco-2 cell monolayer cultured for 2, 3, and 4 weeks.

Uchida Y, Ohtsuki S, Kamiie J, Ohmine K, Iwase R, Terasaki T.

Drug Metab Pharmacokinet. 2015 Apr;30(2):205-8. doi: 10.1016/j.dmpk.2014.11.002. Epub 2014 Dec 5.

PMID:
25770030
44.
45.

Contribution of pannexin 1 and connexin 43 hemichannels to extracellular calcium-dependent transport dynamics in human blood-brain barrier endothelial cells.

Kaneko Y, Tachikawa M, Akaogi R, Fujimoto K, Ishibashi M, Uchida Y, Couraud PO, Ohtsuki S, Hosoya K, Terasaki T.

J Pharmacol Exp Ther. 2015 Apr;353(1):192-200. doi: 10.1124/jpet.114.220210. Epub 2015 Feb 10.

46.

Intracoronary autologous cardiac progenitor cell transfer in patients with hypoplastic left heart syndrome: the TICAP prospective phase 1 controlled trial.

Ishigami S, Ohtsuki S, Tarui S, Ousaka D, Eitoku T, Kondo M, Okuyama M, Kobayashi J, Baba K, Arai S, Kawabata T, Yoshizumi K, Tateishi A, Kuroko Y, Iwasaki T, Sato S, Kasahara S, Sano S, Oh H.

Circ Res. 2015 Feb 13;116(4):653-64. doi: 10.1161/CIRCRESAHA.116.304671. Epub 2014 Nov 17.

47.

Effect of the addition of rice straw on microbial community in a sewage sludge digester.

Nakakihara E, Ikemoto-Yamamoto R, Honda R, Ohtsuki S, Takano M, Suetsugu Y, Watanabe H.

Water Sci Technol. 2014;70(5):819-27. doi: 10.2166/wst.2014.261.

PMID:
25225928
49.

Blood-brain barrier pharmacoproteomics-based reconstruction of the in vivo brain distribution of P-glycoprotein substrates in cynomolgus monkeys.

Uchida Y, Wakayama K, Ohtsuki S, Chiba M, Ohe T, Ishii Y, Terasaki T.

J Pharmacol Exp Ther. 2014 Sep;350(3):578-88. doi: 10.1124/jpet.114.214536. Epub 2014 Jun 19.

50.

Mutations of NOTCH3 in childhood pulmonary arterial hypertension.

Chida A, Shintani M, Matsushita Y, Sato H, Eitoku T, Nakayama T, Furutani Y, Hayama E, Kawamura Y, Inai K, Ohtsuki S, Saji T, Nonoyama S, Nakanishi T.

Mol Genet Genomic Med. 2014 May;2(3):229-39. doi: 10.1002/mgg3.58. Epub 2014 Apr 1.

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