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Sci Immunol. 2016 Jul 29;1(1):aag0851. doi: 10.1126/sciimmunol.aag0851. Epub 2016 Jul 29.

Immune perturbations in HIV-1-infected individuals who make broadly neutralizing antibodies.

Author information

1
Duke University Human Vaccine Institute, Duke University School of Medicine, Durham, NC 27710, USA. hayne002@mc.duke.edu moody007@mc.duke.edu persephone.borrow@ndm.ox.ac.uk.
2
Department of Immunology, Duke University School of Medicine, Durham, NC 27710, USA.
3
Department of Pediatrics, Duke University School of Medicine, Durham, NC 27710, USA.
4
Nuffield Department of Clinical Medicine, University of Oxford, Oxford OX3 7FZ, UK.
5
Duke University Human Vaccine Institute, Duke University School of Medicine, Durham, NC 27710, USA.
6
Department of Medicine, Duke University School of Medicine, Durham, NC 27710, USA.
7
University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
8
Department of Surgery, Duke University School of Medicine, Durham, NC 27710, USA.
9
Department of Pathology, Duke University School of Medicine, Durham, NC 27710, USA.
10
Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20814, USA.
11
Institute for Genomic Medicine, Columbia University, New York, NY 10032, USA.
12
Nuffield Department of Clinical Medicine, University of Oxford, Oxford OX3 7FZ, UK. hayne002@mc.duke.edu moody007@mc.duke.edu persephone.borrow@ndm.ox.ac.uk.

Abstract

Induction of broadly neutralizing antibodies (bnAbs) is a goal of HIV-1 vaccine development. bnAbs occur in some HIV-1-infected individuals and frequently have characteristics of autoantibodies. We have studied cohorts of HIV-1-infected individuals who made bnAbs and compared them with those who did not do so, and determined immune traits associated with the ability to produce bnAbs. HIV-1-infected individuals with bnAbs had a higher frequency of blood autoantibodies, a lower frequency of regulatory CD4+ T cells, a higher frequency of circulating memory T follicular helper CD4+ cells, and a higher T regulatory cell level of programmed cell death-1 expression compared with HIV-1-infected individuals without bnAbs. Thus, induction of HIV-1 bnAbs may require vaccination regimens that transiently mimic immunologic perturbations in HIV-1-infected individuals.

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