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Items: 1 to 50 of 321

1.

A Role for the Krebs Cycle Intermediate Citrate in Metabolic Reprogramming in Innate Immunity and Inflammation.

Williams NC, O'Neill LAJ.

Front Immunol. 2018 Feb 5;9:141. doi: 10.3389/fimmu.2018.00141. eCollection 2018. Review.

PMID:
29459863
2.

Canakinumab for Atherosclerotic Disease.

O'Neill LA, Cooper MA.

N Engl J Med. 2018 Jan 11;378(2):198-9. doi: 10.1056/NEJMc1714635. No abstract available.

PMID:
29322757
3.

GSTO1-1 plays a pro-inflammatory role in models of inflammation, colitis and obesity.

Menon D, Innes A, Oakley AJ, Dahlstrom JE, Jensen LM, Brüstle A, Tummala P, Rooke M, Casarotto MG, Baell JB, Nguyen N, Xie Y, Cuellar M, Strasser J, Dahlin JL, Walters MA, Burgio G, O'Neill LAJ, Board PG.

Sci Rep. 2017 Dec 19;7(1):17832. doi: 10.1038/s41598-017-17861-6.

4.

Metabolic regulation of NLRP3.

Hughes MM, O'Neill LAJ.

Immunol Rev. 2018 Jan;281(1):88-98. doi: 10.1111/imr.12608. Review.

PMID:
29247992
5.

Loss of the molecular clock in myeloid cells exacerbates T cell-mediated CNS autoimmune disease.

Sutton CE, Finlay CM, Raverdeau M, Early JO, DeCourcey J, Zaslona Z, O'Neill LAJ, Mills KHG, Curtis AM.

Nat Commun. 2017 Dec 12;8(1):1923. doi: 10.1038/s41467-017-02111-0.

6.

GOTcha: lncRNA-ACOD1 targets metabolism during viral infection.

Runtsch MC, O'Neill LA.

Cell Res. 2017 Dec 1. doi: 10.1038/cr.2017.153. [Epub ahead of print]

PMID:
29192676
7.

Pyruvate Kinase M2 Is Required for the Expression of the Immune Checkpoint PD-L1 in Immune Cells and Tumors.

Palsson-McDermott EM, Dyck L, Zasłona Z, Menon D, McGettrick AF, Mills KHG, O'Neill LA.

Front Immunol. 2017 Oct 13;8:1300. doi: 10.3389/fimmu.2017.01300. eCollection 2017.

8.

Long-lived tissue resident HIV-1 specific memory CD8+ T cells are generated by skin immunization with live virus vectored microneedle arrays.

Zaric M, Becker PD, Hervouet C, Kalcheva P, Ibarzo Yus B, Cocita C, O'Neill LA, Kwon SY, Klavinskis LS.

J Control Release. 2017 Dec 28;268:166-175. doi: 10.1016/j.jconrel.2017.10.026. Epub 2017 Oct 19.

9.

Specific inhibition of NLRP3 in chikungunya disease reveals a role for inflammasomes in alphavirus-induced inflammation.

Chen W, Foo SS, Zaid A, Teng TS, Herrero LJ, Wolf S, Tharmarajah K, Vu LD, van Vreden C, Taylor A, Freitas JR, Li RW, Woodruff TM, Gordon R, Ojcius DM, Nakaya HI, Kanneganti TD, O'Neill LAJ, Robertson AAB, King NJ, Suhrbier A, Cooper MA, Ng LFP, Mahalingam S.

Nat Microbiol. 2017 Oct;2(10):1435-1445. doi: 10.1038/s41564-017-0015-4. Epub 2017 Aug 28.

PMID:
28848230
10.

Solution structure of the TLR adaptor MAL/TIRAP reveals an intact BB loop and supports MAL Cys91 glutathionylation for signaling.

Hughes MM, Lavrencic P, Coll RC, Ve T, Ryan DG, Williams NC, Menon D, Mansell A, Board PG, Mobli M, Kobe B, O'Neill LAJ.

Proc Natl Acad Sci U S A. 2017 Aug 8;114(32):E6480-E6489. doi: 10.1073/pnas.1701868114. Epub 2017 Jul 24.

11.

A guiding map for inflammation.

Netea MG, Balkwill F, Chonchol M, Cominelli F, Donath MY, Giamarellos-Bourboulis EJ, Golenbock D, Gresnigt MS, Heneka MT, Hoffman HM, Hotchkiss R, Joosten LAB, Kastner DL, Korte M, Latz E, Libby P, Mandrup-Poulsen T, Mantovani A, Mills KHG, Nowak KL, O'Neill LA, Pickkers P, van der Poll T, Ridker PM, Schalkwijk J, Schwartz DA, Siegmund B, Steer CJ, Tilg H, van der Meer JWM, van de Veerdonk FL, Dinarello CA.

Nat Immunol. 2017 Jul 19;18(8):826-831. doi: 10.1038/ni.3790.

PMID:
28722720
12.

Endosomal NOX2 oxidase exacerbates virus pathogenicity and is a target for antiviral therapy.

To EE, Vlahos R, Luong R, Halls ML, Reading PC, King PT, Chan C, Drummond GR, Sobey CG, Broughton BRS, Starkey MR, van der Sluis R, Lewin SR, Bozinovski S, O'Neill LAJ, Quach T, Porter CJH, Brooks DA, O'Leary JJ, Selemidis S.

Nat Commun. 2017 Jul 12;8(1):69. doi: 10.1038/s41467-017-00057-x.

13.

Krebs cycle rewired for macrophage and dendritic cell effector functions.

Ryan DG, O'Neill LAJ.

FEBS Lett. 2017 Oct;591(19):2992-3006. doi: 10.1002/1873-3468.12744. Epub 2017 Jul 26. Review.

PMID:
28685841
14.

MicroRNA-21 Limits Uptake of Listeria monocytogenes by Macrophages to Reduce the Intracellular Niche and Control Infection.

Johnston DGW, Kearney J, Zasłona Z, Williams MA, O'Neill LAJ, Corr SC.

Front Cell Infect Microbiol. 2017 May 23;7:201. doi: 10.3389/fcimb.2017.00201. eCollection 2017.

15.

The intracellular chloride channel proteins CLIC1 and CLIC4 induce IL-1β transcription and activate the NLRP3 inflammasome.

Domingo-Fernández R, Coll RC, Kearney J, Breit S, O'Neill LAJ.

J Biol Chem. 2017 Jul 21;292(29):12077-12087. doi: 10.1074/jbc.M117.797126. Epub 2017 Jun 2.

PMID:
28576828
16.

Myeloid-derived miR-223 regulates intestinal inflammation via repression of the NLRP3 inflammasome.

Neudecker V, Haneklaus M, Jensen O, Khailova L, Masterson JC, Tye H, Biette K, Jedlicka P, Brodsky KS, Gerich ME, Mack M, Robertson AAB, Cooper MA, Furuta GT, Dinarello CA, O'Neill LA, Eltzschig HK, Masters SL, McNamee EN.

J Exp Med. 2017 Jun 5;214(6):1737-1752. doi: 10.1084/jem.20160462. Epub 2017 May 9.

17.

Mitochondria are the powerhouses of immunity.

Mills EL, Kelly B, O'Neill LAJ.

Nat Immunol. 2017 Apr 18;18(5):488-498. doi: 10.1038/ni.3704. Review.

PMID:
28418387
18.

Macrophage Immunometabolism: Where Are We (Going)?

Van den Bossche J, O'Neill LA, Menon D.

Trends Immunol. 2017 Jun;38(6):395-406. doi: 10.1016/j.it.2017.03.001. Epub 2017 Apr 7. Review.

PMID:
28396078
19.

The circadian protein BMAL1 in myeloid cells is a negative regulator of allergic asthma.

Zasłona Z, Case S, Early JO, Lalor SJ, McLoughlin RM, Curtis AM, O'Neill LAJ.

Am J Physiol Lung Cell Mol Physiol. 2017 Jun 1;312(6):L855-L860. doi: 10.1152/ajplung.00072.2017. Epub 2017 Mar 23.

PMID:
28336811
20.

The RNA-binding protein Tristetraprolin (TTP) is a critical negative regulator of the NLRP3 inflammasome.

Haneklaus M, O'Neil JD, Clark AR, Masters SL, O'Neill LAJ.

J Biol Chem. 2017 Apr 28;292(17):6869-6881. doi: 10.1074/jbc.M116.772947. Epub 2017 Mar 16.

PMID:
28302726
21.

The Induction of Pro-IL-1β by Lipopolysaccharide Requires Endogenous Prostaglandin E2 Production.

Zasłona Z, Pålsson-McDermott EM, Menon D, Haneklaus M, Flis E, Prendeville H, Corcoran SE, Peters-Golden M, O'Neill LAJ.

J Immunol. 2017 May 1;198(9):3558-3564. doi: 10.4049/jimmunol.1602072. Epub 2017 Mar 15.

PMID:
28298525
22.

Role for NLRP3 Inflammasome-mediated, IL-1β-Dependent Responses in Severe, Steroid-Resistant Asthma.

Kim RY, Pinkerton JW, Essilfie AT, Robertson AAB, Baines KJ, Brown AC, Mayall JR, Ali MK, Starkey MR, Hansbro NG, Hirota JA, Wood LG, Simpson JL, Knight DA, Wark PA, Gibson PG, O'Neill LAJ, Cooper MA, Horvat JC, Hansbro PM.

Am J Respir Crit Care Med. 2017 Aug 1;196(3):283-297. doi: 10.1164/rccm.201609-1830OC.

PMID:
28252317
23.

The Hunger Games: Salmonella, Anorexia, and NLRP3.

O'Neill LAJ.

Cell Metab. 2017 Feb 7;25(2):225-226. doi: 10.1016/j.cmet.2017.01.015.

24.

Inflammasomes in the lung.

Pinkerton JW, Kim RY, Robertson AAB, Hirota JA, Wood LG, Knight DA, Cooper MA, O'Neill LAJ, Horvat JC, Hansbro PM.

Mol Immunol. 2017 Jun;86:44-55. doi: 10.1016/j.molimm.2017.01.014. Epub 2017 Jan 24. Review.

PMID:
28129896
25.

Glutathione and Glutathione Transferase Omega 1 as Key Posttranslational Regulators in Macrophages.

Hughes MM, McGettrick AF, O'Neill LA.

Microbiol Spectr. 2017 Jan;5(1). doi: 10.1128/microbiolspec.MCHD-0044-2016. Review.

PMID:
28102119
26.

Inhibiting the NLRP3 inflammasome with MCC950 promotes non-phlogistic clearance of amyloid-β and cognitive function in APP/PS1 mice.

Dempsey C, Rubio Araiz A, Bryson KJ, Finucane O, Larkin C, Mills EL, Robertson AAB, Cooper MA, O'Neill LAJ, Lynch MA.

Brain Behav Immun. 2017 Mar;61:306-316. doi: 10.1016/j.bbi.2016.12.014. Epub 2016 Dec 18.

PMID:
28003153
27.

Preface.

McGettrick AF, O'Neill LA.

Semin Immunol. 2016 Oct;28(5):395. doi: 10.1016/j.smim.2016.11.001. No abstract available.

PMID:
27938849
28.

Schlafen-1 causes a cell cycle arrest by inhibiting induction of cyclin D1.

Brady G, Boggan L, Bowie A, O'Neill LA.

J Biol Chem. 2016 Nov 25;291(48):25278. No abstract available.

29.

Glutaminolysis and Fumarate Accumulation Integrate Immunometabolic and Epigenetic Programs in Trained Immunity.

Arts RJ, Novakovic B, Ter Horst R, Carvalho A, Bekkering S, Lachmandas E, Rodrigues F, Silvestre R, Cheng SC, Wang SY, Habibi E, Gonçalves LG, Mesquita I, Cunha C, van Laarhoven A, van de Veerdonk FL, Williams DL, van der Meer JW, Logie C, O'Neill LA, Dinarello CA, Riksen NP, van Crevel R, Clish C, Notebaart RA, Joosten LA, Stunnenberg HG, Xavier RJ, Netea MG.

Cell Metab. 2016 Dec 13;24(6):807-819. doi: 10.1016/j.cmet.2016.10.008. Epub 2016 Nov 17.

30.

IRAK1 and IRAK4 promote phosphorylation, ubiquitination, and degradation of MyD88 adaptor-like (Mal).

Dunne A, Carpenter S, Brikos C, Gray P, Strelow A, Wesche H, Morrice N, O'Neill LA.

J Biol Chem. 2016 Nov 18;291(47):24802. No abstract available.

31.

RAB39a binds caspase-1 and is required for caspase-1-dependent interleukin-1β secretion.

Becker CE, Creagh EM, O'Neill LA.

J Biol Chem. 2016 Nov 18;291(47):24800. No abstract available.

32.

Trypanosoma brucei metabolite indolepyruvate decreases HIF-1α and glycolysis in macrophages as a mechanism of innate immune evasion.

McGettrick AF, Corcoran SE, Barry PJ, McFarland J, Crès C, Curtis AM, Franklin E, Corr SC, Mok KH, Cummins EP, Taylor CT, O'Neill LA, Nolan DP.

Proc Natl Acad Sci U S A. 2016 Nov 29;113(48):E7778-E7787. Epub 2016 Nov 15.

33.

The NLRP3 inflammasome functions as a driver of the myelodysplastic syndrome phenotype.

Basiorka AA, McGraw KL, Eksioglu EA, Chen X, Johnson J, Zhang L, Zhang Q, Irvine BA, Cluzeau T, Sallman DA, Padron E, Komrokji R, Sokol L, Coll RC, Robertson AA, Cooper MA, Cleveland JL, O'Neill LA, Wei S, List AF.

Blood. 2016 Dec 22;128(25):2960-2975. doi: 10.1182/blood-2016-07-730556. Epub 2016 Oct 13.

34.

A Metabolic Roadblock in Inflammatory Macrophages.

O'Neill LA.

Cell Rep. 2016 Oct 11;17(3):625-626. doi: 10.1016/j.celrep.2016.09.085.

35.

Succinate Dehydrogenase Supports Metabolic Repurposing of Mitochondria to Drive Inflammatory Macrophages.

Mills EL, Kelly B, Logan A, Costa ASH, Varma M, Bryant CE, Tourlomousis P, Däbritz JHM, Gottlieb E, Latorre I, Corr SC, McManus G, Ryan D, Jacobs HT, Szibor M, Xavier RJ, Braun T, Frezza C, Murphy MP, O'Neill LA.

Cell. 2016 Oct 6;167(2):457-470.e13. doi: 10.1016/j.cell.2016.08.064. Epub 2016 Sep 22.

36.

HIF1α and metabolic reprogramming in inflammation.

Corcoran SE, O'Neill LA.

J Clin Invest. 2016 Oct 3;126(10):3699-3707. doi: 10.1172/JCI84431. Epub 2016 Aug 29. Review.

37.

Pokémon Go: mobile app user guides.

Anderson N, Steele J, O'Neill LA, Harden LA.

Br J Sports Med. 2017 Oct;51(20):1505-1506. doi: 10.1136/bjsports-2016-096762. Epub 2016 Aug 18. No abstract available.

PMID:
27539503
38.

A guide to immunometabolism for immunologists.

O'Neill LA, Kishton RJ, Rathmell J.

Nat Rev Immunol. 2016 Sep;16(9):553-65. doi: 10.1038/nri.2016.70. Epub 2016 Jul 11. Review.

39.

T helper 1 immunity requires complement-driven NLRP3 inflammasome activity in CD4⁺ T cells.

Arbore G, West EE, Spolski R, Robertson AAB, Klos A, Rheinheimer C, Dutow P, Woodruff TM, Yu ZX, O'Neill LA, Coll RC, Sher A, Leonard WJ, Köhl J, Monk P, Cooper MA, Arno M, Afzali B, Lachmann HJ, Cope AP, Mayer-Barber KD, Kemper C.

Science. 2016 Jun 17;352(6292):aad1210. doi: 10.1126/science.aad1210.

40.

Trained immunity: A program of innate immune memory in health and disease.

Netea MG, Joosten LA, Latz E, Mills KH, Natoli G, Stunnenberg HG, O'Neill LA, Xavier RJ.

Science. 2016 Apr 22;352(6284):aaf1098. doi: 10.1126/science.aaf1098. Epub 2016 Apr 21. Review.

41.

A Common Variant in the Adaptor Mal Regulates Interferon Gamma Signaling.

Ní Cheallaigh C, Sheedy FJ, Harris J, Muñoz-Wolf N, Lee J, West K, McDermott EP, Smyth A, Gleeson LE, Coleman M, Martinez N, Hearnden CH, Tynan GA, Carroll EC, Jones SA, Corr SC, Bernard NJ, Hughes MM, Corcoran SE, O'Sullivan M, Fallon CM, Kornfeld H, Golenbock D, Gordon SV, O'Neill LA, Lavelle EC, Keane J.

Immunity. 2016 Feb 16;44(2):368-79. doi: 10.1016/j.immuni.2016.01.019.

42.

Cutting Edge: Mycobacterium tuberculosis Induces Aerobic Glycolysis in Human Alveolar Macrophages That Is Required for Control of Intracellular Bacillary Replication.

Gleeson LE, Sheedy FJ, Palsson-McDermott EM, Triglia D, O'Leary SM, O'Sullivan MP, O'Neill LA, Keane J.

J Immunol. 2016 Mar 15;196(6):2444-9. doi: 10.4049/jimmunol.1501612. Epub 2016 Feb 12.

43.

Immunometabolism governs dendritic cell and macrophage function.

O'Neill LA, Pearce EJ.

J Exp Med. 2016 Jan 11;213(1):15-23. doi: 10.1084/jem.20151570. Epub 2015 Dec 22. Review.

44.

How Low Cholesterol Is Good for Anti-viral Immunity.

O'Neill LA.

Cell. 2015 Dec 17;163(7):1572-4. doi: 10.1016/j.cell.2015.12.004.

45.

Reprogramming mitochondrial metabolism in macrophages as an anti-inflammatory signal.

Mills EL, O'Neill LA.

Eur J Immunol. 2016 Jan;46(1):13-21. doi: 10.1002/eji.201445427. Review.

46.

"No way Jose!" Clinicians must have authority over patient care: the manager's scope of practice does not cover medical decisions.

O'Neill LA.

Br J Sports Med. 2016 Mar;50(5):259. doi: 10.1136/bjsports-2015-095420. Epub 2015 Dec 1. No abstract available.

PMID:
26626264
47.

The Cellular and Molecular Basis of Translational Immunometabolism.

Norata GD, Caligiuri G, Chavakis T, Matarese G, Netea MG, Nicoletti A, O'Neill LA, Marelli-Berg FM.

Immunity. 2015 Sep 15;43(3):421-34. doi: 10.1016/j.immuni.2015.08.023. Review.

49.

Innate immune memory: a paradigm shift in understanding host defense.

Netea MG, Latz E, Mills KH, O'Neill LA.

Nat Immunol. 2015 Jul;16(7):675-9. doi: 10.1038/ni.3178. No abstract available.

PMID:
26086132
50.

Metabolic reprogramming in macrophages and dendritic cells in innate immunity.

Kelly B, O'Neill LA.

Cell Res. 2015 Jul;25(7):771-84. doi: 10.1038/cr.2015.68. Epub 2015 Jun 5. Review.

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