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Cyclin-dependent kinase 7 is a therapeutic target in high-grade glioma.

Greenall SA, Lim YC, Mitchell CB, Ensbey KS, Stringer BW, Wilding AL, O'Neill GM, McDonald KL, Gough DJ, Day BW, Johns TG.

Oncogenesis. 2017 May 15;6(5):e336. doi: 10.1038/oncsis.2017.33.


The focal adhesion targeting domain of p130Cas confers a mechanosensing function.

Bradbury PM, Turner K, Mitchell C, Griffin KR, Middlemiss S, Lau L, Dagg R, Taran E, Cooper-White J, Fabry B, O'Neill GM.

J Cell Sci. 2017 Apr 1;130(7):1263-1273. doi: 10.1242/jcs.192930. Epub 2017 Feb 21.


Cooperative cell invasion: matrix metalloproteinase-mediated incorporation between cells.

Mitchell CB, O'Neill GM.

Mol Biol Cell. 2016 Nov 1;27(21):3284-3292. Epub 2016 Sep 7.


Rac GTPase regulation of 3D invasion in neuroblastomas lacking MYCN amplification.

Mitchell CB, O'Neill GM.

Cell Adh Migr. 2017 Jan 2;11(1):68-79. doi: 10.1080/19336918.2016.1183868. Epub 2016 May 25.


Differential response of patient-derived primary glioblastoma cells to environmental stiffness.

Grundy TJ, De Leon E, Griffin KR, Stringer BW, Day BW, Fabry B, Cooper-White J, O'Neill GM.

Sci Rep. 2016 Mar 21;6:23353. doi: 10.1038/srep23353.


Thymosin-β4 is a determinant of drug sensitivity for Fenretinide and Vorinostat combination therapy in neuroblastoma.

Cheung BB, Tan O, Koach J, Liu B, Shum MS, Carter DR, Sutton S, Po'uha ST, Chesler L, Haber M, Norris MD, Kavallaris M, Liu T, O'Neill GM, Marshall GM.

Mol Oncol. 2015 Aug;9(7):1484-500. doi: 10.1016/j.molonc.2015.04.005. Epub 2015 Apr 29.


Role of dynamin in elongated cell migration in a 3D matrix.

Lees JG, Gorgani NN, Ammit AJ, McCluskey A, Robinson PJ, O'Neill GM.

Biochim Biophys Acta. 2015 Mar;1853(3):611-8. doi: 10.1016/j.bbamcr.2014.12.008. Epub 2014 Dec 10.


Tropomyosin Tm5NM1 spatially restricts src kinase activity through perturbation of Rab11 vesicle trafficking.

Bach CT, Murray RZ, Owen D, Gaus K, O'Neill GM.

Mol Cell Biol. 2014 Dec;34(24):4436-46. doi: 10.1128/MCB.00796-14. Epub 2014 Oct 6.


Src kinase determines the dynamic exchange of the docking protein NEDD9 (neural precursor cell expressed developmentally down-regulated gene 9) at focal adhesions.

Bradbury P, Bach CT, Paul A, O'Neill GM.

J Biol Chem. 2014 Sep 5;289(36):24792-800. doi: 10.1074/jbc.M113.544106. Epub 2014 Jul 24.


Insights into adhesion biology using single-molecule localization microscopy.

Tabarin T, Pageon SV, Bach CT, Lu Y, O'Neill GM, Gooding JJ, Gaus K.

Chemphyschem. 2014 Mar 17;15(4):606-18. doi: 10.1002/cphc.201301041. Epub 2014 Feb 4. Review.


NEDD9 regulates 3D migratory activity independent of the Rac1 morphology switch in glioma and neuroblastoma.

Zhong J, Bach CT, Shum MS, O'Neill GM.

Mol Cancer Res. 2014 Feb;12(2):264-73. doi: 10.1158/1541-7786.MCR-13-0513. Epub 2013 Dec 13.


Tropomyosin regulates cell migration during skin wound healing.

Lees JG, Ching YW, Adams DH, Bach CT, Samuel MS, Kee AJ, Hardeman EC, Gunning P, Cowin AJ, O'Neill GM.

J Invest Dermatol. 2013 May;133(5):1330-9. doi: 10.1038/jid.2012.489. Epub 2013 Jan 10.


Occupy tissue: the movement in cancer metastasis.

Bradbury P, Fabry B, O'Neill GM.

Cell Adh Migr. 2012 Sep-Oct;6(5):424-32. doi: 10.4161/cam.21559. Epub 2012 Sep 1. Review.


NEDD9 stabilizes focal adhesions, increases binding to the extra-cellular matrix and differentially effects 2D versus 3D cell migration.

Zhong J, Baquiran JB, Bonakdar N, Lees J, Ching YW, Pugacheva E, Fabry B, O'Neill GM.

PLoS One. 2012;7(4):e35058. doi: 10.1371/journal.pone.0035058. Epub 2012 Apr 11.


PP2A phosphatase suppresses function of the mesenchymal invasion regulator NEDD9.

Bradbury P, Mahmassani M, Zhong J, Turner K, Paul A, Verrills NM, O'Neill GM.

Biochim Biophys Acta. 2012 Feb;1823(2):290-7. doi: 10.1016/j.bbamcr.2011.10.011. Epub 2011 Oct 28.


γ-Actin regulates cell migration and modulates the ROCK signaling pathway.

Shum MS, Pasquier E, Po'uha ST, O'Neill GM, Chaponnier C, Gunning PW, Kavallaris M.

FASEB J. 2011 Dec;25(12):4423-33. doi: 10.1096/fj.11-185447. Epub 2011 Sep 9.


Regulation of focal adhesions by flightless i involves inhibition of paxillin phosphorylation via a Rac1-dependent pathway.

Kopecki Z, O'Neill GM, Arkell RM, Cowin AJ.

J Invest Dermatol. 2011 Jul;131(7):1450-9. doi: 10.1038/jid.2011.69. Epub 2011 Mar 24.


Cell adhesion signaling and its impact on tumorigenesis.

Andl CD, Al Moustafa AE, Deramaudt TB, O'Neill GM.

J Oncol. 2010;2010:257809. doi: 10.1155/2010/257809. Epub 2011 Jan 11. No abstract available.


Interior decoration: tropomyosin in actin dynamics and cell migration.

Lees JG, Bach CT, O'Neill GM.

Cell Adh Migr. 2011 Mar-Apr;5(2):181-6. Epub 2011 Mar 1. Review.


Estradiol stabilizes the 105-kDa phospho-form of the adhesion docking protein NEDD9 and suppresses NEDD9-dependent cell spreading in breast cancer cells.

Bradshaw LN, Zhong J, Bradbury P, Mahmassani M, Smith JL, Ammit AJ, O'Neill GM.

Biochim Biophys Acta. 2011 Feb;1813(2):340-5. doi: 10.1016/j.bbamcr.2010.11.018. Epub 2010 Dec 8.


The actin-associating protein Tm5NM1 blocks mesenchymal motility without transition to amoeboid motility.

Lees JG, Bach CT, Bradbury P, Paul A, Gunning PW, O'Neill GM.

Oncogene. 2011 Mar 10;30(10):1241-51. doi: 10.1038/onc.2010.516. Epub 2010 Nov 15.


Mesenchymal migration as a therapeutic target in glioblastoma.

Zhong J, Paul A, Kellie SJ, O'Neill GM.

J Oncol. 2010;2010:430142. doi: 10.1155/2010/430142. Epub 2010 Jun 21.


Tropomyosin isoform modulation of focal adhesion structure and cell migration.

Bach CT, Schevzov G, Bryce NS, Gunning PW, O'Neill GM.

Cell Adh Migr. 2010 Apr-Jun;4(2):226-34. Epub 2010 Apr 7.


The coordination between actin filaments and adhesion in mesenchymal migration.

O'Neill GM.

Cell Adh Migr. 2009 Oct-Dec;3(4):355-7. Epub 2009 Oct 8. Review.


Tropomyosin isoform expression regulates the transition of adhesions to determine cell speed and direction.

Bach CT, Creed S, Zhong J, Mahmassani M, Schevzov G, Stehn J, Cowell LN, Naumanen P, Lappalainen P, Gunning PW, O'Neill GM.

Mol Cell Biol. 2009 Mar;29(6):1506-14. doi: 10.1128/MCB.00857-08. Epub 2009 Jan 5.


Structural insights into the association between BCAR3 and Cas family members, an atypical complex implicated in anti-oestrogen resistance.

Garron ML, Arsenieva D, Zhong J, Bloom AB, Lerner A, O'Neill GM, Arold ST.

J Mol Biol. 2009 Feb 13;386(1):190-203. doi: 10.1016/j.jmb.2008.12.010. Epub 2008 Dec 13.


Divergent regulation of the sarcomere and the cytoskeleton.

Schevzov G, Fath T, Vrhovski B, Vlahovich N, Rajan S, Hook J, Joya JE, Lemckert F, Puttur F, Lin JJ, Hardeman EC, Wieczorek DF, O'Neill GM, Gunning PW.

J Biol Chem. 2008 Jan 4;283(1):275-83. Epub 2007 Oct 18.


Tropomyosins as interpreters of the signalling environment to regulate the local cytoskeleton.

O'Neill GM, Stehn J, Gunning PW.

Semin Cancer Biol. 2008 Feb;18(1):35-44. Epub 2007 Sep 4. Review.


A new central scaffold for metastasis: parsing HEF1/Cas-L/NEDD9.

O'Neill GM, Seo S, Serebriiskii IG, Lessin SR, Golemis EA.

Cancer Res. 2007 Oct 1;67(19):8975-9. Review.


Images in emergency medicine. Bilateral tubal ectopic pregnancies.

O'Neill GM, Costantino TG, Karras D.

Ann Emerg Med. 2007 Oct;50(4):e1-2. No abstract available.


Tamoxifen treatment promotes phosphorylation of the adhesion molecules, p130Cas/BCAR1, FAK and Src, via an adhesion-dependent pathway.

Cowell LN, Graham JD, Bouton AH, Clarke CL, O'Neill GM.

Oncogene. 2006 Dec 7;25(58):7597-607. Epub 2006 Jun 26.


Specialisation of the tropomyosin composition of actin filaments provides new potential targets for chemotherapy.

Stehn JR, Schevzov G, O'Neill GM, Gunning PW.

Curr Cancer Drug Targets. 2006 May;6(3):245-56. Review.


The Cas family docking protein, HEF1, promotes the formation of neurite-like membrane extensions.

Bargon SD, Gunning PW, O'Neill GM.

Biochim Biophys Acta. 2005 Dec 15;1746(2):143-54. Epub 2005 Nov 14.


Altered progesterone receptor isoform expression remodels progestin responsiveness of breast cancer cells.

Graham JD, Yager ML, Hill HD, Byth K, O'Neill GM, Clarke CL.

Mol Endocrinol. 2005 Nov;19(11):2713-35. Epub 2005 Jun 23.


Tissue-specific tropomyosin isoform composition.

Schevzov G, Vrhovski B, Bryce NS, Elmir S, Qiu MR, O'neill GM, Yang N, Verrills NM, Kavallaris M, Gunning PW.

J Histochem Cytochem. 2005 May;53(5):557-70.


Cytoskeletal responsiveness to progestins is dependent on progesterone receptor A levels.

McGowan EM, Weinberger RP, Graham JD, Hill HD, Hughes JA, O'Neill GM, Clarke CL.

J Mol Endocrinol. 2003 Oct;31(2):241-53.


Functional analysis of the actin-binding protein, tropomyosin 1, in neuroblastoma.

Yager ML, Hughes JA, Lovicu FJ, Gunning PW, Weinberger RP, O'Neill GM.

Br J Cancer. 2003 Sep 1;89(5):860-3.


Activation of transglutaminase in mu-calpain null erythrocytes.

O'Neill GM, Prasanna Murthy SN, Lorand L, Khanna R, Liu SC, Hanspal M, Hanada T, Chishti AH.

Biochem Biophys Res Commun. 2003 Jul 25;307(2):327-31.


From correlation to causality: microarrays, cancer, and cancer treatment.

O'Neill GM, Catchpoole DR, Golemis EA.

Biotechniques. 2003 Mar;Suppl:64-71. Review. No abstract available.


The GDP exchange factor AND-34 is expressed in B cells, associates with HEF1, and activates Cdc42.

Cai D, Felekkis KN, Near RI, O'Neill GM, van Seventer JM, Golemis EA, Lerner A.

J Immunol. 2003 Jan 15;170(2):969-78.


Tumor necrosis factor-alpha-induced secretion of RANTES and interleukin-6 from human airway smooth muscle cells: modulation by glucocorticoids and beta-agonists.

Ammit AJ, Lazaar AL, Irani C, O'Neill GM, Gordon ND, Amrani Y, Penn RB, Panettieri RA Jr.

Am J Respir Cell Mol Biol. 2002 Apr;26(4):465-74.


Dissection of HEF1-dependent functions in motility and transcriptional regulation.

Fashena SJ, Einarson MB, O'Neill GM, Patriotis C, Golemis EA.

J Cell Sci. 2002 Jan 1;115(Pt 1):99-111.


Focal adhesion kinase regulates beta1 integrin-dependent T cell migration through an HEF1 effector pathway.

van Seventer GA, Salmen HJ, Law SF, O'Neill GM, Mullen MM, Franz AM, Kanner SB, Golemis EA, van Seventer JM.

Eur J Immunol. 2001 May;31(5):1417-27.


Proteolysis of the docking protein HEF1 and implications for focal adhesion dynamics.

O'Neill GM, Golemis EA.

Mol Cell Biol. 2001 Aug;21(15):5094-108.


The docking protein HEF1 is an apoptotic mediator at focal adhesion sites.

Law SF, O'Neill GM, Fashena SJ, Einarson MB, Golemis EA.

Mol Cell Biol. 2000 Jul;20(14):5184-95.


Integrin signalling: a new Cas(t) of characters enters the stage.

O'Neill GM, Fashena SJ, Golemis EA.

Trends Cell Biol. 2000 Mar;10(3):111-9. Review.


Amplification and expression of the ABC transporters ARA and MRP in a series of multidrug-resistant leukaemia cell sublines.

O'Neill GM, Peters GB, Harvie RM, MacKenzie HB, Henness S, Davey RA.

Br J Cancer. 1998 Jun;77(12):2076-80.

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