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Open access: is there a predator at the door?

Chandra R, Fisher EW, Jones TM, Kennedy DW, Kraus DH, Krouse JH, Link M, Lustig LR, O'Malley BW, Piccirillo JF, Ruben R, Sataloff RT, Schwartz S, Sindwani R, Smith RJ, Stewart MG, Weber PC, Welling DB, Youngs R.

J Laryngol Otol. 2018 Mar;132(3):189-190. doi: 10.1017/S0022215117002225. No abstract available.



OʼMalley BW Jr.

ORL J Otorhinolaryngol Relat Spec. 2017;79(6):I. doi: 10.1159/000485578. Epub 2018 Feb 15. No abstract available.


Open Access: Is There a Predator at the Door?

Chandra R, Fisher EW, Jones TM, Kennedy DW, Kraus DH, Krouse JH, Link M, Lustig LR, O'Malley BW Jr, Piccirillo JF, Ruben R, Sataloff RT, Schwartz S, Sindwani R, Smith RJ, Stewart MG, Weber PC, Welling DB, Youngs R.

Otol Neurotol. 2018 Mar;39(3):271-272. doi: 10.1097/MAO.0000000000001721. No abstract available.


The Development of a Nano-based Approach to Alleviate Cisplatin-Induced Ototoxicity.

Kayyali MN, Ramsey AJ, Higbee-Dempsey EM, Yan L, O'Malley BW Jr, Tsourkas A, Li D.

J Assoc Res Otolaryngol. 2018 Jan 18. doi: 10.1007/s10162-017-0648-2. [Epub ahead of print]


Surgical Management of Oral Cancer.

Shanti RM, O'Malley BW Jr.

Dent Clin North Am. 2018 Jan;62(1):77-86. doi: 10.1016/j.cden.2017.08.005. Epub 2017 Oct 16. Review.


Histone Marks in the 'Driver's Seat': Functional Roles in Steering the Transcription Cycle.

Gates LA, Foulds CE, O'Malley BW.

Trends Biochem Sci. 2017 Dec;42(12):977-989. doi: 10.1016/j.tibs.2017.10.004. Epub 2017 Nov 6. Review.


Open access: Is there a predator at the door?

Chandra R, Fisher EW, Jones TM, Kennedy DW, Kraus DH, Krouse JH, Link M, Lustig LR, O'Malley BW, Piccirillo JF, Ruben R, Sataloff RT, Sindwani R, Smith RJ, Stewart MG, Weber PC, Welling DB, Youngs R.

Clin Otolaryngol. 2018 Apr;43(2):415-416. doi: 10.1111/coa.13014. Epub 2017 Nov 8. No abstract available.


Lesion Oxygenation Associates with Clinical Outcomes in Premalignant and Early Stage Head and Neck Tumors Treated on a Phase 1 Trial of Photodynamic Therapy.

Ahn PH, Finlay JC, Gallagher-Colombo SM, Quon H, O'Malley BW, Weinstein GS, Chalian A, Malloy K, Sollecito T, Greenberg M, Simone CB 2nd, McNulty S, Lin A, Zhu TC, Livolsi V, Feldman M, Mick R, Cengel KA, Busch TM.

Photodiagnosis Photodyn Ther. 2017 Nov 4. pii: S1572-1000(17)30354-X. doi: 10.1016/j.pdpdt.2017.10.015. [Epub ahead of print]


A Novel Nano-approach for Targeted Inner Ear Imaging.

Kayyali MN, Brake L, Ramsey AJ, Wright AC, O'Malley BW, Li DD.

J Nanomed Nanotechnol. 2017 Aug;8(4). pii: 456. doi: 10.4172/2157-7439.1000456. Epub 2017 Aug 31.


Defining the Role of Free Flaps for Transoral Robotic Surgery.

Hatten KM, Brody RM, Weinstein GS, Newman JG, Bur AM, Chalian AA, OʼMalley BW Jr, Rassekh CH, Cannady SB.

Ann Plast Surg. 2018 Jan;80(1):45-49. doi: 10.1097/SAP.0000000000001263.


Growth regulation by estrogen in breast cancer 1 (GREB1) is a novel progesterone-responsive gene required for human endometrial stromal decidualization.

Camden AJ, Szwarc MM, Chadchan SB, DeMayo FJ, O'Malley BW, Lydon JP, Kommagani R.

Mol Hum Reprod. 2017 Sep 1;23(9):646-653. doi: 10.1093/molehr/gax045.


Relapse Rates With Surgery Alone in Human Papillomavirus-Related Intermediate- and High-Risk Group Oropharynx Squamous Cell Cancer: A Multi-Institutional Review.

Routman DM, Funk RK, Tangsriwong K, Lin A, Keeney MG, García JJ, Zarka MA, Lewis JT, Stoddard DG, Moore EJ, Day CN, Zhai Q, Price KA, Lukens JN, Swisher-McClure S, Weinstein GS, O'Malley BW Jr, Foote RL, Ma DJ.

Int J Radiat Oncol Biol Phys. 2017 Nov 15;99(4):938-946. doi: 10.1016/j.ijrobp.2017.06.2453. Epub 2017 Jun 28.


Structural and Functional Impacts of ER Coactivator Sequential Recruitment.

Yi P, Wang Z, Feng Q, Chou CK, Pintilie GD, Shen H, Foulds CE, Fan G, Serysheva I, Ludtke SJ, Schmid MF, Hung MC, Chiu W, O'Malley BW.

Mol Cell. 2017 Sep 7;67(5):733-743.e4. doi: 10.1016/j.molcel.2017.07.026. Epub 2017 Aug 24.


Acetylation on histone H3 lysine 9 mediates a switch from transcription initiation to elongation.

Gates LA, Shi J, Rohira AD, Feng Q, Zhu B, Bedford MT, Sagum CA, Jung SY, Qin J, Tsai MJ, Tsai SY, Li W, Foulds CE, O'Malley BW.

J Biol Chem. 2017 Sep 1;292(35):14456-14472. doi: 10.1074/jbc.M117.802074. Epub 2017 Jul 17.


Evaluation of high-fidelity simulation as a training tool in transoral robotic surgery.

Bur AM, Gomez ED, Newman JG, Weinstein GS, O'Malley BW Jr, Rassekh CH, Kuchenbecker KJ.

Laryngoscope. 2017 Dec;127(12):2790-2795. doi: 10.1002/lary.26733. Epub 2017 Jun 28.


Microbial Signatures Associated with Oropharyngeal and Oral Squamous Cell Carcinomas.

Banerjee S, Tian T, Wei Z, Peck KN, Shih N, Chalian AA, O'Malley BW, Weinstein GS, Feldman MD, Alwine J, Robertson ES.

Sci Rep. 2017 Jun 22;7(1):4036. doi: 10.1038/s41598-017-03466-6.


Crosstalk between histone modifications indicates that inhibition of arginine methyltransferase CARM1 activity reverses HIV latency.

Zhang Z, Nikolai BC, Gates LA, Jung SY, Siwak EB, He B, Rice AP, O'Malley BW, Feng Q.

Nucleic Acids Res. 2017 Sep 19;45(16):9348-9360. doi: 10.1093/nar/gkx550.


Targeting SRC Coactivators Blocks the Tumor-Initiating Capacity of Cancer Stem-like Cells.

Rohira AD, Yan F, Wang L, Wang J, Zhou S, Lu A, Yu Y, Xu J, Lonard DM, O'Malley BW.

Cancer Res. 2017 Aug 15;77(16):4293-4304. doi: 10.1158/0008-5472.CAN-16-2982. Epub 2017 Jun 13.


A Cell-Autonomous Mammalian 12 hr Clock Coordinates Metabolic and Stress Rhythms.

Zhu B, Zhang Q, Pan Y, Mace EM, York B, Antoulas AC, Dacso CC, O'Malley BW.

Cell Metab. 2017 Jun 6;25(6):1305-1319.e9. doi: 10.1016/j.cmet.2017.05.004.


SPOP regulates prostate epithelial cell proliferation and promotes ubiquitination and turnover of c-MYC oncoprotein.

Geng C, Kaochar S, Li M, Rajapakshe K, Fiskus W, Dong J, Foley C, Dong B, Zhang L, Kwon OJ, Shah SS, Bolaki M, Xin L, Ittmann M, O'Malley BW, Coarfa C, Mitsiades N.

Oncogene. 2017 Aug 17;36(33):4767-4777. doi: 10.1038/onc.2017.80. Epub 2017 Apr 17.


Brain nuclear receptors and body weight regulation.

Xu Y, O'Malley BW, Elmquist JK.

J Clin Invest. 2017 Apr 3;127(4):1172-1180. doi: 10.1172/JCI88891. Epub 2017 Feb 20. Review.


Benefits of omitting primary site radiation therapy after transoral robotic surgery: Only time will tell.

Ojerholm E, Lukens JN, Ahn PH, Geiger G, Swisher-McClure S, Newman J, Chalian A, Weinstein G, O'Malley BW Jr, Cohen R, Lin A.

Pract Radiat Oncol. 2017 May - Jun;7(3):e157-e158. doi: 10.1016/j.prro.2016.10.019. Epub 2016 Nov 4. No abstract available.


Transoral Robotic Surgery-Assisted Endoscopy With Primary Site Detection and Treatment in Occult Mucosal Primaries.

Hatten KM, O'Malley BW Jr, Bur AM, Patel MR, Rassekh CH, Newman JG, Cannady SB, Chalian AA, Hodnett BL, Lin A, Lukens JN, Cohen RB, Bauml JM, Montone KT, Livolsi VA, Weinstein GS.

JAMA Otolaryngol Head Neck Surg. 2017 Mar 1;143(3):267-273. doi: 10.1001/jamaoto.2016.3419.


A Gingiva-Derived Mesenchymal Stem Cell-Laden Porcine Small Intestinal Submucosa Extracellular Matrix Construct Promotes Myomucosal Regeneration of the Tongue.

Xu Q, Shanti RM, Zhang Q, Cannady SB, O'Malley BW Jr, Le AD.

Tissue Eng Part A. 2017 Apr;23(7-8):301-312. doi: 10.1089/ten.TEA.2016.0342. Epub 2017 Jan 4.


Molecular Pathways: Targeting Steroid Receptor Coactivators in Cancer.

Lonard DM, O'Malley BW.

Clin Cancer Res. 2016 Nov 15;22(22):5403-5407. doi: 10.1158/1078-0432.CCR-15-1958. Epub 2016 Sep 21.


Origins of the Field of Molecular Endocrinology: A Personal Perspective.

O'Malley BW.

Mol Endocrinol. 2016 Oct;30(10):1015-1018. No abstract available.


Risk of lymph node metastasis and recommendations for elective nodal treatment in squamous cell carcinoma of the nasal cavity and maxillary sinus: a SEER analysis.

Ahn PH, Mitra N, Alonso-Basanta M, Palmer JN, Adappa ND, O'Malley BW Jr, Rassekh C, Chalian A, Cohen RB, Lin A.

Acta Oncol. 2016 Sep - Oct;55(9-10):1107-1114. doi: 10.1080/0284186X.2016.1216656. Epub 2016 Aug 11.


Genetic and Environmental Models of Circadian Disruption Link SRC-2 Function to Hepatic Pathology.

Fleet T, Stashi E, Zhu B, Rajapakshe K, Marcelo KL, Kettner NM, Gorman BK, Coarfa C, Fu L, O'Malley BW, York B.

J Biol Rhythms. 2016 Oct;31(5):443-60. doi: 10.1177/0748730416657921. Epub 2016 Jul 17.


Anterior lateral thigh osteomyocutaneous free flap reconstruction in the head and neck: The anterolateral thigh osteomyocutaneous femur bone flap.

Brody RM, Pandey NC, Bur AM, O'Malley BW Jr, Rassekh CH, Weinstein GS, Chalian AA, Newman JG, Cannady SB.

Head Neck. 2016 Dec;38(12):1788-1793. doi: 10.1002/hed.24521. Epub 2016 Jun 16.


Reprogramming of the Epigenome by MLL1 Links Early-Life Environmental Exposures to Prostate Cancer Risk.

Wang Q, Trevino LS, Wong RL, Medvedovic M, Chen J, Ho SM, Shen J, Foulds CE, Coarfa C, O'Malley BW, Shilatifard A, Walker CL.

Mol Endocrinol. 2016 Aug;30(8):856-71. doi: 10.1210/me.2015-1310. Epub 2016 May 24.


A Novel [15N] Glutamine Flux using LC-MS/MS-SRM for Determination of Nucleosides and Nucleobases.

Jin F, Bhowmik SK, Putluri V, Gu F, Gohlke J, Von Rundstedt FC, Dasgupta S, Krishnapuram R, O'Malley BW, Sreekumar A, Putluri N.

J Anal Bioanal Tech. 2015 Oct;6(5). pii: 267. Epub 2015 Aug 30.


Endoscopy versus imaging: Analysis of surveillance methods in sinonasal malignancy.

Khalili S, Worrall DM, Brooks S, Morris SM, Farquhar D, Newman JG, Learned KO, Ahn PH, Craig J, Kennedy DW, O'Malley BW, Palmer JN, Adappa ND.

Head Neck. 2016 Aug;38(8):1229-33. doi: 10.1002/hed.24413. Epub 2016 May 3.


The Role of Steroid Receptor Coactivators in Hormone Dependent Cancers and Their Potential as Therapeutic Targets.

Wang L, Lonard DM, O'Malley BW.

Horm Cancer. 2016 Aug;7(4):229-35. doi: 10.1007/s12672-016-0261-6. Epub 2016 Apr 28. Review.


Development of potent small-molecule inhibitors to drug the undruggable steroid receptor coactivator-3.

Song X, Chen J, Zhao M, Zhang C, Yu Y, Lonard DM, Chow DC, Palzkill T, Xu J, O'Malley BW, Wang J.

Proc Natl Acad Sci U S A. 2016 May 3;113(18):4970-5. doi: 10.1073/pnas.1604274113. Epub 2016 Apr 15.


Feasibility and relevance of level I substation node counts in oropharyngeal carcinoma.

Rassekh CH, O'Malley BW Jr, Bewley AF, Montone KT, Livolsi VA, Weinstein GS.

Head Neck. 2016 Aug;38(8):1194-200. doi: 10.1002/hed.24356. Epub 2016 Mar 29.


Propensity score analysis of endoscopic and open approaches to malignant paranasal and anterior skull base tumor outcomes.

Farquhar D, Kim L, Worrall D, Chiu A, Lee JY, Khalili S, Grady S, O'Malley BW Jr, Kennedy DW, Newman JG, Palmer JN, Adappa ND.

Laryngoscope. 2016 Aug;126(8):1724-9. doi: 10.1002/lary.25885. Epub 2016 Mar 12.


The REGγ-proteasome forms a regulatory circuit with IκBɛ and NFκB in experimental colitis.

Xu J, Zhou L, Ji L, Chen F, Fortmann K, Zhang K, Liu Q, Li K, Wang W, Wang H, Xie W, Wang Q, Liu J, Zheng B, Zhang P, Huang S, Shi T, Zhang B, Dang Y, Chen J, O'Malley BW, Moses RE, Wang P, Li L, Xiao J, Hoffmann A, Li X.

Nat Commun. 2016 Feb 22;7:10761. doi: 10.1038/ncomms10761.


Toxicities and early outcomes in a phase 1 trial of photodynamic therapy for premalignant and early stage head and neck tumors.

Ahn PH, Quon H, O'Malley BW, Weinstein G, Chalian A, Malloy K, Atkins JH, Sollecito T, Greenberg M, McNulty S, Lin A, Zhu TC, Finlay JC, Cengel K, Livolsi V, Feldman M, Mick R, Busch TM.

Oral Oncol. 2016 Apr;55:37-42. doi: 10.1016/j.oraloncology.2016.01.013. Epub 2016 Feb 8.


HER2 Signaling Drives DNA Anabolism and Proliferation through SRC-3 Phosphorylation and E2F1-Regulated Genes.

Nikolai BC, Lanz RB, York B, Dasgupta S, Mitsiades N, Creighton CJ, Tsimelzon A, Hilsenbeck SG, Lonard DM, Smith CL, O'Malley BW.

Cancer Res. 2016 Mar 15;76(6):1463-75. doi: 10.1158/0008-5472.CAN-15-2383. Epub 2016 Feb 1.


Post-treatment weight change in oral cavity and oropharyngeal squamous cell carcinoma.

Zhang Z, Brown JC, O'Malley BW Jr, Troxel AB, Bauml JM, Rubnitz KR, Grosso CM, Weinstein GS, Schmitz KH.

Support Care Cancer. 2016 May;24(5):2333-2340. doi: 10.1007/s00520-015-3029-6. Epub 2015 Dec 1.


Coactivator-Dependent Oscillation of Chromatin Accessibility Dictates Circadian Gene Amplitude via REV-ERB Loading.

Zhu B, Gates LA, Stashi E, Dasgupta S, Gonzales N, Dean A, Dacso CC, York B, O'Malley BW.

Mol Cell. 2015 Dec 3;60(5):769-783. doi: 10.1016/j.molcel.2015.10.024. Epub 2015 Nov 21.


Correction: Perturbing the Cellular Levels of Steroid Receptor Coactivator-2 Impairs Murine Endometrial Function.

Szwarc MM, Kommagani R, Jeong JW, Wu SP, Tsai SY, Tsai MJ, O'Malley BW, DeMayo FJ, Lydon JP.

PLoS One. 2015 Nov 18;10(11):e0143652. doi: 10.1371/journal.pone.0143652. eCollection 2015. No abstract available.


Nodal metastasis and elective nodal level treatment in sinonasal small-cell and sinonasal undifferentiated carcinoma: a surveillance, epidemiology and end results analysis.

Ahn PH, Mitra N, Alonso-Basanta M, Adappa ND, Palmer JN, O'Malley BW Jr, Rassekh CH, Chalian A, Cohen RB, Lin A.

Br J Radiol. 2016;89(1058):20150488. doi: 10.1259/bjr.20150488. Epub 2015 Nov 11.


Estrogen Receptor β Modulates Apoptosis Complexes and the Inflammasome to Drive the Pathogenesis of Endometriosis.

Han SJ, Jung SY, Wu SP, Hawkins SM, Park MJ, Kyo S, Qin J, Lydon JP, Tsai SY, Tsai MJ, DeMayo FJ, O'Malley BW.

Cell. 2015 Nov 5;163(4):960-74. doi: 10.1016/j.cell.2015.10.034.


SRC-2 orchestrates polygenic inputs for fine-tuning glucose homeostasis.

Fleet T, Zhang B, Lin F, Zhu B, Dasgupta S, Stashi E, Tackett B, Thevananther S, Rajapakshe KI, Gonzales N, Dean A, Mao J, Timchenko N, Malovannaya A, Qin J, Coarfa C, DeMayo F, Dacso CC, Foulds CE, O'Malley BW, York B.

Proc Natl Acad Sci U S A. 2015 Nov 3;112(44):E6068-77. doi: 10.1073/pnas.1519073112. Epub 2015 Oct 20.


The Dual Estrogen Receptor α Inhibitory Effects of the Tissue-Selective Estrogen Complex for Endometrial and Breast Safety.

Han SJ, Begum K, Foulds CE, Hamilton RA, Bailey S, Malovannaya A, Chan D, Qin J, O'Malley BW.

Mol Pharmacol. 2016 Jan;89(1):14-26. doi: 10.1124/mol.115.100925. Epub 2015 Oct 20.


Steroid Receptor Coactivator-3 (SRC-3/AIB1) as a Novel Therapeutic Target in Triple Negative Breast Cancer and Its Inhibition with a Phospho-Bufalin Prodrug.

Song X, Zhang C, Zhao M, Chen H, Liu X, Chen J, Lonard DM, Qin L, Xu J, Wang X, Li F, O'Malley BW, Wang J.

PLoS One. 2015 Oct 2;10(10):e0140011. doi: 10.1371/journal.pone.0140011. eCollection 2015.


Correction: Acceleration of the Glycolytic Flux by Steroid Receptor Coactivator-2 Is Essential for Endometrial Decidualization.

Kommagani R, Szwarc MM, Kovanci E, Gibbons WE, Putluri N, Maity S, Creighton CJ, Sreekumar A, DeMayo FJ, Lydon JP, O'Malley BW.

PLoS Genet. 2015 Sep 29;11(9):e1005515. doi: 10.1371/journal.pgen.1005515. eCollection 2015 Sep. No abstract available.


Upregulation of GSK3β Contributes to Brain Disorders in Elderly REGγ-knockout Mice.

Lv Y, Meng B, Dong H, Jing T, Wu N, Yang Y, Huang L, Moses RE, O'Malley BW, Mei B, Li X.

Neuropsychopharmacology. 2016 Apr;41(5):1340-9. doi: 10.1038/npp.2015.285. Epub 2015 Sep 15.


Comprehensive proteomic profiling identifies the androgen receptor axis and other signaling pathways as targets of microRNAs suppressed in metastatic prostate cancer.

Coarfa C, Fiskus W, Eedunuri VK, Rajapakshe K, Foley C, Chew SA, Shah SS, Geng C, Shou J, Mohamed JS, O'Malley BW, Mitsiades N.

Oncogene. 2016 May 5;35(18):2345-56. doi: 10.1038/onc.2015.295. Epub 2015 Sep 14.


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