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Teriparatide (human PTH1-34) compensates for impaired fracture healing in COX-2 deficient mice.

Yukata K, Xie C, Li TF, Brown ML, Kanchiku T, Zhang X, Awad HA, Schwarz EM, Beck CA, Jonason JH, O'Keefe RJ.

Bone. 2018 Feb 3;110:150-159. doi: 10.1016/j.bone.2018.02.001. [Epub ahead of print]


Loss of Dnmt3b in Chondrocytes Leads to Delayed Endochondral Ossification and Fracture Repair.

Wang C, Abu-Amer Y, O'Keefe RJ, Shen J.

J Bone Miner Res. 2018 Feb;33(2):283-297. doi: 10.1002/jbmr.3305. Epub 2017 Nov 2.


Deletion of EP4 in S100a4-lineage cells reduces scar tissue formation during early but not later stages of tendon healing.

Ackerman JE, Best KT, O'Keefe RJ, Loiselle AE.

Sci Rep. 2017 Aug 17;7(1):8658. doi: 10.1038/s41598-017-09407-7.


DNA methyltransferase 3b regulates articular cartilage homeostasis by altering metabolism.

Shen J, Wang C, Li D, Xu T, Myers J, Ashton JM, Wang T, Zuscik MJ, McAlinden A, O'Keefe RJ.

JCI Insight. 2017 Jun 15;2(12). pii: 93612. doi: 10.1172/jci.insight.93612. [Epub ahead of print]


PGE2 Receptor Subtype 1 (EP1) Regulates Mesenchymal Stromal Cell Osteogenic Differentiation by Modulating Cellular Energy Metabolism.

Feigenson M, Eliseev RA, Jonason JH, Mills BN, O'Keefe RJ.

J Cell Biochem. 2017 Dec;118(12):4383-4393. doi: 10.1002/jcb.26092. Epub 2017 May 31.


Inflammation and epigenetic regulation in osteoarthritis.

Shen J, Abu-Amer Y, O'Keefe RJ, McAlinden A.

Connect Tissue Res. 2017 Jan;58(1):49-63. doi: 10.1080/03008207.2016.1208655. Epub 2016 Jul 7. Review.


BMP-TAK1 (MAP3K7) Induces Adipocyte Differentiation Through PPARγ Signaling.

Zhang Y, O'Keefe RJ, Jonason JH.

J Cell Biochem. 2017 Jan;118(1):204-210. doi: 10.1002/jcb.25626. Epub 2016 Jun 27.


NOTCH signaling in skeletal progenitors is critical for fracture repair.

Wang C, Inzana JA, Mirando AJ, Ren Y, Liu Z, Shen J, O'Keefe RJ, Awad HA, Hilton MJ.

J Clin Invest. 2016 Apr 1;126(4):1471-81. doi: 10.1172/JCI80672. Epub 2016 Mar 7.


Low-Dose and Short-Duration Matrix Metalloproteinase 9 Inhibition Does Not Affect Adhesion Formation during Murine Flexor Tendon Healing.

Orner CA, Geary MB, Hammert WC, O'Keefe RJ, Loiselle AE.

Plast Reconstr Surg. 2016 Mar;137(3):545e-553e. doi: 10.1097/01.prs.0000475823.01907.53.


Notch signaling controls chondrocyte hypertrophy via indirect regulation of Sox9.

Kohn A, Rutkowski TP, Liu Z, Mirando AJ, Zuscik MJ, O'Keefe RJ, Hilton MJ.

Bone Res. 2015 Aug 11;3:15021. doi: 10.1038/boneres.2015.21. eCollection 2015.


Notch signaling in postnatal joint chondrocytes, but not subchondral osteoblasts, is required for articular cartilage and joint maintenance.

Liu Z, Ren Y, Mirando AJ, Wang C, Zuscik MJ, O'Keefe RJ, Hilton MJ.

Osteoarthritis Cartilage. 2016 Apr;24(4):740-51. doi: 10.1016/j.joca.2015.10.015. Epub 2015 Oct 30.


Fibrinolysis as a Target to Enhance Fracture Healing.

O'Keefe RJ.

N Engl J Med. 2015 Oct 29;373(18):1776-8. doi: 10.1056/NEJMcibr1510090. Review. No abstract available.


Increased Insulin mRNA Binding Protein-3 Expression Correlates with Vascular Enhancement of Renal Cell Carcinoma by Intravenous Contrast-CT and is Associated with Bone Metastasis.

Xie C, Li Y, Li Q, Chen Y, Yao J, Yin G, Bi Q, O'Keefe RJ, Schwarz EM, Tyler W.

J Bone Oncol. 2015 Sep;4(3):69-76. Epub 2015 Sep 12.


CCN1 Regulates Chondrocyte Maturation and Cartilage Development.

Zhang Y, Sheu TJ, Hoak D, Shen J, Hilton MJ, Zuscik MJ, Jonason JH, O'Keefe RJ.

J Bone Miner Res. 2016 Mar;31(3):549-59. doi: 10.1002/jbmr.2712.


Systemic EP4 Inhibition Increases Adhesion Formation in a Murine Model of Flexor Tendon Repair.

Geary MB, Orner CA, Bawany F, Awad HA, Hammert WC, O'Keefe RJ, Loiselle AE.

PLoS One. 2015 Aug 27;10(8):e0136351. doi: 10.1371/journal.pone.0136351. eCollection 2015.


Factors Associated With Early Improvement in Low Back Pain After Total Hip Arthroplasty: A Multi-Center Prospective Cohort Analyses.

Chimenti PC, Drinkwater CJ, Li W, Lemay CA, Franklin PD, O'Keefe RJ.

J Arthroplasty. 2016 Jan;31(1):176-9. doi: 10.1016/j.arth.2015.07.028. Epub 2015 Jul 17.


A dual role for NOTCH signaling in joint cartilage maintenance and osteoarthritis.

Liu Z, Chen J, Mirando AJ, Wang C, Zuscik MJ, O'Keefe RJ, Hilton MJ.

Sci Signal. 2015 Jul 21;8(386):ra71. doi: 10.1126/scisignal.aaa3792.


Demonstrating the value of orthopaedic surgery through multicenter trials: AOA critical issues.

Hilibrand AS, Spindler K, O'Keefe RJ.

J Bone Joint Surg Am. 2015 Apr 1;97(7):e35. doi: 10.2106/JBJS.N.00159. Review.


Development of antisense oligonucleotide (ASO) technology against Tgf-β signaling to prevent scarring during flexor tendon repair.

Loiselle AE, Yukata K, Geary MB, Kondabolu S, Shi S, Jonason JH, Awad HA, O'Keefe RJ.

J Orthop Res. 2015 Jun;33(6):859-66. doi: 10.1002/jor.22890.


How do you know it is true? Integrity in research and publications: AOA critical issues.

Buckwalter JA, Tolo VT, O'Keefe RJ.

J Bone Joint Surg Am. 2015 Jan 7;97(1):e2. doi: 10.2106/JBJS.N.00245.


Transient gamma-secretase inhibition accelerates and enhances fracture repair likely via Notch signaling modulation.

Wang C, Shen J, Yukata K, Inzana JA, O'Keefe RJ, Awad HA, Hilton MJ.

Bone. 2015 Apr;73:77-89. doi: 10.1016/j.bone.2014.12.007. Epub 2014 Dec 16.


Loss of the PGE2 receptor EP1 enhances bone acquisition, which protects against age and ovariectomy-induced impairments in bone strength.

Zhang M, Feigenson M, Sheu TJ, Awad HA, Schwarz EM, Jonason JH, Loiselle AE, O'Keefe RJ.

Bone. 2015 Mar;72:92-100. doi: 10.1016/j.bone.2014.11.018. Epub 2014 Nov 29.


Factors impacting musculoskeletal knowledge and clinical confidence in graduating medical students.

DiGiovanni BF, Southgate RD, Mooney CJ, Chu JY, Lambert DR, O'Keefe RJ.

J Bone Joint Surg Am. 2014 Nov 5;96(21):e185. doi: 10.2106/JBJS.M.01283.


NOTCH-Mediated Maintenance and Expansion of Human Bone Marrow Stromal/Stem Cells: A Technology Designed for Orthopedic Regenerative Medicine.

Dong Y, Long T, Wang C, Mirando AJ, Chen J, O'Keefe RJ, Hilton MJ.

Stem Cells Transl Med. 2014 Dec;3(12):1456-66. doi: 10.5966/sctm.2014-0034. Epub 2014 Nov 3.


Primary murine growth plate and articular chondrocyte isolation and cell culture.

Jonason JH, Hoak D, O'Keefe RJ.

Methods Mol Biol. 2015;1226:11-8. doi: 10.1007/978-1-4939-1619-1_2.


Parathyroid hormone 1-34 enhances extracellular matrix deposition and organization during flexor tendon repair.

Lee DJ, Southgate RD, Farhat YM, Loiselle AE, Hammert WC, Awad HA, O'Keefe RJ.

J Orthop Res. 2015 Jan;33(1):17-24. doi: 10.1002/jor.22735. Epub 2014 Sep 29.


The convergence of fracture repair and stem cells: interplay of genes, aging, environmental factors and disease.

Hadjiargyrou M, O'Keefe RJ.

J Bone Miner Res. 2014 Nov;29(11):2307-22. doi: 10.1002/jbmr.2373. Review.


High incidence of hemiarthroplasty for shoulder osteoarthritis among recently graduated orthopaedic surgeons.

Mann T, Baumhauer JF, O'Keefe RJ, Harrast J, Hurwitz SR, Voloshin I.

Clin Orthop Relat Res. 2014 Nov;472(11):3510-6. doi: 10.1007/s11999-014-3823-3. Epub 2014 Aug 22.


The spatiotemporal role of COX-2 in osteogenic and chondrogenic differentiation of periosteum-derived mesenchymal progenitors in fracture repair.

Huang C, Xue M, Chen H, Jiao J, Herschman HR, O'Keefe RJ, Zhang X.

PLoS One. 2014 Jul 2;9(7):e100079. doi: 10.1371/journal.pone.0100079. eCollection 2014.


TGF-β1 Suppresses Plasmin and MMP Activity in Flexor Tendon Cells via PAI-1: Implications for Scarless Flexor Tendon Repair.

Farhat YM, Al-Maliki AA, Easa A, O'Keefe RJ, Schwarz EM, Awad HA.

J Cell Physiol. 2015 Feb;230(2):318-26. doi: 10.1002/jcp.24707.


Delayed fracture healing and increased callus adiposity in a C57BL/6J murine model of obesity-associated type 2 diabetes mellitus.

Brown ML, Yukata K, Farnsworth CW, Chen DG, Awad H, Hilton MJ, O'Keefe RJ, Xing L, Mooney RA, Zuscik MJ.

PLoS One. 2014 Jun 9;9(6):e99656. doi: 10.1371/journal.pone.0099656. eCollection 2014.


Aging periosteal progenitor cells have reduced regenerative responsiveness to bone injury and to the anabolic actions of PTH 1-34 treatment.

Yukata K, Xie C, Li TF, Takahata M, Hoak D, Kondabolu S, Zhang X, Awad HA, Schwarz EM, Beck CA, Jonason JH, O'Keefe RJ.

Bone. 2014 May;62:79-89. doi: 10.1016/j.bone.2014.02.002. Epub 2014 Feb 12.


Isolation and culture of neonatal mouse calvarial osteoblasts.

Jonason JH, O'Keefe RJ.

Methods Mol Biol. 2014;1130:295-305. doi: 10.1007/978-1-62703-989-5_22.


A mouse model of flexor tendon repair.

Hasslund S, O'Keefe RJ, Awad HA.

Methods Mol Biol. 2014;1130:73-88. doi: 10.1007/978-1-62703-989-5_6.


BMP-2 induces ATF4 phosphorylation in chondrocytes through a COX-2/PGE2 dependent signaling pathway.

Li TF, Yukata K, Yin G, Sheu T, Maruyama T, Jonason JH, Hsu W, Zhang X, Xiao G, Konttinen YT, Chen D, O'Keefe RJ.

Osteoarthritis Cartilage. 2014 Mar;22(3):481-9. doi: 10.1016/j.joca.2013.12.020. Epub 2014 Jan 11.


TAK1 regulates SOX9 expression in chondrocytes and is essential for postnatal development of the growth plate and articular cartilages.

Gao L, Sheu TJ, Dong Y, Hoak DM, Zuscik MJ, Schwarz EM, Hilton MJ, O'Keefe RJ, Jonason JH.

J Cell Sci. 2013 Dec 15;126(Pt 24):5704-13. doi: 10.1242/jcs.135483. Epub 2013 Oct 21.


RBP-Jκ-dependent Notch signaling is required for murine articular cartilage and joint maintenance.

Mirando AJ, Liu Z, Moore T, Lang A, Kohn A, Osinski AM, O'Keefe RJ, Mooney RA, Zuscik MJ, Hilton MJ.

Arthritis Rheum. 2013 Oct;65(10):2623-33. doi: 10.1002/art.38076.


Forum on bone and skeletal muscle interactions: summary of the proceedings of an ASBMR workshop.

Bonewald LF, Kiel DP, Clemens TL, Esser K, Orwoll ES, O'Keefe RJ, Fielding RA.

J Bone Miner Res. 2013 Sep;28(9):1857-65. doi: 10.1002/jbmr.1980. Review.


The role of muscle in bone repair: the cells, signals, and tissue responses to injury.

Shah K, Majeed Z, Jonason J, O'Keefe RJ.

Curr Osteoporos Rep. 2013 Jun;11(2):130-5. doi: 10.1007/s11914-013-0146-3. Review.


Cellular and molecular factors in flexor tendon repair and adhesions: a histological and gene expression analysis.

Juneja SC, Schwarz EM, O'Keefe RJ, Awad HA.

Connect Tissue Res. 2013;54(3):218-26. doi: 10.3109/03008207.2013.787418. Epub 2013 Apr 15.


Inhibition of the Wnt-β-catenin and Notch signaling pathways sensitizes osteosarcoma cells to chemotherapy.

Ma Y, Ren Y, Han EQ, Li H, Chen D, Jacobs JJ, Gitelis S, O'Keefe RJ, Konttinen YT, Yin G, Li TF.

Biochem Biophys Res Commun. 2013 Feb 8;431(2):274-9. doi: 10.1016/j.bbrc.2012.12.118. Epub 2013 Jan 3.


Gene expression analysis of the pleiotropic effects of TGF-β1 in an in vitro model of flexor tendon healing.

Farhat YM, Al-Maliki AA, Chen T, Juneja SC, Schwarz EM, O'Keefe RJ, Awad HA.

PLoS One. 2012;7(12):e51411. doi: 10.1371/journal.pone.0051411. Epub 2012 Dec 10.


Assessment and management of the orthopedic and other complications of Proteus syndrome.

Tosi LL, Sapp JC, Allen ES, O'Keefe RJ, Biesecker LG.

J Child Orthop. 2011 Oct;5(5):319-27. Epub 2011 May 28.


PTH-enhanced structural allograft healing is associated with decreased angiopoietin-2-mediated arteriogenesis, mast cell accumulation, and fibrosis.

Dhillon RS, Xie C, Tyler W, Calvi LM, Awad HA, Zuscik MJ, O'Keefe RJ, Schwarz EM.

J Bone Miner Res. 2013 Mar;28(3):586-97. doi: 10.1002/jbmr.1765.


Bone marrow-derived matrix metalloproteinase-9 is associated with fibrous adhesion formation after murine flexor tendon injury.

Loiselle AE, Frisch BJ, Wolenski M, Jacobson JA, Calvi LM, Schwarz EM, Awad HA, O'Keefe RJ.

PLoS One. 2012;7(7):e40602. doi: 10.1371/journal.pone.0040602. Epub 2012 Jul 11.


Cartilage-specific β-catenin signaling regulates chondrocyte maturation, generation of ossification centers, and perichondrial bone formation during skeletal development.

Dao DY, Jonason JH, Zhang Y, Hsu W, Chen D, Hilton MJ, O'Keefe RJ.

J Bone Miner Res. 2012 Aug;27(8):1680-94. doi: 10.1002/jbmr.1639.


Ski inhibits TGF-β/phospho-Smad3 signaling and accelerates hypertrophic differentiation in chondrocytes.

Kim KO, Sampson ER, Maynard RD, O'Keefe RJ, Chen D, Drissi H, Rosier RN, Hilton MJ, Zuscik MJ.

J Cell Biochem. 2012 Jun;113(6):2156-66. doi: 10.1002/jcb.24089.


Conditional activation of β-catenin signaling in mice leads to severe defects in intervertebral disc tissue.

Wang M, Tang D, Shu B, Wang B, Jin H, Hao S, Dresser KA, Shen J, Im HJ, Sampson ER, Rubery PT, Zuscik MJ, Schwarz EM, O'Keefe RJ, Wang Y, Chen D.

Arthritis Rheum. 2012 Aug;64(8):2611-23. doi: 10.1002/art.34469.


Cartilage-specific RBPjκ-dependent and -independent Notch signals regulate cartilage and bone development.

Kohn A, Dong Y, Mirando AJ, Jesse AM, Honjo T, Zuscik MJ, O'Keefe RJ, Hilton MJ.

Development. 2012 Mar;139(6):1198-212. doi: 10.1242/dev.070649.


BMP2, but not BMP4, is crucial for chondrocyte proliferation and maturation during endochondral bone development.

Shu B, Zhang M, Xie R, Wang M, Jin H, Hou W, Tang D, Harris SE, Mishina Y, O'Keefe RJ, Hilton MJ, Wang Y, Chen D.

J Cell Sci. 2011 Oct 15;124(Pt 20):3428-40. doi: 10.1242/jcs.083659. Epub 2011 Oct 7.

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