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Effects on repetitive 24-hour ambulatory blood pressure in subjects with type II diabetes randomized to liraglutide or glimepiride treatment both in combination with metformin: a randomized open parallel-group study.

Jendle J, Fang X, Cao Y, Bojö L, Nilsson BK, Hedberg F, Santos-Pardo I, Nyström T.

J Am Soc Hypertens. 2018 Feb 16. pii: S1933-1711(18)30042-1. doi: 10.1016/j.jash.2018.02.003. [Epub ahead of print]


Corrigendum: Effects on Subclinical Heart Failure in Type 2 Diabetic Subjects on Liraglutide Treatment vs. Glimepiride Both in Combination with Metformin: A Randomized Open Parallel-Group Study.

Nyström T, Santos-Pardo I, Hedberg F, Wardell J, Witt N, Cao Y, Bojö L, Nilsson B, Jendle J.

Front Endocrinol (Lausanne). 2018 Feb 22;9:50. doi: 10.3389/fendo.2018.00050. eCollection 2018.


Type 2 diabetes impairs odour detection, olfactory memory and olfactory neuroplasticity; effects partly reversed by the DPP-4 inhibitor Linagliptin.

Lietzau G, Davidsson W, Östenson CG, Chiazza F, Nathanson D, Pintana H, Skogsberg J, Klein T, Nyström T, Darsalia V, Patrone C.

Acta Neuropathol Commun. 2018 Feb 23;6(1):14. doi: 10.1186/s40478-018-0517-1.


Guidelines and recommendations on yeast cell death nomenclature.

Carmona-Gutierrez D, Bauer MA, Zimmermann A, Aguilera A, Austriaco N, Ayscough K, Balzan R, Bar-Nun S, Barrientos A, Belenky P, Blondel M, Braun RJ, Breitenbach M, Burhans WC, Büttner S, Cavalieri D, Chang M, Cooper KF, Côrte-Real M, Costa V, Cullin C, Dawes I, Dengjel J, Dickman MB, Eisenberg T, Fahrenkrog B, Fasel N, Fröhlich KU, Gargouri A, Giannattasio S, Goffrini P, Gourlay CW, Grant CM, Greenwood MT, Guaragnella N, Heger T, Heinisch J, Herker E, Herrmann JM, Hofer S, Jiménez-Ruiz A, Jungwirth H, Kainz K, Kontoyiannis DP, Ludovico P, Manon S, Martegani E, Mazzoni C, Megeney LA, Meisinger C, Nielsen J, Nyström T, Osiewacz HD, Outeiro TF, Park HO, Pendl T, Petranovic D, Picot S, Polčic P, Powers T, Ramsdale M, Rinnerthaler M, Rockenfeller P, Ruckenstuhl C, Schaffrath R, Segovia M, Severin FF, Sharon A, Sigrist SJ, Sommer-Ruck C, Sousa MJ, Thevelein JM, Thevissen K, Titorenko V, Toledano MB, Tuite M, Vögtle FN, Westermann B, Winderickx J, Wissing S, Wölfl S, Zhang ZJ, Zhao RY, Zhou B, Galluzzi L, Kroemer G, Madeo F.

Microb Cell. 2018 Jan 1;5(1):4-31. doi: 10.15698/mic2018.01.607. Review.


Effects on Subclinical Heart Failure in Type 2 Diabetic Subjects on Liraglutide Treatment vs. Glimepiride Both in Combination with Metformin: A Randomized Open Parallel-Group Study.

Nyström T, Padro Santos I, Hedberg F, Wardell J, Witt N, Cao Y, Bojö L, Nilsson B, Jendle J.

Front Endocrinol (Lausanne). 2017 Nov 14;8:325. doi: 10.3389/fendo.2017.00325. eCollection 2017. Erratum in: Front Endocrinol (Lausanne). 2018 Feb 22;9:50.


Differential effects of soluble and aggregating polyQ proteins on cytotoxicity and type-1 myosin-dependent endocytosis in yeast.

Berglund LL, Hao X, Liu B, Grantham J, Nyström T.

Sci Rep. 2017 Sep 12;7(1):11328. doi: 10.1038/s41598-017-11102-6.


Estimated glucose disposal rate predicts mortality in adults with type 1 diabetes.

Nyström T, Holzmann MJ, Eliasson B, Svensson AM, Sartipy U.

Diabetes Obes Metab. 2018 Mar;20(3):556-563. doi: 10.1111/dom.13110. Epub 2017 Oct 10.


Role of the ribosomal quality control machinery in nucleocytoplasmic translocation of polyQ-expanded huntingtin exon-1.

Zheng J, Yang J, Choe YJ, Hao X, Cao X, Zhao Q, Zhang Y, Franssens V, Hartl FU, Nyström T, Winderickx J, Liu B.

Biochem Biophys Res Commun. 2017 Nov 4;493(1):708-717. doi: 10.1016/j.bbrc.2017.08.126. Epub 2017 Aug 30.


PCI Versus CABG in Patients With Type 1 Diabetes and Multivessel Disease.

Nyström T, Sartipy U, Franzén S, Eliasson B, Gudbjörnsdottir S, Miftaraj M, Lagerqvist B, Svensson AM, Holzmann MJ.

J Am Coll Cardiol. 2017 Sep 19;70(12):1441-1451. doi: 10.1016/j.jacc.2017.07.744. Epub 2017 Aug 26.


Glucagon-like receptor 1 agonists and DPP-4 inhibitors: Anti-diabetic drugs with anti-stroke potential.

Darsalia V, Klein T, Nyström T, Patrone C.

Neuropharmacology. 2017 Aug 18. pii: S0028-3908(17)30389-1. doi: 10.1016/j.neuropharm.2017.08.022. [Epub ahead of print] Review.


Cardiovascular mortality and morbidity in patients with type 2 diabetes following initiation of sodium-glucose co-transporter-2 inhibitors versus other glucose-lowering drugs (CVD-REAL Nordic): a multinational observational analysis.

Birkeland KI, Jørgensen ME, Carstensen B, Persson F, Gulseth HL, Thuresson M, Fenici P, Nathanson D, Nyström T, Eriksson JW, Bodegård J, Norhammar A.

Lancet Diabetes Endocrinol. 2017 Sep;5(9):709-717. doi: 10.1016/S2213-8587(17)30258-9. Epub 2017 Aug 3.


Dapagliflozin is associated with lower risk of cardiovascular events and all-cause mortality in people with type 2 diabetes (CVD-REAL Nordic) when compared with dipeptidyl peptidase-4 inhibitor therapy: A multinational observational study.

Persson F, Nyström T, Jørgensen ME, Carstensen B, Gulseth HL, Thuresson M, Fenici P, Nathanson D, Eriksson JW, Norhammar A, Bodegard J, Birkeland KI.

Diabetes Obes Metab. 2018 Feb;20(2):344-351. doi: 10.1111/dom.13077. Epub 2017 Sep 8.


How and why do toxic conformers of aberrant proteins accumulate during ageing?

Josefson R, Andersson R, Nyström T.

Essays Biochem. 2017 Jul 11;61(3):317-324. doi: 10.1042/EBC20160085. Print 2017 Jul 15. Review.


Type 2 diabetes alters hippocampal gamma oscillations: A potential mechanism behind impaired cognition.

Lietzau G, Darsalia V, Pintana H, Östenson CG, Nyström T, Fisahn A, Patrone C.

Psychoneuroendocrinology. 2017 Aug;82:46-50. doi: 10.1016/j.psyneuen.2017.04.012. Epub 2017 Apr 27.


The Upsides and Downsides of Organelle Interconnectivity.

Gottschling DE, Nyström T.

Cell. 2017 Mar 23;169(1):24-34. doi: 10.1016/j.cell.2017.02.030. Review.


Restricted access: spatial sequestration of damaged proteins during stress and aging.

Hill SM, Hanzén S, Nyström T.

EMBO Rep. 2017 Mar;18(3):377-391. doi: 10.15252/embr.201643458. Epub 2017 Feb 13. Review.


Continuous Glucose Monitoring vs Conventional Therapy for Glycemic Control in Adults With Type 1 Diabetes Treated With Multiple Daily Insulin Injections: The GOLD Randomized Clinical Trial.

Lind M, Polonsky W, Hirsch IB, Heise T, Bolinder J, Dahlqvist S, Schwarz E, Ólafsdóttir AF, Frid A, Wedel H, Ahlén E, Nyström T, Hellman J.

JAMA. 2017 Jan 24;317(4):379-387. doi: 10.1001/jama.2016.19976. Erratum in: JAMA. 2017 May 9;317(18):1912.


Novel oral glucose-lowering drugs are associated with lower risk of all-cause mortality, cardiovascular events and severe hypoglycaemia compared with insulin in patients with type 2 diabetes.

Nyström T, Bodegard J, Nathanson D, Thuresson M, Norhammar A, Eriksson JW.

Diabetes Obes Metab. 2017 Jun;19(6):831-841. doi: 10.1111/dom.12889. Epub 2017 Mar 16.


Second line initiation of insulin compared with DPP-4 inhibitors after metformin monotherapy is associated with increased risk of all-cause mortality, cardiovascular events, and severe hypoglycemia.

Nyström T, Bodegard J, Nathanson D, Thuresson M, Norhammar A, Eriksson JW.

Diabetes Res Clin Pract. 2017 Jan;123:199-208. doi: 10.1016/j.diabres.2016.12.004. Epub 2016 Dec 19.


Stimulation of prolactin receptor induces STAT-5 phosphorylation and cellular invasion in glioblastoma multiforme.

Alkharusi A, Yu S, Landázuri N, Zadjali F, Davodi B, Nyström T, Gräslund T, Rahbar A, Norstedt G.

Oncotarget. 2016 Nov 29;7(48):79572-79583. doi: 10.18632/oncotarget.12840.


Diabetes negatively affects cortical and striatal GABAergic neurons: an effect that is partially counteracted by exendin-4.

Larsson M, Lietzau G, Nathanson D, Östenson CG, Mallard C, Johansson ME, Nyström T, Patrone C, Darsalia V.

Biosci Rep. 2016 Dec 5;36(6). pii: e00421. Print 2016 Dec.


A genome-wide imaging-based screening to identify genes involved in synphilin-1 inclusion formation in Saccharomyces cerevisiae.

Zhao L, Yang Q, Zheng J, Zhu X, Hao X, Song J, Lebacq T, Franssens V, Winderickx J, Nystrom T, Liu B.

Sci Rep. 2016 Jul 21;6:30134. doi: 10.1038/srep30134.


Estimated glucose disposal rate and long-term survival in type 2 diabetes after coronary artery bypass grafting.

Nyström T, Holzmann MJ, Eliasson B, Svensson AM, Kuhl J, Sartipy U.

Heart Vessels. 2017 Mar;32(3):269-278. doi: 10.1007/s00380-016-0875-1. Epub 2016 Jul 11.


Asymmetric Inheritance of Aggregated Proteins and Age Reset in Yeast Are Regulated by Vac17-Dependent Vacuolar Functions.

Hill SM, Hao X, Grönvall J, Spikings-Nordby S, Widlund PO, Amen T, Jörhov A, Josefson R, Kaganovich D, Liu B, Nyström T.

Cell Rep. 2016 Jul 19;16(3):826-38. doi: 10.1016/j.celrep.2016.06.016.


Sulphonylurea compared to DPP-4 inhibitors in combination with metformin carries increased risk of severe hypoglycemia, cardiovascular events, and all-cause mortality.

Eriksson JW, Bodegard J, Nathanson D, Thuresson M, Nyström T, Norhammar A.

Diabetes Res Clin Pract. 2016 Jul;117:39-47. doi: 10.1016/j.diabres.2016.04.055. Epub 2016 May 6.


Pituitary Adenlylate Cyclase Activating Peptide Protects Adult Neural Stem Cells from a Hypoglycaemic milieu.

Mansouri S, Lietzau G, Lundberg M, Nathanson D, Nyström T, Patrone C.

PLoS One. 2016 Jun 15;11(6):e0156867. doi: 10.1371/journal.pone.0156867. eCollection 2016.


Lifespan Control by Redox-Dependent Recruitment of Chaperones to Misfolded Proteins.

Hanzén S, Vielfort K, Yang J, Roger F, Andersson V, Zamarbide-Forés S, Andersson R, Malm L, Palais G, Biteau B, Liu B, Toledano MB, Molin M, Nyström T.

Cell. 2016 Jun 30;166(1):140-51. doi: 10.1016/j.cell.2016.05.006. Epub 2016 Jun 2.


Selective protein degradation ensures cellular longevity.

Malmgren Hill S, Nyström T.

Elife. 2016 Jun 1;5. pii: e17185. doi: 10.7554/eLife.17185.


Incidence, prevalence and mortality of type 2 diabetes requiring glucose-lowering treatment, and associated risks of cardiovascular complications: a nationwide study in Sweden, 2006-2013.

Norhammar A, Bodegård J, Nyström T, Thuresson M, Eriksson JW, Nathanson D.

Diabetologia. 2016 Aug;59(8):1692-701. doi: 10.1007/s00125-016-3971-y. Epub 2016 May 18.


Spatial sequestration and detoxification of Huntingtin by the ribosome quality control complex.

Yang J, Hao X, Cao X, Liu B, Nyström T.

Elife. 2016 Apr 1;5. pii: e11792. doi: 10.7554/eLife.11792.


Gliptin-mediated neuroprotection against stroke requires chronic pretreatment and is independent of glucagon-like peptide-1 receptor.

Darsalia V, Larsson M, Lietzau G, Nathanson D, Nyström T, Klein T, Patrone C.

Diabetes Obes Metab. 2016 May;18(5):537-41. doi: 10.1111/dom.12641. Epub 2016 Mar 17. Erratum in: Diabetes Obes Metab. 2018 Apr;20(4):1086.


Role of Prolactin Receptors in Lymphangioleiomyomatosis.

Alkharusi A, Lesma E, Ancona S, Chiaramonte E, Nyström T, Gorio A, Norstedt G.

PLoS One. 2016 Jan 14;11(1):e0146653. doi: 10.1371/journal.pone.0146653. eCollection 2016.


Exenatide infusion decreases atrial natriuretic peptide levels by reducing cardiac filling pressures in type 2 diabetes patients with decompensated congestive heart failure.

Nathanson D, Frick M, Ullman B, Nyström T.

Diabetol Metab Syndr. 2016 Jan 12;8:5. doi: 10.1186/s13098-015-0116-2. eCollection 2016.


Type 2 diabetes-induced neuronal pathology in the piriform cortex of the rat is reversed by the GLP-1 receptor agonist exendin-4.

Lietzau G, Nyström T, Östenson CG, Darsalia V, Patrone C.

Oncotarget. 2016 Feb 2;7(5):5865-76. doi: 10.18632/oncotarget.6823.


Reply: Association of Glycemic Control in Type 1 Diabetes With Long-Term Risk After CABG.

Nyström T, Holzmann MJ, Sartipy U.

J Am Coll Cardiol. 2015 Dec 22;66(24):2810-2811. doi: 10.1016/j.jacc.2015.09.093. No abstract available.


Interview with Professor Thomas Nyström, awardee of the Emil Christian Hansen Gold Medal 2015.

Nyström T.

FEMS Yeast Res. 2015 Dec;15(8). pii: fov104. doi: 10.1093/femsyr/fov104. No abstract available.


Suppressor of cytokine signaling 2 (SOCS2) deletion protects against multiple low dose streptozotocin-induced type 1 diabetes in adult male mice.

Alkharusi A, Mirecki-Garrido M, Ma Z, Zadjali F, Flores-Morales A, Nyström T, Castrillo A, Bjorklund A, Norstedt G, Fernandez-Pérez L.

Horm Mol Biol Clin Investig. 2016 Apr 1;26(1):67-76. doi: 10.1515/hmbci-2015-0036.


Long-Term Risk of Stroke in Patients With Type 1 and Type 2 Diabetes Following Coronary Artery Bypass Grafting.

Nyström T, Holzmann MJ, Sartipy U.

J Am Heart Assoc. 2015 Nov 9;4(11). pii: e002411. doi: 10.1161/JAHA.115.002411.


Relationship between preoperative hemoglobin A1c levels and long-term mortality after coronary artery bypass grafting in patients with type 2 diabetes mellitus.

Kuhl J, Sartipy U, Eliasson B, Nyström T, Holzmann MJ.

Int J Cardiol. 2016 Jan 1;202:291-6. doi: 10.1016/j.ijcard.2015.09.008. Epub 2015 Sep 12.


In vivo parameters influencing 2-Cys Prx oligomerization: The role of enzyme sulfinylation.

Noichri Y, Palais G, Ruby V, D'Autreaux B, Delaunay-Moisan A, Nyström T, Molin M, Toledano MB.

Redox Biol. 2015 Dec;6:326-33. doi: 10.1016/j.redox.2015.08.011. Epub 2015 Aug 20.


Earlier intensified insulin treatment of Type 1 diabetes and its association with long-term macrovascular and renal complications.

Rathsman B, Donner M, Ursing C, Nyström T.

Diabet Med. 2016 Apr;33(4):463-70. doi: 10.1111/dme.12897. Epub 2015 Oct 8.


Visual attraction in Drosophila larvae develops during a critical period and is modulated by crowding conditions.

Slepian Z, Sundby K, Glier S, McDaniels J, Nystrom T, Mukherjee S, Acton ST, Condron B.

J Comp Physiol A Neuroethol Sens Neural Behav Physiol. 2015 Oct;201(10):1019-27. doi: 10.1007/s00359-015-1034-3. Epub 2015 Aug 12.


Glycemic Control in Type 1 Diabetes and Long-Term Risk of Cardiovascular Events or Death After Coronary Artery Bypass Grafting.

Nyström T, Holzmann MJ, Eliasson B, Kuhl J, Sartipy U.

J Am Coll Cardiol. 2015 Aug 4;66(5):535-43. doi: 10.1016/j.jacc.2015.05.054.


The impact of transcutaneous oxygen pressure measurement in patients with suspected critical lower limb ischemia.

Rosfors S, Kanni L, Nyström T.

Int Angiol. 2016 Oct;35(5):492-7. Epub 2015 Jul 29.


Glucagon-Like Peptide-1 Receptor Activation Does not Affect Re-Endothelialization but Reduces Intimal Hyperplasia via Direct Effects on Smooth Muscle Cells in a Nondiabetic Model of Arterial Injury.

Eriksson L, Saxelin R, Röhl S, Roy J, Caidahl K, Nyström T, Hedin U, Razuvaev A.

J Vasc Res. 2015;52(1):41-52. doi: 10.1159/000381097. Epub 2015 May 7.


Long-term prognosis in patients with type 1 and 2 diabetes mellitus after coronary artery bypass grafting.

Holzmann MJ, Rathsman B, Eliasson B, Kuhl J, Svensson AM, Nyström T, Sartipy U.

J Am Coll Cardiol. 2015 Apr 28;65(16):1644-1652. doi: 10.1016/j.jacc.2015.02.052.


Antidiabetic agents and endothelial dysfunction - beyond glucose control.

Eriksson L, Nyström T.

Basic Clin Pharmacol Toxicol. 2015 Jul;117(1):15-25. doi: 10.1111/bcpt.12402. Epub 2015 Apr 19. Review.


The dual role of a yeast metacaspase: What doesn't kill you makes you stronger.

Hill SM, Nyström T.

Bioessays. 2015 May;37(5):525-31. doi: 10.1002/bies.201400208. Epub 2015 Feb 13.


Glucagon-like receptor 1 agonists and DPP-4 inhibitors: potential therapies for the treatment of stroke.

Darsalia V, Larsson M, Nathanson D, Klein T, Nyström T, Patrone C.

J Cereb Blood Flow Metab. 2015 May;35(5):718-23. doi: 10.1038/jcbfm.2015.17. Epub 2015 Feb 11. Review.

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