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Items: 1 to 50 of 201

1.

Prime-boost vaccination with recombinant protein and adenovirus-vector expressing Plasmodium vivax circumsporozoite protein (CSP) partially protects mice against Pb/Pv sporozoite challenge.

de Camargo TM, de Freitas EO, Gimenez AM, Lima LC, de Almeida Caramico K, Françoso KS, Bruna-Romero O, Andolina C, Nosten F, Rénia L, Ertl HCJ, Nussenzweig RS, Nussenzweig V, Rodrigues MM, Reyes-Sandoval A, Soares IS.

Sci Rep. 2018 Jan 18;8(1):1118. doi: 10.1038/s41598-017-19063-6.

2.

Vaccine Containing the Three Allelic Variants of the Plasmodium vivax Circumsporozoite Antigen Induces Protection in Mice after Challenge with a Transgenic Rodent Malaria Parasite.

Gimenez AM, Lima LC, Françoso KS, Denapoli PMA, Panatieri R, Bargieri DY, Thiberge JM, Andolina C, Nosten F, Renia L, Nussenzweig RS, Nussenzweig V, Amino R, Rodrigues MM, Soares IS.

Front Immunol. 2017 Oct 11;8:1275. doi: 10.3389/fimmu.2017.01275. eCollection 2017.

3.

Human CD8+ T cells mediate protective immunity induced by a human malaria vaccine in human immune system mice.

Li X, Huang J, Zhang M, Funakoshi R, Sheetij D, Spaccapelo R, Crisanti A, Nussenzweig V, Nussenzweig RS, Tsuji M.

Vaccine. 2016 Aug 31;34(38):4501-4506. doi: 10.1016/j.vaccine.2016.08.006. Epub 2016 Aug 5.

4.

Human immune system mice immunized with Plasmodium falciparum circumsporozoite protein induce protective human humoral immunity against malaria.

Huang J, Li X, Coelho-dos-Reis JG, Zhang M, Mitchell R, Nogueira RT, Tsao T, Noe AR, Ayala R, Sahi V, Gutierrez GM, Nussenzweig V, Wilson JM, Nardin EH, Nussenzweig RS, Tsuji M.

J Immunol Methods. 2015 Dec;427:42-50. doi: 10.1016/j.jim.2015.09.005. Epub 2015 Sep 26.

PMID:
26410104
5.

Immunogenicity of a prime-boost vaccine containing the circumsporozoite proteins of Plasmodium vivax in rodents.

Teixeira LH, Tararam CA, Lasaro MO, Camacho AG, Ersching J, Leal MT, Herrera S, Bruna-Romero O, Soares IS, Nussenzweig RS, Ertl HC, Nussenzweig V, Rodrigues MM.

Infect Immun. 2014 Feb;82(2):793-807. doi: 10.1128/IAI.01410-13. Epub 2013 Dec 9.

6.

Antibodies to Plasmodium circumsporozoite protein (CSP) inhibit sporozoite's cell traversal activity.

Mishra S, Nussenzweig RS, Nussenzweig V.

J Immunol Methods. 2012 Mar 30;377(1-2):47-52. doi: 10.1016/j.jim.2012.01.009. Epub 2012 Jan 28.

7.

TLR5-dependent immunogenicity of a recombinant fusion protein containing an immunodominant epitope of malarial circumsporozoite protein and the FliC flagellin of Salmonella Typhimurium.

Camacho AG, Teixeira LH, Bargieri DY, Boscardin SB, Soares IS, Nussenzweig RS, Nussenzweig V, Rodrigues MM.

Mem Inst Oswaldo Cruz. 2011 Aug;106 Suppl 1:167-71.

8.

Identification of non-CSP antigens bearing CD8 epitopes in mice immunized with irradiated sporozoites.

Mishra S, Rai U, Shiratsuchi T, Li X, Vanloubbeeck Y, Cohen J, Nussenzweig RS, Winzeler EA, Tsuji M, Nussenzweig V.

Vaccine. 2011 Oct 6;29(43):7335-42. doi: 10.1016/j.vaccine.2011.07.081. Epub 2011 Jul 30.

9.

Breakthroughs towards a malaria vaccine.

Nussenzweig RS, Krettli AU.

Hist Cienc Saude Manguinhos. 2011 Jun 1;18(2):559-64.

10.

The Plasmodium eukaryotic initiation factor-2alpha kinase IK2 controls the latency of sporozoites in the mosquito salivary glands.

Zhang M, Fennell C, Ranford-Cartwright L, Sakthivel R, Gueirard P, Meister S, Caspi A, Doerig C, Nussenzweig RS, Tuteja R, Sullivan WJ Jr, Roos DS, Fontoura BM, Ménard R, Winzeler EA, Nussenzweig V.

J Exp Med. 2010 Jul 5;207(7):1465-74. doi: 10.1084/jem.20091975. Epub 2010 Jun 28.

11.

Immunogenicity and protective efficacy of a recombinant yellow fever vaccine against the murine malarial parasite Plasmodium yoelii.

Stoyanov CT, Boscardin SB, Deroubaix S, Barba-Spaeth G, Franco D, Nussenzweig RS, Nussenzweig M, Rice CM.

Vaccine. 2010 Jun 23;28(29):4644-52. doi: 10.1016/j.vaccine.2010.04.071. Epub 2010 May 6.

12.

The circumsporozoite protein is an immunodominant protective antigen in irradiated sporozoites.

Kumar KA, Sano G, Boscardin S, Nussenzweig RS, Nussenzweig MC, Zavala F, Nussenzweig V.

Nature. 2006 Dec 14;444(7121):937-40. Epub 2006 Dec 6.

PMID:
17151604
13.

Antigen targeting to dendritic cells elicits long-lived T cell help for antibody responses.

Boscardin SB, Hafalla JC, Masilamani RF, Kamphorst AO, Zebroski HA, Rai U, Morrot A, Zavala F, Steinman RM, Nussenzweig RS, Nussenzweig MC.

J Exp Med. 2006 Mar 20;203(3):599-606. Epub 2006 Feb 27.

14.

Yellow fever 17D as a vaccine vector for microbial CTL epitopes: protection in a rodent malaria model.

Tao D, Barba-Spaeth G, Rai U, Nussenzweig V, Rice CM, Nussenzweig RS.

J Exp Med. 2005 Jan 17;201(2):201-9.

15.
16.

Delayed-type hypersensitivity in volunteers immunized with a synthetic multi-antigen peptide vaccine (PfCS-MAP1NYU) against Plasmodium falciparum sporozoites.

Kublin JG, Lowitt MH, Hamilton RG, Oliveira GA, Nardin EH, Nussenzweig RS, Schmeckpeper BJ, Diggs CL, Bodison SA, Edelman R.

Vaccine. 2002 Mar 15;20(13-14):1853-61.

PMID:
11906775
17.

Surface expression of an immunodominant malaria protein B cell epitope by yellow fever virus.

Bonaldo MC, Garratt RC, Caufour PS, Freire MS, Rodrigues MM, Nussenzweig RS, Galler R.

J Mol Biol. 2002 Jan 25;315(4):873-85.

PMID:
11812154
18.

Complete, long-lasting protection against malaria of mice primed and boosted with two distinct viral vectors expressing the same plasmodial antigen.

Bruña-Romero O, González-Aseguinolaza G, Hafalla JC, Tsuji M, Nussenzweig RS.

Proc Natl Acad Sci U S A. 2001 Sep 25;98(20):11491-6. Epub 2001 Sep 11.

19.

Gene targeting in the rodent malaria parasite Plasmodium yoelii.

Mota MM, Thathy V, Nussenzweig RS, Nussenzweig V.

Mol Biochem Parasitol. 2001 Apr 6;113(2):271-8.

PMID:
11295181
20.

A striking property of recombinant poxviruses: efficient inducers of in vivo expansion of primed CD8(+) T cells.

Zavala F, Rodrigues M, Rodriguez D, Rodriguez JR, Nussenzweig RS, Esteban M.

Virology. 2001 Feb 15;280(2):155-9. Review. No abstract available.

21.

Migration of Plasmodium sporozoites through cells before infection.

Mota MM, Pradel G, Vanderberg JP, Hafalla JC, Frevert U, Nussenzweig RS, Nussenzweig V, Rodríguez A.

Science. 2001 Jan 5;291(5501):141-4.

22.

A totally synthetic polyoxime malaria vaccine containing Plasmodium falciparum B cell and universal T cell epitopes elicits immune responses in volunteers of diverse HLA types.

Nardin EH, Calvo-Calle JM, Oliveira GA, Nussenzweig RS, Schneider M, Tiercy JM, Loutan L, Hochstrasser D, Rose K.

J Immunol. 2001 Jan 1;166(1):481-9.

23.

Synthetic malaria peptide vaccine elicits high levels of antibodies in vaccinees of defined HLA genotypes.

Nardin EH, Oliveira GA, Calvo-Calle JM, Castro ZR, Nussenzweig RS, Schmeckpeper B, Hall BF, Diggs C, Bodison S, Edelman R.

J Infect Dis. 2000 Nov;182(5):1486-96. Epub 2000 Oct 9.

PMID:
11023472
24.

Immunogenicity of Ty-VLP bearing a CD8(+) T cell epitope of the CS protein of P. yoelii: enhanced memory response by boosting with recombinant vaccinia virus

Oliveira-Ferreira J, Myahira Y, Layton GT, Savage N, Esteban M, Rodriguez D, Rodriguez JR, Nussenzweig RS, Zavala F.

Vaccine. 2000 Jun 15;18(25):2923. No abstract available.

PMID:
10812236
25.

Immunogenicity of Ty-VLP bearing a CD8(+) T cell epitope of the CS protein of P. yoelii: enhanced memory response by boosting with recombinant vaccinia virus.

Oliveira-Ferreira J, Miyahira Y, Layton GT, Savage N, Esteban M, Rodriguez D, Rodriguez JR, Nussenzweig RS, Zavala F.

Vaccine. 2000 Mar 6;18(17):1863-9. Erratum in: Vaccine 2000 Jun 15;18(25):2923. Myahira Y [corrected to Miyahira Y].

PMID:
10699335
26.

Pre-erythrocytic malaria vaccine: mechanisms of protective immunity and human vaccine trials.

Nardin E, Zavala F, Nussenzweig V, Nussenzweig RS.

Parassitologia. 1999 Sep;41(1-3):397-402. Review.

PMID:
10697892
27.

Interferon-gamma-independent CD8+ T cell-mediated protective anti-malaria immunity elicited by recombinant adenovirus.

Rodrigues EG, Claassen J, Lee S, Wilson JM, Nussenzweig RS, Tsuji M.

Parasite Immunol. 2000 Mar;22(3):157-60.

28.

Preclinical evaluation of a synthetic Plasmodium falciparum MAP malaria vaccine in Aotus monkeys and mice.

Moreno CA, Rodriguez R, Oliveira GA, Ferreira V, Nussenzweig RS, Moya Castro ZR, Calvo-Calle JM, Nardin E.

Vaccine. 1999 Aug 20;18(1-2):89-99.

PMID:
10501239
29.

Subtle mutagenesis by ends-in recombination in malaria parasites.

Nunes A, Thathy V, Bruderer T, Sultan AA, Nussenzweig RS, Ménard R.

Mol Cell Biol. 1999 Apr;19(4):2895-902.

30.

Interferon-gamma responses are associated with resistance to reinfection with Plasmodium falciparum in young African children.

Luty AJ, Lell B, Schmidt-Ott R, Lehman LG, Luckner D, Greve B, Matousek P, Herbich K, Schmid D, Migot-Nabias F, Deloron P, Nussenzweig RS, Kremsner PG.

J Infect Dis. 1999 Apr;179(4):980-8.

PMID:
10068595
31.

Efficient induction of protective anti-malaria immunity by recombinant adenovirus.

Rodrigues EG, Zavala F, Nussenzweig RS, Wilson JM, Tsuji M.

Vaccine. 1998 Nov;16(19):1812-7.

PMID:
9795385
32.
33.

Recombinant viruses expressing a human malaria antigen can elicit potentially protective immune CD8+ responses in mice.

Miyahira Y, García-Sastre A, Rodriguez D, Rodriguez JR, Murata K, Tsuji M, Palese P, Esteban M, Zavala F, Nussenzweig RS.

Proc Natl Acad Sci U S A. 1998 Mar 31;95(7):3954-9.

34.

TRAP is necessary for gliding motility and infectivity of plasmodium sporozoites.

Sultan AA, Thathy V, Frevert U, Robson KJ, Crisanti A, Nussenzweig V, Nussenzweig RS, Ménard R.

Cell. 1997 Aug 8;90(3):511-22.

35.

Development of novel influenza virus vaccines and vectors.

Palese P, Zavala F, Muster T, Nussenzweig RS, García-Sastre A.

J Infect Dis. 1997 Aug;176 Suppl 1:S45-9. Review.

PMID:
9240694
36.

Circumsporozoite protein is required for development of malaria sporozoites in mosquitoes.

Ménard R, Sultan AA, Cortes C, Altszuler R, van Dijk MR, Janse CJ, Waters AP, Nussenzweig RS, Nussenzweig V.

Nature. 1997 Jan 23;385(6614):336-40.

PMID:
9002517
37.

A malaria vaccine based on a sporozoite antigen.

Nussenzweig RS, Zavala F.

N Engl J Med. 1997 Jan 9;336(2):128-30. No abstract available.

PMID:
8988893
38.

Plasmodium yoelii: peptide immunization induces protective CD4+ T cells against a previously unrecognized cryptic epitope of the circumsporozoite protein.

Takita-Sonoda Y, Tsuji M, Kamboj K, Nussenzweig RS, Clavijo P, Zavala F.

Exp Parasitol. 1996 Nov;84(2):223-30.

PMID:
8932772
39.

Characterization of in vivo primary and secondary CD8+ T cell responses induced by recombinant influenza and vaccinia viruses.

Murata K, García-Sastre A, Tsuji M, Rodrigues M, Rodriguez D, Rodriguez JR, Nussenzweig RS, Palese P, Esteban M, Zavala F.

Cell Immunol. 1996 Oct 10;173(1):96-107.

PMID:
8871605
40.

Phenotypic and functional properties of murine gamma delta T cell clones derived from malaria immunized, alpha beta T cell-deficient mice.

Tsuji M, Eyster CL, O'Brien RL, Born WK, Bapna M, Reichel M, Nussenzweig RS, Zavala F.

Int Immunol. 1996 Mar;8(3):359-66.

PMID:
8728988
41.

Detection of anti-Plasmodium falciparum antibodies directed against a repetitive peptide of the gametocyte antigen Pfs2400 in malaria patients in Brazil.

Marrelli MT, Nussenzweig RS, Collins WE, Kloetzel JK.

Ann Trop Med Parasitol. 1995 Dec;89(6):593-99.

PMID:
8745934
42.

Development of antimalaria immunity in mice lacking IFN-gamma receptor.

Tsuji M, Miyahira Y, Nussenzweig RS, Aguet M, Reichel M, Zavala F.

J Immunol. 1995 May 15;154(10):5338-44.

PMID:
7537305
43.

The use of multiple antigen peptides in the analysis and induction of protective immune responses against infectious diseases.

Nardin EH, Oliveira GA, Calvo-Calle JM, Nussenzweig RS.

Adv Immunol. 1995;60:105-49. Review. No abstract available.

PMID:
8607369
44.

Influenza and vaccinia viruses expressing malaria CD8+ T and B cell epitopes. Comparison of their immunogenicity and capacity to induce protective immunity.

Rodrigues M, Li S, Murata K, Rodriguez D, Rodriguez JR, Bacik I, Bennink JR, Yewdell JW, Garcia-Sastre A, Nussenzweig RS, et al.

J Immunol. 1994 Nov 15;153(10):4636-48.

PMID:
7525709
45.

Malaria vaccines: multiple targets.

Nussenzweig RS, Long CA.

Science. 1994 Sep 2;265(5177):1381-3. Review. No abstract available.

PMID:
8073276
47.

Gamma delta T cells contribute to immunity against the liver stages of malaria in alpha beta T-cell-deficient mice.

Tsuji M, Mombaerts P, Lefrancois L, Nussenzweig RS, Zavala F, Tonegawa S.

Proc Natl Acad Sci U S A. 1994 Jan 4;91(1):345-9.

48.

Demonstration of heat-shock protein 70 in the sporozoite stage of malaria parasites.

Tsuji M, Mattei D, Nussenzweig RS, Eichinger D, Zavala F.

Parasitol Res. 1994;80(1):16-21.

PMID:
8153120
49.
50.

Anophelines in the state of Acre, Brazil, infected with Plasmodium falciparum, P. vivax, the variant P. vivax VK247 and P. malariae.

Branquinho MS, Lagos CB, Rocha RM, Natal D, Barata JM, Cochrane AH, Nardin E, Nussenzweig RS, Kloetzel JK.

Trans R Soc Trop Med Hyg. 1993 Jul-Aug;87(4):391-4.

PMID:
8249059

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