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Items: 1 to 50 of 253

1.

Real-time observation of flexible domain movements in CRISPR-Cas9.

Osuka S, Isomura K, Kajimoto S, Komori T, Nishimasu H, Shima T, Nureki O, Uemura S.

EMBO J. 2018 Apr 12. pii: e96941. doi: 10.15252/embj.201796941. [Epub ahead of print]

2.

PIK3CA and KRAS mutations in cell free circulating DNA are useful markers for monitoring ovarian clear cell carcinoma.

Morikawa A, Hayashi T, Shimizu N, Kobayashi M, Taniue K, Takahashi A, Tachibana K, Saito M, Kawabata A, Iida Y, Ueda K, Saito M, Yanaihara N, Tanabe H, Yamada K, Takano H, Nureki O, Okamoto A, Akiyama T.

Oncotarget. 2018 Feb 22;9(20):15266-15274. doi: 10.18632/oncotarget.24555. eCollection 2018 Mar 16.

3.

Generation of tumor antigen-specific murine CD8+ T cells with enhanced anti-tumor activity via highly efficient CRISPR/Cas9 genome editing.

Ouchi Y, Patil A, Tamura Y, Nishimasu H, Negishi A, Paul SK, Takemura N, Satoh T, Kimura Y, Kurachi M, Nureki O, Nakai K, Kiyono H, Uematsu S.

Int Immunol. 2018 Apr 3;30(4):141-154. doi: 10.1093/intimm/dxy006.

PMID:
29617862
4.

Functional roles of Mg2+ binding sites in ion-dependent gating of a Mg2+ channel, MgtE, revealed by solution NMR.

Maruyama T, Imai S, Kusakizako T, Hattori M, Ishitani R, Nureki O, Ito K, Maturana AD, Shimada I, Osawa M.

Elife. 2018 Apr 3;7. pii: e31596. doi: 10.7554/eLife.31596.

5.

Crystallographic Analysis of MATE-Type Multidrug Exporter with Its Inhibitors.

Kusakizako T, Tanaka Y, Hipolito CJ, Suga H, Nureki O.

Methods Mol Biol. 2018;1700:37-57. doi: 10.1007/978-1-4939-7454-2_3.

PMID:
29177824
6.

Production and rearing of germ-free X-SCID pigs.

Hara H, Shibata H, Nakano K, Abe T, Uosaki H, Ohnuki T, Hishikawa S, Kunita S, Watanabe M, Nureki O, Nagashima H, Hanazono Y.

Exp Anim. 2017 Nov 21. doi: 10.1538/expanim.17-0095. [Epub ahead of print]

7.

Structural basis for xenobiotic extrusion by eukaryotic MATE transporter.

Miyauchi H, Moriyama S, Kusakizako T, Kumazaki K, Nakane T, Yamashita K, Hirata K, Dohmae N, Nishizawa T, Ito K, Miyaji T, Moriyama Y, Ishitani R, Nureki O.

Nat Commun. 2017 Nov 21;8(1):1633. doi: 10.1038/s41467-017-01541-0.

8.

Capturing an initial intermediate during the P450nor enzymatic reaction using time-resolved XFEL crystallography and caged-substrate.

Tosha T, Nomura T, Nishida T, Saeki N, Okubayashi K, Yamagiwa R, Sugahara M, Nakane T, Yamashita K, Hirata K, Ueno G, Kimura T, Hisano T, Muramoto K, Sawai H, Takeda H, Mizohata E, Yamashita A, Kanematsu Y, Takano Y, Nango E, Tanaka R, Nureki O, Shoji O, Ikemoto Y, Murakami H, Owada S, Tono K, Yabashi M, Yamamoto M, Ago H, Iwata S, Sugimoto H, Shiro Y, Kubo M.

Nat Commun. 2017 Nov 17;8(1):1585. doi: 10.1038/s41467-017-01702-1.

9.

Real-space and real-time dynamics of CRISPR-Cas9 visualized by high-speed atomic force microscopy.

Shibata M, Nishimasu H, Kodera N, Hirano S, Ando T, Uchihashi T, Nureki O.

Nat Commun. 2017 Nov 10;8(1):1430. doi: 10.1038/s41467-017-01466-8.

10.

Prognostic relevance of integrated genetic profiling in adult T-cell leukemia/lymphoma.

Kataoka K, Iwanaga M, Yasunaga JI, Nagata Y, Kitanaka A, Kameda T, Yoshimitsu M, Shiraishi Y, Sato-Otsubo A, Sanada M, Chiba K, Tanaka H, Ochi Y, Aoki K, Suzuki H, Shiozawa Y, Yoshizato T, Sato Y, Yoshida K, Nosaka K, Hishizawa M, Itonaga H, Imaizumi Y, Munakata W, Shide K, Kubuki Y, Hidaka T, Nakamaki T, Ishiyama K, Miyawaki S, Ishii R, Nureki O, Tobinai K, Miyazaki Y, Takaori-Kondo A, Shibata T, Miyano S, Ishitsuka K, Utsunomiya A, Shimoda K, Matsuoka M, Watanabe T, Ogawa S.

Blood. 2018 Jan 11;131(2):215-225. doi: 10.1182/blood-2017-01-761874. Epub 2017 Oct 30.

PMID:
29084771
11.

Structural insights into the competitive inhibition of the ATP-gated P2X receptor channel.

Kasuya G, Yamaura T, Ma XB, Nakamura R, Takemoto M, Nagumo H, Tanaka E, Dohmae N, Nakane T, Yu Y, Ishitani R, Matsuzaki O, Hattori M, Nureki O.

Nat Commun. 2017 Oct 12;8(1):876. doi: 10.1038/s41467-017-00887-9.

12.

Structure of the triose-phosphate/phosphate translocator reveals the basis of substrate specificity.

Lee Y, Nishizawa T, Takemoto M, Kumazaki K, Yamashita K, Hirata K, Minoda A, Nagatoishi S, Tsumoto K, Ishitani R, Nureki O.

Nat Plants. 2017 Oct;3(10):825-832. doi: 10.1038/s41477-017-0022-8. Epub 2017 Oct 2.

PMID:
28970497
13.

XFEL structures of the influenza M2 proton channel: Room temperature water networks and insights into proton conduction.

Thomaston JL, Woldeyes RA, Nakane T, Yamashita A, Tanaka T, Koiwai K, Brewster AS, Barad BA, Chen Y, Lemmin T, Uervirojnangkoorn M, Arima T, Kobayashi J, Masuda T, Suzuki M, Sugahara M, Sauter NK, Tanaka R, Nureki O, Tono K, Joti Y, Nango E, Iwata S, Yumoto F, Fraser JS, DeGrado WF.

Proc Natl Acad Sci U S A. 2017 Dec 19;114(51):13357-13362. doi: 10.1073/pnas.1705624114. Epub 2017 Aug 23.

14.

SecY-SecA fusion protein retains the ability to mediate protein transport.

Sugano Y, Furukawa A, Nureki O, Tanaka Y, Tsukazaki T.

PLoS One. 2017 Aug 18;12(8):e0183434. doi: 10.1371/journal.pone.0183434. eCollection 2017.

15.

X-ray structures of endothelin ETB receptor bound to clinical antagonist bosentan and its analog.

Shihoya W, Nishizawa T, Yamashita K, Inoue A, Hirata K, Kadji FMN, Okuta A, Tani K, Aoki J, Fujiyoshi Y, Doi T, Nureki O.

Nat Struct Mol Biol. 2017 Sep;24(9):758-764. doi: 10.1038/nsmb.3450. Epub 2017 Aug 14.

PMID:
28805809
16.

Structural insights into ligand recognition by the lysophosphatidic acid receptor LPA6.

Taniguchi R, Inoue A, Sayama M, Uwamizu A, Yamashita K, Hirata K, Yoshida M, Tanaka Y, Kato HE, Nakada-Nakura Y, Otani Y, Nishizawa T, Doi T, Ohwada T, Ishitani R, Aoki J, Nureki O.

Nature. 2017 Aug 17;548(7667):356-360. doi: 10.1038/nature23448. Epub 2017 Aug 9.

PMID:
28792932
17.

Structural Basis for the Canonical and Non-canonical PAM Recognition by CRISPR-Cpf1.

Yamano T, Zetsche B, Ishitani R, Zhang F, Nishimasu H, Nureki O.

Mol Cell. 2017 Aug 17;67(4):633-645.e3. doi: 10.1016/j.molcel.2017.06.035. Epub 2017 Aug 3.

PMID:
28781234
18.

ATP-dependent modulation of MgtE in Mg2+ homeostasis.

Tomita A, Zhang M, Jin F, Zhuang W, Takeda H, Maruyama T, Osawa M, Hashimoto KI, Kawasaki H, Ito K, Dohmae N, Ishitani R, Shimada I, Yan Z, Hattori M, Nureki O.

Nat Commun. 2017 Jul 27;8(1):148. doi: 10.1038/s41467-017-00082-w.

19.

Serial femtosecond crystallography structure of cytochrome c oxidase at room temperature.

Andersson R, Safari C, Dods R, Nango E, Tanaka R, Yamashita A, Nakane T, Tono K, Joti Y, Båth P, Dunevall E, Bosman R, Nureki O, Iwata S, Neutze R, Brändén G.

Sci Rep. 2017 Jul 3;7(1):4518. doi: 10.1038/s41598-017-04817-z.

20.

CRISPR/Cas9-mediated genome editing via postnatal administration of AAV vector cures haemophilia B mice.

Ohmori T, Nagao Y, Mizukami H, Sakata A, Muramatsu SI, Ozawa K, Tominaga SI, Hanazono Y, Nishimura S, Nureki O, Sakata Y.

Sci Rep. 2017 Jun 23;7(1):4159. doi: 10.1038/s41598-017-04625-5.

21.

Structural Basis for the Altered PAM Recognition by Engineered CRISPR-Cpf1.

Nishimasu H, Yamano T, Gao L, Zhang F, Ishitani R, Nureki O.

Mol Cell. 2017 Jul 6;67(1):139-147.e2. doi: 10.1016/j.molcel.2017.04.019. Epub 2017 Jun 6.

PMID:
28595896
22.

Engineered Cpf1 variants with altered PAM specificities.

Gao L, Cox DBT, Yan WX, Manteiga JC, Schneider MW, Yamano T, Nishimasu H, Nureki O, Crosetto N, Zhang F.

Nat Biotechnol. 2017 Aug;35(8):789-792. doi: 10.1038/nbt.3900. Epub 2017 Jun 5.

23.

Applications of the CRISPR-Cas9 system in kidney research.

Higashijima Y, Hirano S, Nangaku M, Nureki O.

Kidney Int. 2017 Aug;92(2):324-335. doi: 10.1016/j.kint.2017.01.037. Epub 2017 Apr 20. Review.

PMID:
28433382
24.

Cyclic GMP-AMP as an Endogenous Second Messenger in Innate Immune Signaling by Cytosolic DNA.

Kato K, Omura H, Ishitani R, Nureki O.

Annu Rev Biochem. 2017 Jun 20;86:541-566. doi: 10.1146/annurev-biochem-061516-044813. Epub 2017 Apr 7. Review.

PMID:
28399655
25.

Hydroxyethyl cellulose matrix applied to serial crystallography.

Sugahara M, Nakane T, Masuda T, Suzuki M, Inoue S, Song C, Tanaka R, Nakatsu T, Mizohata E, Yumoto F, Tono K, Joti Y, Kameshima T, Hatsui T, Yabashi M, Nureki O, Numata K, Nango E, Iwata S.

Sci Rep. 2017 Apr 6;7(1):703. doi: 10.1038/s41598-017-00761-0.

26.

Atomic resolution structure of serine protease proteinase K at ambient temperature.

Masuda T, Suzuki M, Inoue S, Song C, Nakane T, Nango E, Tanaka R, Tono K, Joti Y, Kameshima T, Hatsui T, Yabashi M, Mikami B, Nureki O, Numata K, Iwata S, Sugahara M.

Sci Rep. 2017 Mar 31;7:45604. doi: 10.1038/srep45604.

27.

Structural insights into the nucleotide base specificity of P2X receptors.

Kasuya G, Fujiwara Y, Tsukamoto H, Morinaga S, Ryu S, Touhara K, Ishitani R, Furutani Y, Hattori M, Nureki O.

Sci Rep. 2017 Mar 23;7:45208. doi: 10.1038/srep45208.

28.

Crystal Structure of the Minimal Cas9 from Campylobacter jejuni Reveals the Molecular Diversity in the CRISPR-Cas9 Systems.

Yamada M, Watanabe Y, Gootenberg JS, Hirano H, Ran FA, Nakane T, Ishitani R, Zhang F, Nishimasu H, Nureki O.

Mol Cell. 2017 Mar 16;65(6):1109-1121.e3. doi: 10.1016/j.molcel.2017.02.007.

29.

Light-induced structural changes and the site of O=O bond formation in PSII caught by XFEL.

Suga M, Akita F, Sugahara M, Kubo M, Nakajima Y, Nakane T, Yamashita K, Umena Y, Nakabayashi M, Yamane T, Nakano T, Suzuki M, Masuda T, Inoue S, Kimura T, Nomura T, Yonekura S, Yu LJ, Sakamoto T, Motomura T, Chen JH, Kato Y, Noguchi T, Tono K, Joti Y, Kameshima T, Hatsui T, Nango E, Tanaka R, Naitow H, Matsuura Y, Yamashita A, Yamamoto M, Nureki O, Yabashi M, Ishikawa T, Iwata S, Shen JR.

Nature. 2017 Mar 2;543(7643):131-135. doi: 10.1038/nature21400. Epub 2017 Feb 20.

PMID:
28219079
30.

Correction: Breakpoint Cluster Region-Mediated Inflammation Is Dependent on Casein Kinase II.

Meng J, Jiang JJ, Atsumi T, Bando H, Okuyama Y, Sabharwal L, Nakagawa I, Higuchi H, Ota M, Okawara M, Ishitani R, Nureki O, Higo D, Arima Y, Ogura H, Kamimura D, Murakami M.

J Immunol. 2017 Jan 15;198(2):971. doi: 10.4049/jimmunol.1601918. No abstract available.

31.

A three-dimensional movie of structural changes in bacteriorhodopsin.

Nango E, Royant A, Kubo M, Nakane T, Wickstrand C, Kimura T, Tanaka T, Tono K, Song C, Tanaka R, Arima T, Yamashita A, Kobayashi J, Hosaka T, Mizohata E, Nogly P, Sugahara M, Nam D, Nomura T, Shimamura T, Im D, Fujiwara T, Yamanaka Y, Jeon B, Nishizawa T, Oda K, Fukuda M, Andersson R, Båth P, Dods R, Davidsson J, Matsuoka S, Kawatake S, Murata M, Nureki O, Owada S, Kameshima T, Hatsui T, Joti Y, Schertler G, Yabashi M, Bondar AN, Standfuss J, Neutze R, Iwata S.

Science. 2016 Dec 23;354(6319):1552-1557. doi: 10.1126/science.aah3497.

PMID:
28008064
32.

Structures and mechanisms of CRISPR RNA-guided effector nucleases.

Nishimasu H, Nureki O.

Curr Opin Struct Biol. 2017 Apr;43:68-78. doi: 10.1016/j.sbi.2016.11.013. Epub 2016 Nov 30. Review.

33.

Crystal structures of the TRIC trimeric intracellular cation channel orthologues.

Kasuya G, Hiraizumi M, Maturana AD, Kumazaki K, Fujiwara Y, Liu K, Nakada-Nakura Y, Iwata S, Tsukada K, Komori T, Uemura S, Goto Y, Nakane T, Takemoto M, Kato HE, Yamashita K, Wada M, Ito K, Ishitani R, Hattori M, Nureki O.

Cell Res. 2016 Dec;26(12):1288-1301. doi: 10.1038/cr.2016.140.

34.

The light-driven sodium ion pump: A new player in rhodopsin research.

Kato HE, Inoue K, Kandori H, Nureki O.

Bioessays. 2016 Dec;38(12):1274-1282. doi: 10.1002/bies.201600065. Epub 2016 Nov 17. Review.

PMID:
27859420
35.

Membrane protein structure determination by SAD, SIR, or SIRAS phasing in serial femtosecond crystallography using an iododetergent.

Nakane T, Hanashima S, Suzuki M, Saiki H, Hayashi T, Kakinouchi K, Sugiyama S, Kawatake S, Matsuoka S, Matsumori N, Nango E, Kobayashi J, Shimamura T, Kimura K, Mori C, Kunishima N, Sugahara M, Takakyu Y, Inoue S, Masuda T, Hosaka T, Tono K, Joti Y, Kameshima T, Hatsui T, Yabashi M, Inoue T, Nureki O, Iwata S, Murata M, Mizohata E.

Proc Natl Acad Sci U S A. 2016 Nov 15;113(46):13039-13044. Epub 2016 Oct 31.

36.

Structural and Functional Analysis of DDX41: a bispecific immune receptor for DNA and cyclic dinucleotide.

Omura H, Oikawa D, Nakane T, Kato M, Ishii R, Ishitani R, Tokunaga F, Nureki O.

Sci Rep. 2016 Oct 10;6:34756. doi: 10.1038/srep34756.

37.

Crystal Structure of Silkworm PIWI-Clade Argonaute Siwi Bound to piRNA.

Matsumoto N, Nishimasu H, Sakakibara K, Nishida KM, Hirano T, Ishitani R, Siomi H, Siomi MC, Nureki O.

Cell. 2016 Oct 6;167(2):484-497.e9. doi: 10.1016/j.cell.2016.09.002. Epub 2016 Sep 29.

38.

Role of Asn112 in a Light-Driven Sodium Ion-Pumping Rhodopsin.

Abe-Yoshizumi R, Inoue K, Kato HE, Nureki O, Kandori H.

Biochemistry. 2016 Oct 18;55(41):5790-5797. doi: 10.1021/acs.biochem.6b00741. Epub 2016 Oct 6.

PMID:
27673340
39.

Breakpoint Cluster Region-Mediated Inflammation Is Dependent on Casein Kinase II.

Meng J, Jiang JJ, Atsumi T, Bando H, Okuyama Y, Sabharwal L, Nakagawa I, Higuchi H, Ota M, Okawara M, Ishitani R, Nureki O, Higo D, Arima Y, Ogura H, Kamimura D, Murakami M.

J Immunol. 2016 Oct 15;197(8):3111-3119. Epub 2016 Sep 14. Erratum in: J Immunol. 2017 Jan 15;198(2):971.

40.

Activation mechanism of endothelin ETB receptor by endothelin-1.

Shihoya W, Nishizawa T, Okuta A, Tani K, Dohmae N, Fujiyoshi Y, Nureki O, Doi T.

Nature. 2016 Sep 15;537(7620):363-368. doi: 10.1038/nature19319. Epub 2016 Sep 5.

PMID:
27595334
41.

Linear ubiquitination is involved in the pathogenesis of optineurin-associated amyotrophic lateral sclerosis.

Nakazawa S, Oikawa D, Ishii R, Ayaki T, Takahashi H, Takeda H, Ishitani R, Kamei K, Takeyoshi I, Kawakami H, Iwai K, Hatada I, Sawasaki T, Ito H, Nureki O, Tokunaga F.

Nat Commun. 2016 Aug 24;7:12547. doi: 10.1038/ncomms12547.

42.

Crystal structure of the plant receptor-like kinase TDR in complex with the TDIF peptide.

Morita J, Kato K, Nakane T, Kondo Y, Fukuda H, Nishimasu H, Ishitani R, Nureki O.

Nat Commun. 2016 Aug 8;7:12383. doi: 10.1038/ncomms12383.

43.

Structural and functional insights into IZUMO1 recognition by JUNO in mammalian fertilization.

Kato K, Satouh Y, Nishimasu H, Kurabayashi A, Morita J, Fujihara Y, Oji A, Ishitani R, Ikawa M, Nureki O.

Nat Commun. 2016 Jul 15;7:12198. doi: 10.1038/ncomms12198.

44.

ENPP1 processes protein ADP-ribosylation in vitro.

Palazzo L, Daniels CM, Nettleship JE, Rahman N, McPherson RL, Ong SE, Kato K, Nureki O, Leung AK, Ahel I.

FEBS J. 2016 Sep;283(18):3371-88. doi: 10.1111/febs.13811. Epub 2016 Aug 5.

45.

LCP crystallization and X-ray diffraction analysis of VcmN, a MATE transporter from Vibrio cholerae.

Kusakizako T, Tanaka Y, Hipolito CJ, Kuroda T, Ishitani R, Suga H, Nureki O.

Acta Crystallogr F Struct Biol Commun. 2016 Jul;72(Pt 7):552-7. doi: 10.1107/S2053230X16008931. Epub 2016 Jun 22.

46.

Structural basis for amino acid export by DMT superfamily transporter YddG.

Tsuchiya H, Doki S, Takemoto M, Ikuta T, Higuchi T, Fukui K, Usuda Y, Tabuchi E, Nagatoishi S, Tsumoto K, Nishizawa T, Ito K, Dohmae N, Ishitani R, Nureki O.

Nature. 2016 Jun 16;534(7607):417-20. doi: 10.1038/nature17991. Epub 2016 May 30.

PMID:
27281193
47.

Data processing pipeline for serial femtosecond crystallography at SACLA.

Nakane T, Joti Y, Tono K, Yabashi M, Nango E, Iwata S, Ishitani R, Nureki O.

J Appl Crystallogr. 2016 Apr 18;49(Pt 3):1035-1041. eCollection 2016 Jun 1.

48.

Crystal Structure of Cpf1 in Complex with Guide RNA and Target DNA.

Yamano T, Nishimasu H, Zetsche B, Hirano H, Slaymaker IM, Li Y, Fedorova I, Nakane T, Makarova KS, Koonin EV, Ishitani R, Zhang F, Nureki O.

Cell. 2016 May 5;165(4):949-62. doi: 10.1016/j.cell.2016.04.003. Epub 2016 Apr 21.

49.

Oil-free hyaluronic acid matrix for serial femtosecond crystallography.

Sugahara M, Song C, Suzuki M, Masuda T, Inoue S, Nakane T, Yumoto F, Nango E, Tanaka R, Tono K, Joti Y, Kameshima T, Hatsui T, Yabashi M, Nureki O, Numata K, Iwata S.

Sci Rep. 2016 Apr 18;6:24484. doi: 10.1038/srep24484.

50.

Conductance of P2X4 purinergic receptor is determined by conformational equilibrium in the transmembrane region.

Minato Y, Suzuki S, Hara T, Kofuku Y, Kasuya G, Fujiwara Y, Igarashi S, Suzuki E, Nureki O, Hattori M, Ueda T, Shimada I.

Proc Natl Acad Sci U S A. 2016 Apr 26;113(17):4741-6. doi: 10.1073/pnas.1600519113. Epub 2016 Apr 11.

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