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Zc3h10 is a novel mitochondrial regulator.

Audano M, Pedretti S, Cermenati G, Brioschi E, Diaferia GR, Ghisletti S, Cuomo A, Bonaldi T, Salerno F, Mora M, Grigore L, Garlaschelli K, Baragetti A, Bonacina F, Catapano AL, Norata GD, Crestani M, Caruso D, Saez E, De Fabiani E, Mitro N.

EMBO Rep. 2018 Mar 5. pii: e45531. doi: 10.15252/embr.201745531. [Epub ahead of print]


The Interplay of Lipids, Lipoproteins, and Immunity in Atherosclerosis.

Pirillo A, Bonacina F, Norata GD, Catapano AL.

Curr Atheroscler Rep. 2018 Feb 14;20(3):12. doi: 10.1007/s11883-018-0715-0. Review.


Proprotein Convertase Subtilisin-Kexin type-9 (PCSK9) and triglyceride-rich lipoprotein metabolism: Facts and gaps.

Baragetti A, Grejtakova D, Casula M, Olmastroni E, Jotti GS, Norata GD, Catapano AL, Bellosta S.

Pharmacol Res. 2018 Feb 8;130:1-11. doi: 10.1016/j.phrs.2018.01.025. [Epub ahead of print] Review.


Regulatory T Cell Migration Is Dependent on Glucokinase-Mediated Glycolysis.

Kishore M, Cheung KCP, Fu H, Bonacina F, Wang G, Coe D, Ward EJ, Colamatteo A, Jangani M, Baragetti A, Matarese G, Smith DM, Haas R, Mauro C, Wraith DC, Okkenhaug K, Catapano AL, De Rosa V, Norata GD, Marelli-Berg FM.

Immunity. 2017 Nov 21;47(5):875-889.e10. doi: 10.1016/j.immuni.2017.10.017.


Disease trends over time and CD4+CCR5+ T-cells expansion predict carotid atherosclerosis development in patients with systemic lupus erythematosus.

Baragetti A, Ramirez GA, Magnoni M, Garlaschelli K, Grigore L, Berteotti M, Scotti I, Bozzolo E, Berti A, Camici PG, Catapano AL, Manfredi AA, Ammirati E, Norata GD.

Nutr Metab Cardiovasc Dis. 2018 Jan;28(1):53-63. doi: 10.1016/j.numecd.2017.09.001. Epub 2017 Sep 18.


Targeting Cholesterol in Non-ischemic Heart Failure: A Role for LDLR Gene Therapy?

Catapano AL, Pirillo A, Norata GD.

Mol Ther. 2017 Nov 1;25(11):2435-2437. doi: 10.1016/j.ymthe.2017.10.008. Epub 2017 Oct 19. No abstract available.


Anti-PCSK9 antibodies for the treatment of heterozygous familial hypercholesterolemia: patient selection and perspectives.

Catapano AL, Pirillo A, Norata GD.

Vasc Health Risk Manag. 2017 Sep 4;13:343-351. doi: 10.2147/VHRM.S130338. eCollection 2017. Review.


Strategies for the use of nonstatin therapies.

Pirillo A, Norata GD, Catapano AL.

Curr Opin Lipidol. 2017 Dec;28(6):458-464. doi: 10.1097/MOL.0000000000000459.


PCSK9 deficiency results in increased ectopic fat accumulation in experimental models and in humans.

Baragetti A, Balzarotti G, Grigore L, Pellegatta F, Guerrini U, Pisano G, Fracanzani AL, Fargion S, Norata GD, Catapano AL.

Eur J Prev Cardiol. 2017 Nov;24(17):1870-1877. doi: 10.1177/2047487317724342. Epub 2017 Jul 31.


PCSK9 inhibition in statin-intolerant HeFH patients: What's new?

Casula M, Pirillo A, Norata GD, Catapano AL.

Eur J Prev Cardiol. 2017 Sep;24(14):1525-1527. doi: 10.1177/2047487317721980. Epub 2017 Jul 21. No abstract available.


Arctigenin improves vascular tone and decreases inflammation in human saphenous vein.

Daci A, Neziri B, Krasniqi S, Cavolli R, Alaj R, Norata GD, Beretta G.

Eur J Pharmacol. 2017 Sep 5;810:51-56. doi: 10.1016/j.ejphar.2017.06.004. Epub 2017 Jun 8.


A past and present overview of macrophage metabolism and functional outcomes.

Curi R, de Siqueira Mendes R, de Campos Crispin LA, Norata GD, Sampaio SC, Newsholme P.

Clin Sci (Lond). 2017 Jun 15;131(12):1329-1342. doi: 10.1042/CS20170220. Review.


mTORC1 activity repression by late endosomal phosphatidylinositol 3,4-bisphosphate.

Marat AL, Wallroth A, Lo WT, Müller R, Norata GD, Falasca M, Schultz C, Haucke V.

Science. 2017 Jun 2;356(6341):968-972. doi: 10.1126/science.aaf8310.


Long pentraxin PTX3 as a prognostic marker of cardiovascular mortality in patients with chronic kidney disease.

Baragetti A, Norata GD.

Pol Arch Intern Med. 2017 Mar 31;127(3):152-153. doi: 10.20452/pamw.3989. Epub 2017 Mar 31. No abstract available.


Vascular inflammation and low-density lipoproteins: is cholesterol the link? A lesson from the clinical trials.

Catapano AL, Pirillo A, Norata GD.

Br J Pharmacol. 2017 Nov;174(22):3973-3985. doi: 10.1111/bph.13805. Epub 2017 May 5. Review.


Translating the microRNA signature of microvesicles derived from human coronary artery smooth muscle cells in patients with familial hypercholesterolemia and coronary artery disease.

de Gonzalo-Calvo D, Cenarro A, Garlaschelli K, Pellegatta F, Vilades D, Nasarre L, Camino-Lopez S, Crespo J, Carreras F, Leta R, Catapano AL, Norata GD, Civeira F, Llorente-Cortes V.

J Mol Cell Cardiol. 2017 May;106:55-67. doi: 10.1016/j.yjmcc.2017.03.005. Epub 2017 Mar 23.


T Follicular Helper Cells Promote a Beneficial Gut Ecosystem for Host Metabolic Homeostasis by Sensing Microbiota-Derived Extracellular ATP.

Perruzza L, Gargari G, Proietti M, Fosso B, D'Erchia AM, Faliti CE, Rezzonico-Jost T, Scribano D, Mauri L, Colombo D, Pellegrini G, Moregola A, Mooser C, Pesole G, Nicoletti M, Norata GD, Geuking MB, McCoy KD, Guglielmetti S, Grassi F.

Cell Rep. 2017 Mar 14;18(11):2566-2575. doi: 10.1016/j.celrep.2017.02.061.


Translating the biology of adipokines in atherosclerosis and cardiovascular diseases: Gaps and open questions.

Ruscica M, Baragetti A, Catapano AL, Norata GD.

Nutr Metab Cardiovasc Dis. 2017 May;27(5):379-395. doi: 10.1016/j.numecd.2016.12.005. Epub 2016 Dec 23. Review.


Obesity-Induced Metabolic Stress Leads to Biased Effector Memory CD4+ T Cell Differentiation via PI3K p110δ-Akt-Mediated Signals.

Mauro C, Smith J, Cucchi D, Coe D, Fu H, Bonacina F, Baragetti A, Cermenati G, Caruso D, Mitro N, Catapano AL, Ammirati E, Longhi MP, Okkenhaug K, Norata GD, Marelli-Berg FM.

Cell Metab. 2017 Mar 7;25(3):593-609. doi: 10.1016/j.cmet.2017.01.008. Epub 2017 Feb 9.


Circulating CD14+ and CD14highCD16- classical monocytes are reduced in patients with signs of plaque neovascularization in the carotid artery.

Ammirati E, Moroni F, Magnoni M, Di Terlizzi S, Villa C, Sizzano F, Palini A, Garlaschelli K, Tripiciano F, Scotti I, Catapano AL, Manfredi AA, Norata GD, Camici PG.

Atherosclerosis. 2016 Dec;255:171-178. doi: 10.1016/j.atherosclerosis.2016.10.004. Epub 2016 Oct 6.


Epicardial Adipose Tissue (EAT) Thickness Is Associated with Cardiovascular and Liver Damage in Nonalcoholic Fatty Liver Disease.

Fracanzani AL, Pisano G, Consonni D, Tiraboschi S, Baragetti A, Bertelli C, Norata GD, Dongiovanni P, Valenti L, Grigore L, Tonella T, Catapano A, Fargion S.

PLoS One. 2016 Sep 14;11(9):e0162473. doi: 10.1371/journal.pone.0162473. eCollection 2016.


Genetically determined telomeres shortening is associated with carotid atherosclerosis progression and increased incidence of cardiovascular events.

Baragetti A, Palmen J, Garlaschelli K, Grigore L, Humphries SE, Talmud PJ, Catapano AL, Norata GD.

Int J Cardiol. 2016 Nov 15;223:43-45. doi: 10.1016/j.ijcard.2016.08.164. Epub 2016 Aug 8. No abstract available.


Biology of proprotein convertase subtilisin kexin 9: beyond low-density lipoprotein cholesterol lowering.

Norata GD, Tavori H, Pirillo A, Fazio S, Catapano AL.

Cardiovasc Res. 2016 Oct;112(1):429-42. doi: 10.1093/cvr/cvw194. Epub 2016 Aug 5. Review.


Applicability of the 2013 ACC/AHA Risk Assessment and Cholesterol Treatment Guidelines in the real world: results from a multiethnic case-control study.

Magnoni M, Berteotti M, Norata GD, Limite LR, Peretto G, Cristell N, Maseri A, Cianflone D.

Ann Med. 2016;48(4):282-92. doi: 10.3109/07853890.2016.1168934. Epub 2016 Apr 7.


Vascular pentraxin 3 controls arterial thrombosis by targeting collagen and fibrinogen induced platelets aggregation.

Bonacina F, Barbieri SS, Cutuli L, Amadio P, Doni A, Sironi M, Tartari S, Mantovani A, Bottazzi B, Garlanda C, Tremoli E, Catapano AL, Norata GD.

Biochim Biophys Acta. 2016 Jun;1862(6):1182-90. doi: 10.1016/j.bbadis.2016.03.007. Epub 2016 Mar 11.


Niemann-Pick C1-Like 1 (NPC1L1) Inhibition and Cardiovascular Diseases.

Pirillo A, Catapano AL, Norata GD.

Curr Med Chem. 2016;23(10):983-99. Review.


Subclinical atherosclerosis is associated with Epicardial Fat Thickness and hepatic steatosis in the general population.

Baragetti A, Pisano G, Bertelli C, Garlaschelli K, Grigore L, Fracanzani AL, Fargion S, Norata GD, Catapano AL.

Nutr Metab Cardiovasc Dis. 2016 Feb;26(2):141-53. doi: 10.1016/j.numecd.2015.10.013. Epub 2015 Nov 2.


Normative values for carotid intima media thickness and its progression: Are they transferrable outside of their cohort of origin?

Liao X, Norata GD, Polak JF, Stehouwer CD, Catapano A, Rundek T, Ezhov M, Sander D, Thompson SG, Lorenz MW; PROG-IMT study group, Balakhonova T, Safarova M, Grigore L, Empana JP, Lin HJ, McLachlan S, Bokemark L, Ronkainen K, Schminke U, Lind L, Willeit P, Yanez DN, Steinmetz H, Poppert H, Desvarieux M, Ikram MA, Johnsen SH, Iglseder B, Friera A, Xie W, Plichart M, Su TC, Srinivasan SR, Schmidt C, Tuomainen TP, Völzke H, Nijpels G, Willeit J, Franco OH, Suarez C, Zhao D, Ducimetiere P, Chien KL, Robertson C, Bergström G, Kauhanen J, Dörr M, Dekker JM, Kiechl S, Sitzer M, Bickel H, Sacco RL, Hofman A, Mathiesen EB, Gabriel R, Liu J, Berenson G, Kavousi M, Price JF.

Eur J Prev Cardiol. 2016 Jul;23(11):1165-73. doi: 10.1177/2047487315625543. Epub 2016 Jan 8. Review.


Polymorphic Variants of SCN1A and EPHX1 Influence Plasma Carbamazepine Concentration, Metabolism and Pharmacoresistance in a Population of Kosovar Albanian Epileptic Patients.

Daci A, Beretta G, Vllasaliu D, Shala A, Govori V, Norata GD, Krasniqi S.

PLoS One. 2015 Nov 10;10(11):e0142408. doi: 10.1371/journal.pone.0142408. eCollection 2015.


Apolipoprotein C-III: From Pathophysiology to Pharmacology.

Norata GD, Tsimikas S, Pirillo A, Catapano AL.

Trends Pharmacol Sci. 2015 Oct;36(10):675-687. doi: 10.1016/ Review.


The Cellular and Molecular Basis of Translational Immunometabolism.

Norata GD, Caligiuri G, Chavakis T, Matarese G, Netea MG, Nicoletti A, O'Neill LA, Marelli-Berg FM.

Immunity. 2015 Sep 15;43(3):421-34. doi: 10.1016/j.immuni.2015.08.023. Review.


Functional Analysis of a Carotid Intima-Media Thickness Locus Implicates BCAR1 and Suggests a Causal Variant.

Boardman-Pretty F, Smith AJ, Cooper J, Palmen J, Folkersen L, Hamsten A, Catapano AL, Melander O, Price JF, Kumari M, Deanfield JE, Kivimäki M, Gertow K, Baragetti A, Norata GD, Humphries SE.

Circ Cardiovasc Genet. 2015 Oct;8(5):696-706. doi: 10.1161/CIRCGENETICS.115.001062. Epub 2015 Aug 14.


Carotid intima-media thickness progression and risk of vascular events in people with diabetes: results from the PROG-IMT collaboration.

Lorenz MW, Price JF, Robertson C, Bots ML, Polak JF, Poppert H, Kavousi M, Dörr M, Stensland E, Ducimetiere P, Ronkainen K, Kiechl S, Sitzer M, Rundek T, Lind L, Liu J, Bergström G, Grigore L, Bokemark L, Friera A, Yanez D, Bickel H, Ikram MA, Völzke H, Johnsen SH, Empana JP, Tuomainen TP, Willeit P, Steinmetz H, Desvarieux M, Xie W, Schmidt C, Norata GD, Suarez C, Sander D, Hofman A, Schminke U, Mathiesen E, Plichart M, Kauhanen J, Willeit J, Sacco RL, McLachlan S, Zhao D, Fagerberg B, Catapano AL, Gabriel R, Franco OH, Bülbül A, Scheckenbach F, Pflug A, Gao L, Thompson SG.

Diabetes Care. 2015 Oct;38(10):1921-9. doi: 10.2337/dc14-2732. Epub 2015 Jul 15. Review.


PI3K-C2γ is a Rab5 effector selectively controlling endosomal Akt2 activation downstream of insulin signalling.

Braccini L, Ciraolo E, Campa CC, Perino A, Longo DL, Tibolla G, Pregnolato M, Cao Y, Tassone B, Damilano F, Laffargue M, Calautti E, Falasca M, Norata GD, Backer JM, Hirsch E.

Nat Commun. 2015 Jun 23;6:7400. doi: 10.1038/ncomms8400.


An acidic microenvironment sets the humoral pattern recognition molecule PTX3 in a tissue repair mode.

Doni A, Musso T, Morone D, Bastone A, Zambelli V, Sironi M, Castagnoli C, Cambieri I, Stravalaci M, Pasqualini F, Laface I, Valentino S, Tartari S, Ponzetta A, Maina V, Barbieri SS, Tremoli E, Catapano AL, Norata GD, Bottazzi B, Garlanda C, Mantovani A.

J Exp Med. 2015 Jun 1;212(6):905-25. doi: 10.1084/jem.20141268. Epub 2015 May 11.


Markers of inflammation associated with plaque progression and instability in patients with carotid atherosclerosis.

Ammirati E, Moroni F, Norata GD, Magnoni M, Camici PG.

Mediators Inflamm. 2015;2015:718329. doi: 10.1155/2015/718329. Epub 2015 Apr 16. Review.


IDOL N342S Variant, Atherosclerosis Progression and Cardiovascular Disorders in the Italian General Population.

Dhyani A, Tibolla G, Baragetti A, Garlaschelli K, Pellegatta F, Grigore L, Norata GD, Catapano AL.

PLoS One. 2015 Apr 30;10(4):e0122414. doi: 10.1371/journal.pone.0122414. eCollection 2015.


Fibronectin extra domain A stabilises atherosclerotic plaques in apolipoprotein E and in LDL-receptor-deficient mice.

Pulakazhi Venu VK, Uboldi P, Dhyani A, Patrini A, Baetta R, Ferri N, Corsini A, Muro AF, Catapano AL, Norata GD.

Thromb Haemost. 2015 Jul;114(1):186-97. doi: 10.1160/TH14-09-0790. Epub 2015 Apr 16.


Peak inflammation in atherosclerosis, primary biliary cirrhosis and autoimmune arthritis is counter-intuitively associated with regulatory T cell enrichment.

Garetto S, Trovato AE, Lleo A, Sala F, Martini E, Betz AG, Norata GD, Invernizzi P, Kallikourdis M.

Immunobiology. 2015 Aug;220(8):1025-9. doi: 10.1016/j.imbio.2015.02.006. Epub 2015 Feb 26.


Homozygous familial hypobetalipoproteinemia: two novel mutations in the splicing sites of apolipoprotein B gene and review of the literature.

Cefalù AB, Norata GD, Ghiglioni DG, Noto D, Uboldi P, Garlaschelli K, Baragetti A, Spina R, Valenti V, Pederiva C, Riva E, Terracciano L, Zoja A, Grigore L, Averna MR, Catapano AL.

Atherosclerosis. 2015 Mar;239(1):209-17. doi: 10.1016/j.atherosclerosis.2015.01.014. Epub 2015 Jan 19. Review.


HDL in infectious diseases and sepsis.

Pirillo A, Catapano AL, Norata GD.

Handb Exp Pharmacol. 2015;224:483-508. doi: 10.1007/978-3-319-09665-0_15. Review.


Impact of systemic inflammation and autoimmune diseases on apoA-I and HDL plasma levels and functions.

Montecucco F, Favari E, Norata GD, Ronda N, Nofer JR, Vuilleumier N.

Handb Exp Pharmacol. 2015;224:455-82. doi: 10.1007/978-3-319-09665-0_14. Review.


The arachidonic acid metabolome serves as a conserved regulator of cholesterol metabolism.

Demetz E, Schroll A, Auer K, Heim C, Patsch JR, Eller P, Theurl M, Theurl I, Theurl M, Seifert M, Lener D, Stanzl U, Haschka D, Asshoff M, Dichtl S, Nairz M, Huber E, Stadlinger M, Moschen AR, Li X, Pallweber P, Scharnagl H, Stojakovic T, März W, Kleber ME, Garlaschelli K, Uboldi P, Catapano AL, Stellaard F, Rudling M, Kuba K, Imai Y, Arita M, Schuetz JD, Pramstaller PP, Tietge UJ, Trauner M, Norata GD, Claudel T, Hicks AA, Weiss G, Tancevski I.

Cell Metab. 2014 Nov 4;20(5):787-98.


Inflammatory markers and extent and progression of early atherosclerosis: Meta-analysis of individual-participant-data from 20 prospective studies of the PROG-IMT collaboration.

Willeit P, Thompson SG, Agewall S, Bergström G, Bickel H, Catapano AL, Chien KL, de Groot E, Empana JP, Etgen T, Franco OH, Iglseder B, Johnsen SH, Kavousi M, Lind L, Liu J, Mathiesen EB, Norata GD, Olsen MH, Papagianni A, Poppert H, Price JF, Sacco RL, Yanez DN, Zhao D, Schminke U, Bülbül A, Polak JF, Sitzer M, Hofman A, Grigore L, Dörr M, Su TC, Ducimetière P, Xie W, Ronkainen K, Kiechl S, Rundek T, Robertson C, Fagerberg B, Bokemark L, Steinmetz H, Ikram MA, Völzke H, Lin HJ, Plichart M, Tuomainen TP, Desvarieux M, McLachlan S, Schmidt C, Kauhanen J, Willeit J, Lorenz MW, Sander D; PROG-IMT study group.

Eur J Prev Cardiol. 2016 Jan;23(2):194-205. doi: 10.1177/2047487314560664. Epub 2014 Nov 21.


Telomere shortening over 6 years is associated with increased subclinical carotid vascular damage and worse cardiovascular prognosis in the general population.

Baragetti A, Palmen J, Garlaschelli K, Grigore L, Pellegatta F, Tragni E, Catapano AL, Humphries SE, Norata GD, Talmud PJ.

J Intern Med. 2015 Apr;277(4):478-87. doi: 10.1111/joim.12282. Epub 2014 Jul 19.


MiR-143/145 deficiency attenuates the progression of atherosclerosis in Ldlr-/-mice.

Sala F, Aranda JF, Rotllan N, Ramírez CM, Aryal B, Elia L, Condorelli G, Catapano AL, Fernández-Hernando C, Norata GD.

Thromb Haemost. 2014 Oct;112(4):796-802. doi: 10.1160/TH13-11-0905. Epub 2014 Jul 10. Erratum in: Thromb Haemost. 2015 Jul;114(1):210.


[PCSK9 inhibitors and dyslipidemias: an update on clinical evidence].

Norata GD.

G Ital Cardiol (Rome). 2014 May;15(5):301-5. doi: 10.1714/1563.17029. Review. Italian.


Novel concepts in HDL pharmacology.

Remaley AT, Norata GD, Catapano AL.

Cardiovasc Res. 2014 Aug 1;103(3):423-8. doi: 10.1093/cvr/cvu141. Epub 2014 Jun 20. Review.


HDL in innate and adaptive immunity.

Catapano AL, Pirillo A, Bonacina F, Norata GD.

Cardiovasc Res. 2014 Aug 1;103(3):372-83. doi: 10.1093/cvr/cvu150. Epub 2014 Jun 15. Review.


PCSK9 inhibition for the treatment of hypercholesterolemia: promises and emerging challenges.

Norata GD, Tibolla G, Catapano AL.

Vascul Pharmacol. 2014 Aug;62(2):103-11. doi: 10.1016/j.vph.2014.05.011. Epub 2014 Jun 9. Review.


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