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Items: 26

1.

Discovery of Novel and Highly Selective Inhibitors of Calpain for the Treatment of Alzheimer's Disease: 2-(3-Phenyl-1H-pyrazol-1-yl)-nicotinamides.

Kling A, Jantos K, Mack H, Hornberger W, Drescher K, Nimmrich V, Relo A, Wicke K, Hutchins CW, Lao Y, Marsh K, Moeller A.

J Med Chem. 2017 Aug 24;60(16):7123-7138. doi: 10.1021/acs.jmedchem.7b00731. Epub 2017 Aug 15.

PMID:
28759231
2.

Anticonvulsant effects of structurally diverse GABA(B) positive allosteric modulators in the DBA/2J audiogenic seizure test: Comparison to baclofen and utility as a pharmacodynamic screening model.

Brown JW, Moeller A, Schmidt M, Turner SC, Nimmrich V, Ma J, Rueter LE, van der Kam E, Zhang M.

Neuropharmacology. 2016 Feb;101:358-69. doi: 10.1016/j.neuropharm.2015.10.009. Epub 2015 Oct 22.

PMID:
26471422
3.

A monoclonal antibody against the receptor for advanced glycation end products attenuates inflammatory and neuropathic pain in the mouse.

Brederson JD, Strakhova M, Mills C, Barlow E, Meyer A, Nimmrich V, Leddy M, Simler G, Schmidt M, Jarvis M, Lacy S.

Eur J Pain. 2016 Apr;20(4):607-14. doi: 10.1002/ejp.775. Epub 2015 Sep 22.

PMID:
26392119
4.

Neuronal Network Oscillations in Neurodegenerative Diseases.

Nimmrich V, Draguhn A, Axmacher N.

Neuromolecular Med. 2015 Sep;17(3):270-84. doi: 10.1007/s12017-015-8355-9. Epub 2015 Apr 29. Review.

PMID:
25920466
5.

Calcium channel blockers and dementia.

Nimmrich V, Eckert A.

Br J Pharmacol. 2013 Jul;169(6):1203-10. doi: 10.1111/bph.12240. Review.

6.

Synthetic Aβ oligomers (Aβ(1-42) globulomer) modulate presynaptic calcium currents: prevention of Aβ-induced synaptic deficits by calcium channel blockers.

Hermann D, Mezler M, Müller MK, Wicke K, Gross G, Draguhn A, Bruehl C, Nimmrich V.

Eur J Pharmacol. 2013 Feb 28;702(1-3):44-55. doi: 10.1016/j.ejphar.2013.01.030. Epub 2013 Jan 30.

PMID:
23376566
7.

Establishment of a secondary screening assay for P/Q-type calcium channel blockers.

Hermann D, Mezler M, Swensen AM, Bruehl C, Obergrußerger A, Wicke K, Schoemaker H, Gross G, Draguhn A, Nimmrich V.

Comb Chem High Throughput Screen. 2013 Mar;16(3):233-43.

PMID:
23228050
8.

P/Q-type calcium channel modulators.

Nimmrich V, Gross G.

Br J Pharmacol. 2012 Oct;167(4):741-59. doi: 10.1111/j.1476-5381.2012.02069.x. Review.

9.

Development and validation of a fluorescence-based HTS assay for the identification of P/Q-type calcium channel blockers.

Mezler M, Hermann D, Swensen AM, Draguhn A, Terstappen GC, Gross G, Schoemaker H, Freiberg G, Pratt S, Gopalakrishnan SM, Nimmrich V.

Comb Chem High Throughput Screen. 2012 Jun 1;15(5):372-85.

PMID:
22272661
10.

A β-amyloid oligomer directly modulates P/Q-type calcium currents in Xenopus oocytes.

Mezler M, Barghorn S, Schoemaker H, Gross G, Nimmrich V.

Br J Pharmacol. 2012 Mar;165(5):1572-83. doi: 10.1111/j.1476-5381.2011.01646.x.

11.

Generation and therapeutic efficacy of highly oligomer-specific beta-amyloid antibodies.

Hillen H, Barghorn S, Striebinger A, Labkovsky B, Müller R, Nimmrich V, Nolte MW, Perez-Cruz C, van der Auwera I, van Leuven F, van Gaalen M, Bespalov AY, Schoemaker H, Sullivan JP, Ebert U.

J Neurosci. 2010 Aug 4;30(31):10369-79. doi: 10.1523/JNEUROSCI.5721-09.2010.

12.

Calpain inhibition prevents amyloid-beta-induced neurodegeneration and associated behavioral dysfunction in rats.

Granic I, Nyakas C, Luiten PG, Eisel UL, Halmy LG, Gross G, Schoemaker H, Möller A, Nimmrich V.

Neuropharmacology. 2010 Sep-Oct;59(4-5):334-42. doi: 10.1016/j.neuropharm.2010.07.013. Epub 2010 Jul 23.

PMID:
20650285
13.

Inhibition of calpain prevents NMDA-induced cell death and beta-amyloid-induced synaptic dysfunction in hippocampal slice cultures.

Nimmrich V, Reymann KG, Strassburger M, Schöder UH, Gross G, Hahn A, Schoemaker H, Wicke K, Möller A.

Br J Pharmacol. 2010 Apr;159(7):1523-31. doi: 10.1111/j.1476-5381.2010.00652.x. Epub 2010 Mar 3.

14.
15.

Synaptic transmission is impaired prior to plaque formation in amyloid precursor protein-overexpressing mice without altering behaviorally-correlated sharp wave-ripple complexes.

Hermann D, Both M, Ebert U, Gross G, Schoemaker H, Draguhn A, Wicke K, Nimmrich V.

Neuroscience. 2009 Sep 15;162(4):1081-90. doi: 10.1016/j.neuroscience.2009.05.044. Epub 2009 May 27.

PMID:
19477243
16.

Inhibition of Calpain Prevents N-Methyl-D-aspartate-Induced Degeneration of the Nucleus Basalis and Associated Behavioral Dysfunction.

Nimmrich V, Szabo R, Nyakas C, Granic I, Reymann KG, Schröder UH, Gross G, Schoemaker H, Wicke K, Möller A, Luiten P.

J Pharmacol Exp Ther. 2008 Nov;327(2):343-52. doi: 10.1124/jpet.108.142679. Epub 2008 Aug 13.

17.

Non-invasive characterization of beta-amyloid(1-40) vasoactivity by functional magnetic resonance imaging in mice.

Luo F, Seifert TR, Edalji R, Loebbert RW, Hradil VP, Harlan J, Schmidt M, Nimmrich V, Cox BF, Fox GB.

Neuroscience. 2008 Jul 31;155(1):263-9. doi: 10.1016/j.neuroscience.2008.04.021. Epub 2008 Jun 4.

PMID:
18534764
18.

Amyloid beta oligomers (A beta(1-42) globulomer) suppress spontaneous synaptic activity by inhibition of P/Q-type calcium currents.

Nimmrich V, Grimm C, Draguhn A, Barghorn S, Lehmann A, Schoemaker H, Hillen H, Gross G, Ebert U, Bruehl C.

J Neurosci. 2008 Jan 23;28(4):788-97. doi: 10.1523/JNEUROSCI.4771-07.2008.

19.

Globular amyloid beta-peptide oligomer - a homogenous and stable neuropathological protein in Alzheimer's disease.

Barghorn S, Nimmrich V, Striebinger A, Krantz C, Keller P, Janson B, Bahr M, Schmidt M, Bitner RS, Harlan J, Barlow E, Ebert U, Hillen H.

J Neurochem. 2005 Nov;95(3):834-47. Epub 2005 Aug 31.

20.

Induced sharp wave-ripple complexes in the absence of synaptic inhibition in mouse hippocampal slices.

Nimmrich V, Maier N, Schmitz D, Draguhn A.

J Physiol. 2005 Mar 15;563(Pt 3):663-70. Epub 2005 Jan 20.

21.

Dendritic BC1 RNA: modulation by kindling-induced afterdischarges.

Nimmrich V, Hargreaves EL, Muslimov IA, Bianchi R, Tiedge H.

Brain Res Mol Brain Res. 2005 Jan 5;133(1):110-8.

PMID:
15661371
22.

Dendritic transport and localization of protein kinase Mzeta mRNA: implications for molecular memory consolidation.

Muslimov IA, Nimmrich V, Hernandez AI, Tcherepanov A, Sacktor TC, Tiedge H.

J Biol Chem. 2004 Dec 10;279(50):52613-22. Epub 2004 Sep 15.

23.

Cellular and network mechanisms underlying spontaneous sharp wave-ripple complexes in mouse hippocampal slices.

Maier N, Nimmrich V, Draguhn A.

J Physiol. 2003 Aug 1;550(Pt 3):873-87. Epub 2003 Jun 13.

24.

Long-term maintenance of mature hippocampal slices in vitro.

Xiang Z, Hrabetova S, Moskowitz SI, Casaccia-Bonnefil P, Young SR, Nimmrich VC, Tiedge H, Einheber S, Karnup S, Bianchi R, Bergold PJ.

J Neurosci Methods. 2000 Jun 1;98(2):145-54.

PMID:
10880828
25.

Interaction of plakophilins with desmoplakin and intermediate filament proteins: an in vitro analysis.

Hofmann I, Mertens C, Brettel M, Nimmrich V, Schnölzer M, Herrmann H.

J Cell Sci. 2000 Jul;113 ( Pt 13):2471-83.

26.

Truncation mutagenesis of the non-alpha-helical carboxyterminal tail domain of vimentin reveals contributions to cellular localization but not to filament assembly.

Rogers KR, Eckelt A, Nimmrich V, Janssen KP, Schliwa M, Herrmann H, Franke WW.

Eur J Cell Biol. 1995 Feb;66(2):136-50.

PMID:
7774600

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