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Items: 8


Skp2-dependent reactivation of AKT drives resistance to PI3K inhibitors.

Clement E, Inuzuka H, Nihira NT, Wei W, Toker A.

Sci Signal. 2018 Mar 13;11(521). pii: eaao3810. doi: 10.1126/scisignal.aao3810.


Physiological functions of FBW7 in cancer and metabolism.

Shimizu K, Nihira NT, Inuzuka H, Wei W.

Cell Signal. 2018 Jun;46:15-22. doi: 10.1016/j.cellsig.2018.02.009. Epub 2018 Feb 21. Review.


Cyclin D-CDK4 kinase destabilizes PD-L1 via cullin 3-SPOP to control cancer immune surveillance.

Zhang J, Bu X, Wang H, Zhu Y, Geng Y, Nihira NT, Tan Y, Ci Y, Wu F, Dai X, Guo J, Huang YH, Fan C, Ren S, Sun Y, Freeman GJ, Sicinski P, Wei W.

Nature. 2018 Jan 4;553(7686):91-95. doi: 10.1038/nature25015. Epub 2017 Nov 16.


Acetylation-dependent regulation of MDM2 E3 ligase activity dictates its oncogenic function.

Nihira NT, Ogura K, Shimizu K, North BJ, Zhang J, Gao D, Inuzuka H, Wei W.

Sci Signal. 2017 Feb 14;10(466). pii: eaai8026. doi: 10.1126/scisignal.aai8026.


G1 cyclins link proliferation, pluripotency and differentiation of embryonic stem cells.

Liu L, Michowski W, Inuzuka H, Shimizu K, Nihira NT, Chick JM, Li N, Geng Y, Meng AY, Ordureau A, Kołodziejczyk A, Ligon KL, Bronson RT, Polyak K, Harper JW, Gygi SP, Wei W, Sicinski P.

Nat Cell Biol. 2017 Mar;19(3):177-188. doi: 10.1038/ncb3474. Epub 2017 Feb 13.


The SCFβ-TRCP E3 ubiquitin ligase complex targets Lipin1 for ubiquitination and degradation to promote hepatic lipogenesis.

Shimizu K, Fukushima H, Ogura K, Lien EC, Nihira NT, Zhang J, North BJ, Guo A, Nagashima K, Nakagawa T, Hoshikawa S, Watahiki A, Okabe K, Yamada A, Toker A, Asara JM, Fukumoto S, Nakayama KI, Nakayama K, Inuzuka H, Wei W.

Sci Signal. 2017 Jan 3;10(460). pii: eaah4117. doi: 10.1126/scisignal.aah4117.


Diminished DYRK2 sensitizes hormone receptor-positive breast cancer to everolimus by the escape from degrading mTOR.

Mimoto R, Nihira NT, Hirooka S, Takeyama H, Yoshida K.

Cancer Lett. 2017 Jan 1;384:27-38. doi: 10.1016/j.canlet.2016.10.015. Epub 2016 Oct 13.


Engagement of DYRK2 in proper control for cell division.

Nihira NT, Yoshida K.

Cell Cycle. 2015;14(6):802-7. doi: 10.1080/15384101.2015.1007751. Review.

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