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Items: 1 to 50 of 166

1.

Impaired DNA demethylation of C/EBP sites causes premature aging.

Schäfer A, Mekker B, Mallick M, Vastolo V, Karaulanov E, Sebastian D, von der Lippen C, Epe B, Downes DJ, Scholz C, Niehrs C.

Genes Dev. 2018 Jun 8. doi: 10.1101/gad.311969.118. [Epub ahead of print]

PMID:
29884649
2.

Postnatal Skeletal Deletion of Dickkopf-1 Increases Bone Formation and Bone Volume in Male and Female Mice, Despite Increased Sclerostin Expression.

Colditz J, Thiele S, Baschant U, Niehrs C, Bonewald LF, Hofbauer LC, Rauner M.

J Bone Miner Res. 2018 May 7. doi: 10.1002/jbmr.3463. [Epub ahead of print]

PMID:
29734465
3.

DKK3 (Dickkopf 3) Alters Atherosclerotic Plaque Phenotype Involving Vascular Progenitor and Fibroblast Differentiation Into Smooth Muscle Cells.

Karamariti E, Zhai C, Yu B, Qiao L, Wang Z, Potter CMF, Wong MM, Simpson RML, Zhang Z, Wang X, Del Barco Barrantes I, Niehrs C, Kong D, Zhao Q, Zhang Y, Hu Y, Zhang C, Xu Q.

Arterioscler Thromb Vasc Biol. 2018 Feb;38(2):425-437. doi: 10.1161/ATVBAHA.117.310079. Epub 2017 Dec 28.

PMID:
29284609
4.

Stk33 is required for spermatid differentiation and male fertility in mice.

Martins LR, Bung RK, Koch S, Richter K, Schwarzmüller L, Terhardt D, Kurtulmus B, Niehrs C, Rouhi A, Lohmann I, Pereira G, Fröhling S, Glimm H, Scholl C.

Dev Biol. 2018 Jan 1;433(1):84-93. doi: 10.1016/j.ydbio.2017.11.007. Epub 2017 Nov 16.

PMID:
29155043
5.

Angiopoietin-like 4 Is a Wnt Signaling Antagonist that Promotes LRP6 Turnover.

Kirsch N, Chang LS, Koch S, Glinka A, Dolde C, Colozza G, Benitez MDJ, De Robertis EM, Niehrs C.

Dev Cell. 2017 Oct 9;43(1):71-82.e6. doi: 10.1016/j.devcel.2017.09.011.

PMID:
29017031
6.

Role of the DNA repair glycosylase OGG1 in the activation of murine splenocytes.

Seifermann M, Ulges A, Bopp T, Melcea S, Schäfer A, Oka S, Nakabeppu Y, Klungland A, Niehrs C, Epe B.

DNA Repair (Amst). 2017 Oct;58:13-20. doi: 10.1016/j.dnarep.2017.08.005. Epub 2017 Aug 12.

PMID:
28843610
7.

A Cytokine-Like Protein Dickkopf-Related Protein 3 Is Atheroprotective.

Yu B, Kiechl S, Qi D, Wang X, Song Y, Weger S, Mayr A, Le Bras A, Karamariti E, Zhang Z, Barco Barrantes ID, Niehrs C, Schett G, Hu Y, Wang W, Willeit J, Qu A, Xu Q.

Circulation. 2017 Sep 12;136(11):1022-1036. doi: 10.1161/CIRCULATIONAHA.117.027690. Epub 2017 Jul 3.

8.

RNA fate determination through cotranscriptional adenosine methylation and microprocessor binding.

Knuckles P, Carl SH, Musheev M, Niehrs C, Wenger A, Bühler M.

Nat Struct Mol Biol. 2017 Jul;24(7):561-569. doi: 10.1038/nsmb.3419. Epub 2017 Jun 5.

PMID:
28581511
9.

Parkinson's disease-associated receptor GPR37 is an ER chaperone for LRP6.

Berger BS, Acebron SP, Herbst J, Koch S, Niehrs C.

EMBO Rep. 2017 May;18(5):712-725. doi: 10.15252/embr.201643585. Epub 2017 Mar 24.

10.

Overcoming drug resistance by cell-penetrating peptide-mediated delivery of a doxorubicin dimer with high DNA-binding affinity.

Lelle M, Freidel C, Kaloyanova S, Tabujew I, Schramm A, Musheev M, Niehrs C, Müllen K, Peneva K.

Eur J Med Chem. 2017 Apr 21;130:336-345. doi: 10.1016/j.ejmech.2017.02.056. Epub 2017 Feb 27.

PMID:
28273560
11.

DNA repair and erasure of 5-methylcytosine in vertebrates.

Schomacher L, Niehrs C.

Bioessays. 2017 Mar;39(3). doi: 10.1002/bies.201600218. Epub 2017 Jan 18. Review.

PMID:
28098352
12.

β-Catenin-Independent Roles of Wnt/LRP6 Signaling.

Acebron SP, Niehrs C.

Trends Cell Biol. 2016 Dec;26(12):956-967. doi: 10.1016/j.tcb.2016.07.009. Epub 2016 Aug 24. Review.

PMID:
27568239
13.

Enhancers reside in a unique epigenetic environment during early zebrafish development.

Kaaij LJ, Mokry M, Zhou M, Musheev M, Geeven G, Melquiond AS, de Jesus Domingues AM, de Laat W, Niehrs C, Smith AD, Ketting RF.

Genome Biol. 2016 Jul 5;17(1):146. doi: 10.1186/s13059-016-1013-1.

14.

Sticking Around: Short-Range Activity of Wnt Ligands.

Boutros M, Niehrs C.

Dev Cell. 2016 Mar 7;36(5):485-6. doi: 10.1016/j.devcel.2016.02.018.

15.

Endothelial RSPO3 Controls Vascular Stability and Pruning through Non-canonical WNT/Ca(2+)/NFAT Signaling.

Scholz B, Korn C, Wojtarowicz J, Mogler C, Augustin I, Boutros M, Niehrs C, Augustin HG.

Dev Cell. 2016 Jan 11;36(1):79-93. doi: 10.1016/j.devcel.2015.12.015.

16.

Neil DNA glycosylases promote substrate turnover by Tdg during DNA demethylation.

Schomacher L, Han D, Musheev MU, Arab K, Kienhöfer S, von Seggern A, Niehrs C.

Nat Struct Mol Biol. 2016 Feb;23(2):116-124. doi: 10.1038/nsmb.3151. Epub 2016 Jan 11.

17.

Post-transcriptional Wnt Signaling Governs Epididymal Sperm Maturation.

Koch S, Acebron SP, Herbst J, Hatiboglu G, Niehrs C.

Cell. 2015 Nov 19;163(5):1225-1236. doi: 10.1016/j.cell.2015.10.029.

18.

GADD45a physically and functionally interacts with TET1.

Kienhöfer S, Musheev MU, Stapf U, Helm M, Schomacher L, Niehrs C, Schäfer A.

Differentiation. 2015 Jul-Oct;90(1-3):59-68. doi: 10.1016/j.diff.2015.10.003. Epub 2015 Nov 3.

19.

Octreotide-Mediated Tumor-Targeted Drug Delivery via a Cleavable Doxorubicin-Peptide Conjugate.

Lelle M, Kaloyanova S, Freidel C, Theodoropoulou M, Musheev M, Niehrs C, Stalla G, Peneva K.

Mol Pharm. 2015 Dec 7;12(12):4290-300. doi: 10.1021/acs.molpharmaceut.5b00487. Epub 2015 Nov 17.

PMID:
26524088
20.

Morpholinos: Antisense and Sensibility.

Blum M, De Robertis EM, Wallingford JB, Niehrs C.

Dev Cell. 2015 Oct 26;35(2):145-9. doi: 10.1016/j.devcel.2015.09.017. Review.

21.

Dickkopf 3 Promotes the Differentiation of a Rostrolateral Midbrain Dopaminergic Neuronal Subset In Vivo and from Pluripotent Stem Cells In Vitro in the Mouse.

Fukusumi Y, Meier F, Götz S, Matheus F, Irmler M, Beckervordersandforth R, Faus-Kessler T, Minina E, Rauser B, Zhang J, Arenas E, Andersson E, Niehrs C, Beckers J, Simeone A, Wurst W, Prakash N.

J Neurosci. 2015 Sep 30;35(39):13385-401. doi: 10.1523/JNEUROSCI.1722-15.2015.

22.

Fate Specification of Neural Plate Border by Canonical Wnt Signaling and Grhl3 is Crucial for Neural Tube Closure.

Kimura-Yoshida C, Mochida K, Ellwanger K, Niehrs C, Matsuo I.

EBioMedicine. 2015 Apr 18;2(6):513-27. doi: 10.1016/j.ebiom.2015.04.012. eCollection 2015 Jun.

23.

DAZL regulates Tet1 translation in murine embryonic stem cells.

Welling M, Chen HH, Muñoz J, Musheev MU, Kester L, Junker JP, Mischerikow N, Arbab M, Kuijk E, Silberstein L, Kharchenko PV, Geens M, Niehrs C, van de Velde H, van Oudenaarden A, Heck AJ, Geijsen N.

EMBO Rep. 2015 Jul;16(7):791-802. doi: 10.15252/embr.201540538. Epub 2015 Jun 15.

24.

Maternal Wnt/STOP signaling promotes cell division during early Xenopus embryogenesis.

Huang YL, Anvarian Z, Döderlein G, Acebron SP, Niehrs C.

Proc Natl Acad Sci U S A. 2015 May 5;112(18):5732-7. doi: 10.1073/pnas.1423533112. Epub 2015 Apr 21.

25.

Herbert Steinbeisser: a life with the Xenopus embryo.

De Robertis EM, Niehrs C.

Int J Dev Biol. 2014;58(5):299-302. doi: 10.1387/ijdb.140117ed. No abstract available.

26.

Long noncoding RNA TARID directs demethylation and activation of the tumor suppressor TCF21 via GADD45A.

Arab K, Park YJ, Lindroth AM, Schäfer A, Oakes C, Weichenhan D, Lukanova A, Lundin E, Risch A, Meister M, Dienemann H, Dyckhoff G, Herold-Mende C, Grummt I, Niehrs C, Plass C.

Mol Cell. 2014 Aug 21;55(4):604-14. doi: 10.1016/j.molcel.2014.06.031. Epub 2014 Jul 31.

27.

Wnt-Fzd signaling sensitizes peripheral sensory neurons via distinct noncanonical pathways.

Simonetti M, Agarwal N, Stösser S, Bali KK, Karaulanov E, Kamble R, Pospisilova B, Kurejova M, Birchmeier W, Niehrs C, Heppenstall P, Kuner R.

Neuron. 2014 Jul 2;83(1):104-21. doi: 10.1016/j.neuron.2014.05.037.

28.

Mitotic wnt signaling promotes protein stabilization and regulates cell size.

Acebron SP, Karaulanov E, Berger BS, Huang YL, Niehrs C.

Mol Cell. 2014 May 22;54(4):663-74. doi: 10.1016/j.molcel.2014.04.014. Epub 2014 May 15.

29.

Polarized Wnt signaling regulates ectodermal cell fate in Xenopus.

Huang YL, Niehrs C.

Dev Cell. 2014 Apr 28;29(2):250-7. doi: 10.1016/j.devcel.2014.03.015.

30.

RAB8B is required for activity and caveolar endocytosis of LRP6.

Demir K, Kirsch N, Beretta CA, Erdmann G, Ingelfinger D, Moro E, Argenton F, Carl M, Niehrs C, Boutros M.

Cell Rep. 2013 Sep 26;4(6):1224-34. doi: 10.1016/j.celrep.2013.08.008. Epub 2013 Sep 12.

31.

Downregulation of Dickkopf-3 disrupts prostate acinar morphogenesis through TGF-β/Smad signalling.

Romero D, Kawano Y, Bengoa N, Walker MM, Maltry N, Niehrs C, Waxman J, Kypta R.

J Cell Sci. 2013 Apr 15;126(Pt 8):1858-67. doi: 10.1242/jcs.119388. Epub 2013 Feb 26.

32.

RNA helicase DDX3 is a regulatory subunit of casein kinase 1 in Wnt-β-catenin signaling.

Cruciat CM, Dolde C, de Groot RE, Ohkawara B, Reinhard C, Korswagen HC, Niehrs C.

Science. 2013 Mar 22;339(6126):1436-41. doi: 10.1126/science.1231499. Epub 2013 Feb 14.

33.

Loss of Dickkopf-1 restores neurogenesis in old age and counteracts cognitive decline.

Seib DR, Corsini NS, Ellwanger K, Plaas C, Mateos A, Pitzer C, Niehrs C, Celikel T, Martin-Villalba A.

Cell Stem Cell. 2013 Feb 7;12(2):204-14. doi: 10.1016/j.stem.2012.11.010.

34.

Ing1 functions in DNA demethylation by directing Gadd45a to H3K4me3.

Schäfer A, Karaulanov E, Stapf U, Döderlein G, Niehrs C.

Genes Dev. 2013 Feb 1;27(3):261-73. doi: 10.1101/gad.186916.112.

35.

The complex world of WNT receptor signalling.

Niehrs C.

Nat Rev Mol Cell Biol. 2012 Dec;13(12):767-79. doi: 10.1038/nrm3470. Epub 2012 Nov 15. Review.

PMID:
23151663
36.

GADD45G functions in male sex determination by promoting p38 signaling and Sry expression.

Gierl MS, Gruhn WH, von Seggern A, Maltry N, Niehrs C.

Dev Cell. 2012 Nov 13;23(5):1032-42. doi: 10.1016/j.devcel.2012.09.014. Epub 2012 Oct 25.

37.

Secreted and transmembrane wnt inhibitors and activators.

Cruciat CM, Niehrs C.

Cold Spring Harb Perspect Biol. 2013 Mar 1;5(3):a015081. doi: 10.1101/cshperspect.a015081. Review.

38.

Dkk3 is a component of the genetic circuitry regulating aldosterone biosynthesis in the adrenal cortex.

El Wakil A, Bandulik S, Guy N, Bendahhou S, Zennaro MC, Niehrs C, Mari B, Warth R, Barhanin J, Lalli E.

Hum Mol Genet. 2012 Nov 15;21(22):4922-9. doi: 10.1093/hmg/dds333. Epub 2012 Aug 23.

PMID:
22918120
39.

Identification of RARRES1 as a core regulator in liver fibrosis.

Teufel A, Becker D, Weber SN, Dooley S, Breitkopf-Heinlein K, Maass T, Hochrath K, Krupp M, Marquardt JU, Kolb M, Korn B, Niehrs C, Zimmermann T, Godoy P, Galle PR, Lammert F.

J Mol Med (Berl). 2012 Dec;90(12):1439-47. doi: 10.1007/s00109-012-0919-7. Epub 2012 Jun 6.

PMID:
22669512
40.

Mitotic and mitogenic Wnt signalling.

Niehrs C, Acebron SP.

EMBO J. 2012 Jun 13;31(12):2705-13. doi: 10.1038/emboj.2012.124. Epub 2012 May 22. Review.

41.

Active DNA demethylation by Gadd45 and DNA repair.

Niehrs C, Schäfer A.

Trends Cell Biol. 2012 Apr;22(4):220-7. doi: 10.1016/j.tcb.2012.01.002. Epub 2012 Feb 15. Review.

PMID:
22341196
42.

Dickkopf-3, an immune modulator in peripheral CD8 T-cell tolerance.

Papatriantafyllou M, Moldenhauer G, Ludwig J, Tafuri A, Garbi N, Hollmann G, Küblbeck G, Klevenz A, Schmitt S, Pougialis G, Niehrs C, Gröne HJ, Hämmerling GJ, Arnold B, Oelert T.

Proc Natl Acad Sci U S A. 2012 Jan 31;109(5):1631-6. doi: 10.1073/pnas.1115980109. Epub 2012 Jan 17.

43.

LGR4 and LGR5 are R-spondin receptors mediating Wnt/β-catenin and Wnt/PCP signalling.

Glinka A, Dolde C, Kirsch N, Huang YL, Kazanskaya O, Ingelfinger D, Boutros M, Cruciat CM, Niehrs C.

EMBO Rep. 2011 Sep 30;12(10):1055-61. doi: 10.1038/embor.2011.175.

44.

Gadd45a and Gadd45g regulate neural development and exit from pluripotency in Xenopus.

Kaufmann LT, Niehrs C.

Mech Dev. 2011 Sep-Dec;128(7-10):401-11. doi: 10.1016/j.mod.2011.08.002. Epub 2011 Aug 10.

45.

Gadd45a, Gadd45b and Gadd45g expression during mouse embryonic development.

Kaufmann LT, Gierl MS, Niehrs C.

Gene Expr Patterns. 2011 Dec;11(8):465-70. doi: 10.1016/j.gep.2011.07.005. Epub 2011 Aug 6.

PMID:
21843656
46.

Negative feedback in the bone morphogenetic protein 4 (BMP4) synexpression group governs its dynamic signaling range and canalizes development.

Paulsen M, Legewie S, Eils R, Karaulanov E, Niehrs C.

Proc Natl Acad Sci U S A. 2011 Jun 21;108(25):10202-7. doi: 10.1073/pnas.1100179108. Epub 2011 Jun 1.

47.

Polymorphisms in CTNNBL1 in relation to colorectal cancer with evolutionary implications.

Huhn S, Ingelfinger D, Bermejo JL, Bevier M, Pardini B, Naccarati A, Steinke V, Rahner N, Holinski-Feder E, Morak M, Schackert HK, Görgens H, Pox CP, Goecke T, Kloor M, Loeffler M, Büttner R, Vodickova L, Novotny J, Demir K, Cruciat CM, Renneberg R, Huber W, Niehrs C, Boutros M, Propping P, Vodièka P, Hemminki K, Försti A.

Int J Mol Epidemiol Genet. 2011 Jan 1;2(1):36-50. Epub 2010 Nov 25.

48.

Transmembrane protein 198 promotes LRP6 phosphorylation and Wnt signaling activation.

Liang J, Fu Y, Cruciat CM, Jia S, Wang Y, Tong Z, Tao Q, Ingelfinger D, Boutros M, Meng A, Niehrs C, Wu W.

Mol Cell Biol. 2011 Jul;31(13):2577-90. doi: 10.1128/MCB.05103-11. Epub 2011 May 2.

49.

Rspo3 binds syndecan 4 and induces Wnt/PCP signaling via clathrin-mediated endocytosis to promote morphogenesis.

Ohkawara B, Glinka A, Niehrs C.

Dev Cell. 2011 Mar 15;20(3):303-14. doi: 10.1016/j.devcel.2011.01.006.

50.

Negative autoregulation of Oct3/4 through Cdx1 promotes the onset of gastrulation.

Rousso SZ, Schyr RB, Gur M, Zouela N, Kot-Leibovich H, Shabtai Y, Koutsi-Urshanski N, Baldessari D, Pillemer G, Niehrs C, Fainsod A.

Dev Dyn. 2011 Apr;240(4):796-807. doi: 10.1002/dvdy.22588. Epub 2011 Feb 28.

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