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Items: 1 to 50 of 779

1.

Neurobiological links between depression and AD: The role of TGF-β1 signaling as a new pharmacological target.

Caraci F, Spampinato SF, Morgese MG, Tascedda F, Salluzzo MG, Giambirtone MC, Caruso G, Munafò A, Torrisi SA, Leggio GM, Trabace L, Nicoletti F, Drago F, Sortino MA, Copani A.

Pharmacol Res. 2018 Feb 10. pii: S1043-6618(17)31600-6. doi: 10.1016/j.phrs.2018.02.007. [Epub ahead of print] Review.

PMID:
29438781
2.

Ageing: from inflammation to cancer.

Leonardi GC, Accardi G, Monastero R, Nicoletti F, Libra M.

Immun Ageing. 2018 Jan 19;15:1. doi: 10.1186/s12979-017-0112-5. eCollection 2018. Review.

3.

Selective Blockade of the Metabotropic Glutamate Receptor mGluR5 Protects Mouse Livers in In Vitro and Ex Vivo Models of Ischemia Reperfusion Injury.

Ferrigno A, Berardo C, Di Pasqua LG, Siciliano V, Richelmi P, Nicoletti F, Vairetti M.

Int J Mol Sci. 2018 Jan 23;19(2). pii: E314. doi: 10.3390/ijms19020314.

4.

Correction: Optical control of pain in vivo with a photoactive mGlu5 receptor negative allosteric modulator.

Font J, López-Cano M, Notartomaso S, Scarselli P, Di Prieto P, Bresolí-Obach R, Battaglia G, Malhaire F, Rovira X, Catena J, Giraldo J, Pin JP, Fernández-Dueñas V, Goudet C, Nonell S, Nicoletti F, Llebaria A, Ciruela F.

Elife. 2018 Jan 8;7. pii: e34752. doi: 10.7554/eLife.34752. No abstract available.

5.

Metabotropic glutamate receptors: the potential for therapeutic applications in Alzheimer's disease.

Caraci F, Nicoletti F, Copani A.

Curr Opin Pharmacol. 2017 Dec 23;38:1-7. doi: 10.1016/j.coph.2017.12.001. [Epub ahead of print] Review.

PMID:
29278824
6.

A small dose of apomorphine counteracts the deleterious effects of middle cerebral artery occlusion in different models.

Mastroiacovo F, Gaglione A, Busceti CL, Ryskalin L, Bozza G, Nicoletti F, Orzi F, Fornai F.

Arch Ital Biol. 2017 Sep 1;155(3):110-117. doi: 10.12871/00039829201732.

PMID:
29220863
7.

Shedding of Microvesicles from Microglia Contributes to the Effects Induced by Metabotropic Glutamate Receptor 5 Activation on Neuronal Death.

Beneventano M, Spampinato SF, Merlo S, Chisari M, Platania P, Ragusa M, Purrello M, Nicoletti F, Sortino MA.

Front Pharmacol. 2017 Nov 9;8:812. doi: 10.3389/fphar.2017.00812. eCollection 2017.

8.

Systematic Morphometry of Catecholamine Nuclei in the Brainstem.

Bucci D, Busceti CL, Calierno MT, Di Pietro P, Madonna M, Biagioni F, Ryskalin L, Limanaqi F, Nicoletti F, Fornai F.

Front Neuroanat. 2017 Nov 2;11:98. doi: 10.3389/fnana.2017.00098. eCollection 2017.

9.

Functional partnership between mGlu3 and mGlu5 metabotropic glutamate receptors in the central nervous system.

Di Menna L, Joffe ME, Iacovelli L, Orlando R, Lindsley CW, Mairesse J, Gressèns P, Cannella M, Caraci F, Copani A, Bruno V, Battaglia G, Conn PJ, Nicoletti F.

Neuropharmacology. 2018 Jan;128:301-313. doi: 10.1016/j.neuropharm.2017.10.026. Epub 2017 Oct 25.

PMID:
29079293
10.

Involvement of the Nrf2/HO-1/CO axis and therapeutic intervention with the CO-releasing molecule CORM-A1, in a murine model of autoimmune hepatitis.

Mangano K, Cavalli E, Mammana S, Basile MS, Caltabiano R, Pesce A, Puleo S, Atanasov AG, Magro G, Nicoletti F, Fagone P.

J Cell Physiol. 2018 May;233(5):4156-4165. doi: 10.1002/jcp.26223. Epub 2017 Dec 29.

PMID:
29034470
11.

Immuno-pharmacological characterization of group II metabotropic glutamate receptors controlling glutamate exocytosis in mouse cortex and spinal cord.

Olivero G, Bonfiglio T, Vergassola M, Usai C, Riozzi B, Battaglia G, Nicoletti F, Pittaluga A.

Br J Pharmacol. 2017 Dec;174(24):4785-4796. doi: 10.1111/bph.14061. Epub 2017 Oct 29.

PMID:
28967122
12.

Evaluation of hyaluronic acid-P40 conjugated cream in a mouse model of dermatitis induced by oxazolone.

Mangano K, Vergalito F, Mammana S, Mariano A, De Pasquale R, Meloscia A, Bartollino S, Guerra G, Nicoletti F, Di Marco R.

Exp Ther Med. 2017 Sep;14(3):2439-2444. doi: 10.3892/etm.2017.4810. Epub 2017 Jul 19.

13.

Permissive role for mGlu1 metabotropic glutamate receptors in excitotoxic retinal degeneration.

Liberatore F, Bucci D, Mascio G, Madonna M, Di Pietro P, Beneventano M, Puliti AM, Battaglia G, Bruno V, Nicoletti F, Romano MR.

Neuroscience. 2017 Nov 5;363:142-149. doi: 10.1016/j.neuroscience.2017.09.005. Epub 2017 Sep 14.

PMID:
28918254
14.

Alterations in the α2 δ ligand, thrombospondin-1, in a rat model of spontaneous absence epilepsy and in patients with idiopathic/genetic generalized epilepsies.

Santolini I, Celli R, Cannella M, Imbriglio T, Guiducci M, Parisi P, Schubert J, Iacomino M, Zara F, Lerche H; EuroEPINOMICS CoGIE Consortium; Genetic Commission of Italian League Against Epilepsy (LICE), Moyanova S, Ngomba RT, van Luijtelaar G, Battaglia G, Bruno V, Striano P, Nicoletti F.

Epilepsia. 2017 Nov;58(11):1993-2001. doi: 10.1111/epi.13898. Epub 2017 Sep 15.

PMID:
28913875
15.

Genetic deletion of mGlu2 metabotropic glutamate receptors improves the short-term outcome of cerebral transient focal ischemia.

Mastroiacovo F, Moyanova S, Cannella M, Gaglione A, Verhaeghe R, Bozza G, Madonna M, Motolese M, Traficante A, Riozzi B, Bruno V, Battaglia G, Lodge D, Nicoletti F.

Mol Brain. 2017 Aug 18;10(1):39. doi: 10.1186/s13041-017-0319-6.

16.

Acquired Immune Resistance Follows Complete Tumor Regression without Loss of Target Antigens or IFNγ Signaling.

Donia M, Harbst K, van Buuren M, Kvistborg P, Lindberg MF, Andersen R, Idorn M, Munir Ahmad S, Ellebæk E, Mueller A, Fagone P, Nicoletti F, Libra M, Lauss M, Hadrup SR, Schmidt H, Andersen MH, Thor Straten P, Nilsson JA, Schumacher TN, Seliger B, Jönsson G, Svane IM.

Cancer Res. 2017 Sep 1;77(17):4562-4566. doi: 10.1158/0008-5472.CAN-16-3172. Epub 2017 Jun 27.

PMID:
28655789
17.

Effects of resveratrol, curcumin, berberine and other nutraceuticals on aging, cancer development, cancer stem cells and microRNAs.

McCubrey JA, Lertpiriyapong K, Steelman LS, Abrams SL, Yang LV, Murata RM, Rosalen PL, Scalisi A, Neri LM, Cocco L, Ratti S, Martelli AM, Laidler P, Dulińska-Litewka J, Rakus D, Gizak A, Lombardi P, Nicoletti F, Candido S, Libra M, Montalto G, Cervello M.

Aging (Albany NY). 2017 Jun 12;9(6):1477-1536. doi: 10.18632/aging.101250.

18.

Changes in serum levels of kynurenine metabolites in paediatric patients affected by ADHD.

Evangelisti M, De Rossi P, Rabasco J, Donfrancesco R, Lionetto L, Capi M, Sani G, Simmaco M, Nicoletti F, Villa MP.

Eur Child Adolesc Psychiatry. 2017 Dec;26(12):1433-1441. doi: 10.1007/s00787-017-1002-2. Epub 2017 May 19.

PMID:
28527020
19.

Vasorelaxing Action of the Kynurenine Metabolite, Xanthurenic Acid: The Missing Link in Endotoxin-Induced Hypotension?

Fazio F, Carrizzo A, Lionetto L, Damato A, Capocci L, Ambrosio M, Battaglia G, Bruno V, Madonna M, Simmaco M, Nicoletti F, Vecchione C.

Front Pharmacol. 2017 May 1;8:214. doi: 10.3389/fphar.2017.00214. eCollection 2017.

20.

Potential use of modulators of oxidative stress as add-on therapy in patients with anxiety disorders.

Boldrini P, Fusco A, Nicoletti F, Badiani A, Saso L.

Curr Drug Targets. 2017 Apr 25. doi: 10.2174/1389450118666170425153356. [Epub ahead of print]

PMID:
28443504
21.

Optical control of pain in vivo with a photoactive mGlu5 receptor negative allosteric modulator.

Font J, López-Cano M, Notartomaso S, Scarselli P, Di Pietro P, Bresolí-Obach R, Battaglia G, Malhaire F, Rovira X, Catena J, Giraldo J, Pin JP, Fernández-Dueñas V, Goudet C, Nonell S, Nicoletti F, Llebaria A, Ciruela F.

Elife. 2017 Apr 11;6. pii: e23545. doi: 10.7554/eLife.23545. Erratum in: Elife. 2018 Jan 08;7:.

22.

Dickkopf-3 Upregulates VEGF in Cultured Human Endothelial Cells by Activating Activin Receptor-Like Kinase 1 (ALK1) Pathway.

Busceti CL, Marchitti S, Bianchi F, Di Pietro P, Riozzi B, Stanzione R, Cannella M, Battaglia G, Bruno V, Volpe M, Fornai F, Nicoletti F, Rubattu S.

Front Pharmacol. 2017 Mar 14;8:111. doi: 10.3389/fphar.2017.00111. eCollection 2017.

23.

Analgesia induced by the epigenetic drug, L-acetylcarnitine, outlasts the end of treatment in mouse models of chronic inflammatory and neuropathic pain.

Notartomaso S, Mascio G, Bernabucci M, Zappulla C, Scarselli P, Cannella M, Imbriglio T, Gradini R, Battaglia G, Bruno V, Nicoletti F.

Mol Pain. 2017 Jan;13:1744806917697009. doi: 10.1177/1744806917697009.

24.

Identification of novel chemotherapeutic strategies for metastatic uveal melanoma.

Fagone P, Caltabiano R, Russo A, Lupo G, Anfuso CD, Basile MS, Longo A, Nicoletti F, De Pasquale R, Libra M, Reibaldi M.

Sci Rep. 2017 Mar 17;7:44564. doi: 10.1038/srep44564.

25.

The α2δ Subunit and Absence Epilepsy: Beyond Calcium Channels?

Celli R, Santolini I, Guiducci M, van Luijtelaar G, Parisi P, Striano P, Gradini R, Battaglia G, Ngomba RT, Nicoletti F.

Curr Neuropharmacol. 2017;15(6):918-925. doi: 10.2174/1570159X15666170309105451.

26.

The role of adiponectin receptors in the regulation of synaptic transmission in the hippocampus.

Weisz F, Piccinin S, Mango D, Ngomba RT, Mercuri NB, Nicoletti F, Nisticò R.

Synapse. 2017 May;71(5). doi: 10.1002/syn.21964. Epub 2017 Feb 21.

PMID:
28187508
27.

Acid-sensing ion channel 1a is required for mGlu receptor dependent long-term depression in the hippocampus.

Mango D, Braksator E, Battaglia G, Marcelli S, Mercuri NB, Feligioni M, Nicoletti F, Bashir ZI, Nisticò R.

Pharmacol Res. 2017 May;119:12-19. doi: 10.1016/j.phrs.2017.01.028. Epub 2017 Jan 27.

PMID:
28137639
28.

Kynurenine pathway metabolites in migraine.

Nicoletti F.

J Headache Pain. 2015 Dec;16(Suppl 1):A1. doi: 10.1186/1129-2377-16-S1-A1. No abstract available. Erratum in: J Headache Pain. 2017 Dec;18(1):11.

29.

O066. Kynurenine pathway metabolites in cluster headache.

Curto M, Lionetto L, Capi M, Negro A, D'Alonzo L, Nicoletti F, Martelletti P.

J Headache Pain. 2015 Dec;16(Suppl 1):A87. doi: 10.1186/1129-2377-16-S1-A87. No abstract available. Erratum in: J Headache Pain. 2017 Dec;18(1):11.

30.

Anti-angiogenic Therapy in Cancer: Downsides and New Pivots for Precision Medicine.

Lupo G, Caporarello N, Olivieri M, Cristaldi M, Motta C, Bramanti V, Avola R, Salmeri M, Nicoletti F, Anfuso CD.

Front Pharmacol. 2017 Jan 6;7:519. doi: 10.3389/fphar.2016.00519. eCollection 2016. Review.

31.

Roles of GSK-3 and microRNAs on epithelial mesenchymal transition and cancer stem cells.

McCubrey JA, Fitzgerald TL, Yang LV, Lertpiriyapong K, Steelman LS, Abrams SL, Montalto G, Cervello M, Neri LM, Cocco L, Martelli AM, Laidler P, Dulińska-Litewka J, Rakus D, Gizak A, Nicoletti F, Falzone L, Candido S, Libra M.

Oncotarget. 2017 Feb 21;8(8):14221-14250. doi: 10.18632/oncotarget.13991. Review.

32.

Diagnostic utility of cyclin D1 in the diagnosis of small round blue cell tumors in children and adolescents.

Magro G, Salvatorelli L, Alaggio R, D'Agata V, Nicoletti F, Di Cataldo A, Parenti R.

Hum Pathol. 2017 Feb;60:58-65. doi: 10.1016/j.humpath.2016.07.038. Epub 2016 Oct 28.

PMID:
27984122
33.

Metabotropic glutamate receptors, 5 years on.

Collingridge GL, Manahan-Vaughan D, Nicoletti F, Schoepp DD.

Neuropharmacology. 2017 Mar 15;115:1-3. doi: 10.1016/j.neuropharm.2016.09.029. Epub 2016 Nov 29. No abstract available.

PMID:
27908770
34.

Paradoxical sleep deprivation in rats causes a selective reduction in the expression of type-2 metabotropic glutamate receptors in the hippocampus.

Panaccione I, Iacovelli L, di Nuzzo L, Nardecchia F, Mauro G, Janiri D, De Blasi A, Sani G, Nicoletti F, Orlando R.

Pharmacol Res. 2017 Mar;117:46-53. doi: 10.1016/j.phrs.2016.11.029. Epub 2016 Nov 23.

PMID:
27890550
35.

Growth hormone deficiency and hypopituitarism in adults after complicated mild traumatic brain injury.

Giuliano S, Talarico S, Bruno L, Nicoletti FB, Ceccotti C, Belfiore A.

Endocrine. 2017 Oct;58(1):115-123. doi: 10.1007/s12020-016-1183-3. Epub 2016 Nov 23.

PMID:
27878771
36.

HIV-protease inhibitors for the treatment of cancer: Repositioning HIV protease inhibitors while developing more potent NO-hybridized derivatives?

Maksimovic-Ivanic D, Fagone P, McCubrey J, Bendtzen K, Mijatovic S, Nicoletti F.

Int J Cancer. 2017 Apr 15;140(8):1713-1726. doi: 10.1002/ijc.30529. Epub 2017 Jan 20. Review.

PMID:
27870005
37.

Fluoxetine Prevents Aβ1-42-Induced Toxicity via a Paracrine Signaling Mediated by Transforming-Growth-Factor-β1.

Caraci F, Tascedda F, Merlo S, Benatti C, Spampinato SF, Munafò A, Leggio GM, Nicoletti F, Brunello N, Drago F, Sortino MA, Copani A.

Front Pharmacol. 2016 Oct 25;7:389. eCollection 2016.

38.

Type-7 metabotropic glutamate receptors negatively regulate α1-adrenergic receptor signalling.

Iacovelli L, Di Menna L, Peterlik D, Stangl C, Orlando R, Molinaro G, De Blasi A, Bruno V, Battaglia G, Flor PJ, Uschold-Schmidt N, Nicoletti F.

Neuropharmacology. 2017 Feb;113(Pt A):343-353. doi: 10.1016/j.neuropharm.2016.10.018. Epub 2016 Oct 18.

PMID:
27769854
39.

Effects of mutations in Wnt/β-catenin, hedgehog, Notch and PI3K pathways on GSK-3 activity-Diverse effects on cell growth, metabolism and cancer.

McCubrey JA, Rakus D, Gizak A, Steelman LS, Abrams SL, Lertpiriyapong K, Fitzgerald TL, Yang LV, Montalto G, Cervello M, Libra M, Nicoletti F, Scalisi A, Torino F, Fenga C, Neri LM, Marmiroli S, Cocco L, Martelli AM.

Biochim Biophys Acta. 2016 Dec;1863(12):2942-2976. doi: 10.1016/j.bbamcr.2016.09.004. Epub 2016 Sep 6. Review.

40.

Hedonic sensitivity to natural rewards is affected by prenatal stress in a sex-dependent manner.

Reynaert ML, Marrocco J, Mairesse J, Lionetto L, Simmaco M, Deruyter L, Allorge D, Moles A, Pittaluga A, Maccari S, Morley-Fletcher S, Van Camp G, Nicoletti F.

Addict Biol. 2016 Nov;21(6):1072-1085. doi: 10.1111/adb.12270. Epub 2015 May 26.

PMID:
26011513
41.

Standardized bovine colostrum derivative impedes development of type 1 diabetes in rodents.

Nikolic I, Stojanovic I, Vujicic M, Fagone P, Mangano K, Stosic-Grujicic S, Nicoletti F, Saksida T.

Immunobiology. 2017 Feb;222(2):272-279. doi: 10.1016/j.imbio.2016.09.013. Epub 2016 Sep 24.

PMID:
27693017
42.

Shedding Light on Metabotropic Glutamate Receptors.

Nicoletti F.

Cell Chem Biol. 2016 Aug 18;23(8):887-8. doi: 10.1016/j.chembiol.2016.08.001.

43.

Expression of the K+/Cl- cotransporter, KCC2, in cerebellar Purkinje cells is regulated by group-I metabotropic glutamate receptors.

Notartomaso S, Mascio G, Scarselli P, Martinello K, Fucile S, Gradini R, Bruno V, Battaglia G, Nicoletti F.

Neuropharmacology. 2017 Mar 15;115:51-59. doi: 10.1016/j.neuropharm.2016.07.032. Epub 2016 Aug 3.

PMID:
27498071
44.

Cinnabarinic acid and xanthurenic acid: Two kynurenine metabolites that interact with metabotropic glutamate receptors.

Fazio F, Lionetto L, Curto M, Iacovelli L, Copeland CS, Neale SA, Bruno V, Battaglia G, Salt TE, Nicoletti F.

Neuropharmacology. 2017 Jan;112(Pt B):365-372. doi: 10.1016/j.neuropharm.2016.06.020. Epub 2016 Jun 21. Review.

PMID:
27342123
45.

Corrigendum to "Expression of DNA methylation genes in secondary progressive multiple sclerosis" [J. Neuroimmunol. 290 (2016 Jan. 15) 66-9].

Fagone P, Mangano K, Di Marco R, Touil-Boukoffa C, Chikovani T, Signorelli S, Lombardo GA, Patti F, Mammana S, Nicoletti F.

J Neuroimmunol. 2016 Jun 15;295-296:163. doi: 10.1016/j.jneuroim.2016.02.013. Epub 2016 Mar 4. No abstract available.

PMID:
27235362
46.

Increased Total Urinary Cortisol (tUC) and Serum Brain-derived Neurotrophic Factor (BDNF) Ratio in Alzheimer Disease (AD)-affected Patients.

Curto M, Martocchia A, Ferracuti S, Comite F, Scaccianoce S, Girardi P, Nicoletti F, Falaschi P.

Alzheimer Dis Assoc Disord. 2017 Apr-Jun;31(2):173-176. doi: 10.1097/WAD.0000000000000156. No abstract available.

PMID:
27196536
47.

H2020 and Beyond: Skip Discrepancy between Theory and Practice of Personalized Medicine. A Position Paper by the Italian Society of Personalized Medicine.

Borro M, Simmaco M, Aceti A, Barni S, De Luca A, Fineschi V, Frati P, Girardi P, Miozzo M, Nati G, Nicoletti F, Santini D, Marchetti P.

Curr Pharm Biotechnol. 2016;17(10):926-9.

PMID:
27194357
48.

The anti-absence effect of mGlu5 receptor amplification with VU0360172 is maintained during and after antiepileptogenesis.

D'Amore V, Raaijmakers RH, Santolini I, van Rijn CM, Ngomba RT, Nicoletti F, van Luijtelaar G.

Pharmacol Biochem Behav. 2016 Jul-Aug;146-147:50-9. doi: 10.1016/j.pbb.2016.05.004. Epub 2016 May 10.

PMID:
27178815
49.

The impact of metabotropic glutamate receptors into active neurodegenerative processes: A "dark side" in the development of new symptomatic treatments for neurologic and psychiatric disorders.

Bruno V, Caraci F, Copani A, Matrisciano F, Nicoletti F, Battaglia G.

Neuropharmacology. 2017 Mar 15;115:180-192. doi: 10.1016/j.neuropharm.2016.04.044. Epub 2016 Apr 30. Review.

PMID:
27140693
50.

Safety, bioavailability, and pharmacokinetics of VGX-1027-A novel oral anti-inflammatory drug in healthy human subjects.

Lee JC, Menacherry S, Diehl MC, Giffear MD, White CJ, Juba R, Bagarazzi ML, Muthumani K, Boyer J, Agarwal V, Nicoletti F, Bart S, Kim JJ, Weiner DB, Sardesai NY.

Clin Pharmacol Drug Dev. 2016 Mar;5(2):91-101. doi: 10.1002/cpdd.193. Epub 2015 Jun 8.

PMID:
27138022

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