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Hepatitis transactivator protein X promotes extracellular matrix modification through HIF/LOX pathway in liver cancer.

Tse AP, Sze KM, Shea QT, Chiu EY, Tsang FH, Chiu DK, Zhang MS, Lee D, Xu IM, Chan CY, Koh HY, Wong CM, Zheng YP, Ng IO, Wong CC.

Oncogenesis. 2018 May 25;7(5):44. doi: 10.1038/s41389-018-0052-8.


Preleukemic and second-hit mutational events in an acute myeloid leukemia patient with a novel germline RUNX1 mutation.

Ng IK, Lee J, Ng C, Kosmo B, Chiu L, Seah E, Mok MMH, Tan K, Osato M, Chng WJ, Yan B, Tan LK.

Biomark Res. 2018 May 11;6:16. doi: 10.1186/s40364-018-0130-2. eCollection 2018.


Evolution of Diabetes Care in Hong Kong: From the Hong Kong Diabetes Register to JADE-PEARL Program to RAMP and PEP Program.

Ng IHY, Cheung KKT, Yau TTL, Chow E, Ozaki R, Chan JCN.

Endocrinol Metab (Seoul). 2018 Mar;33(1):17-32. doi: 10.3803/EnM.2018.33.1.17. Review.


Data set for the reporting of intrahepatic cholangiocarcinoma, perihilar cholangiocarcinoma and hepatocellular carcinoma: recommendations from the International Collaboration on Cancer Reporting (ICCR).

Burt AD, Alves V, Bedossa P, Clouston A, Guido M, Hübscher S, Kakar S, Ng I, Park YN, Reeves H, Wyatt J, Yeh MM, Ellis DW.

Histopathology. 2018 Mar 24. doi: 10.1111/his.13520. [Epub ahead of print] Review.


True left-sided gallbladder: a rare anatomical anomaly and its associated surgical challenges.

Quah GS, Ng IE, Punch G, Richardson AJ.

ANZ J Surg. 2018 Mar 7. doi: 10.1111/ans.14453. [Epub ahead of print] No abstract available.


IRAK1 Augments Cancer Stemness and Drug Resistance via the AP-1/AKR1B10 Signaling Cascade in Hepatocellular Carcinoma.

Cheng BY, Lau EY, Leung HW, Leung CO, Ho NP, Gurung S, Cheng LK, Lin CH, Lo RC, Ma S, Ng IO, Lee TK.

Cancer Res. 2018 May 1;78(9):2332-2342. doi: 10.1158/0008-5472.CAN-17-2445. Epub 2018 Feb 26.


Cripto-1 contributes to stemness in hepatocellular carcinoma by stabilizing Dishevelled-3 and activating Wnt/β-catenin pathway.

Lo RC, Leung CO, Chan KK, Ho DW, Wong CM, Lee TK, Ng IO.

Cell Death Differ. 2018 Feb 14. doi: 10.1038/s41418-018-0059-x. [Epub ahead of print]


Corrigendum to "The Biological Foundation of the Genetic Association of TOMM40 with Late-onset Alzheimer's disease" [Biochim. Biophys. Acta 1863/11 (2017) 2973-2986].

Zietlow K, Charalambous L, Ng I, Gagrani S, Mihovilovic M, Luo S, Rock DL, Saunders A, Roses AD, Kirby Gottschalk W.

Biochim Biophys Acta. 2018 Apr;1864(4 Pt A):1216. doi: 10.1016/j.bbadis.2018.01.017. Epub 2018 Jan 31. No abstract available.


cHCC-CCA: Consensus terminology for primary liver carcinomas with both hepatocytic and cholangiocytic differentation.

Brunt E, Aishima S, Clavien PA, Fowler K, Goodman Z, Gores G, Gouw A, Kagen A, Klimstra D, Komuta M, Kondo F, Miksad R, Nakano M, Nakanuma Y, Ng I, Paradis V, Nyun Park Y, Quaglia A, Roncalli M, Roskams T, Sakamoto M, Saxena R, Sempoux C, Sirlin C, Stueck A, Thung S, Tsui WMS, Wang XW, Wee A, Yano H, Yeh M, Zen Y, Zucman-Rossi J, Theise N.

Hepatology. 2018 Jan 23. doi: 10.1002/hep.29789. [Epub ahead of print]


Expression of hepatic progenitor cell markers in acute cellular rejection of liver allografts-An immunohistochemical study.

Lo RC, Chan KK, Leung CO, Ng IO.

Clin Transplant. 2018 Mar;32(3):e13203. doi: 10.1111/ctr.13203. Epub 2018 Feb 2.


Development and validation of a brief diabetic foot ulceration risk checklist among diabetic patients: a multicenter longitudinal study in China.

Zhou Q, Peng M, Zhou L, Bai J, Tong A, Liu M, Ng II, Cheng Y, Cai Y, Yang Y, Chen Y, Gao S, Li Z, Fu X, Shen M, Zhang J, Chen X.

Sci Rep. 2018 Jan 17;8(1):962. doi: 10.1038/s41598-018-19268-3.


A highly efficient two-stage cultivation strategy for lutein production using heterotrophic culture of Chlorella sorokiniana MB-1-M12.

Chen CY, Lu IC, Nagarajan D, Chang CH, Ng IS, Lee DJ, Chang JS.

Bioresour Technol. 2018 Apr;253:141-147. doi: 10.1016/j.biortech.2018.01.027. Epub 2018 Jan 6.


Non-coding RNAs in hepatocellular carcinoma: molecular functions and pathological implications.

Wong CM, Tsang FH, Ng IO.

Nat Rev Gastroenterol Hepatol. 2018 Mar;15(3):137-151. doi: 10.1038/nrgastro.2017.169. Epub 2018 Jan 10. Review.


Identification of Gold Sensing Peptide by Integrative Proteomics and a Bacterial Two-Component System.

Ng IS, Yu YJ, Yi YC, Tan SI, Huang BC, Han YL.

Front Chem. 2017 Dec 22;5:127. doi: 10.3389/fchem.2017.00127. eCollection 2017.


IsoPlot: a database for comparison of mRNA isoforms in fruit fly and mosquitoes.

Ng IM, Huang JH, Tsai SC, Tsai HK.

Database (Oxford). 2017 Jan 1;2017. doi: 10.1093/database/bax069.


Oval Cells Contribute to Fibrogenesis of Marginal Liver Grafts under Stepwise Regulation of Aldose Reductase and Notch Signaling.

Liu XB, Lo CM, Cheng Q, Ng KT, Shao Y, Li CX, Chung SK, Ng IOL, Yu J, Man K.

Theranostics. 2017 Oct 24;7(19):4879-4893. doi: 10.7150/thno.20085. eCollection 2017.


RNA N6-methyladenosine methyltransferase-like 3 promotes liver cancer progression through YTHDF2-dependent posttranscriptional silencing of SOCS2.

Chen M, Wei L, Law CT, Tsang FH, Shen J, Cheng CL, Tsang LH, Ho DW, Chiu DK, Lee JM, Wong CC, Ng IO, Wong CM.

Hepatology. 2018 Jun;67(6):2254-2270. doi: 10.1002/hep.29683. Epub 2018 Apr 19.


A randomised controlled trial comparing high-flow nasal oxygen with standard management for conscious sedation during bronchoscopy.

Douglas N, Ng I, Nazeem F, Lee K, Mezzavia P, Krieser R, Steinfort D, Irving L, Segal R.

Anaesthesia. 2018 Feb;73(2):169-176. doi: 10.1111/anae.14156. Epub 2017 Nov 24.


Outcomes of Asian patients with localized prostate cancer treated with combined intensity modulated radiation therapy (IMRT) and high dose rate (HDR) brachytherapy: A single institution experience.

Ng IWS, Tey JCS, Soon YY, Tseng MSF, Chen D, Lim KHC.

Asia Pac J Clin Oncol. 2017 Nov 23. doi: 10.1111/ajco.12819. [Epub ahead of print]


Outcomes of neoadjuvant chemoradiotherapy followed by total mesorectal excision surgery for locally advanced rectal cancer: a single-institution experience.

Tseng MSF, Zheng H, Ng IWS, Leong YH, Leong CN, Yong WP, Cheong WK, Tey JCS.

Singapore Med J. 2017 Nov 13. doi: 10.11622/smedj.2017105. [Epub ahead of print]


Infectious disease transmission: survey of contacts between hospital-based healthcare workers and working adults from the general population.

Jiang L, Ng IHL, Hou Y, Li D, Tan LWL, Ho HJA, Chen MI.

J Hosp Infect. 2018 Apr;98(4):404-411. doi: 10.1016/j.jhin.2017.10.020. Epub 2017 Oct 31.


Asymmetric localization of DLC1 defines avian trunk neural crest polarity for directional delamination and migration.

Liu JA, Rao Y, Cheung MPL, Hui MN, Wu MH, Chan LK, Ng IO, Niu B, Cheah KSE, Sharma R, Hodgson L, Cheung M.

Nat Commun. 2017 Oct 30;8(1):1185. doi: 10.1038/s41467-017-01107-0.


Immunoglobulin G4-related sclerosing disease involving the mandible.

Tong AC, Ng IO, Lo MC.

Hong Kong Med J. 2017 Oct;23(5):534-6. doi: 10.12809/hkmj154733. No abstract available.


Nuclear Met promotes hepatocellular carcinoma tumorigenesis and metastasis by upregulation of TAK1 and activation of NF-κB pathway.

Tey SK, Tse EYT, Mao X, Ko FCF, Wong AST, Lo RC, Ng IO, Yam JWP.

Cancer Lett. 2017 Dec 28;411:150-161. doi: 10.1016/j.canlet.2017.09.047. Epub 2017 Oct 6.


Hypoxia inducible factor HIF-1 promotes myeloid-derived suppressor cells accumulation through ENTPD2/CD39L1 in hepatocellular carcinoma.

Chiu DK, Tse AP, Xu IM, Di Cui J, Lai RK, Li LL, Koh HY, Tsang FH, Wei LL, Wong CM, Ng IO, Wong CC.

Nat Commun. 2017 Sep 11;8(1):517. doi: 10.1038/s41467-017-00530-7.


Expression of Synthetic Phytoene Synthase Gene to Enhance β-Carotene Production in Scenedesmus sp. CPC2.

Chen CY, Kao AL, Tsai ZC, Shen YM, Kao PH, Ng IS, Chang JS.

Biotechnol J. 2017 Nov;12(11). doi: 10.1002/biot.201700204. Epub 2017 Sep 28.


Recent Developments on Genetic Engineering of Microalgae for Biofuels and Bio-Based Chemicals.

Ng IS, Tan SI, Kao PH, Chang YK, Chang JS.

Biotechnol J. 2017 Oct;12(10). doi: 10.1002/biot.201600644. Epub 2017 Sep 18. Review.


Mechanosensing in liver regeneration.

Song Z, Gupta K, Ng IC, Xing J, Yang YA, Yu H.

Semin Cell Dev Biol. 2017 Nov;71:153-167. doi: 10.1016/j.semcdb.2017.07.041. Epub 2017 Jul 30. Review.


The biological foundation of the genetic association of TOMM40 with late-onset Alzheimer's disease.

Zeitlow K, Charlambous L, Ng I, Gagrani S, Mihovilovic M, Luo S, Rock DL, Saunders A, Roses AD, Gottschalk WK.

Biochim Biophys Acta. 2017 Nov;1863(11):2973-2986. doi: 10.1016/j.bbadis.2017.07.031. Epub 2017 Jul 30. Erratum in: Biochim Biophys Acta. 2018 Jan 27;:.


Liver allograft biopsies with histological cholestasis: a clinicopathological study of 254 cases from a single centre.

Lo RC, Chan KK, Chok KS, Ng IO.

J Clin Pathol. 2018 Jan;71(1):72-78. doi: 10.1136/jclinpath-2017-204334. Epub 2017 Jul 27.


Rapidly Fatal Radiation-induced Glioblastoma.

Ng I, Tan CL, Yeo TT, Vellayappan B.

Cureus. 2017 Jun 11;9(6):e1336. doi: 10.7759/cureus.1336.


Secretory Stanniocalcin 1 promotes metastasis of hepatocellular carcinoma through activation of JNK signaling pathway.

Chan KK, Leung CO, Wong CC, Ho DW, Chok KS, Lai CL, Ng IO, Lo RC.

Cancer Lett. 2017 Sep 10;403:330-338. doi: 10.1016/j.canlet.2017.06.034. Epub 2017 Jul 6.


Identifying large indels in targeted next generation sequencing assays for myeloid neoplasms: a cautionary tale of the ZRSR1 pseudogene.

Ng IK, Ng C, Low JJ, Chiu L, Seah E, Ng CH, Chng WJ, Yan B, Ban KHK.

J Clin Pathol. 2017 Dec;70(12):1069-1073. doi: 10.1136/jclinpath-2017-204440. Epub 2017 Jul 4.


5-Aminolevulinic acid promotes arachidonic acid biosynthesis in the red microalga Porphyridium purpureum.

Jiao K, Chang J, Zeng X, Ng IS, Xiao Z, Sun Y, Tang X, Lin L.

Biotechnol Biofuels. 2017 Jun 26;10:168. doi: 10.1186/s13068-017-0855-4. eCollection 2017.


Stearoyl-CoA desaturase regulates sorafenib resistance via modulation of ER stress-induced differentiation.

Ma MKF, Lau EYT, Leung DHW, Lo J, Ho NPY, Cheng LKW, Ma S, Lin CH, Copland JA, Ding J, Lo RCL, Ng IOL, Lee TKW.

J Hepatol. 2017 Nov;67(5):979-990. doi: 10.1016/j.jhep.2017.06.015. Epub 2017 Jun 22.


The C-terminus of PufX plays a key role in dimerisation and assembly of the reaction center light-harvesting 1 complex from Rhodobacter sphaeroides.

Qian P, Martin EC, Ng IW, Hunter CN.

Biochim Biophys Acta. 2017 Sep;1858(9):795-803. doi: 10.1016/j.bbabio.2017.06.001. Epub 2017 Jun 3.


Histone methyltransferase G9a promotes liver cancer development by epigenetic silencing of tumor suppressor gene RARRES3.

Wei L, Chiu DK, Tsang FH, Law CT, Cheng CL, Au SL, Lee JM, Wong CC, Ng IO, Wong CM.

J Hepatol. 2017 Oct;67(4):758-769. doi: 10.1016/j.jhep.2017.05.015. Epub 2017 May 19.


CRISPRi mediated phosphoenolpyruvate carboxylase regulation to enhance the production of lipid in Chlamydomonas reinhardtii.

Kao PH, Ng IS.

Bioresour Technol. 2017 Dec;245(Pt B):1527-1537. doi: 10.1016/j.biortech.2017.04.111. Epub 2017 May 4.


Dishevelled-3 phosphorylation is governed by HIPK2/PP1Cα/ITCH axis and the non-phosphorylated form promotes cancer stemness via LGR5 in hepatocellular carcinoma.

Tsui YM, Sze KM, Tung EK, Ho DW, Lee TK, Ng IO.

Oncotarget. 2017 Jun 13;8(24):39430-39442. doi: 10.18632/oncotarget.17049.


Folate cycle enzyme MTHFD1L confers metabolic advantages in hepatocellular carcinoma.

Lee D, Xu IM, Chiu DK, Lai RK, Tse AP, Lan Li L, Law CT, Tsang FH, Wei LL, Chan CY, Wong CM, Ng IO, Wong CC.

J Clin Invest. 2017 May 1;127(5):1856-1872. doi: 10.1172/JCI90253. Epub 2017 Apr 10.


Hepatic IFIT3 predicts interferon-α therapeutic response in patients of hepatocellular carcinoma.

Yang Y, Zhou Y, Hou J, Bai C, Li Z, Fan J, Ng IOL, Zhou W, Sun H, Dong Q, Lee JMF, Lo CM, Man K, Yang Y, Li N, Ding G, Yu Y, Cao X.

Hepatology. 2017 Jul;66(1):152-166. doi: 10.1002/hep.29156. Epub 2017 May 26.


SENP1 promotes hypoxia-induced cancer stemness by HIF-1α deSUMOylation and SENP1/HIF-1α positive feedback loop.

Cui CP, Wong CC, Kai AK, Ho DW, Lau EY, Tsui YM, Chan LK, Cheung TT, Chok KS, Chan ACY, Lo RC, Lee JM, Lee TK, Ng IOL.

Gut. 2017 Dec;66(12):2149-2159. doi: 10.1136/gutjnl-2016-313264. Epub 2017 Mar 3.


Actomyosin contractility drives bile regurgitation as an early response during obstructive cholestasis.

Gupta K, Li Q, Fan JJ, Fong ELS, Song Z, Mo S, Tang H, Ng IC, Ng CW, Pawijit P, Zhuo S, Dong CY, Low BC, Wee A, Dan YY, Kanchanawong P, So P, Viasnoff V, Yu H.

J Hepatol. 2017 Jun;66(6):1231-1240. doi: 10.1016/j.jhep.2017.01.026. Epub 2017 Feb 9.


C-terminal truncated hepatitis B virus X protein regulates tumorigenicity, self-renewal and drug resistance via STAT3/Nanog signaling pathway.

Ching RHH, Sze KMF, Lau EYT, Chiu YT, Lee JMF, Ng IOL, Lee TKW.

Oncotarget. 2017 Apr 4;8(14):23507-23516. doi: 10.18632/oncotarget.15183.


Impact of pH regulation on multicopper oxidase production and swarming motility in the bacterium Proteus hauseri ZMd44.

Su C, Chen Z, Ng IS.

Biotechnol Appl Biochem. 2018 Mar;65(2):212-219. doi: 10.1002/bab.1556. Epub 2017 Jun 1.


Clinical implications of DNMT3A mutations in a Southeast Asian cohort of acute myeloid leukaemia patients.

Tan M, Ng IKS, Chen Z, Ban K, Ng C, Chiu L, Seah E, Lin M, Tai BC, Yan B, Ng CH, Chng WJ.

J Clin Pathol. 2017 Aug;70(8):669-676. doi: 10.1136/jclinpath-2016-204195. Epub 2017 Jan 18.


miR-874-3p is down-regulated in hepatocellular carcinoma and negatively regulates PIN1 expression.

Leong KW, Cheng CW, Wong CM, Ng IO, Kwong YL, Tse E.

Oncotarget. 2017 Feb 14;8(7):11343-11355. doi: 10.18632/oncotarget.14526.


Resilience Style Questionnaire.

Mak WW, Ng IS, Wong CC, Law RW.

Assessment. 2016 Dec 1:1073191116683798. doi: 10.1177/1073191116683798. [Epub ahead of print]


Down syndrome in diverse populations.

Kruszka P, Porras AR, Sobering AK, Ikolo FA, La Qua S, Shotelersuk V, Chung BH, Mok GT, Uwineza A, Mutesa L, Moresco A, Obregon MG, Sokunbi OJ, Kalu N, Joseph DA, Ikebudu D, Ugwu CE, Okoromah CA, Addissie YA, Pardo KL, Brough JJ, Lee NC, Girisha KM, Patil SJ, Ng IS, Min BC, Jamuar SS, Tibrewal S, Wallang B, Ganesh S, Sirisena ND, Dissanayake VH, Paththinige CS, Prabodha LB, Richieri-Costa A, Muthukumarasamy P, Thong MK, Jones KL, Abdul-Rahman OA, Ekure EN, Adeyemo AA, Summar M, Linguraru MG, Muenke M.

Am J Med Genet A. 2017 Jan;173(1):42-53. doi: 10.1002/ajmg.a.38043.


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