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Items: 1 to 50 of 94

1.

Clopidogrel but Not Prasugrel Significantly Inhibits the CYP2C8-Mediated Metabolism of Montelukast in Humans.

Itkonen MK, Tornio A, Filppula AM, Neuvonen M, Neuvonen PJ, Niemi M, Backman JT.

Clin Pharmacol Ther. 2017 Nov 24. doi: 10.1002/cpt.947. [Epub ahead of print]

PMID:
29171020
2.

Origin and Evolution of the Bartonella Gene Transfer Agent.

Tamarit D, Neuvonen MM, Engel P, Guy L, Andersson SGE.

Mol Biol Evol. 2018 Feb 1;35(2):451-464. doi: 10.1093/molbev/msx299.

PMID:
29161442
3.

Clopidogrel Carboxylic Acid Glucuronidation is Mediated Mainly by UGT2B7, UGT2B4, and UGT2B17: Implications for Pharmacogenetics and Drug-Drug Interactions.

Kahma H, Filppula AM, Neuvonen M, Tarkiainen EK, Tornio A, Holmberg MT, Itkonen MK, Finel M, Neuvonen PJ, Niemi M, Backman JT.

Drug Metab Dispos. 2018 Feb;46(2):141-150. doi: 10.1124/dmd.117.078162. Epub 2017 Nov 14.

PMID:
29138287
4.

Social Morbidity in Relation to Bowel Functional Outcomes and Quality of Life in Anorectal Malformations and Hirschsprung's Disease.

Kyrklund K, Neuvonen MI, Pakarinen MP, Rintala RJ.

Eur J Pediatr Surg. 2017 Oct 23. doi: 10.1055/s-0037-1607356. [Epub ahead of print] No abstract available.

PMID:
29059696
5.

Effects of Genetic Variants on Carboxylesterase 1 Gene Expression, and Clopidogrel Pharmacokinetics and Antiplatelet Effects.

Neuvonen M, Tarkiainen EK, Tornio A, Hirvensalo P, Tapaninen T, Paile-Hyvärinen M, Itkonen MK, Holmberg MT, Kärjä V, Männistö VT, Neuvonen PJ, Pihlajamäki J, Backman JT, Niemi M.

Basic Clin Pharmacol Toxicol. 2018 Mar;122(3):341-345. doi: 10.1111/bcpt.12916. Epub 2017 Nov 17.

PMID:
28990360
6.

Comprehensive Pharmacogenomic Study Reveals an Important Role of UGT1A3 in Montelukast Pharmacokinetics.

Hirvensalo P, Tornio A, Neuvonen M, Tapaninen T, Paile-Hyvärinen M, Kärjä V, Männistö VT, Pihlajamäki J, Backman JT, Niemi M.

Clin Pharmacol Ther. 2017 Sep 23. doi: 10.1002/cpt.891. [Epub ahead of print]

PMID:
28940478
7.

Metastatic state of parent cells influences the uptake and functionality of prostate cancer cell-derived extracellular vesicles.

Lázaro-Ibáñez E, Neuvonen M, Takatalo M, Thanigai Arasu U, Capasso C, Cerullo V, Rhim JS, Rilla K, Yliperttula M, Siljander PR.

J Extracell Vesicles. 2017 Aug 10;6(1):1354645. doi: 10.1080/20013078.2017.1354645. eCollection 2017.

8.

Analgesic Plasma Concentrations of Oxycodone After Surgery for Breast Cancer-Which Factors Matter?

Cajanus K, Neuvonen M, Koskela O, Kaunisto MA, Neuvonen PJ, Niemi M, Kalso E.

Clin Pharmacol Ther. 2017 Jun 23. doi: 10.1002/cpt.771. [Epub ahead of print]

PMID:
28643329
9.

Introducing inducible fluorescent split cholesterol oxidase to mammalian cells.

Chernov KG, Neuvonen M, Brock I, Ikonen E, Verkhusha VV.

J Biol Chem. 2017 May 26;292(21):8811-8822. doi: 10.1074/jbc.M116.761718. Epub 2017 Apr 7.

PMID:
28391244
10.

Lower urinary tract symptoms and sexual functions after endorectal pull-through for Hirschsprung disease: controlled long-term outcomes.

Neuvonen M, Kyrklund K, Taskinen S, Koivusalo A, Rintala RJ, Pakarinen MP.

J Pediatr Surg. 2017 Aug;52(8):1296-1301. doi: 10.1016/j.jpedsurg.2017.02.013. Epub 2017 Mar 6.

PMID:
28341232
11.

Bowel Function and Quality of Life After Transanal Endorectal Pull-through for Hirschsprung Disease: Controlled Outcomes up to Adulthood.

Neuvonen MI, Kyrklund K, Rintala RJ, Pakarinen MP.

Ann Surg. 2017 Mar;265(3):622-629. doi: 10.1097/SLA.0000000000001695.

PMID:
28169931
12.

A Nordic multicenter survey of long-term bowel function after transanal endorectal pull-through in 200 patients with rectosigmoid Hirschsprung disease.

Bjørnland K, Pakarinen MP, Stenstrøm P, Stensrud KJ, Neuvonen M, Granström AL, Graneli C, Pripp AH, Arnbjörnsson E, Emblem R, Wester T, Rintala RJ; Nordic Pediatric Surgery Study Consortium.

J Pediatr Surg. 2017 Sep;52(9):1458-1464. doi: 10.1016/j.jpedsurg.2017.01.001. Epub 2017 Jan 5.

PMID:
28094015
13.

The genome of Rhizobiales bacteria in predatory ants reveals urease gene functions but no genes for nitrogen fixation.

Neuvonen MM, Tamarit D, Näslund K, Liebig J, Feldhaar H, Moran NA, Guy L, Andersson SG.

Sci Rep. 2016 Dec 15;6:39197. doi: 10.1038/srep39197.

14.

Clopidogrel Markedly Increases Plasma Concentrations of CYP2C8 Substrate Pioglitazone.

Itkonen MK, Tornio A, Neuvonen M, Neuvonen PJ, Niemi M, Backman JT.

Drug Metab Dispos. 2016 Aug;44(8):1364-71. doi: 10.1124/dmd.116.070375. Epub 2016 Jun 3.

15.

Correction for Thaa et al., Differential Phosphatidylinositol-3-Kinase-Akt-mTOR Activation by Semliki Forest and Chikungunya Viruses Is Dependent on nsP3 and Connected to Replication Complex Internalization.

Thaa B, Biasiotto R, Eng K, Neuvonen M, Götte B, Rheinemann L, Mutso M, Utt A, Varghese F, Balistreri G, Merits A, Ahola T, M McInerney G.

J Virol. 2016 Mar 28;90(8):4256. doi: 10.1128/JVI.00202-16. Print 2016 Apr. No abstract available.

16.

Healthcare decision-making in end stage renal disease-patient preferences and clinical correlates.

Jayanti A, Neuvonen M, Wearden A, Morris J, Foden P, Brenchley P, Mitra S; BASIC-HHD study group.

BMC Nephrol. 2015 Nov 14;16:189. doi: 10.1186/s12882-015-0180-8.

17.

Differential Phosphatidylinositol-3-Kinase-Akt-mTOR Activation by Semliki Forest and Chikungunya Viruses Is Dependent on nsP3 and Connected to Replication Complex Internalization.

Thaa B, Biasiotto R, Eng K, Neuvonen M, Götte B, Rheinemann L, Mutso M, Utt A, Varghese F, Balistreri G, Merits A, Ahola T, McInerney GM.

J Virol. 2015 Nov;89(22):11420-37. doi: 10.1128/JVI.01579-15. Epub 2015 Sep 2. Erratum in: J Virol. 2016 Apr 15;90(8):4256.

18.

Clopidogrel Has No Clinically Meaningful Effect on the Pharmacokinetics of the Organic Anion Transporting Polypeptide 1B1 and Cytochrome P450 3A4 Substrate Simvastatin.

Itkonen MK, Tornio A, Neuvonen M, Neuvonen PJ, Niemi M, Backman JT.

Drug Metab Dispos. 2015 Nov;43(11):1655-60. doi: 10.1124/dmd.115.065938. Epub 2015 Sep 1.

19.

SLCO1B1 polymorphism markedly affects the pharmacokinetics of lovastatin acid.

Tornio A, Vakkilainen J, Neuvonen M, Backman JT, Neuvonen PJ, Niemi M.

Pharmacogenet Genomics. 2015 Aug;25(8):382-7. doi: 10.1097/FPC.0000000000000148.

PMID:
26020121
20.

A population-based, complete follow-up of 146 consecutive patients after transanal mucosectomy for Hirschsprung disease.

Neuvonen MI, Kyrklund K, Lindahl HG, Koivusalo AI, Rintala RJ, Pakarinen MP.

J Pediatr Surg. 2015 Oct;50(10):1653-8. doi: 10.1016/j.jpedsurg.2015.02.006. Epub 2015 Feb 14.

PMID:
25783387
21.

Carboxylesterase 1 c.428G>A single nucleotide variation increases the antiplatelet effects of clopidogrel by reducing its hydrolysis in humans.

Tarkiainen EK, Holmberg MT, Tornio A, Neuvonen M, Neuvonen PJ, Backman JT, Niemi M.

Clin Pharmacol Ther. 2015 Jun;97(6):650-8. doi: 10.1002/cpt.101. Epub 2015 May 9.

PMID:
25704243
22.

Effect of grapefruit juice on the bioactivation of prasugrel.

Holmberg MT, Tornio A, Hyvärinen H, Neuvonen M, Neuvonen PJ, Backman JT, Niemi M.

Br J Clin Pharmacol. 2015 Jul;80(1):139-45. doi: 10.1111/bcp.12581. Epub 2015 Jun 1.

23.

Ketamine coadministration attenuates morphine tolerance and leads to increased brain concentrations of both drugs in the rat.

Lilius TO, Jokinen V, Neuvonen MS, Niemi M, Kalso EA, Rauhala PV.

Br J Pharmacol. 2015 Jun;172(11):2799-813. doi: 10.1111/bph.12974.

24.

Paroxetine markedly increases plasma concentrations of ophthalmic timolol; CYP2D6 inhibitors may increase the risk of cardiovascular adverse effects of 0.5% timolol eye drops.

Mäenpää J, Volotinen-Maja M, Kautiainen H, Neuvonen M, Niemi M, Neuvonen PJ, Backman JT.

Drug Metab Dispos. 2014 Dec;42(12):2068-76. doi: 10.1124/dmd.114.059576. Epub 2014 Sep 26.

25.

Enzymatic oxidation of cholesterol: properties and functional effects of cholestenone in cell membranes.

Neuvonen M, Manna M, Mokkila S, Javanainen M, Rog T, Liu Z, Bittman R, Vattulainen I, Ikonen E.

PLoS One. 2014 Aug 26;9(8):e103743. doi: 10.1371/journal.pone.0103743. eCollection 2014.

26.

Glucuronidation converts clopidogrel to a strong time-dependent inhibitor of CYP2C8: a phase II metabolite as a perpetrator of drug-drug interactions.

Tornio A, Filppula AM, Kailari O, Neuvonen M, Nyrönen TH, Tapaninen T, Neuvonen PJ, Niemi M, Backman JT.

Clin Pharmacol Ther. 2014 Oct;96(4):498-507. doi: 10.1038/clpt.2014.141. Epub 2014 Jun 27.

PMID:
24971633
27.

Grapefruit juice inhibits the metabolic activation of clopidogrel.

Holmberg MT, Tornio A, Neuvonen M, Neuvonen PJ, Backman JT, Niemi M.

Clin Pharmacol Ther. 2014 Mar;95(3):307-13. doi: 10.1038/clpt.2013.192. Epub 2013 Sep 25.

PMID:
24067745
28.

The mineralocorticoid receptor antagonist spironolactone enhances morphine antinociception.

Lilius TO, Jokinen V, Neuvonen MS, Väänänen AJ, Niemi M, Rauhala PV, Kalso EA.

Eur J Pain. 2014 Mar;18(3):386-95. doi: 10.1002/j.1532-2149.2013.00371.x. Epub 2013 Jul 30.

PMID:
23900882
29.

Rifampicin markedly decreases the exposure to oral and intravenous tramadol.

Saarikoski T, Saari TI, Hagelberg NM, Neuvonen M, Neuvonen PJ, Scheinin M, Olkkola KT, Laine K.

Eur J Clin Pharmacol. 2013 Jun;69(6):1293-301. doi: 10.1007/s00228-012-1460-x. Epub 2012 Dec 15.

PMID:
23242004
30.

Grapefruit juice markedly increases the plasma concentrations and antiplatelet effects of ticagrelor in healthy subjects.

Holmberg MT, Tornio A, Joutsi-Korhonen L, Neuvonen M, Neuvonen PJ, Lassila R, Niemi M, Backman JT.

Br J Clin Pharmacol. 2013 Jun;75(6):1488-96. doi: 10.1111/bcp.12026.

31.

Ticlopidine inhibits both O-demethylation and renal clearance of tramadol, increasing the exposure to it, but itraconazole has no marked effect on the ticlopidine-tramadol interaction.

Hagelberg NM, Saarikoski T, Saari TI, Neuvonen M, Neuvonen PJ, Turpeinen M, Scheinin M, Laine K, Olkkola KT.

Eur J Clin Pharmacol. 2013 Apr;69(4):867-75. doi: 10.1007/s00228-012-1433-0. Epub 2012 Oct 26.

PMID:
23099620
32.

Autoinhibition of CYP3A4 leads to important role of CYP2C8 in imatinib metabolism: variability in CYP2C8 activity may alter plasma concentrations and response.

Filppula AM, Neuvonen M, Laitila J, Neuvonen PJ, Backman JT.

Drug Metab Dispos. 2013 Jan;41(1):50-9. doi: 10.1124/dmd.112.048017. Epub 2012 Oct 1.

33.

Carboxylesterase 1 polymorphism impairs oseltamivir bioactivation in humans.

Tarkiainen EK, Backman JT, Neuvonen M, Neuvonen PJ, Schwab M, Niemi M.

Clin Pharmacol Ther. 2012 Jul;92(1):68-71. doi: 10.1038/clpt.2012.13. Epub 2012 May 16.

PMID:
22588607
34.

SH3 domain-mediated recruitment of host cell amphiphysins by alphavirus nsP3 promotes viral RNA replication.

Neuvonen M, Kazlauskas A, Martikainen M, Hinkkanen A, Ahola T, Saksela K.

PLoS Pathog. 2011 Nov;7(11):e1002383. doi: 10.1371/journal.ppat.1002383. Epub 2011 Nov 17.

35.

Interaction of oxycodone and voriconazole-a case series of patients with cancer pain supports the findings of randomised controlled studies with healthy subjects.

Hagelberg NM, Nieminen TH, Saari TI, Neuvonen M, Neuvonen PJ, Laine K, Olkkola KT.

Eur J Clin Pharmacol. 2011 Aug;67(8):863-4. doi: 10.1007/s00228-010-0969-0. Epub 2011 Jan 11. No abstract available.

PMID:
21221959
36.

Elimination of intravenous oxycodone in the elderly: a pharmacokinetic study in postoperative orthopaedic patients of different age groups.

Liukas A, Kuusniemi K, Aantaa R, Virolainen P, Neuvonen M, Neuvonen PJ, Olkkola KT.

Drugs Aging. 2011 Jan 1;28(1):41-50. doi: 10.2165/11586140-000000000-00000.

PMID:
21174486
37.

Oxycodone concentrations are greatly increased by the concomitant use of ritonavir or lopinavir/ritonavir.

Nieminen TH, Hagelberg NM, Saari TI, Neuvonen M, Neuvonen PJ, Laine K, Olkkola KT.

Eur J Clin Pharmacol. 2010 Oct;66(10):977-85. doi: 10.1007/s00228-010-0879-1. Epub 2010 Aug 10.

PMID:
20697700
38.

Grapefruit juice enhances the exposure to oral oxycodone.

Nieminen TH, Hagelberg NM, Saari TI, Neuvonen M, Neuvonen PJ, Laine K, Olkkola KT.

Basic Clin Pharmacol Toxicol. 2010 Oct;107(4):782-8. doi: 10.1111/j.1742-7843.2010.00582.x.

39.

St John's wort greatly reduces the concentrations of oral oxycodone.

Nieminen TH, Hagelberg NM, Saari TI, Neuvonen M, Laine K, Neuvonen PJ, Olkkola KT.

Eur J Pain. 2010 Sep;14(8):854-9. doi: 10.1016/j.ejpain.2009.12.007. Epub 2010 Jan 27.

PMID:
20106684
40.

Effects of itraconazole on the pharmacokinetics and pharmacodynamics of intravenously and orally administered oxycodone.

Saari TI, Grönlund J, Hagelberg NM, Neuvonen M, Laine K, Neuvonen PJ, Olkkola KT.

Eur J Clin Pharmacol. 2010 Apr;66(4):387-97. doi: 10.1007/s00228-009-0775-8.

PMID:
20076952
41.

Impacts of changes in water quality on recreation behavior and benefits in Finland.

Vesterinen J, Pouta E, Huhtala A, Neuvonen M.

J Environ Manage. 2010 Mar-Apr;91(4):984-94. doi: 10.1016/j.jenvman.2009.12.005. Epub 2009 Dec 28.

PMID:
20036782
42.

High performance liquid chromatography-tandem mass spectrometry for the determination of bile acid concentrations in human plasma.

Xiang X, Han Y, Neuvonen M, Laitila J, Neuvonen PJ, Niemi M.

J Chromatogr B Analyt Technol Biomed Life Sci. 2010 Jan 1;878(1):51-60. doi: 10.1016/j.jchromb.2009.11.019.

PMID:
19945922
43.

CYP2C8 activity recovers within 96 hours after gemfibrozil dosing: estimation of CYP2C8 half-life using repaglinide as an in vivo probe.

Backman JT, Honkalammi J, Neuvonen M, Kurkinen KJ, Tornio A, Niemi M, Neuvonen PJ.

Drug Metab Dispos. 2009 Dec;37(12):2359-66. doi: 10.1124/dmd.109.029728. Epub 2009 Sep 22.

44.

No significant effect of ABCB1 haplotypes on the pharmacokinetics of fluvastatin, pravastatin, lovastatin, and rosuvastatin.

Keskitalo JE, Kurkinen KJ, Neuvonen M, Backman JT, Neuvonen PJ, Niemi M.

Br J Clin Pharmacol. 2009 Aug;68(2):207-13. doi: 10.1111/j.1365-2125.2009.03440.x.

45.

Rifampin greatly reduces the plasma concentrations of intravenous and oral oxycodone.

Nieminen TH, Hagelberg NM, Saari TI, Pertovaara A, Neuvonen M, Laine K, Neuvonen PJ, Olkkola KT.

Anesthesiology. 2009 Jun;110(6):1371-8. doi: 10.1097/ALN.0b013e31819faa54.

PMID:
19417618
46.

Effect of SLCO1B1 polymorphism on the plasma concentrations of bile acids and bile acid synthesis marker in humans.

Xiang X, Han Y, Neuvonen M, Pasanen MK, Kalliokoski A, Backman JT, Laitila J, Neuvonen PJ, Niemi M.

Pharmacogenet Genomics. 2009 Jun;19(6):447-57. doi: 10.1097/FPC.0b013e32832bcf7b.

PMID:
19387419
47.

The crystal structures of Chikungunya and Venezuelan equine encephalitis virus nsP3 macro domains define a conserved adenosine binding pocket.

Malet H, Coutard B, Jamal S, Dutartre H, Papageorgiou N, Neuvonen M, Ahola T, Forrester N, Gould EA, Lafitte D, Ferron F, Lescar J, Gorbalenya AE, de Lamballerie X, Canard B.

J Virol. 2009 Jul;83(13):6534-45. doi: 10.1128/JVI.00189-09. Epub 2009 Apr 22.

48.

Plasma concentrations of oral oxycodone are greatly increased in the elderly.

Liukas A, Kuusniemi K, Aantaa R, Virolainen P, Neuvonen M, Neuvonen PJ, Olkkola KT.

Clin Pharmacol Ther. 2008 Oct;84(4):462-7.

PMID:
19238650
49.

Itraconazole, a potent inhibitor of P-glycoprotein, moderately increases plasma concentrations of oral morphine.

Heiskanen T, Backman JT, Neuvonen M, Kontinen VK, Neuvonen PJ, Kalso E.

Acta Anaesthesiol Scand. 2008 Nov;52(10):1319-26. doi: 10.1111/j.1399-6576.2008.01739.x.

PMID:
19025521
50.

Differential activities of cellular and viral macro domain proteins in binding of ADP-ribose metabolites.

Neuvonen M, Ahola T.

J Mol Biol. 2009 Jan 9;385(1):212-25. doi: 10.1016/j.jmb.2008.10.045. Epub 2008 Nov 1.

PMID:
18983849

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