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Items: 1 to 50 of 140

1.

Induction of cell killing and autophagy by amphiphilic pyrrolidine derivatives on human pancreatic cancer cells.

Bello C, Bai J, Zambron BK, Elías-Rodríguez P, Gajate C, Robina I, Caffa I, Cea M, Montecucco F, Nencioni A, Nahimana A, Aubry D, Breton C, Duchosal MA, Mollinedo F, Vogel P.

Eur J Med Chem. 2018 Apr 25;150:457-478. doi: 10.1016/j.ejmech.2018.02.086. Epub 2018 Mar 2.

PMID:
29547833
2.

Cancer cell metabolic plasticity allows resistance to NAMPT inhibition but invariably induces dependence on LDHA.

Thongon N, Zucal C, D'Agostino VG, Tebaldi T, Ravera S, Zamporlini F, Piacente F, Moschoi R, Raffaelli N, Quattrone A, Nencioni A, Peyron JF, Provenzani A.

Cancer Metab. 2018 Mar 8;6:1. doi: 10.1186/s40170-018-0174-7. eCollection 2018.

3.

Delirium, Frailty, and Fast-Track Surgery in Oncogeriatrics: Is There a Link?

Monacelli F, Signori A, Prefumo M, Giannotti C, Nencioni A, Romairone E, Scabini S, Odetti P.

Dement Geriatr Cogn Dis Extra. 2018 Feb 7;8(1):33-41. doi: 10.1159/000486519. eCollection 2018 Jan-Apr.

4.

Effects of Brazilian scorpion venoms on the central nervous system.

Nencioni ALA, Neto EB, de Freitas LA, Dorce VAC.

J Venom Anim Toxins Incl Trop Dis. 2018 Jan 23;24:3. doi: 10.1186/s40409-018-0139-x. eCollection 2018. Review.

5.

Depletion of SIRT6 enzymatic activity increases acute myeloid leukemia cells' vulnerability to DNA-damaging agents.

Cagnetta A, Soncini D, Orecchioni S, Talarico G, Minetto P, Guolo F, Retali V, Colombo N, Carminati E, Clavio M, Miglino M, Bergamaschi M, Nahimana A, Duchosal M, Todoerti K, Neri A, Passalacqua M, Bruzzone S, Nencioni A, Bertolini F, Gobbi M, Lemoli RM, Cea M.

Haematologica. 2018 Jan;103(1):80-90. doi: 10.3324/haematol.2017.176248. Epub 2017 Oct 12.

6.

SIRT6 inhibitors with salicylate-like structure show immunosuppressive and chemosensitizing effects.

Damonte P, Sociali G, Parenti MD, Soncini D, Bauer I, Boero S, Grozio A, Holtey MV, Piacente F, Becherini P, Sanguineti R, Salis A, Damonte G, Cea M, Murone M, Poggi A, Nencioni A, Del Rio A, Bruzzone S.

Bioorg Med Chem. 2017 Oct 15;25(20):5849-5858. doi: 10.1016/j.bmc.2017.09.023. Epub 2017 Sep 19.

PMID:
28958848
7.

Nicotinic acid: A case for a vitamin that moonlights for cancer?

Piacente F, Caffa I, Nencioni A.

Cell Cycle. 2017 Sep 17;16(18):1635-1636. doi: 10.1080/15384101.2017.1360633. Epub 2017 Aug 3. No abstract available.

PMID:
28771080
8.

Vitamin C, Aging and Alzheimer's Disease.

Monacelli F, Acquarone E, Giannotti C, Borghi R, Nencioni A.

Nutrients. 2017 Jun 27;9(7). pii: E670. doi: 10.3390/nu9070670. Review.

9.

Perinatal effects of scorpion venoms: maternal and offspring development.

Dorce ALC, Martins ADN, Dorce VAC, Nencioni ALA.

J Venom Anim Toxins Incl Trop Dis. 2017 Jun 14;23:31. doi: 10.1186/s40409-017-0121-z. eCollection 2017. Review.

10.

Validation of the Photography Method for Nutritional Intake Assessment in Hospitalized Elderly Subjects.

Monacelli F, Sartini M, Bassoli V, Becchetti D, Biagini AL, Nencioni A, Cea M, Borghi R, Torre F, Odetti P.

J Nutr Health Aging. 2017;21(6):614-621. doi: 10.1007/s12603-016-0814-y.

PMID:
28537324
11.

Validated high-performance anion-exchange chromatography with pulsed amperometric detection method for the determination of residual keratan sulfate and other glucosamine impurities in sodium chondroitin sulfate.

Bottelli S, Grillo G, Barindelli E, Nencioni A, Di Maria A, Fossati T.

J Chromatogr A. 2017 Jul 7;1505:43-49. doi: 10.1016/j.chroma.2017.04.045. Epub 2017 May 10.

PMID:
28535934
12.

Personality traits and behavioral disturbances in dementia: A new risk factor?

Monacelli F, Prefumo M, Ientile L, Nencioni A, Serafini G, Signori A, Odetti P.

Geriatr Gerontol Int. 2017 May;17(5):851-852. doi: 10.1111/ggi.12954. No abstract available.

PMID:
28508497
13.

Nicotinic Acid Phosphoribosyltransferase Regulates Cancer Cell Metabolism, Susceptibility to NAMPT Inhibitors, and DNA Repair.

Piacente F, Caffa I, Ravera S, Sociali G, Passalacqua M, Vellone VG, Becherini P, Reverberi D, Monacelli F, Ballestrero A, Odetti P, Cagnetta A, Cea M, Nahimana A, Duchosal M, Bruzzone S, Nencioni A.

Cancer Res. 2017 Jul 15;77(14):3857-3869. doi: 10.1158/0008-5472.CAN-16-3079. Epub 2017 May 15.

PMID:
28507103
14.

Pharmacological Sirt6 inhibition improves glucose tolerance in a type 2 diabetes mouse model.

Sociali G, Magnone M, Ravera S, Damonte P, Vigliarolo T, Von Holtey M, Vellone VG, Millo E, Caffa I, Cea M, Parenti MD, Del Rio A, Murone M, Mostoslavsky R, Grozio A, Nencioni A, Bruzzone S.

FASEB J. 2017 Jul;31(7):3138-3149. doi: 10.1096/fj.201601294R. Epub 2017 Apr 6.

PMID:
28386046
15.

Regulation and Function of Extracellular Nicotinamide Phosphoribosyltransferase/Visfatin.

Carbone F, Liberale L, Bonaventura A, Vecchiè A, Casula M, Cea M, Monacelli F, Caffa I, Bruzzone S, Montecucco F, Nencioni A.

Compr Physiol. 2017 Mar 16;7(2):603-621. doi: 10.1002/cphy.c160029. Review.

PMID:
28333382
16.

Some pharmacological effects of Tityus obscurus venom in rats and mice.

de Paula Santos-da-Silva A, Candido DM, Nencioni ALA, Kimura LF, Prezotto-Neto JP, Barbaro KC, Chalkidis HM, Dorce VAC.

Toxicon. 2017 Feb;126:51-58. doi: 10.1016/j.toxicon.2016.12.008. Epub 2016 Dec 22.

17.

Algoplus® Scale in Older Patients with Dementia: A Reliable Real-World Pain Assessment Tool.

Monacelli F, Signori A, Roffredo L, Pace K, Nencioni A, Pickering G, Nicolas M, Odetti P.

J Alzheimers Dis. 2017;56(2):519-527. doi: 10.3233/JAD-160790.

PMID:
27935555
18.

Do Cancer Drugs Counteract Neurodegeneration? Repurposing for Alzheimer's Disease.

Monacelli F, Cea M, Borghi R, Odetti P, Nencioni A.

J Alzheimers Dis. 2017;55(4):1295-1306. doi: 10.3233/JAD-160840. Review.

PMID:
27834781
19.

Evaluation of prognostic indices in elderly hospitalized patients.

Monacelli F, Tafuro M, Molfetta L, Sartini M, Nencioni A, Cea M, Borghi R, Montecucco F, Odetti P.

Geriatr Gerontol Int. 2017 Jun;17(6):1015-1021. doi: 10.1111/ggi.12801. Epub 2016 Jun 15.

PMID:
27302412
20.

Dual NAMPT and BTK Targeting Leads to Synergistic Killing of Waldenström Macroglobulinemia Cells Regardless of MYD88 and CXCR4 Somatic Mutation Status.

Cea M, Cagnetta A, Acharya C, Acharya P, Tai YT, Yang C, Lovera D, Soncini D, Miglino M, Fraternali-Orcioni G, Mastracci L, Nencioni A, Montecucco F, Monacelli F, Ballestrero A, Hideshima T, Chauhan D, Gobbi M, Lemoli RM, Munshi N, Treon SP, Anderson KC.

Clin Cancer Res. 2016 Dec 15;22(24):6099-6109. Epub 2016 Jun 10.

21.

Systems medicine in colorectal cancer: from a mathematical model toward a new type of clinical trial.

Castagnino N, Maffei M, Tortolina L, Zoppoli G, Piras D, Nencioni A, Moran E, Ballestrero A, Patrone F, Parodi S.

Wiley Interdiscip Rev Syst Biol Med. 2016 Jul;8(4):314-36. doi: 10.1002/wsbm.1342. Epub 2016 May 30. Review.

PMID:
27240214
22.

Synthesis and biological characterization of 3-(imidazol-1-ylmethyl)piperidine sulfonamides as aromatase inhibitors.

Di Matteo M, Ammazzalorso A, Andreoli F, Caffa I, De Filippis B, Fantacuzzi M, Giampietro L, Maccallini C, Nencioni A, Parenti MD, Soncini D, Del Rio A, Amoroso R.

Bioorg Med Chem Lett. 2016 Jul 1;26(13):3192-3194. doi: 10.1016/j.bmcl.2016.04.078. Epub 2016 Apr 28.

PMID:
27161804
23.

The GSK3β inhibitor BIS I reverts YAP-dependent EMT signature in PDAC cell lines by decreasing SMADs expression level.

Thongon N, Castiglioni I, Zucal C, Latorre E, D'Agostino V, Bauer I, Pancher M, Ballestrero A, Feldmann G, Nencioni A, Provenzani A.

Oncotarget. 2016 May 3;7(18):26551-66. doi: 10.18632/oncotarget.8437.

24.

Variations of ATP and its metabolites in the hippocampus of rats subjected to pilocarpine-induced temporal lobe epilepsy.

Doná F, Conceição IM, Ulrich H, Ribeiro EB, Freitas TA, Nencioni AL, da Silva Fernandes MJ.

Purinergic Signal. 2016 Jun;12(2):295-302. doi: 10.1007/s11302-016-9504-9. Epub 2016 Mar 3.

25.

Squalene epoxidase is a bona fide oncogene by amplification with clinical relevance in breast cancer.

Brown DN, Caffa I, Cirmena G, Piras D, Garuti A, Gallo M, Alberti S, Nencioni A, Ballestrero A, Zoppoli G.

Sci Rep. 2016 Jan 18;6:19435. doi: 10.1038/srep19435.

26.

Sirt6 regulates dendritic cell differentiation, maturation, and function.

Lasigliè D, Boero S, Bauer I, Morando S, Damonte P, Cea M, Monacelli F, Odetti P, Ballestrero A, Uccelli A, Mostoslavsky R, Poggi A, Nencioni A.

Aging (Albany NY). 2016 Jan;8(1):34-49.

27.

Effect of maternal exposure to Tityus bahiensis scorpion venom during lactation on the offspring of rats.

Martins Ado N, Nencioni AL, Dorce AL, Paulo ME, Frare EO, Dorce VA.

Reprod Toxicol. 2016 Jan;59:147-58. doi: 10.1016/j.reprotox.2015.12.008. Epub 2015 Dec 30.

PMID:
26746106
28.

Update on cardiotoxicity of anti-cancer treatments.

Rosa GM, Gigli L, Tagliasacchi MI, Di Iorio C, Carbone F, Nencioni A, Montecucco F, Brunelli C.

Eur J Clin Invest. 2016 Mar;46(3):264-84. doi: 10.1111/eci.12589. Epub 2016 Jan 21. Review.

PMID:
26728634
29.

Systems Medicine in Oncology: Signaling Network Modeling and New-Generation Decision-Support Systems.

Parodi S, Riccardi G, Castagnino N, Tortolina L, Maffei M, Zoppoli G, Nencioni A, Ballestrero A, Patrone F.

Methods Mol Biol. 2016;1386:181-219. doi: 10.1007/978-1-4939-3283-2_10. Review.

PMID:
26677185
30.

Evidence for a role of the histone deacetylase SIRT6 in DNA damage response of multiple myeloma cells.

Cea M, Cagnetta A, Adamia S, Acharya C, Tai YT, Fulciniti M, Ohguchi H, Munshi A, Acharya P, Bhasin MK, Zhong L, Carrasco R, Monacelli F, Ballestrero A, Richardson P, Gobbi M, Lemoli RM, Munshi N, Hideshima T, Nencioni A, Chauhan D, Anderson KC.

Blood. 2016 Mar 3;127(9):1138-50. doi: 10.1182/blood-2015-06-649970. Epub 2015 Dec 16.

31.

Antitumor effect of combined NAMPT and CD73 inhibition in an ovarian cancer model.

Sociali G, Raffaghello L, Magnone M, Zamporlini F, Emionite L, Sturla L, Bianchi G, Vigliarolo T, Nahimana A, Nencioni A, Raffaelli N, Bruzzone S.

Oncotarget. 2016 Jan 19;7(3):2968-84. doi: 10.18632/oncotarget.6502.

32.

Fasting plus tyrosine kinase inhibitors in cancer.

Caffa I, Longo VD, Nencioni A.

Aging (Albany NY). 2015 Dec;7(12):1026-7. No abstract available.

33.

EIF2A-dependent translational arrest protects leukemia cells from the energetic stress induced by NAMPT inhibition.

Zucal C, D'Agostino VG, Casini A, Mantelli B, Thongon N, Soncini D, Caffa I, Cea M, Ballestrero A, Quattrone A, Indraccolo S, Nencioni A, Provenzani A.

BMC Cancer. 2015 Nov 5;15:855. doi: 10.1186/s12885-015-1845-1.

34.

Quinazolinedione SIRT6 inhibitors sensitize cancer cells to chemotherapeutics.

Sociali G, Galeno L, Parenti MD, Grozio A, Bauer I, Passalacqua M, Boero S, Donadini A, Millo E, Bellotti M, Sturla L, Damonte P, Puddu A, Ferroni C, Varchi G, Franceschi C, Ballestrero A, Poggi A, Bruzzone S, Nencioni A, Del Rio A.

Eur J Med Chem. 2015 Sep 18;102:530-9. doi: 10.1016/j.ejmech.2015.08.024. Epub 2015 Aug 14.

PMID:
26310895
35.

Diminazene enhances stability of atherosclerotic plaques in ApoE-deficient mice.

Fraga-Silva RA, Montecucco F, Costa-Fraga FP, Nencioni A, Caffa I, Bragina ME, Mach F, Raizada MK, Santos RAS, da Silva RF, Stergiopulos N.

Vascul Pharmacol. 2015 Nov;74:103-113. doi: 10.1016/j.vph.2015.08.014. Epub 2015 Aug 22.

36.

Intrahippocampal injection of TsTX-I increases the levels of INF-γ in the cerebral tissue but not the levels of glutamate.

Rodriguez RV, Dorce VA, de Freitas LA, Dorce AL, Lebrun I, Sobral AC, Portaro FC, Kuniyoshi AK, Carvalho DC, Nencioni AL.

Toxicon. 2015 Sep;103:155-9. doi: 10.1016/j.toxicon.2015.07.006. Epub 2015 Jul 7.

PMID:
26163314
37.

Tityus bahiensis scorpion venom injected to dams during pregnancy affects some cytokines of fetuses.

Dorce AL, Frare EO, Paulo ME, Dorce VA, Nencioni AL.

Toxicon. 2015 Sep;103:114-8. doi: 10.1016/j.toxicon.2015.06.023. Epub 2015 Jun 30.

PMID:
26140840
38.

Selectivity hot-spots of sirtuin catalytic cores.

Parenti MD, Bruzzone S, Nencioni A, Del Rio A.

Mol Biosyst. 2015 Aug;11(8):2263-72. doi: 10.1039/c5mb00205b.

PMID:
26061123
39.

APO866 Increases Antitumor Activity of Cyclosporin-A by Inducing Mitochondrial and Endoplasmic Reticulum Stress in Leukemia Cells.

Cagnetta A, Caffa I, Acharya C, Soncini D, Acharya P, Adamia S, Pierri I, Bergamaschi M, Garuti A, Fraternali G, Mastracci L, Provenzani A, Zucal C, Damonte G, Salis A, Montecucco F, Patrone F, Ballestrero A, Bruzzone S, Gobbi M, Nencioni A, Cea M.

Clin Cancer Res. 2015 Sep 1;21(17):3934-45. doi: 10.1158/1078-0432.CCR-14-3023. Epub 2015 May 11.

40.

Treatment with KLEPTOSE® CRYSMEB reduces mouse atherogenesis by impacting on lipid profile and Th1 lymphocyte response.

Montecucco F, Lenglet S, Carbone F, Boero S, Pelli G, Burger F, Roth A, Bertolotto M, Nencioni A, Cea M, Dallegri F, Fraga-Silva RA, Fougère L, Elfakir C, Gassner AL, Rudaz S, Parissaux X, Wils D, Salomé M, Vuilleumier N, Poggi A, Mach F.

Vascul Pharmacol. 2015 Sep;72:197-208. doi: 10.1016/j.vph.2015.04.008. Epub 2015 Apr 25.

PMID:
25921922
41.

Fasting potentiates the anticancer activity of tyrosine kinase inhibitors by strengthening MAPK signaling inhibition.

Caffa I, D'Agostino V, Damonte P, Soncini D, Cea M, Monacelli F, Odetti P, Ballestrero A, Provenzani A, Longo VD, Nencioni A.

Oncotarget. 2015 May 20;6(14):11820-32.

42.

Advances in dynamic modeling of colorectal cancer signaling-network regions, a path toward targeted therapies.

Tortolina L, Duffy DJ, Maffei M, Castagnino N, Carmody AM, Kolch W, Kholodenko BN, De Ambrosi C, Barla A, Biganzoli EM, Nencioni A, Patrone F, Ballestrero A, Zoppoli G, Verri A, Parodi S.

Oncotarget. 2015 Mar 10;6(7):5041-58.

43.

Amnestic mild cognitive impairment and conversion to Alzheimer's disease: insulin resistance and glycoxidation as early biomarker clusters.

Monacelli F, Borghi R, Cammarata S, Nencioni A, Piccini A, Tabaton M, Odetti P.

J Alzheimers Dis. 2015;45(1):89-95. doi: 10.3233/JAD-142511.

PMID:
25471189
44.

Nicotinamide phosphoribosyltransferase promotes epithelial-to-mesenchymal transition as a soluble factor independent of its enzymatic activity.

Soncini D, Caffa I, Zoppoli G, Cea M, Cagnetta A, Passalacqua M, Mastracci L, Boero S, Montecucco F, Sociali G, Lasigliè D, Damonte P, Grozio A, Mannino E, Poggi A, D'Agostino VG, Monacelli F, Provenzani A, Odetti P, Ballestrero A, Bruzzone S, Nencioni A.

J Biol Chem. 2014 Dec 5;289(49):34189-204. doi: 10.1074/jbc.M114.594721. Epub 2014 Oct 20.

45.

Discovery of novel and selective SIRT6 inhibitors.

Parenti MD, Grozio A, Bauer I, Galeno L, Damonte P, Millo E, Sociali G, Franceschi C, Ballestrero A, Bruzzone S, Del Rio A, Nencioni A.

J Med Chem. 2014 Jun 12;57(11):4796-804. doi: 10.1021/jm500487d. Epub 2014 May 19.

PMID:
24785705
46.

Role of genotype-based approach in the clinical management of adult acute myeloid leukemia with normal cytogenetics.

Cagnetta A, Adamia S, Acharya C, Patrone F, Miglino M, Nencioni A, Gobbi M, Cea M.

Leuk Res. 2014 Jun;38(6):649-59. doi: 10.1016/j.leukres.2014.03.006. Epub 2014 Mar 18. Review.

PMID:
24726781
47.

Statin treatment is associated with reduction in serum levels of receptor activator of NF-κB ligand and neutrophil activation in patients with severe carotid stenosis.

Lenglet S, Quercioli A, Fabre M, Galan K, Pelli G, Nencioni A, Bauer I, Pende A, Python M, Bertolotto M, Spinella G, Pane B, Palombo D, Dallegri F, Mach F, Vuilleumier N, Montecucco F.

Mediators Inflamm. 2014;2014:720987. doi: 10.1155/2014/720987. Epub 2014 Feb 6.

48.

Mild reproductive effects of the Tityus bahiensis scorpion venom in rats.

Dorce AL, Dorce VA, Nencioni AL.

J Venom Anim Toxins Incl Trop Dis. 2014 Feb 12;20(1):4. doi: 10.1186/1678-9199-20-4.

49.

TLR activation of tumor-associated macrophages from ovarian cancer patients triggers cytolytic activity of NK cells.

Bellora F, Castriconi R, Dondero A, Pessino A, Nencioni A, Liggieri G, Moretta L, Mantovani A, Moretta A, Bottino C.

Eur J Immunol. 2014 Jun;44(6):1814-22. doi: 10.1002/eji.201344130. Epub 2014 Mar 6.

50.

Treatment with Angiotensin-(1-7) reduces inflammation in carotid atherosclerotic plaques.

Fraga-Silva RA, Savergnini SQ, Montecucco F, Nencioni A, Caffa I, Soncini D, Costa-Fraga FP, De Sousa FB, Sinisterra RD, Capettini LA, Lenglet S, Galan K, Pelli G, Bertolotto M, Pende A, Spinella G, Pane B, Dallegri F, Palombo D, Mach F, Stergiopulos N, Santos RA, da Silva RF.

Thromb Haemost. 2014 Apr 1;111(4):736-47. doi: 10.1160/TH13-06-0448. Epub 2014 Feb 6.

PMID:
24499778

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