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Loss of mitochondrial protease ClpP protects mice from diet-induced obesity and insulin resistance.

Bhaskaran S, Pharaoh G, Ranjit R, Murphy A, Matsuzaki S, Nair BC, Forbes B, Gispert S, Auburger G, Humphries KM, Kinter M, Griffin TM, Deepa SS.

EMBO Rep. 2018 Feb 2. pii: e45009. doi: 10.15252/embr.201745009. [Epub ahead of print]


Therapeutic utility of natural estrogen receptor beta agonists on ovarian cancer.

Liu J, Viswanadhapalli S, Garcia L, Zhou M, Nair BC, Kost E, Rao Tekmal R, Li R, Rao MK, Curiel T, Vadlamudi RK, Sareddy GR.

Oncotarget. 2017 Jul 25;8(30):50002-50014. doi: 10.18632/oncotarget.18442.


Down-regulation of the mitochondrial matrix peptidase ClpP in muscle cells causes mitochondrial dysfunction and decreases cell proliferation.

Deepa SS, Bhaskaran S, Ranjit R, Qaisar R, Nair BC, Liu Y, Walsh ME, Fok WC, Van Remmen H.

Free Radic Biol Med. 2016 Feb;91:281-92. doi: 10.1016/j.freeradbiomed.2015.12.021. Epub 2015 Dec 23.


Aberrant Expression of proPTPRN2 in Cancer Cells Confers Resistance to Apoptosis.

Sorokin AV, Nair BC, Wei Y, Aziz KE, Evdokimova V, Hung MC, Chen J.

Cancer Res. 2015 May 1;75(9):1846-58. doi: 10.1158/0008-5472.CAN-14-2718. Epub 2015 Apr 15.


Novel role of PELP1 in regulating chemotherapy response in mutant p53-expressing triple negative breast cancer cells.

Krishnan SR, Nair BC, Sareddy GR, Roy SS, Natarajan M, Suzuki T, Peng Y, Raj G, Vadlamudi RK.

Breast Cancer Res Treat. 2015 Apr;150(3):487-99. doi: 10.1007/s10549-015-3339-x. Epub 2015 Mar 19.


Proteomic analysis of the human cyclin-dependent kinase family reveals a novel CDK5 complex involved in cell growth and migration.

Xu S, Li X, Gong Z, Wang W, Li Y, Nair BC, Piao H, Yang K, Wu G, Chen J.

Mol Cell Proteomics. 2014 Nov;13(11):2986-3000. doi: 10.1074/mcp.M113.036699. Epub 2014 Aug 5.


Proline, glutamic acid and leucine-rich protein-1 is essential for optimal p53-mediated DNA damage response.

Nair BC, Krishnan SR, Sareddy GR, Mann M, Xu B, Natarajan M, Hasty P, Brann D, Tekmal RR, Vadlamudi RK.

Cell Death Differ. 2014 Sep;21(9):1409-18. doi: 10.1038/cdd.2014.55. Epub 2014 May 2.


KDM1 is a novel therapeutic target for the treatment of gliomas.

Sareddy GR, Nair BC, Krishnan SK, Gonugunta VK, Zhang QG, Suzuki T, Miyata N, Brenner AJ, Brann DW, Vadlamudi RK.

Oncotarget. 2013 Jan;4(1):18-28.


Proliferating cell nuclear antigen (PCNA)-binding protein C1orf124 is a regulator of translesion synthesis.

Ghosal G, Leung JW, Nair BC, Fong KW, Chen J.

J Biol Chem. 2012 Oct 5;287(41):34225-33. doi: 10.1074/jbc.M112.400135. Epub 2012 Aug 17.


Therapeutic significance of estrogen receptor β agonists in gliomas.

Sareddy GR, Nair BC, Gonugunta VK, Zhang QG, Brenner A, Brann DW, Tekmal RR, Vadlamudi RK.

Mol Cancer Ther. 2012 May;11(5):1174-82. doi: 10.1158/1535-7163.MCT-11-0960. Epub 2012 Mar 21.


Roscovitine confers tumor suppressive effect on therapy-resistant breast tumor cells.

Nair BC, Vallabhaneni S, Tekmal RR, Vadlamudi RK.

Breast Cancer Res. 2011 Aug 11;13(3):R80. doi: 10.1186/bcr2929.


Regulation of rDNA transcription by proto-oncogene PELP1.

Gonugunta VK, Nair BC, Rajhans R, Sareddy GR, Nair SS, Vadlamudi RK.

PLoS One. 2011;6(6):e21095. doi: 10.1371/journal.pone.0021095. Epub 2011 Jun 13.


Integrin-linked kinase 1: role in hormonal cancer progression.

Cortez V, Nair BC, Chakravarty D, Vadlamudi RK.

Front Biosci (Schol Ed). 2011 Jan 1;3:788-96. Review.


Conjunctival melanoma: bladder and upper urinary tract metastases.

Nair BC, Williams NC, Cui C, Summers D, Mastrangelo MJ, Hubosky SG, Shields CL, Shields JA, Sato T.

J Clin Oncol. 2011 Mar 20;29(9):e216-9. doi: 10.1200/JCO.2010.32.3584. Epub 2010 Dec 28. No abstract available.


Significance of ER-Src axis in hormonal therapy resistance.

Vallabhaneni S, Nair BC, Cortez V, Challa R, Chakravarty D, Tekmal RR, Vadlamudi RK.

Breast Cancer Res Treat. 2011 Nov;130(2):377-85. doi: 10.1007/s10549-010-1312-2. Epub 2010 Dec 24.


Cyclin-dependent kinase-mediated phosphorylation plays a critical role in the oncogenic functions of PELP1.

Nair BC, Nair SS, Chakravarty D, Challa R, Manavathi B, Yew PR, Kumar R, Tekmal RR, Vadlamudi RK.

Cancer Res. 2010 Sep 15;70(18):7166-75. doi: 10.1158/0008-5472.CAN-10-0628. Epub 2010 Aug 31.


Extranuclear functions of ER impact invasive migration and metastasis by breast cancer cells.

Chakravarty D, Nair SS, Santhamma B, Nair BC, Wang L, Bandyopadhyay A, Agyin JK, Brann D, Sun LZ, Yeh IT, Lee FY, Tekmal RR, Kumar R, Vadlamudi RK.

Cancer Res. 2010 May 15;70(10):4092-101. doi: 10.1158/0008-5472.CAN-09-3834. Epub 2010 May 11.


PELP1 is a reader of histone H3 methylation that facilitates oestrogen receptor-alpha target gene activation by regulating lysine demethylase 1 specificity.

Nair SS, Nair BC, Cortez V, Chakravarty D, Metzger E, Schüle R, Brann DW, Tekmal RR, Vadlamudi RK.

EMBO Rep. 2010 Jun;11(6):438-44. doi: 10.1038/embor.2010.62. Epub 2010 May 7.


ZD6474 coerces breast cancer for an apoptotic journey.

Nair BC, Vadlamudi RK.

Cancer Biol Ther. 2010 Apr 15;9(8):604-6. Epub 2010 Apr 27. No abstract available.


Regulation of aromatase induction by nuclear receptor coregulator PELP1.

Vadlamudi RK, Rajhans R, Chakravarty D, Nair BC, Nair SS, Evans DB, Chen S, Tekmal RR.

J Steroid Biochem Mol Biol. 2010 Feb 28;118(4-5):211-8. doi: 10.1016/j.jsbmb.2009.09.009. Epub 2009 Sep 30.


Regulation of hormonal therapy resistance by cell cycle machinery.

Nair BC, Vadlamudi RK.

Gene Ther Mol Biol. 2008 Jan 1;12:395.


Cloning and characterisation of the ahpA gene of Pasteurella multocida serogroup b:2 (strain P52): short communication.

Rani SS, Chaturvedi VK, Gupta PK, Joseph S, Nair BC, Pandey KD.

Acta Vet Hung. 2006 Dec;54(4):449-53.


Analysis of karyometric variables in spontaneously occurring canine mammary tumors.

Nair BC, Kumar S, Rani S, Paliwal OP.

Anal Quant Cytol Histol. 2006 Oct;28(5):292-6.


Polyvalent HIV-1 Env vaccine formulations delivered by the DNA priming plus protein boosting approach are effective in generating neutralizing antibodies against primary human immunodeficiency virus type 1 isolates from subtypes A, B, C, D and E.

Wang S, Pal R, Mascola JR, Chou TH, Mboudjeka I, Shen S, Liu Q, Whitney S, Keen T, Nair BC, Kalyanaraman VS, Markham P, Lu S.

Virology. 2006 Jun 20;350(1):34-47. Epub 2006 Apr 17.


Immunization of rhesus macaques with a polyvalent DNA prime/protein boost human immunodeficiency virus type 1 vaccine elicits protective antibody response against simian human immunodeficiency virus of R5 phenotype.

Pal R, Kalyanaraman VS, Nair BC, Whitney S, Keen T, Hocker L, Hudacik L, Rose N, Mboudjeka I, Shen S, Wu-Chou TH, Montefiori D, Mascola J, Markham P, Lu S.

Virology. 2006 May 10;348(2):341-53.


Definitive toxicology and biodistribution study of a polyvalent DNA prime/protein boost human immunodeficiency virus type 1 (HIV-1) vaccine in rabbits.

Pal R, Yu Q, Wang S, Kalyanaraman VS, Nair BC, Hudacik L, Whitney S, Keen T, Hung CL, Hocker L, Kennedy JS, Markham P, Lu S.

Vaccine. 2006 Feb 20;24(8):1225-34. Epub 2005 Oct 10.


Polyvalent DNA prime and envelope protein boost HIV-1 vaccine elicits humoral and cellular responses and controls plasma viremia in rhesus macaques following rectal challenge with an R5 SHIV isolate.

Pal R, Wang S, Kalyanaraman VS, Nair BC, Whitney S, Keen T, Hocker L, Hudacik L, Rose N, Cristillo A, Mboudjeka I, Shen S, Wu-Chou TH, Montefiori D, Mascola J, Lu S, Markham P.

J Med Primatol. 2005 Oct;34(5-6):226-36.


A 120 kDa nuclear phospholipase Cgamma1 protein fragment is stimulated in vivo by EGF signal phosphorylating nuclear membrane EGFR.

Klein C, Gensburger C, Freyermuth S, Nair BC, Labourdette G, Malviya AN.

Biochemistry. 2004 Dec 21;43(50):15873-83.


Human immunodeficiency virus type 1 capsid protein is a substrate of the retroviral proteinase while integrase is resistant toward proteolysis.

Tözsér J, Shulenin S, Kádas J, Boross P, Bagossi P, Copeland TD, Nair BC, Sarngadharan MG, Oroszlan S.

Virology. 2003 May 25;310(1):16-23.


Human herpesvirus 8-encoded vGPCR activates nuclear factor of activated T cells and collaborates with human immunodeficiency virus type 1 Tat.

Pati S, Foulke JS Jr, Barabitskaya O, Kim J, Nair BC, Hone D, Smart J, Feldman RA, Reitz M.

J Virol. 2003 May;77(10):5759-73.


Inflammatory cytokines synergize with the HIV-1 Tat protein to promote angiogenesis and Kaposi's sarcoma via induction of basic fibroblast growth factor and the alpha v beta 3 integrin.

Barillari G, Sgadari C, Palladino C, Gendelman R, Caputo A, Morris CB, Nair BC, Markham P, Nel A, Stürzl M, Ensoli B.

J Immunol. 1999 Aug 15;163(4):1929-35.


The Tat protein of human immunodeficiency virus type-1 promotes vascular cell growth and locomotion by engaging the alpha5beta1 and alphavbeta3 integrins and by mobilizing sequestered basic fibroblast growth factor.

Barillari G, Sgadari C, Fiorelli V, Samaniego F, Colombini S, Manzari V, Modesti A, Nair BC, Cafaro A, Stürzl M, Ensoli B.

Blood. 1999 Jul 15;94(2):663-72.


Pentoxifylline-induced thrombocytopenia.

Acharya S, Nair BC.

Int J Dermatol. 1997 Aug;36(8):635-6. No abstract available.


Enzyme immunoassay using native envelope glycoprotein (gp160) for detection of human immunodeficiency virus type 1 antibodies.

Nair BC, Ford G, Kalyanaraman VS, Zafari M, Fang C, Sarngadharan MG.

J Clin Microbiol. 1994 Jun;32(6):1449-56.


Glycoprotein of human immunodeficiency virus type 1 synthesized in chronically infected Molt3 cells acquires heterogeneous oligosaccharide structures.

Pal R, di Marzo Veronese F, Nair BC, Rittenhouse S, Hoke G, Mumbauer S, Sarngadharan MG.

Biochem Biophys Res Commun. 1993 Nov 15;196(3):1335-42.


Delineation of immunoreactive, conserved regions in the external glycoprotein of the human immunodeficiency virus type 1.

di Marzo Veronese F, Rahman R, Pal R, Boyer C, Romano J, Kalyanaraman VS, Nair BC, Gallo RC, Sarngadharan MG.

AIDS Res Hum Retroviruses. 1992 Jun;8(6):1125-32.


Identification of a major growth factor for AIDS-Kaposi's sarcoma cells as oncostatin M.

Nair BC, DeVico AL, Nakamura S, Copeland TD, Chen Y, Patel A, O'Neil T, Oroszlan S, Gallo RC, Sarngadharan MG.

Science. 1992 Mar 13;255(5050):1430-2.


Characterization of a neutralizing monoclonal antibody to the external glycoprotein of HIV-1.

Pal R, di Marzo Veronese F, Nair BC, Rahman R, Hoke G, Mumbauer SW, Sarngadharan MG.

Intervirology. 1992;34(2):86-93.


Phosphorothioate oligodeoxycytidine interferes with binding of HIV-1 gp120 to CD4.

Stein CA, Neckers LM, Nair BC, Mumbauer S, Hoke G, Pal R.

J Acquir Immune Defic Syndr. 1991;4(7):686-93.


Rat alkaline phosphatase. II. Structural similarities between the osteosarcoma, bone, kidney, and placenta isoenzymes.

Nair BC, Johnson DE, Majeska RJ, Rodkey JA, Bennett CD, Rodan GA.

Arch Biochem Biophys. 1987 Apr;254(1):28-34.


Glucocorticoid regulation of alkaline phosphatase in the osteoblastic osteosarcoma cell line ROS 17/2.8.

Majeska RJ, Nair BC, Rodan GA.

Endocrinology. 1985 Jan;116(1):170-9.


Biological effects of a purified lipopolysaccharide from Bacteroides gingivalis.

Nair BC, Mayberry WR, Dziak R, Chen PB, Levine MJ, Hausmann E.

J Periodontal Res. 1983 Jan;18(1):40-9. No abstract available.


Partial purification and characterization of the bone resorption factor from Actinomyces viscosus.

Hausmann E, Nair BC, Knox KW, Broady KW, Wicken AJ, Brown M, Dziak R.

Calcif Tissue Int. 1982 Jan;34(1):49-53. No abstract available.


Immunological comparison of phospholipases A2 present in rattlesnake (genus Crotalus) venoms.

Nair C, Nair BC, Elliott WB.

Toxicon. 1980;18(5-6):675-80. No abstract available.


Isolation and partial characterization of a phospholipase A2 from the venom of Crotalus scutulatus salvini.

Nair BC, Nair C, Elliott WB.

Toxicon. 1979;17(6):557-69. No abstract available.


Immunologic comparison of phospholipases A present in Hymenoptera insect venoms.

Nair BC, Nair C, Denne S, Wypych J, Arbesman CE, Elliott WB.

J Allergy Clin Immunol. 1976 Jul;58(1 PT 1):101-9.


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