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Items: 37


ASK family kinases mediate cellular stress and redox signaling to circadian clock.

Imamura K, Yoshitane H, Hattori K, Yamaguchi M, Yoshida K, Okubo T, Naguro I, Ichijo H, Fukada Y.

Proc Natl Acad Sci U S A. 2018 Mar 19. pii: 201719298. doi: 10.1073/pnas.1719298115. [Epub ahead of print]


A PP6-ASK3 Module Coordinates the Bidirectional Cell Volume Regulation under Osmotic Stress.

Watanabe K, Umeda T, Niwa K, Naguro I, Ichijo H.

Cell Rep. 2018 Mar 13;22(11):2809-2817. doi: 10.1016/j.celrep.2018.02.045.


TRIM48 Promotes ASK1 Activation and Cell Death through Ubiquitination-Dependent Degradation of the ASK1-Negative Regulator PRMT1.

Hirata Y, Katagiri K, Nagaoka K, Morishita T, Kudoh Y, Hatta T, Naguro I, Kano K, Udagawa T, Natsume T, Aoki J, Inada T, Noguchi T, Ichijo H, Matsuzawa A.

Cell Rep. 2017 Nov 28;21(9):2447-2457. doi: 10.1016/j.celrep.2017.11.007.


mASKing cancer cells in a tumor microenvironment.

Kamiyama M, Naguro I, Ichijo H.

Cell Cycle. 2018 Jan 4:1-2. doi: 10.1080/15384101.2017.1407402. [Epub ahead of print] No abstract available.


Cold stress-induced ferroptosis involves the ASK1-p38 pathway.

Hattori K, Ishikawa H, Sakauchi C, Takayanagi S, Naguro I, Ichijo H.

EMBO Rep. 2017 Nov;18(11):2067-2078. doi: 10.15252/embr.201744228. Epub 2017 Sep 8.


ASK1 facilitates tumor metastasis through phosphorylation of an ADP receptor P2Y12 in platelets.

Kamiyama M, Shirai T, Tamura S, Suzuki-Inoue K, Ehata S, Takahashi K, Miyazono K, Hayakawa Y, Sato T, Takeda K, Naguro I, Ichijo H.

Cell Death Differ. 2017 Dec;24(12):2066-2076. doi: 10.1038/cdd.2017.114. Epub 2017 Jul 28.


Involvement of apoptosis signal-regulating kinase-1 in house dust mite-induced allergic asthma in mice.

Maruoka S, Gon Y, Mizumura K, Okamoto S, Tsuya K, Shikano S, Soda K, Naguro I, Ichijo H, Hashimoto S.

Allergol Int. 2017 Sep;66S:S50-S52. doi: 10.1016/j.alit.2017.05.007. Epub 2017 Jun 16. No abstract available.


ASK family and cancer.

Ryuno H, Naguro I, Kamiyama M.

Adv Biol Regul. 2017 Dec;66:72-84. doi: 10.1016/j.jbior.2017.05.003. Epub 2017 May 20. Review.


KLHDC10 Deficiency Protects Mice against TNFα-Induced Systemic Inflammation.

Yamaguchi N, Sekine S, Naguro I, Sekine Y, Ichijo H.

PLoS One. 2016 Sep 15;11(9):e0163118. doi: 10.1371/journal.pone.0163118. eCollection 2016.


The aspartyl protease DDI2 activates Nrf1 to compensate for proteasome dysfunction.

Koizumi S, Irie T, Hirayama S, Sakurai Y, Yashiroda H, Naguro I, Ichijo H, Hamazaki J, Murata S.

Elife. 2016 Aug 16;5. pii: e18357. doi: 10.7554/eLife.18357.


Mitogen-activated protein kinases as key players in osmotic stress signaling.

Zhou X, Naguro I, Ichijo H, Watanabe K.

Biochim Biophys Acta. 2016 Sep;1860(9):2037-52. doi: 10.1016/j.bbagen.2016.05.032. Epub 2016 May 31. Review.


PO-16 - ASK1 regulates tumor lung metastasis and platelet functions.

Kamiyama M, Naguro I, Ichijo H.

Thromb Res. 2016 Apr;140 Suppl 1:S182. doi: 10.1016/S0049-3848(16)30149-9. Epub 2016 Apr 8.


The Ablation of Mitochondrial Protein Phosphatase Pgam5 Confers Resistance Against Metabolic Stress.

Sekine S, Yao A, Hattori K, Sugawara S, Naguro I, Koike M, Uchiyama Y, Takeda K, Ichijo H.

EBioMedicine. 2016 Jan 29;5:82-92. doi: 10.1016/j.ebiom.2016.01.031. eCollection 2016 Mar.


ASK1 signalling regulates brown and beige adipocyte function.

Hattori K, Naguro I, Okabe K, Funatsu T, Furutani S, Takeda K, Ichijo H.

Nat Commun. 2016 Apr 5;7:11158. doi: 10.1038/ncomms11158.


Osmotic stress induces the phosphorylation of WNK4 Ser575 via the p38MAPK-MK pathway.

Maruyama J, Kobayashi Y, Umeda T, Vandewalle A, Takeda K, Ichijo H, Naguro I.

Sci Rep. 2016 Jan 6;6:18710. doi: 10.1038/srep18710.


The ASK1-specific inhibitors K811 and K812 prolong survival in a mouse model of amyotrophic lateral sclerosis.

Fujisawa T, Takahashi M, Tsukamoto Y, Yamaguchi N, Nakoji M, Endo M, Kodaira H, Hayashi Y, Nishitoh H, Naguro I, Homma K, Ichijo H.

Hum Mol Genet. 2016 Jan 15;25(2):245-53. doi: 10.1093/hmg/ddv467. Epub 2015 Nov 24.


A systematic immunoprecipitation approach reinforces the concept of common conformational alterations in amyotrophic lateral sclerosis-linked SOD1 mutants.

Fujisawa T, Yamaguchi N, Kadowaki H, Tsukamoto Y, Tsuburaya N, Tsubota A, Takahashi H, Naguro I, Takahashi Y, Goto J, Tsuji S, Nishitoh H, Homma K, Ichijo H.

Neurobiol Dis. 2015 Oct;82:478-486. doi: 10.1016/j.nbd.2015.08.010. Epub 2015 Aug 18.


In vivo gene manipulation reveals the impact of stress-responsive MAPK pathways on tumor progression.

Kamiyama M, Naguro I, Ichijo H.

Cancer Sci. 2015 Jul;106(7):785-96. doi: 10.1111/cas.12676. Epub 2015 May 25. Review.


Apoptosis Signal-regulating Kinase 1 (ASK1)-p38 Pathway-dependent Cytoplasmic Translocation of the Orphan Nuclear Receptor NR4A2 Is Required for Oxidative Stress-induced Necrosis.

Watanabe T, Sekine S, Naguro I, Sekine Y, Ichijo H.

J Biol Chem. 2015 Apr 24;290(17):10791-803. doi: 10.1074/jbc.M114.623280. Epub 2015 Mar 9.


The DEAH-box RNA helicase DHX15 activates NF-κB and MAPK signaling downstream of MAVS during antiviral responses.

Mosallanejad K, Sekine Y, Ishikura-Kinoshita S, Kumagai K, Nagano T, Matsuzawa A, Takeda K, Naguro I, Ichijo H.

Sci Signal. 2014 Apr 29;7(323):ra40. doi: 10.1126/scisignal.2004841.


Apoptosis signal-regulating kinase 1 as a therapeutic target.

Kawarazaki Y, Ichijo H, Naguro I.

Expert Opin Ther Targets. 2014 Jun;18(6):651-64. doi: 10.1517/14728222.2014.896903. Epub 2014 Mar 24. Review.


Roquin-2 promotes ubiquitin-mediated degradation of ASK1 to regulate stress responses.

Maruyama T, Araki T, Kawarazaki Y, Naguro I, Heynen S, Aza-Blanc P, Ronai Z, Matsuzawa A, Ichijo H.

Sci Signal. 2014 Jan 21;7(309):ra8. doi: 10.1126/scisignal.2004822.


SOD1 as a molecular switch for initiating the homeostatic ER stress response under zinc deficiency.

Homma K, Fujisawa T, Tsuburaya N, Yamaguchi N, Kadowaki H, Takeda K, Nishitoh H, Matsuzawa A, Naguro I, Ichijo H.

Mol Cell. 2013 Oct 10;52(1):75-86. doi: 10.1016/j.molcel.2013.08.038. Epub 2013 Sep 26.


A novel monoclonal antibody reveals a conformational alteration shared by amyotrophic lateral sclerosis-linked SOD1 mutants.

Fujisawa T, Homma K, Yamaguchi N, Kadowaki H, Tsuburaya N, Naguro I, Matsuzawa A, Takeda K, Takahashi Y, Goto J, Tsuji S, Nishitoh H, Ichijo H.

Ann Neurol. 2012 Nov;72(5):739-49. doi: 10.1002/ana.23668.


ASK3 responds to osmotic stress and regulates blood pressure by suppressing WNK1-SPAK/OSR1 signaling in the kidney.

Naguro I, Umeda T, Kobayashi Y, Maruyama J, Hattori K, Shimizu Y, Kataoka K, Kim-Mitsuyama S, Uchida S, Vandewalle A, Noguchi T, Nishitoh H, Matsuzawa A, Takeda K, Ichijo H.

Nat Commun. 2012;3:1285. doi: 10.1038/ncomms2283.


Activation mechanisms of ASK1 in response to various stresses and its significance in intracellular signaling.

Shiizaki S, Naguro I, Ichijo H.

Adv Biol Regul. 2013 Jan;53(1):135-44. doi: 10.1016/j.jbior.2012.09.006. Epub 2012 Sep 13. Review.


p38 MAPKs regulate the expression of genes in the dopamine synthesis pathway through phosphorylation of NR4A nuclear receptors.

Sekine Y, Takagahara S, Hatanaka R, Watanabe T, Oguchi H, Noguchi T, Naguro I, Kobayashi K, Tsunoda M, Funatsu T, Nomura H, Toyoda T, Matsuki N, Kuranaga E, Miura M, Takeda K, Ichijo H.

J Cell Sci. 2011 Sep 1;124(Pt 17):3006-16. doi: 10.1242/jcs.085902.


Apoptosis signaling kinases: from stress response to health outcomes.

Takeda K, Naguro I, Nishitoh H, Matsuzawa A, Ichijo H.

Antioxid Redox Signal. 2011 Aug 1;15(3):719-61. doi: 10.1089/ars.2010.3392. Epub 2011 Apr 20. Review.


CHIP-dependent termination of MEKK2 regulates temporal ERK activation required for proper hyperosmotic response.

Maruyama T, Kadowaki H, Okamoto N, Nagai A, Naguro I, Matsuzawa A, Shibuya H, Tanaka K, Murata S, Takeda K, Nishitoh H, Ichijo H.

EMBO J. 2010 Aug 4;29(15):2501-14. doi: 10.1038/emboj.2010.141. Epub 2010 Jun 29.


The roles of ASK family proteins in stress responses and diseases.

Hattori K, Naguro I, Runchel C, Ichijo H.

Cell Commun Signal. 2009 Apr 24;7:9. doi: 10.1186/1478-811X-7-9.


Stress-activated MAP kinase cascades in cellular senescence.

Maruyama J, Naguro I, Takeda K, Ichijo H.

Curr Med Chem. 2009;16(10):1229-35. Review.


ASK1 and ASK2 differentially regulate the counteracting roles of apoptosis and inflammation in tumorigenesis.

Iriyama T, Takeda K, Nakamura H, Morimoto Y, Kuroiwa T, Mizukami J, Umeda T, Noguchi T, Naguro I, Nishitoh H, Saegusa K, Tobiume K, Homma T, Shimada Y, Tsuda H, Aiko S, Imoto I, Inazawa J, Chida K, Kamei Y, Kozuma S, Taketani Y, Matsuzawa A, Ichijo H.

EMBO J. 2009 Apr 8;28(7):843-53. doi: 10.1038/emboj.2009.32. Epub 2009 Feb 12.


Requirement of reactive oxygen species-dependent activation of ASK1-p38 MAPK pathway for extracellular ATP-induced apoptosis in macrophage.

Noguchi T, Ishii K, Fukutomi H, Naguro I, Matsuzawa A, Takeda K, Ichijo H.

J Biol Chem. 2008 Mar 21;283(12):7657-65. doi: 10.1074/jbc.M708402200. Epub 2008 Jan 22.


Apoptosis signal-regulating kinase 1 in stress and immune response.

Takeda K, Noguchi T, Naguro I, Ichijo H.

Annu Rev Pharmacol Toxicol. 2008;48:199-225. Review.


Apoptosis signal-regulating kinase (ASK) 2 functions as a mitogen-activated protein kinase kinase kinase in a heteromeric complex with ASK1.

Takeda K, Shimozono R, Noguchi T, Umeda T, Morimoto Y, Naguro I, Tobiume K, Saitoh M, Matsuzawa A, Ichijo H.

J Biol Chem. 2007 Mar 9;282(10):7522-31. Epub 2007 Jan 8.


Multiple transcripts of Ca2+ channel alpha1-subunits and a novel spliced variant of the alpha1C-subunit in rat ductus arteriosus.

Yokoyama U, Minamisawa S, Adachi-Akahane S, Akaike T, Naguro I, Funakoshi K, Iwamoto M, Nakagome M, Uemura N, Hori H, Yokota S, Ishikawa Y.

Am J Physiol Heart Circ Physiol. 2006 Apr;290(4):H1660-70. Epub 2005 Nov 4.

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