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Items: 1 to 50 of 78

1.

Establishment of an abnormal vascular patterning model in the mouse retina.

Morita A, Sawada S, Mori A, Arima S, Sakamoto K, Nagamitsu T, Nakahara T.

J Pharmacol Sci. 2018 Apr;136(4):177-188. doi: 10.1016/j.jphs.2018.03.002. Epub 2018 Mar 14.

2.

Corrigendum: Total synthesis and absolute configuration of avenolide, extracellular factor in Streptomyces avermitilis.

Uchida M, Takamatsu S, Arima S, Miyamoto KT, Kitani S, Nihira T, Ikeda H, Nagamitsu T.

J Antibiot (Tokyo). 2018 Feb;71(2):348. doi: 10.1038/ja.2017.148.

PMID:
29375136
3.

Retinal neuronal cell loss prevents abnormal retinal vascular growth in a rat model of retinopathy of prematurity.

Nakano A, Asano D, Kondo R, Mori A, Arima S, Ushikubo H, Sakamoto K, Nagamitsu T, Ishii K, Nakahara T.

Exp Eye Res. 2018 Mar;168:115-127. doi: 10.1016/j.exer.2017.12.007. Epub 2018 Feb 2.

PMID:
29339088
4.

Design and Synthesis of A-Ring Simplified Pyripyropene A Analogues as Potent and Selective Synthetic SOAT2 Inhibitors.

Ohtawa M, Arima S, Ichida N, Terayama T, Ohno H, Yamazaki T, Ohshiro T, Sato N, Omura S, Tomoda H, Nagamitsu T.

ChemMedChem. 2018 Mar 6;13(5):411-421. doi: 10.1002/cmdc.201700645. Epub 2018 Jan 30.

PMID:
29323466
5.

Transient phenotypic changes in endothelial cells and pericytes in neonatal mouse retina following short-term blockade of vascular endothelial growth factor receptors.

Morita A, Mori A, Arima S, Sakamoto K, Nagamitsu T, Ishii K, Nakahara T.

Dev Dyn. 2018 May;247(5):699-711. doi: 10.1002/dvdy.24614. Epub 2018 Jan 5.

PMID:
29247590
6.

Scopranones with Two Atypical Scooplike Moieties Produced by Streptomyces sp. BYK-11038.

Uchida R, Lee D, Suwa I, Ohtawa M, Watanabe N, Demachi A, Ohte S, Katagiri T, Nagamitsu T, Tomoda H.

Org Lett. 2017 Nov 3;19(21):5980-5983. doi: 10.1021/acs.orglett.7b03003.

PMID:
29063763
7.

Insecticide Susceptibility in Asian Honey Bees (Apis cerana (Hymenoptera: Apidae)) and Implications for Wild Honey Bees in Asia.

Yasuda M, Sakamoto Y, Goka K, Nagamitsu T, Taki H.

J Econ Entomol. 2017 Apr 1;110(2):447-452. doi: 10.1093/jee/tox032.

PMID:
28334064
8.

Development of a new air-stable structure-simplified nafuredin-γ analog as a potent and selective nematode complex I inhibitor.

Ohtawa M, Arima S, Shimizu R, Hanatani N, Shimizu E, Shiomi K, Kita K, Ōmura S, Nagamitsu T.

J Antibiot (Tokyo). 2017 May;70(5):647-654. doi: 10.1038/ja.2017.16. Epub 2017 Feb 22.

PMID:
28223689
9.

A delay in vascularization induces abnormal astrocyte proliferation and migration in the mouse retina.

Morita A, Ushikubo H, Mori A, Arima S, Sakamoto K, Nagamitsu T, Ishii K, Nakahara T.

Dev Dyn. 2017 Mar;246(3):186-200. doi: 10.1002/dvdy.24484. Epub 2017 Feb 3.

10.

Genetic Structure and Potential Environmental Determinants of Local Genetic Diversity in Japanese Honeybees (Apis cerana japonica).

Nagamitsu T, Yasuda M, Saito-Morooka F, Inoue MN, Nishiyama M, Goka K, Sugiura S, Maeto K, Okabe K, Taki H.

PLoS One. 2016 Nov 29;11(11):e0167233. doi: 10.1371/journal.pone.0167233. eCollection 2016.

11.

Synthesis and Structural Revision of Cyslabdan.

Ohtawa M, Hishinuma Y, Takagi E, Yamada T, Ito F, Arima S, Uchida R, Kim YP, Ōmura S, Tomoda H, Nagamitsu T.

Chem Pharm Bull (Tokyo). 2016;64(9):1370-7. doi: 10.1248/cpb.c16-00382.

12.

Simplifungin and Valsafungins, Antifungal Antibiotics of Fungal Origin.

Ishijima H, Uchida R, Ohtawa M, Kondo A, Nagai K, Shima K, Nonaka K, Masuma R, Iwamoto S, Onodera H, Nagamitsu T, Tomoda H.

J Org Chem. 2016 Sep 2;81(17):7373-83. doi: 10.1021/acs.joc.6b00952. Epub 2016 Aug 19.

PMID:
27400027
13.
14.

New pyripyropene A derivatives, highly SOAT2-selective inhibitors, improve hypercholesterolemia and atherosclerosis in atherogenic mouse models.

Ohshiro T, Ohtawa M, Nagamitsu T, Matsuda D, Yagyu H, Davis MA, Rudel LL, Ishibashi S, Tomoda H.

J Pharmacol Exp Ther. 2015 Nov;355(2):299-307. doi: 10.1124/jpet.115.227348. Epub 2015 Sep 3.

15.

Design, synthesis, and biological evaluation of air-stable nafuredin-γ analogs as complex I inhibitors.

Ohtawa M, Matsunaga M, Fukunaga K, Shimizu R, Shimizu E, Arima S, Ohmori J, Kita K, Shiomi K, Omura S, Nagamitsu T.

Bioorg Med Chem. 2015 Mar 1;23(5):932-43. doi: 10.1016/j.bmc.2015.01.030. Epub 2015 Jan 22.

PMID:
25659618
16.

Novel terpenes generated by heterologous expression of bacterial terpene synthase genes in an engineered Streptomyces host.

Yamada Y, Arima S, Nagamitsu T, Johmoto K, Uekusa H, Eguchi T, Shin-ya K, Cane DE, Ikeda H.

J Antibiot (Tokyo). 2015 Jun;68(6):385-94. doi: 10.1038/ja.2014.171. Epub 2015 Jan 21.

17.

Synthesis and biological activity of 5-(4-methoxyphenyl)-oxazole derivatives.

Yamamuro D, Uchida R, Ohtawa M, Arima S, Futamura Y, Katane M, Homma H, Nagamitsu T, Osada H, Tomoda H.

Bioorg Med Chem Lett. 2015 Jan 15;25(2):313-6. doi: 10.1016/j.bmcl.2014.11.042. Epub 2014 Nov 22.

PMID:
25488842
18.

Sex expression and inbreeding depression in progeny derived from an extraordinary hermaphrodite of Salix subfragilis.

Nagamitsu T, Futamura N.

Bot Stud. 2014 Dec;55(1):3. doi: 10.1186/1999-3110-55-3. Epub 2014 Jan 14.

19.

In vitro metabolism of pyripyropene A and ACAT inhibitory activity of its metabolites.

Matsuda D, Ohshiro T, Ohtawa M, Yamazaki H, Nagamitsu T, Tomoda H.

J Antibiot (Tokyo). 2015 Jan;68(1):27-34. doi: 10.1038/ja.2014.91. Epub 2014 Jul 9.

PMID:
25005817
20.

Treatment of mid-pregnant mice with KRN633, an inhibitor of vascular endothelial growth factor receptor tyrosine kinase, induces abnormal retinal vascular patterning in their newborn pups.

Morita A, Nakahara T, Abe N, Kurauchi Y, Mori A, Sakamoto K, Nagamitsu T, Ishii K.

Birth Defects Res B Dev Reprod Toxicol. 2014 Aug;101(4):293-9. doi: 10.1002/bdrb.21112. Epub 2014 May 15.

PMID:
24831925
21.

Synthesis and biological activity of Citridone A and its derivatives.

Fukuda T, Shimoyama K, Nagamitsu T, Tomoda H.

J Antibiot (Tokyo). 2014 Jun;67(6):445-50. doi: 10.1038/ja.2014.14. Epub 2014 Mar 19.

PMID:
24643052
22.

Effects of pre- and post-natal treatment with KRN633, an inhibitor of vascular endothelial growth factor receptor tyrosine kinase, on retinal vascular development and patterning in mice.

Morita A, Nakahara T, Abe N, Kurauchi Y, Mori A, Sakamoto K, Nagamitsu T, Ishii K.

Exp Eye Res. 2014 Mar;120:127-37. doi: 10.1016/j.exer.2014.01.009. Epub 2014 Jan 23.

PMID:
24462631
23.

KRN633, an inhibitor of vascular endothelial growth factor receptor tyrosine kinase, induces intrauterine growth restriction in mice.

Abe N, Nakahara T, Morita A, Wada Y, Mori A, Sakamoto K, Nagamitsu T, Ishii K.

Birth Defects Res B Dev Reprod Toxicol. 2013 Aug;98(4):297-303. doi: 10.1002/bdrb.21064. Epub 2013 Jun 18.

PMID:
23780833
24.

Genetic differentiation in Elaeocarpus photiniifolia (Elaeocarpaceae) associated with geographic distribution and habitat variation in the Bonin (Ogasawara) Islands.

Sugai K, Setsuko S, Nagamitsu T, Murakami N, Kato H, Yoshimaru H.

J Plant Res. 2013 Nov;126(6):763-74. doi: 10.1007/s10265-013-0571-5. Epub 2013 Jun 9.

PMID:
23748372
25.

Synthesis and structure-activity relationship of pyripyropene A derivatives as potent and selective acyl-CoA:cholesterol acyltransferase 2 (ACAT2) inhibitors: part 3.

Ohtawa M, Yamazaki H, Ohte S, Matsuda D, Ohshiro T, Rudel LL, Ōmura S, Tomoda H, Nagamitsu T.

Bioorg Med Chem Lett. 2013 Jul 1;23(13):3798-801. doi: 10.1016/j.bmcl.2013.04.075. Epub 2013 May 8.

PMID:
23711919
26.

Synthesis and structure-activity relationship of pyripyropene A derivatives as potent and selective acyl-CoA:cholesterol acyltransferase 2 (ACAT2) inhibitors: part 2.

Ohtawa M, Yamazaki H, Matsuda D, Ohshiro T, Rudel LL, Ōmura S, Tomoda H, Nagamitsu T.

Bioorg Med Chem Lett. 2013 May 1;23(9):2659-62. doi: 10.1016/j.bmcl.2013.02.088. Epub 2013 Mar 6.

PMID:
23535327
27.
28.

Synthesis and structure-activity relationship of pyripyropene A derivatives as potent and selective acyl-CoA:cholesterol acyltransferase 2 (ACAT2) inhibitors: part 1.

Ohtawa M, Yamazaki H, Ohte S, Matsuda D, Ohshiro T, Rudel LL, Omura S, Tomoda H, Nagamitsu T.

Bioorg Med Chem Lett. 2013 Mar 1;23(5):1285-7. doi: 10.1016/j.bmcl.2012.12.099. Epub 2013 Jan 9.

PMID:
23369538
29.

Role of vascular endothelial growth factor in maintenance of pregnancy in mice.

Wada Y, Ozaki H, Abe N, Mori A, Sakamoto K, Nagamitsu T, Nakahara T, Ishii K.

Endocrinology. 2013 Feb;154(2):900-10. doi: 10.1210/en.2012-1967. Epub 2013 Jan 10.

PMID:
23307787
30.

Stereoselective total synthesis of atpenins a4 and b, harzianopyridone, and NBRI23477 B.

Ohtawa M, Sugiyama K, Hiura T, Izawa S, Shiomi K, Omura S, Nagamitsu T.

Chem Pharm Bull (Tokyo). 2012;60(7):898-906.

31.

Impact of negative frequency-dependent selection on mating pattern and genetic structure: a comparative analysis of the S-locus and nuclear SSR loci in Prunus lannesiana var. speciosa.

Shuri K, Saika K, Junko K, Michiharu K, Nagamitsu T, Iwata H, Tsumura Y, Mukai Y.

Heredity (Edinb). 2012 Sep;109(3):188-98. doi: 10.1038/hdy.2012.29. Epub 2012 Jun 6.

32.

Potentiation of bleomycin in Jurkat cells by fungal pycnidione.

Kaneko M, Matsuda D, Ohtawa M, Fukuda T, Nagamitsu T, Yamori T, Tomoda H.

Biol Pharm Bull. 2012;35(1):18-28.

33.

Total synthesis and absolute configuration of avenolide, extracellular factor in Streptomyces avermitilis.

Uchida M, Takamatsu S, Arima S, Miyamoto KT, Kitani S, Nihira T, Ikeda H, Nagamitsu T.

J Antibiot (Tokyo). 2011 Dec;64(12):781-7. doi: 10.1038/ja.2011.90. Epub 2011 Oct 12. Erratum in: J Antibiot (Tokyo). 2018 Feb;71(2):348.

PMID:
21989459
34.

Avenolide, a Streptomyces hormone controlling antibiotic production in Streptomyces avermitilis.

Kitani S, Miyamoto KT, Takamatsu S, Herawati E, Iguchi H, Nishitomi K, Uchida M, Nagamitsu T, Omura S, Ikeda H, Nihira T.

Proc Natl Acad Sci U S A. 2011 Sep 27;108(39):16410-5. doi: 10.1073/pnas.1113908108. Epub 2011 Sep 19.

35.

Total synthesis of citridone A.

Miyagawa T, Nagai K, Yamada A, Sugihara Y, Fukuda T, Fukuda T, Uchida R, Tomoda H, Omura S, Nagamitsu T.

Org Lett. 2011 Mar 4;13(5):1158-61. doi: 10.1021/ol200022a. Epub 2011 Feb 9.

PMID:
21306130
36.

Effects of KRN633, an inhibitor of vascular endothelial growth factor receptor-2 tyrosine kinase, on vascular development of placenta and fetus of mid-pregnancy in mice.

Wada Y, Ozaki H, Abe N, Nagamitsu T, Ohta H, Nakahara T, Ishii K.

J Pharmacol Sci. 2010;112(3):290-8. Epub 2010 Mar 2.

37.

Structure and total synthesis of fungal calpinactam, a new antimycobacterial agent.

Koyama N, Kojima S, Fukuda T, Nagamitsu T, Yasuhara T, Omura S, Tomoda H.

Org Lett. 2010 Feb 5;12(3):432-5. doi: 10.1021/ol902553z.

PMID:
20030344
38.

Eighteen microsatellite loci in Salix arbutifolia (Salicaceae) and cross-species amplification in Salix and Populus species.

Hoshikawa T, Kikuchi S, Nagamitsu T, Tomaru N.

Mol Ecol Resour. 2009 Jul;9(4):1202-5. doi: 10.1111/j.1755-0998.2009.02607.x. Epub 2009 Mar 17.

PMID:
21564876
39.

Enantioselective total synthesis of atpenin A5.

Ohtawa M, Ogihara S, Sugiyama K, Shiomi K, Harigaya Y, Nagamitsu T, Omura S.

J Antibiot (Tokyo). 2009 Jun;62(6):289-94. doi: 10.1038/ja.2009.29. Epub 2009 Apr 17.

PMID:
19373276
40.

Total synthesis of amidepsine B and revision of its absolute configuration.

Nagamitsu T, Marumoto K, Nagayasu A, Fukuda T, Arima S, Uchida R, Ohshiro T, Harigaya Y, Tomoda H, Omura S.

J Antibiot (Tokyo). 2009 Feb;62(2):69-74. doi: 10.1038/ja.2008.12. Epub 2009 Jan 23.

PMID:
19198634
41.

Selectivity of pyripyropene derivatives in inhibition toward acyl-CoA:cholesterol acyltransferase 2 isozyme.

Ohshiro T, Ohte S, Matsuda D, Ohtawa M, Nagamitsu T, Sunazuka T, Harigaya Y, Rudel LL, Omura S, Tomoda H.

J Antibiot (Tokyo). 2008 Aug;61(8):503-8. doi: 10.1038/ja.2008.67.

PMID:
18997389
42.

Population fluctuations of light-attracted chrysomelid beetles in relation to supra-annual environmental changes in a Bornean rainforest.

Kishimoto-Yamada K, Itioka T, Sakai S, Momose K, Nagamitsu T, Kaliang H, Meleng P, Chong L, Hamid Karim AA, Yamane S, Kato M, Reid CA, Nakashizuka T, Inoue T.

Bull Entomol Res. 2009 Jun;99(3):217-27. doi: 10.1017/S000748530800624X. Epub 2008 Oct 31.

PMID:
18976509
43.

Total synthesis of salinosporamide A.

Fukuda T, Sugiyama K, Arima S, Harigaya Y, Nagamitsu T, Omura S.

Org Lett. 2008 Oct 2;10(19):4239-42. doi: 10.1021/ol8016066. Epub 2008 Sep 3.

PMID:
18763797
44.

Total synthesis of borrelidin.

Nagamitsu T, Takano D, Marumoto K, Fukuda T, Furuya K, Otoguro K, Takeda K, Kuwajima I, Harigaya Y, Omura S.

J Org Chem. 2007 Apr 13;72(8):2744-56. Epub 2007 Mar 14.

PMID:
17355148
45.

Structure elucidation of fungal sespendole, an inhibitor of lipid droplet synthesis in macrophages.

Uchida R, Kim YP, Nagamitsu T, Tomoda H, Omura S.

J Antibiot (Tokyo). 2006 Jun;59(6):338-44.

PMID:
16915817
46.

Azithromycin inhibits the formation of flagellar filaments without suppressing flagellin synthesis in Salmonella enterica serovar typhimurium.

Matsui H, Eguchi M, Ohsumi K, Nakamura A, Isshiki Y, Sekiya K, Kikuchi Y, Nagamitsu T, Masuma R, Sunazuka T, Omura S.

Antimicrob Agents Chemother. 2005 Aug;49(8):3396-403.

47.

Macrolides with promotive activity of monocyte to macrophage differentiation.

Yoshida K, Sunazuka T, Nagai K, Sugawara A, Cho A, Nagamitsu T, Harigaya Y, Otoguro K, Akagawa KS, Omura S.

J Antibiot (Tokyo). 2005 Jan;58(1):79-81. No abstract available.

PMID:
15813186
48.

A gamma-lactone form nafuredin, nafuredin-gamma, also inhibits helminth complex I.

Shiomi K, Ui H, Suzuki H, Hatano H, Nagamitsu T, Takano D, Miyadera H, Yamashita T, Kita K, Miyoshi H, Harder A, Tomoda H, Omura S.

J Antibiot (Tokyo). 2005 Jan;58(1):50-5.

PMID:
15813180
49.

Total synthesis of (-)-borrelidin.

Nagamitsu T, Takano D, Fukuda T, Otoguro K, Kuwajima I, Harigaya Y, Omura S.

Org Lett. 2004 May 27;6(11):1865-7.

PMID:
15151434
50.

Total synthesis of nafuredin, a selective NADH-fumarate reductase inhibitor.

Takano D, Nagamitsu T, Ui H, Shiomi K, Yamaguchi Y, Masuma R, Kuwajima I, Omura S.

Org Lett. 2001 Jul 26;3(15):2289-91.

PMID:
11463298

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