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Items: 48


BBSome trains remove activated GPCRs from cilia by enabling passage through the transition zone.

Ye F, Nager AR, Nachury MV.

J Cell Biol. 2018 Feb 26. pii: jcb.201709041. doi: 10.1083/jcb.201709041. [Epub ahead of print]


A CRISPR-based screen for Hedgehog signaling provides insights into ciliary function and ciliopathies.

Breslow DK, Hoogendoorn S, Kopp AR, Morgens DW, Vu BK, Kennedy MC, Han K, Li A, Hess GT, Bassik MC, Chen JK, Nachury MV.

Nat Genet. 2018 Feb 19. doi: 10.1038/s41588-018-0054-7. [Epub ahead of print]


BORC Regulates the Axonal Transport of Synaptic Vesicle Precursors by Activating ARL-8.

Niwa S, Tao L, Lu SY, Liew GM, Feng W, Nachury MV, Shen K.

Curr Biol. 2017 Sep 11;27(17):2569-2578.e4. doi: 10.1016/j.cub.2017.07.013. Epub 2017 Aug 17.


Chemical structure-guided design of dynapyrazoles, cell-permeable dynein inhibitors with a unique mode of action.

Steinman JB, Santarossa CC, Miller RM, Yu LS, Serpinskaya AS, Furukawa H, Morimoto S, Tanaka Y, Nishitani M, Asano M, Zalyte R, Ondrus AE, Johnson AG, Ye F, Nachury MV, Fukase Y, Aso K, Foley MA, Gelfand VI, Chen JK, Carter AP, Kapoor TM.

Elife. 2017 May 19;6. pii: e25174. doi: 10.7554/eLife.25174.


Microtubules acquire resistance from mechanical breakage through intralumenal acetylation.

Xu Z, Schaedel L, Portran D, Aguilar A, Gaillard J, Marinkovich MP, Théry M, Nachury MV.

Science. 2017 Apr 21;356(6335):328-332. doi: 10.1126/science.aai8764.


Membrane traffic control by cytoskeletal and molecular machines.

Lee TH, Nachury MV.

Mol Biol Cell. 2017 Mar 15;28(6):697-698. doi: 10.1091/mbc.E16-11-0795. No abstract available.


Fifteen years of research on oral-facial-digital syndromes: from 1 to 16 causal genes.

Bruel AL, Franco B, Duffourd Y, Thevenon J, Jego L, Lopez E, Deleuze JF, Doummar D, Giles RH, Johnson CA, Huynen MA, Chevrier V, Burglen L, Morleo M, Desguerres I, Pierquin G, Doray B, Gilbert-Dussardier B, Reversade B, Steichen-Gersdorf E, Baumann C, Panigrahi I, Fargeot-Espaliat A, Dieux A, David A, Goldenberg A, Bongers E, Gaillard D, Argente J, Aral B, Gigot N, St-Onge J, Birnbaum D, Phadke SR, Cormier-Daire V, Eguether T, Pazour GJ, Herranz-Pérez V, Goldstein JS, Pasquier L, Loget P, Saunier S, Mégarbané A, Rosnet O, Leroux MR, Wallingford JB, Blacque OE, Nachury MV, Attie-Bitach T, Rivière JB, Faivre L, Thauvin-Robinet C.

J Med Genet. 2017 Jun;54(6):371-380. doi: 10.1136/jmedgenet-2016-104436. Epub 2017 Mar 13. Review.


Tubulin acetylation protects long-lived microtubules against mechanical ageing.

Portran D, Schaedel L, Xu Z, Théry M, Nachury MV.

Nat Cell Biol. 2017 Apr;19(4):391-398. doi: 10.1038/ncb3481. Epub 2017 Feb 27.


An Actin Network Dispatches Ciliary GPCRs into Extracellular Vesicles to Modulate Signaling.

Nager AR, Goldstein JS, Herranz-Pérez V, Portran D, Ye F, Garcia-Verdugo JM, Nachury MV.

Cell. 2017 Jan 12;168(1-2):252-263.e14. doi: 10.1016/j.cell.2016.11.036. Epub 2016 Dec 22.


Loss of the BBSome perturbs endocytic trafficking and disrupts virulence of Trypanosoma brucei.

Langousis G, Shimogawa MM, Saada EA, Vashisht AA, Spreafico R, Nager AR, Barshop WD, Nachury MV, Wohlschlegel JA, Hill KL.

Proc Natl Acad Sci U S A. 2016 Jan 19;113(3):632-7. doi: 10.1073/pnas.1518079113. Epub 2015 Dec 31.


Proteomics of Primary Cilia by Proximity Labeling.

Mick DU, Rodrigues RB, Leib RD, Adams CM, Chien AS, Gygi SP, Nachury MV.

Dev Cell. 2015 Nov 23;35(4):497-512. doi: 10.1016/j.devcel.2015.10.015. Epub 2015 Nov 12.


Cytoplasmic Dynein Antagonists with Improved Potency and Isoform Selectivity.

See SK, Hoogendoorn S, Chung AH, Ye F, Steinman JB, Sakata-Kato T, Miller RM, Cupido T, Zalyte R, Carter AP, Nachury MV, Kapoor TM, Chen JK.

ACS Chem Biol. 2016 Jan 15;11(1):53-60. doi: 10.1021/acschembio.5b00895. Epub 2015 Nov 11.


Microtubules self-repair in response to mechanical stress.

Schaedel L, John K, Gaillard J, Nachury MV, Blanchoin L, Théry M.

Nat Mater. 2015 Nov;14(11):1156-63. doi: 10.1038/nmat4396. Epub 2015 Sep 7.


Analysis of soluble protein entry into primary cilia using semipermeabilized cells.

Breslow DK, Nachury MV.

Methods Cell Biol. 2015;127:203-21. doi: 10.1016/bs.mcb.2014.12.006. Epub 2015 Feb 14.


Structural biology. Structural basis for Notch1 engagement of Delta-like 4.

Luca VC, Jude KM, Pierce NW, Nachury MV, Fischer S, Garcia KC.

Science. 2015 Feb 20;347(6224):847-53. doi: 10.1126/science.1261093.


The intraflagellar transport protein IFT27 promotes BBSome exit from cilia through the GTPase ARL6/BBS3.

Liew GM, Ye F, Nager AR, Murphy JP, Lee JS, Aguiar M, Breslow DK, Gygi SP, Nachury MV.

Dev Cell. 2014 Nov 10;31(3):265-78. doi: 10.1016/j.devcel.2014.09.004. Epub 2014 Oct 30.


Structural basis for membrane targeting of the BBSome by ARL6.

Mourão A, Nager AR, Nachury MV, Lorentzen E.

Nat Struct Mol Biol. 2014 Dec;21(12):1035-41. doi: 10.1038/nsmb.2920. Epub 2014 Nov 17.


How do cilia organize signalling cascades?

Nachury MV.

Philos Trans R Soc Lond B Biol Sci. 2014 Sep 5;369(1650). pii: 20130465. doi: 10.1098/rstb.2013.0465. Review.


The oral-facial-digital syndrome gene C2CD3 encodes a positive regulator of centriole elongation.

Thauvin-Robinet C, Lee JS, Lopez E, Herranz-Pérez V, Shida T, Franco B, Jego L, Ye F, Pasquier L, Loget P, Gigot N, Aral B, Lopes CA, St-Onge J, Bruel AL, Thevenon J, González-Granero S, Alby C, Munnich A, Vekemans M, Huet F, Fry AM, Saunier S, Rivière JB, Attié-Bitach T, Garcia-Verdugo JM, Faivre L, Mégarbané A, Nachury MV.

Nat Genet. 2014 Aug;46(8):905-11. doi: 10.1038/ng.3031. Epub 2014 Jul 6.


Α-tubulin K40 acetylation is required for contact inhibition of proliferation and cell-substrate adhesion.

Aguilar A, Becker L, Tedeschi T, Heller S, Iomini C, Nachury MV.

Mol Biol Cell. 2014 Jun 15;25(12):1854-66. doi: 10.1091/mbc.E13-10-0609. Epub 2014 Apr 17.


Effects of tubulin acetylation and tubulin acetyltransferase binding on microtubule structure.

Howes SC, Alushin GM, Shida T, Nachury MV, Nogales E.

Mol Biol Cell. 2014 Jan;25(2):257-66. doi: 10.1091/mbc.E13-07-0387. Epub 2013 Nov 13.


Cilia grow by taking a bite out of the cell.

Pierce NW, Nachury MV.

Dev Cell. 2013 Oct 28;27(2):126-127. doi: 10.1016/j.devcel.2013.10.013.


An in vitro assay for entry into cilia reveals unique properties of the soluble diffusion barrier.

Breslow DK, Koslover EF, Seydel F, Spakowitz AJ, Nachury MV.

J Cell Biol. 2013 Oct 14;203(1):129-47. doi: 10.1083/jcb.201212024. Epub 2013 Oct 7.


αTAT1 catalyses microtubule acetylation at clathrin-coated pits.

Montagnac G, Meas-Yedid V, Irondelle M, Castro-Castro A, Franco M, Shida T, Nachury MV, Benmerah A, Olivo-Marin JC, Chavrier P.

Nature. 2013 Oct 24;502(7472):567-70. doi: 10.1038/nature12571. Epub 2013 Oct 6.


Exome sequencing of Bardet-Biedl syndrome patient identifies a null mutation in the BBSome subunit BBIP1 (BBS18).

Scheidecker S, Etard C, Pierce NW, Geoffroy V, Schaefer E, Muller J, Chennen K, Flori E, Pelletier V, Poch O, Marion V, Stoetzel C, Strähle U, Nachury MV, Dollfus H.

J Med Genet. 2014 Feb;51(2):132-6. doi: 10.1136/jmedgenet-2013-101785. Epub 2013 Sep 11.


Single molecule imaging reveals a major role for diffusion in the exploration of ciliary space by signaling receptors.

Ye F, Breslow DK, Koslover EF, Spakowitz AJ, Nelson WJ, Nachury MV.

Elife. 2013 Aug 6;2:e00654. doi: 10.7554/eLife.00654.


Structure of the α-tubulin acetyltransferase, αTAT1, and implications for tubulin-specific acetylation.

Friedmann DR, Aguilar A, Fan J, Nachury MV, Marmorstein R.

Proc Natl Acad Sci U S A. 2012 Nov 27;109(48):19655-60. doi: 10.1073/pnas.1209357109. Epub 2012 Oct 15.


A novel protein LZTFL1 regulates ciliary trafficking of the BBSome and Smoothened.

Seo S, Zhang Q, Bugge K, Breslow DK, Searby CC, Nachury MV, Sheffield VC.

PLoS Genet. 2011 Nov;7(11):e1002358. doi: 10.1371/journal.pgen.1002358. Epub 2011 Nov 3.


Give chance a chance.

Nachury MV.

Mol Biol Cell. 2011 Nov;22(21):3919-20. doi: 10.1091/mbc.E11-05-0453.


Primary cilia: how to keep the riff-raff in the plasma membrane.

Breslow DK, Nachury MV.

Curr Biol. 2011 Jun 7;21(11):R434-6. doi: 10.1016/j.cub.2011.04.039.


Primary cilia membrane assembly is initiated by Rab11 and transport protein particle II (TRAPPII) complex-dependent trafficking of Rabin8 to the centrosome.

Westlake CJ, Baye LM, Nachury MV, Wright KJ, Ervin KE, Phu L, Chalouni C, Beck JS, Kirkpatrick DS, Slusarski DC, Sheffield VC, Scheller RH, Jackson PK.

Proc Natl Acad Sci U S A. 2011 Feb 15;108(7):2759-64. doi: 10.1073/pnas.1018823108. Epub 2011 Jan 27.


The major alpha-tubulin K40 acetyltransferase alphaTAT1 promotes rapid ciliogenesis and efficient mechanosensation.

Shida T, Cueva JG, Xu Z, Goodman MB, Nachury MV.

Proc Natl Acad Sci U S A. 2010 Dec 14;107(50):21517-22. doi: 10.1073/pnas.1013728107. Epub 2010 Nov 10.


The conserved Bardet-Biedl syndrome proteins assemble a coat that traffics membrane proteins to cilia.

Jin H, White SR, Shida T, Schulz S, Aguiar M, Gygi SP, Bazan JF, Nachury MV.

Cell. 2010 Jun 25;141(7):1208-19. doi: 10.1016/j.cell.2010.05.015.


A septin diffusion barrier at the base of the primary cilium maintains ciliary membrane protein distribution.

Hu Q, Milenkovic L, Jin H, Scott MP, Nachury MV, Spiliotis ET, Nelson WJ.

Science. 2010 Jul 23;329(5990):436-9. doi: 10.1126/science.1191054. Epub 2010 Jun 17.


The perennial organelle: assembly and disassembly of the primary cilium.

Seeley ES, Nachury MV.

J Cell Sci. 2010 Feb 15;123(Pt 4):511-8. doi: 10.1242/jcs.061093. Review.


Trafficking to the ciliary membrane: how to get across the periciliary diffusion barrier?

Nachury MV, Seeley ES, Jin H.

Annu Rev Cell Dev Biol. 2010;26:59-87. doi: 10.1146/annurev.cellbio.042308.113337. Review.


The BBSome.

Jin H, Nachury MV.

Curr Biol. 2009 Jun 23;19(12):R472-3. doi: 10.1016/j.cub.2009.04.015. No abstract available.


Constructing and deconstructing roles for the primary cilium in tissue architecture and cancer.

Seeley ES, Nachury MV.

Methods Cell Biol. 2009;94:299-313. doi: 10.1016/S0091-679X(08)94015-2. Epub 2009 Dec 23. Review.


A BBSome subunit links ciliogenesis, microtubule stability, and acetylation.

Loktev AV, Zhang Q, Beck JS, Searby CC, Scheetz TE, Bazan JF, Slusarski DC, Sheffield VC, Jackson PK, Nachury MV.

Dev Cell. 2008 Dec;15(6):854-65. doi: 10.1016/j.devcel.2008.11.001.


The nucleolar phosphatase Cdc14B is dispensable for chromosome segregation and mitotic exit in human cells.

Berdougo E, Nachury MV, Jackson PK, Jallepalli PV.

Cell Cycle. 2008 May 1;7(9):1184-90. Epub 2008 Feb 13.


Tandem affinity purification of the BBSome, a critical regulator of Rab8 in ciliogenesis.

Nachury MV.

Methods Enzymol. 2008;439:501-13. doi: 10.1016/S0076-6879(07)00434-X.


The END network couples spindle pole assembly to inhibition of the anaphase-promoting complex/cyclosome in early mitosis.

Ban KH, Torres JZ, Miller JJ, Mikhailov A, Nachury MV, Tung JJ, Rieder CL, Jackson PK.

Dev Cell. 2007 Jul;13(1):29-42.


A core complex of BBS proteins cooperates with the GTPase Rab8 to promote ciliary membrane biogenesis.

Nachury MV, Loktev AV, Zhang Q, Westlake CJ, Peränen J, Merdes A, Slusarski DC, Scheller RH, Bazan JF, Sheffield VC, Jackson PK.

Cell. 2007 Jun 15;129(6):1201-13.


Emi1 stably binds and inhibits the anaphase-promoting complex/cyclosome as a pseudosubstrate inhibitor.

Miller JJ, Summers MK, Hansen DV, Nachury MV, Lehman NL, Loktev A, Jackson PK.

Genes Dev. 2006 Sep 1;20(17):2410-20. Epub 2006 Aug 18.


Importin beta is a mitotic target of the small GTPase Ran in spindle assembly.

Nachury MV, Maresca TJ, Salmon WC, Waterman-Storer CM, Heald R, Weis K.

Cell. 2001 Jan 12;104(1):95-106.


The direction of transport through the nuclear pore can be inverted.

Nachury MV, Weis K.

Proc Natl Acad Sci U S A. 1999 Aug 17;96(17):9622-7.


Cloning and characterization of hSRP1 gamma, a tissue-specific nuclear transport factor.

Nachury MV, Ryder UW, Lamond AI, Weis K.

Proc Natl Acad Sci U S A. 1998 Jan 20;95(2):582-7.

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